The network for 'negative regulation of metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

NameDescriptionProbabilityFunc Analog Organism
pha-4Protein PHA-40.889
egl-18Protein EGL-180.805
vab-3Protein VAB-30.770
lmn-1Protein LMN-10.718
egl-13Protein EGL-130.589
npp-7Protein NPP-70.547
nhr-67Protein NHR-670.527
zip-7Protein ZIP-70.497
cacn-1Protein CACN-10.477
his-16Protein HIS-160.451
lin-66Protein LIN-660.436
snr-2Protein SNR-20.427
hcp-3Protein HCP-30.423
fkb-6Protein FKB-60.421
elt-6Protein ELT-60.417
kle-2Protein KLE-20.412
CELE_C17E4.6Protein C17E4.60.411
hlh-11Protein HLH-110.406
unc-62Protein UNC-620.400
nhr-6Protein NHR-60.394
his-5Protein HIS-50.392
lsy-2Protein LSY-20.389
rsp-1Protein RSP-10.382
sma-6Protein SMA-60.376
hlh-2Protein HLH-20.370
oma-2Protein OMA-20.366
his-1Protein HIS-10.364
CELE_C24H12.5Protein C24H12.50.362
glp-1Protein GLP-10.359
unc-37Protein UNC-370.359
jmjd-2Protein JMJD-20.357
csn-4Protein CSN-40.342
atn-1Protein ATN-10.338
lin-53Protein LIN-530.338
his-31Protein HIS-310.333
npp-4Protein NPP-40.332
his-45Protein HIS-450.325
egg-6Protein EGG-60.325
hlh-1Protein HLH-10.324
mom-4Protein MOM-40.323
unc-59Protein UNC-590.317
hrp-1Protein HRP-10.311
F22B3.4Protein F22B3.40.310
hum-5Protein HUM-50.310
pry-1Protein PRY-10.310
CELE_C25A1.4Protein C25A1.40.306
zyg-1Protein ZYG-10.304
CELE_C23G10.8Protein C23G10.80.301
CELE_F58A4.2Protein F58A4.20.298
F33D11.10Protein F33D11.100.297
C32D5.11Protein C32D5.110.296
egl-46Protein EGL-460.290
asb-2Protein ASB-20.290
mdf-2Protein MDF-20.289
tam-1Protein TAM-10.289
klp-19Protein KLP-190.289
uaf-1Protein UAF-10.287
dpf-3Protein DPF-30.285
tbx-8Protein TBX-80.284
plk-1Protein PLK-10.283
spc-1Protein SPC-10.282
his-52Protein HIS-520.277
B0336.3Protein B0336.30.276
cids-2Protein CIDS-20.272
F25H5.5Protein F25H5.50.269
gls-1Protein GLS-10.268
madf-5Protein MADF-50.267
F21A10.2Protein F21A10.20.267
ceh-22Protein CEH-220.264
his-50Protein HIS-500.260
atg-2Protein ATG-20.259
zyg-9Protein ZYG-90.259
his-42Protein HIS-420.257
dlc-1Protein DLC-10.257
eat-4Protein EAT-40.253
swsn-3Protein SWSN-30.253
ima-3Protein IMA-30.252
egl-15Protein EGL-150.250
sea-2Protein SEA-20.248
brc-1Protein BRC-10.245
Y17G7B.20Protein Y17G7B.200.245
D1081.8Protein D1081.80.243
mcm-4Protein MCM-40.242
mab-5Protein MAB-50.235
age-1Protein AGE-10.235
lin-11Protein LIN-110.232
F56C9.10Protein F56C9.100.231
vps-33.2Protein VPS-33.20.230
aap-1Protein AAP-10.228
rnp-7Protein RNP-70.228
his-3Protein HIS-30.226
his-39Protein HIS-390.221
rad-26Protein RAD-260.220
CELE_C17H12.13Protein C17H12.130.220
alg-2Protein ALG-20.220
T28C6.7Protein T28C6.70.220
egl-44Protein EGL-440.219
F11E6.7Protein F11E6.70.215
Y42H9AR.4Protein Y42H9AR.40.215
oac-46Protein OAC-460.214
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fgf3fibroblast growth factor 30.887
gata6GATA-binding protein 60.849
dlx3bdistal-less homeobox gene 3b0.793
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.738
fgf8afibroblast growth factor 8 a0.651
otpborthopedia homolog b0.586
ndr2nodal-related 20.559
foxi1forkhead box I10.558
tp53tumor protein p530.549
dusp6dual specificity phosphatase 60.506
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.495
pkd2polycystic kidney disease 20.474
etv5bets variant 5b0.458
pax8paired box gene 80.451
nclnucleolin0.443
dlx1adistal-less homeobox gene 1a0.439
zfp36l1azinc finger protein 36, C3H type-like 1a0.438
gli1GLI-Kruppel family member 10.433
inspreproinsulin0.423
sall1asal-like 1a (Drosophila)0.420
tgfb3transforming growth factor, beta 30.417
fzd8afrizzled homolog 8a0.415
spry4sprouty (Drosophila) homolog 40.403
gro1groucho 10.402
sox9bSRY-box containing gene 9b0.399
ntlano tail a0.395
tbx18T-box 180.392
gata5GATA-binding protein 50.392
klf4Kruppel-like factor 40.389
cav1caveolin 10.380
socs3asuppressor of cytokine signaling 3a0.363
tfap2atranscription factor AP-2 alpha0.362
pou3f3aPOU class 3 homeobox 3a0.359
fgf19fibroblast growth factor 190.358
igf1rbinsulin-like growth factor 1b receptor0.344
jag1bjagged 1b0.341
snai1bsnail homolog 1b (Drosophila)0.337
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.336
pou3f2POU class 3 homeobox 20.336
ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.334
tfebtranscription factor EB0.323
robo3roundabout homolog 30.318
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.309
sox19aSRY-box containing gene 19a0.308
ascl1aachaete-scute complex-like 1a (Drosophila)0.303
her8ahairy-related 8a0.301
runx1runt-related transcription factor 10.297
junjun proto-oncogene0.296
bmp2bbone morphogenetic protein 2b0.294
dag1dystroglycan 10.292
lhx1aLIM homeobox 1a0.292
bocbrother of CDO0.292
tal1T-cell acute lymphocytic leukemia 10.287
dctdopachrome tautomerase0.282
runx2brunt-related transcription factor 2b0.277
srsf2serine/arginine-rich splicing factor 20.276
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.274
mchr1bmelanin-concentrating hormone receptor 1b0.273
pcnaproliferating cell nuclear antigen0.269
furinafurin (paired basic amino acid cleaving enzyme) a0.266
tbx1T-box 10.263
satb2SATB homeobox 20.261
tbx6T-box gene 60.250
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.243
eomesaeomesodermin homolog a0.241
gdnfglial cell derived neurotrophic factor0.239
hp1bp3heterochromatin protein 1, binding protein 30.233
fgf20afibroblast growth factor 20a0.232
ezh2enhancer of zeste homolog 2 (Drosophila)0.230
ppargperoxisome proliferator activated receptor gamma0.229
notch1anotch homolog 1a0.228
her7hairy and enhancer of split related-70.227
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.227
supt5hsuppressor of Ty 5 homolog (S. cerevisiae)0.226
fzd7afrizzled homolog 7a0.225
sox11bSRY-box containing gene 11b0.223
nkx2.3NK2 transcription factor related 30.222
whsc1Wolf-Hirschhorn syndrome candidate 10.221
hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.217
tll1tolloid-like 10.216
alcambactivated leukocyte cell adhesion molecule b0.215
smosmoothened homolog (Drosophila)0.213
rad21RAD21 homolog (S. pombe)0.212
acvr1lactivin A receptor, type I like0.209
jag2jagged 20.208
birc5bbaculoviral IAP repeat-containing 5B0.207
flot2aflotillin 2a0.207
tshz1teashirt family zinc finger 10.204
metmet proto-oncogene (hepatocyte growth factor receptor)0.203
wnt5bwingless-type MMTV integration site family, member 5b0.197
tardbpTAR DNA binding protein0.197
zff9zinc finger protein 90.197
emx3empty spiracles homeobox 30.196
cry1acryptochrome 1a0.194
nfe2l2nuclear factor (erythroid-derived 2)-like 20.193
ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.193
junbjun B proto-oncogene0.191
hnrnpkheterogeneous nuclear ribonucleoprotein K0.189
sox4aSRY-box containing gene 4a0.188
robo1roundabout homolog 10.187
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
JunJun oncogene0.665
Nedd4neural precursor cell expressed, developmentally down-regulated 40.548
Tgfbr2transforming growth factor, beta receptor II0.543
Cd9CD9 molecule0.536
Zfp36zinc finger protein 360.516
Hand2heart and neural crest derivatives expressed 20.514
Nfyanuclear transcription factor-Y alpha0.513
FosFBJ osteosarcoma oncogene0.463
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.459
Creb1cAMP responsive element binding protein 10.456
Sfrs1splicing factor, arginine/serine-rich 10.455
Vimvimentin0.436
Dlg1discs, large homolog 1 (Drosophila)0.432
Ifitm3interferon induced transmembrane protein 30.423
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.422
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.419
Mapk3mitogen activated protein kinase 30.414
Eif4heukaryotic translation initiation factor 4H0.414
Casp2caspase 20.398
Cd63Cd63 molecule0.394
S100a10S100 calcium binding protein A100.392
Rhocras homolog gene family, member C0.391
Metmet proto-oncogene0.389
Btg2BTG family, member 20.386
Dusp1dual specificity phosphatase 10.378
Hoxc4homeo box C40.375
Errfi1ERBB receptor feedback inhibitor 10.372
Junbjun B proto-oncogene0.372
Calcrlcalcitonin receptor-like0.371
Hspb1heat shock protein 10.369
Tcfe2atranscription factor E2a0.368
Dchs1dachsous 1 (Drosophila)0.368
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.363
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.358
Gja1gap junction protein, alpha 10.357
LOC100363106LRRG00130-like0.350
Hnrpdheterogeneous nuclear ribonucleoprotein D0.343
Synposynaptopodin0.340
Ptmsparathymosin0.336
Pim1pim-1 oncogene0.328
Kdm6blysine (K)-specific demethylase 6B0.328
Nek9NIMA (never in mitosis gene a)- related kinase 90.326
Stat3signal transducer and activator of transcription 30.324
Prrx1paired related homeobox 10.323
Klf9Kruppel-like factor 90.320
Anxa4annexin A40.320
Phkg1phosphorylase kinase, gamma 10.316
Atp1b3ATPase, Na+/K+ transporting, beta 3 polypeptide0.311
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.310
Fgd4FYVE, RhoGEF and PH domain containing 40.310
Fgafibrinogen alpha chain0.309
Stat5bsignal transducer and activator of transcription 5B0.306
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.305
Dynll1dynein light chain LC8-type 10.300
Foxd3forkhead box D30.300
Slco2a1solute carrier organic anion transporter family, member 2a10.300
Nrasneuroblastoma ras oncogene0.298
Myo1bmyosin Ib0.296
Gfi1growth factor independent 1 transcription repressor0.295
Klf6Kruppel-like factor 60.295
Hes1hairy and enhancer of split 1 (Drosophila)0.293
Top2atopoisomerase (DNA) II alpha0.290
Smad7SMAD family member 70.288
Rhobras homolog gene family, member B0.287
Hspd1heat shock protein 1 (chaperonin)0.285
Lig3ligase III, DNA, ATP-dependent0.281
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.279
Chrna7cholinergic receptor, nicotinic, alpha 70.279
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.276
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.275
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.275
Anxa5annexin A50.270
Ier2immediate early response 20.268
Ahraryl hydrocarbon receptor0.267
Hoxd3homeo box D30.265
Siah1aseven in absentia 1A0.265
Pou3f2POU class 3 homeobox 20.264
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.263
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.262
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.261
Fgf18fibroblast growth factor 180.260
Ncanneurocan0.256
Procprotein C0.255
Serpinb7serpin peptidase inhibitor, clade B (ovalbumin), member 70.255
Nr2f2nuclear receptor subfamily 2, group F, member 20.254
Asgr1asialoglycoprotein receptor 10.253
Metap2methionyl aminopeptidase 20.251
Smad3SMAD family member 30.248
Bcl2B-cell CLL/lymphoma 20.248
Hnrnprheterogeneous nuclear ribonucleoprotein R0.247
Anxa2annexin A20.247
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.244
Tefthyrotrophic embryonic factor0.243
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.243
Irs1insulin receptor substrate 10.242
Pcnaproliferating cell nuclear antigen0.239
Ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.239
Pzppregnancy-zone protein0.237
FaslgFas ligand (TNF superfamily, member 6)0.237
S100a6S100 calcium binding protein A60.237
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism