The network for 'negative regulation of neurogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of neurogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons.

NameDescriptionProbabilityFunc Analog Organism
pha-4Protein PHA-40.633
egl-18Protein EGL-180.575
pry-1Protein PRY-10.216
ten-1Protein TEN-10.193
egl-46Protein EGL-460.131
irx-1Protein IRX-10.126
let-60Protein LET-600.123
hlh-1Protein HLH-10.120
somi-1Protein SOMI-10.116
vab-10Protein VAB-100.113
exc-5Protein EXC-50.087
ceh-22Protein CEH-220.081
tbb-4Protein TBB-40.081
lrp-2Protein LRP-20.080
hlh-2Protein HLH-20.078
B0491.5Protein B0491.50.078
atg-2Protein ATG-20.077
F29B9.11Protein F29B9.110.076
lin-11Protein LIN-110.074
gln-1Protein GLN-10.072
vab-3Protein VAB-30.071
clh-5Protein CLH-50.070
elc-1Protein ELC-10.069
cnd-1Protein CND-10.067
unc-73Protein UNC-730.067
F11D5.1Protein F11D5.10.067
eor-1Protein EOR-10.064
lag-2Protein LAG-20.064
ina-1Protein INA-10.063
bar-1Protein BAR-10.062
trim-9Protein TRIM-90.060
pop-1Protein POP-10.060
ncam-1Protein NCAM-10.059
flh-1Protein FLH-10.057
nhr-14Protein NHR-140.057
F36D4.5Protein F36D4.50.057
sel-12Protein SEL-120.055
tag-303Protein TAG-3030.055
fmi-1Protein FMI-10.054
ptr-2Protein PTR-20.054
sel-10Protein SEL-100.052
sel-8Protein SEL-80.052
pig-1Protein PIG-10.052
ain-1Protein AIN-10.052
sur-2Protein SUR-20.052
wrm-1Protein WRM-10.052
cpna-1Protein CPNA-10.052
tbx-8Protein TBX-80.052
phat-5Protein PHAT-50.051
CELE_Y64G10A.7Protein Y64G10A.70.051
plc-1Protein PLC-10.050
cls-1Protein CLS-10.050
elt-6Protein ELT-60.050
lin-17Protein LIN-170.050
R10E12.2Protein R10E12.20.050
C06E4.2Protein C06E4.20.050
F43D9.1Protein F43D9.10.049
tlk-1Protein TLK-10.049
odd-2Protein ODD-20.049
ard-1Protein ARD-10.049
ceh-27Protein CEH-270.048
F28E10.1Protein F28E10.10.048
sdz-28Protein SDZ-280.048
nhr-67Protein NHR-670.048
rbr-2Protein RBR-20.048
hlh-30Protein HLH-300.047
pept-3Protein PEPT-30.047
Y47D3B.11Protein Y47D3B.110.047
hmp-1Protein HMP-10.046
plx-2Protein PLX-20.046
egl-36Protein EGL-360.046
ajm-1Protein AJM-10.045
hnd-1Protein HND-10.045
mom-2Protein MOM-20.045
swsn-7Protein SWSN-70.044
syg-1Protein SYG-10.044
CELE_B0513.5Protein B0513.50.044
saeg-1Protein SAEG-10.044
ttx-1Protein TTX-10.044
jac-1Protein JAC-10.044
unc-62Protein UNC-620.044
sel-7Protein SEL-70.043
lntl-1Protein LNTL-10.043
fem-3Protein FEM-30.043
cfz-2Protein CFZ-20.042
mef-2Protein MEF-20.042
F18E9.3Protein F18E9.30.042
lim-8Protein LIM-80.042
ast-1Protein AST-10.042
unc-129Protein UNC-1290.041
daf-3Protein DAF-30.041
pax-3Protein PAX-30.041
CELE_T04H1.2Protein T04H1.20.040
crm-1Protein CRM-10.040
cav-1Protein CAV-10.040
let-526Protein LET-5260.039
pde-4Protein PDE-40.039
pal-1Protein PAL-10.039
nhr-2Protein NHR-20.039
mbk-2Protein MBK-20.039
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cdh2cadherin 2, neuronal0.984
alcamaactivated leukocyte cell adhesion molecule a0.955
ascl1aachaete-scute complex-like 1a (Drosophila)0.902
ptf1apancreas specific transcription factor, 1a0.895
tbx2bT-box 2b0.824
pax6apaired box gene 6a0.823
dlcdeltaC0.808
gli1GLI-Kruppel family member 10.781
pax2apaired box gene 2a0.774
dlddeltaD0.769
shhasonic hedgehog a0.743
dladeltaA0.704
gli2aGLI-Kruppel family member GLI2a0.694
tbx1T-box 10.629
neo1neogenin 10.612
fzd7afrizzled homolog 7a0.546
notch1anotch homolog 1a0.541
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.540
robo2roundabout homolog 20.501
foxa1forkhead box A10.469
neurod4neurogenic differentiation 40.449
foxd3forkhead box D30.443
otpborthopedia homolog b0.435
jag2jagged 20.401
wnt11rwingless-type MMTV integration site family, member 11, related0.395
chdchordin0.359
atoh1aatonal homolog 1a0.358
fgf8afibroblast growth factor 8 a0.342
barhl2BarH-like 20.326
notch3notch homolog 30.268
sox11bSRY-box containing gene 11b0.266
foxi1forkhead box I10.260
lef1lymphocyte enhancer binding factor 10.256
fzd10frizzled homolog 100.252
bocbrother of CDO0.245
kal1aKallmann syndrome 1a sequence0.209
phox2apaired-like homeobox 2a0.208
tp53tumor protein p530.203
pax7apaired box gene 7a0.200
her12hairy-related 120.196
otx2orthodenticle homolog 20.190
neurog1neurogenin 10.185
ascl1bachaete-scute complex-like 1b (Drosophila)0.177
fgfr2fibroblast growth factor receptor 20.176
shhbsonic hedgehog b0.173
irx1airoquois homeobox protein 1, a0.170
hoxb2ahomeo box B2a0.167
mecomMDS1 and EVI1 complex locus0.165
olig2oligodendrocyte lineage transcription factor 20.164
efnb1ephrin B10.164
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.162
foxp2forkhead box P20.158
irx5airoquois homeobox protein 5a0.153
dlbdeltaB0.151
nkx2.5NK2 transcription factor related 50.143
her7hairy and enhancer of split related-70.142
pbx4pre-B-cell leukemia transcription factor 40.141
bdnfbrain-derived neurotrophic factor0.139
aldh1a2aldehyde dehydrogenase 1 family, member A20.137
sulf2sulfatase 20.135
sox2SRY-box containing gene 20.133
zic1zic family member 1 (odd-paired homolog, Drosophila)0.133
insm1ainsulinoma-associated 1a0.128
neurodneurogenic differentiation0.125
her6hairy-related 60.124
emx2empty spiracles homeobox 20.124
slit3slit (Drosophila) homolog 30.122
spry4sprouty (Drosophila) homolog 40.118
twist3twist30.117
rarabretinoic acid receptor, alpha b0.114
dag1dystroglycan 10.114
cdoncell adhesion molecule-related/down-regulated by oncogenes0.109
foxn4forkhead box N40.106
sox3SRY-box containing gene 30.105
fgfr4fibroblast growth factor receptor 40.103
wnt5bwingless-type MMTV integration site family, member 5b0.099
vsx2visual system homeobox 20.098
arxaristaless related homeobox0.096
cdx4caudal type homeo box transcription factor 40.091
smosmoothened homolog (Drosophila)0.090
her4.2hairy-related 4.20.089
her15.1hairy and enhancer of split-related 15.10.089
gro1groucho 10.087
her8ahairy-related 8a0.086
nova2neuro-oncological ventral antigen 20.083
oprm1opioid receptor, mu 10.080
gli3GLI-Kruppel family member GLI30.080
eya1eyes absent homolog 10.078
coe2coe20.077
nr2e1nuclear receptor subfamily 2, group E, member 10.076
mstnbmyostatin b0.076
her1hairy-related 10.076
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.075
hmx3homeo box (H6 family) 30.072
pax6bpaired box gene 6b0.072
hoxb3ahomeo box B3a0.072
jag1bjagged 1b0.071
fstafollistatin a0.070
rad21RAD21 homolog (S. pombe)0.070
sulf1sulfatase 10.069
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
NNotch0.910
putpunt0.900
pblpebble0.859
tkvthickveins0.826
wgwingless0.809
NetBNetrin-B0.780
Stat92ESignal-transducer and activator of transcription protein at 92E0.752
armarmadillo0.748
shishibire0.727
cicubitus interruptus0.692
unc-5CG8166 gene product from transcript CG8166-RA0.691
Ras85DRas oncogene at 85D0.686
slp1sloppy paired 10.684
atoatonal0.674
Akt1CG4006 gene product from transcript CG4006-RA0.668
Pi3K92ECG4141 gene product from transcript CG4141-RB0.644
spispitz0.639
MadMothers against dpp0.614
dacdachshund0.574
Ptp69DProtein tyrosine phosphatase 69D0.570
DlDelta0.567
MED11Mediator complex subunit 110.554
MED27Mediator complex subunit 270.540
E(spl)Enhancer of split0.536
HLHmbetaE(spl) region transcript mbeta0.527
eyaeyes absent0.473
HLHmgammaE(spl) region transcript mgamma0.470
hpohippo0.456
snssticks and stones0.447
KrKruppel0.443
nejnejire0.439
edechinoid0.438
Su(H)Suppressor of Hairless0.427
MED6Mediator complex subunit 60.415
drprdraper0.380
dpndeadpan0.370
dockdreadlocks0.358
slmbsupernumerary limbs0.357
Ten-mTenascin major0.354
Rca1Regulator of cyclin A10.347
MED4Mediator complex subunit 40.340
HLHm7E(spl) region transcript m70.335
pydpolychaetoid0.332
ykiyorkie0.331
giggigas0.324
CG12424CG12424 gene product from transcript CG12424-RC0.321
enengrailed0.316
HGTXCG13475 gene product from transcript CG13475-RB0.309
commcommissureless0.308
ptcpatched0.296
bskbasket0.293
AntpAntennapedia0.287
Ten-aTenascin accessory0.282
dmdiminutive0.280
EgfrEpidermal growth factor receptor0.280
sdscalloped0.275
faffat facets0.273
mammastermind0.273
AlkCG8250 gene product from transcript CG8250-RA0.269
MED31Mediator complex subunit 310.268
ph-ppolyhomeotic proximal0.264
grogroucho0.260
sosine oculis0.258
rokRho-kinase0.258
Tao-1CG14217 gene product from transcript CG14217-RF0.257
Su(var)2-10Suppressor of variegation 2-100.253
rlrolled0.249
cdicenter divider0.247
TBPHCG10327 gene product from transcript CG10327-RC0.244
Pk61CProtein kinase 61C0.234
roboroundabout0.230
Fas1Fasciclin 10.229
gcmglial cells missing0.229
rstroughest0.228
PoxnPox neuro0.227
Gp150CG5820 gene product from transcript CG5820-RA0.227
ash2absent, small, or homeotic discs 20.226
kluklumpfuss0.224
lolalongitudinals lacking0.221
m4E(spl) region transcript m40.221
tgotango0.216
cazcabeza0.216
snostrawberry notch0.213
fzfrizzled0.213
Gap1GTPase-activating protein 10.209
tintinman0.207
MED9Mediator complex subunit 90.204
dapdacapo0.203
sevsevenless0.203
tutlturtle0.197
rorough0.197
CycACyclin A0.196
coscosta0.194
HLHmdeltaE(spl) region transcript mdelta0.190
dshdishevelled0.182
aopanterior open0.175
lblladybird late0.175
MybMyb oncogene-like0.174
SAKSak kinase0.174
SerSerrate0.174
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HDAC1histone deacetylase 10.956
CCT8chaperonin containing TCP1, subunit 8 (theta)0.899
JAG1jagged 10.728
NOTCH1notch 10.683
FGF1fibroblast growth factor 1 (acidic)0.494
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.476
TCP1t-complex 10.448
NOTCH3notch 30.425
SMAD4SMAD family member 40.337
PSEN2presenilin 2 (Alzheimer disease 4)0.333
GSK3Bglycogen synthase kinase 3 beta0.302
POU3F2POU class 3 homeobox 20.286
PBX1pre-B-cell leukemia homeobox 10.281
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.268
LUC7L2LUC7-like 2 (S. cerevisiae)0.267
SCHIP1schwannomin interacting protein 10.260
LRP1low density lipoprotein receptor-related protein 10.245
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.233
PAX3paired box 30.221
ZMYND11zinc finger, MYND-type containing 110.217
MEIS1Meis homeobox 10.198
ARID1AAT rich interactive domain 1A (SWI-like)0.198
NCOR1nuclear receptor corepressor 10.179
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.167
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.158
BMP2bone morphogenetic protein 20.155
COX5Bcytochrome c oxidase subunit Vb0.155
PSEN1presenilin 10.144
BMP7bone morphogenetic protein 70.143
SMAD2SMAD family member 20.139
RNF11ring finger protein 110.137
BBS10Bardet-Biedl syndrome 100.137
SKILSKI-like oncogene0.134
NR4A1nuclear receptor subfamily 4, group A, member 10.127
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.126
MMP14matrix metallopeptidase 14 (membrane-inserted)0.126
BTRCbeta-transducin repeat containing0.125
TGFB3transforming growth factor, beta 30.123
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.122
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.112
GRB7growth factor receptor-bound protein 70.111
ALBalbumin0.111
JAG2jagged 20.109
NCOA1nuclear receptor coactivator 10.107
NEDD4neural precursor cell expressed, developmentally down-regulated 40.102
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.099
STMN2stathmin-like 20.098
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.097
APCadenomatous polyposis coli0.097
TCF4transcription factor 40.091
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.091
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.087
SOX1SRY (sex determining region Y)-box 10.086
GET4golgi to ER traffic protein 4 homolog (S. cerevisiae)0.084
TBL1XR1transducin (beta)-like 1 X-linked receptor 10.084
SMAD7SMAD family member 70.084
NEDD9neural precursor cell expressed, developmentally down-regulated 90.081
SMAD5SMAD family member 50.080
PTPN1protein tyrosine phosphatase, non-receptor type 10.079
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.079
SNW1SNW domain containing 10.079
HDAC2histone deacetylase 20.078
DLL1delta-like 1 (Drosophila)0.077
IL1R1interleukin 1 receptor, type I0.077
OLIG2oligodendrocyte lineage transcription factor 20.076
TTRtransthyretin0.076
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.075
FYNFYN oncogene related to SRC, FGR, YES0.073
SMAD1SMAD family member 10.073
A2Malpha-2-macroglobulin0.069
SETDB1SET domain, bifurcated 10.069
SIN3ASIN3 homolog A, transcription regulator (yeast)0.067
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.067
MEIS2Meis homeobox 20.067
FBLN1fibulin 10.066
RNF5ring finger protein 50.065
SNAI1snail homolog 1 (Drosophila)0.063
SOX2SRY (sex determining region Y)-box 20.063
FBXW11F-box and WD repeat domain containing 110.062
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.062
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.061
FGF8fibroblast growth factor 8 (androgen-induced)0.059
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.057
FOXD3forkhead box D30.056
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.055
CDK6cyclin-dependent kinase 60.054
FGFR2fibroblast growth factor receptor 20.054
CDK8cyclin-dependent kinase 80.054
MED21mediator complex subunit 210.053
NGFRnerve growth factor receptor0.053
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.053
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.052
SOX11SRY (sex determining region Y)-box 110.051
CPEcarboxypeptidase E0.050
VEGFAvascular endothelial growth factor A0.049
C17orf28chromosome 17 open reading frame 280.048
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.048
SFRP1secreted frizzled-related protein 10.048
BMPR1Bbone morphogenetic protein receptor, type IB0.047
ATXN1ataxin 10.047
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nr4a3nuclear receptor subfamily 4, group A, member 30.273
Ascl1achaete-scute complex homolog 1 (Drosophila)0.265
Pls3plastin 3 (T-isoform)0.261
Cd9CD9 molecule0.232
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.218
Anxa5annexin A50.202
S100a11S100 calcium binding protein A11 (calizzarin)0.176
Ehd2EH-domain containing 20.174
Sv2asynaptic vesicle glycoprotein 2a0.159
Dab2disabled homolog 2 (Drosophila)0.153
Acanaggrecan0.142
S100a6S100 calcium binding protein A60.128
Ageradvanced glycosylation end product-specific receptor0.127
Accn2amiloride-sensitive cation channel 2, neuronal0.123
Tcf4transcription factor 40.122
Nckap1NCK-associated protein 10.120
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.118
Vcpvalosin-containing protein0.116
Prlhprolactin releasing hormone0.113
Anxa2annexin A20.113
Rab7aRAB7A, member RAS oncogene family0.112
Gabrb1gamma-aminobutyric acid (GABA) A receptor, beta 10.111
Epn2epsin 20.109
Fgfr2fibroblast growth factor receptor 20.109
Anxa1annexin A10.107
Chrna9cholinergic receptor, nicotinic, alpha 90.104
Lzts1leucine zipper, putative tumor suppressor 10.101
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.100
Myh10myosin, heavy chain 10, non-muscle0.097
Calcrcalcitonin receptor0.097
Relnreelin0.095
Rararetinoic acid receptor, alpha0.094
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.093
Fn3kfructosamine 3 kinase0.092
Nptnneuroplastin0.091
Ecel1endothelin converting enzyme-like 10.091
Efemp1EGF-containing fibulin-like extracellular matrix protein 10.090
Cyp4a3cytochrome P450, family 4, subfamily a, polypeptide 30.089
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.089
Onecut1one cut homeobox 10.087
Dnm1dynamin 10.086
Enpp6ectonucleotide pyrophosphatase/phosphodiesterase 60.085
Nedd4neural precursor cell expressed, developmentally down-regulated 40.085
Myo16myosin XVI0.085
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.084
Otx1orthodenticle homeobox 10.082
Appamyloid beta (A4) precursor protein0.081
Col4a3collagen, type IV, alpha 30.080
Col9a1collagen, type IX, alpha 10.080
St18suppression of tumorigenicity 180.080
Trehtrehalase (brush-border membrane glycoprotein)0.079
Crygdcrystallin, gamma D0.079
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.078
Sox13SRY (sex determining region Y)-box 130.077
Astn1astrotactin 10.076
Dgkgdiacylglycerol kinase, gamma0.074
Gdf11growth differentiation factor 110.073
Gpc1glypican 10.073
Gdpd2glycerophosphodiester phosphodiesterase domain containing 20.073
Gna15guanine nucleotide binding protein, alpha 150.073
Myo5amyosin VA0.073
Gdi1GDP dissociation inhibitor 10.072
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.072
S100a4S100 calcium-binding protein A40.072
AhnakAHNAK nucleoprotein0.071
Fgf13fibroblast growth factor 130.071
RGD1310773similar to hypothetical protein FLJ318100.071
LOC100362824caveolin 2-like0.070
Sgsm1small G protein signaling modulator 10.070
Myh9myosin, heavy chain 9, non-muscle0.069
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.067
Pnmal2PNMA-like 20.066
Notch1Notch homolog 1, translocation-associated (Drosophila)0.065
Bex4brain expressed, X-linked 40.064
Anxa4annexin A40.064
Il13interleukin 130.063
Dok1docking protein 10.062
S100bS100 calcium binding protein B0.062
Fut2fucosyltransferase 2 (secretor status included)0.062
Gng3guanine nucleotide binding protein (G protein), gamma 30.062
Gja6gap junction protein, alpha 60.061
Unc5bunc-5 homolog B (C. elegans)0.060
Galr3galanin receptor 30.059
Marcksmyristoylated alanine rich protein kinase C substrate0.059
Fermt2fermitin family homolog 2 (Drosophila)0.059
Itgamintegrin, alpha M0.058
Ncam1neural cell adhesion molecule 10.058
Thtyrosine hydroxylase0.057
Obp2bodorant binding protein 2B0.056
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.056
Kapkidney androgen regulated protein0.056
Psapprosaposin0.055
Id1inhibitor of DNA binding 10.055
Slc6a1solute carrier family 6 (neurotransmitter transporter, GABA), member 10.054
Ivlinvolucrin0.054
Egr3early growth response 30.054
Nlgn2neuroligin 20.054
Crybb1crystallin, beta B10.054
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.054
Gja1gap junction protein, alpha 10.053
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism