The network for 'negative regulation of nucleobase containing compound metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of nucleobase containing compound metabolic process

Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.965
pha-4Protein PHA-40.764
elt-6Protein ELT-60.511
eya-1Protein EYA-10.455
lin-53Protein LIN-530.433
his-64Protein HIS-640.391
attf-2Protein ATTF-20.344
zip-7Protein ZIP-70.327
his-1Protein HIS-10.317
his-16Protein HIS-160.311
cdt-2Protein CDT-20.289
let-502Protein LET-5020.265
mes-4Protein MES-40.255
his-31Protein HIS-310.248
his-68Protein HIS-680.246
egl-27Protein EGL-270.230
his-5Protein HIS-50.221
his-48Protein HIS-480.209
hlh-2Protein HLH-20.205
rad-26Protein RAD-260.198
T20F7.1Protein T20F7.10.191
C34F6.9Protein C34F6.90.182
wrm-1Protein WRM-10.182
lin-13Protein LIN-130.174
daf-4Protein DAF-40.170
his-46Protein HIS-460.157
dbl-1Protein DBL-10.157
hlh-1Protein HLH-10.155
fkh-2Protein FKH-20.155
hcp-3Protein HCP-30.151
his-52Protein HIS-520.150
nhr-2Protein NHR-20.146
nfya-1Protein NFYA-10.146
pop-1Protein POP-10.145
lin-40Protein LIN-400.145
hlh-11Protein HLH-110.142
nhr-67Protein NHR-670.142
atg-2Protein ATG-20.142
daf-21Protein DAF-210.140
mab-5Protein MAB-50.139
his-47Protein HIS-470.138
qua-1Protein QUA-10.138
C55B6.1Protein C55B6.10.135
zyg-1Protein ZYG-10.133
lin-11Protein LIN-110.133
pdr-1Protein PDR-10.129
his-3Protein HIS-30.129
egl-46Protein EGL-460.127
mat-3Protein MAT-30.125
pabp-2Protein PABP-20.124
cnd-1Protein CND-10.121
rfp-1Protein RFP-10.120
prp-8Protein PRP-80.120
CELE_F19F10.9Protein F19F10.90.115
his-61Protein HIS-610.114
his-30Protein HIS-300.113
bar-1Protein BAR-10.111
cfim-2Protein CFIM-20.111
his-29Protein HIS-290.108
T27A8.2Protein T27A8.20.106
Y87G2A.1Protein Y87G2A.10.105
rha-1Protein RHA-10.104
irx-1Protein IRX-10.102
rsp-1Protein RSP-10.101
let-418Protein LET-4180.098
mix-1Protein MIX-10.097
R11D1.1Protein R11D1.10.097
exc-7Protein EXC-70.096
fkb-6Protein FKB-60.096
tag-260Protein TAG-2600.096
eor-1Protein EOR-10.095
his-62Protein HIS-620.094
hda-1Protein HDA-10.094
tbx-8Protein TBX-80.093
ceh-27Protein CEH-270.091
T18D3.1Protein T18D3.10.091
flt-1Protein FLT-10.091
his-38Protein HIS-380.090
klp-19Protein KLP-190.090
plc-1Protein PLC-10.087
patr-1Protein PATR-10.087
npp-7Protein NPP-70.086
egl-13Protein EGL-130.086
nhr-25Protein NHR-250.084
F39B2.1Protein F39B2.10.084
his-50Protein HIS-500.083
unc-62Protein UNC-620.083
his-4Protein HIS-40.082
CELE_C23G10.8Protein C23G10.80.081
cpna-3Protein CPNA-30.080
glp-1Protein GLP-10.080
mls-2Protein MLS-20.079
his-39Protein HIS-390.079
dcr-1Protein DCR-10.079
csn-4Protein CSN-40.078
his-15Protein HIS-150.078
daf-14Protein DAF-140.077
unc-53Protein UNC-530.076
hmg-1.1Protein HMG-1.10.076
capg-1Protein CAPG-10.075
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ndr2nodal-related 20.973
lhx5LIM homeobox 50.906
wt1awilms tumor 1a0.897
fgf3fibroblast growth factor 30.894
lhx1aLIM homeobox 1a0.888
tbx6T-box gene 60.815
bmp2bbone morphogenetic protein 2b0.775
gro1groucho 10.773
dlx2adistal-less homeobox gene 2a0.723
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.721
snai1bsnail homolog 1b (Drosophila)0.714
jag2jagged 20.705
pou3f3aPOU class 3 homeobox 3a0.702
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.674
gata6GATA-binding protein 60.645
sox19aSRY-box containing gene 19a0.618
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.590
twist3twist30.580
pcnaproliferating cell nuclear antigen0.579
per2period homolog 2 (Drosophila)0.575
dusp6dual specificity phosphatase 60.564
tfap2atranscription factor AP-2 alpha0.545
chdchordin0.531
pax2apaired box gene 2a0.517
inspreproinsulin0.513
sox9bSRY-box containing gene 9b0.497
eng2aengrailed 2a0.483
evx1even-skipped homeobox 10.482
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.478
mab21l2mab-21-like 20.467
traf4atnf receptor-associated factor 4a0.465
pbx1apre-B-cell leukemia transcription factor 1a0.454
dlx1adistal-less homeobox gene 1a0.451
foxa2forkhead box A20.448
aldh1a2aldehyde dehydrogenase 1 family, member A20.432
cry1acryptochrome 1a0.429
lft2lefty20.424
esr2aestrogen receptor 2a0.423
otx2orthodenticle homolog 20.418
znf703zinc finger protein 7030.405
flhfloating head0.405
foxi1forkhead box I10.397
egr1early growth response 10.395
pitx2paired-like homeodomain transcription factor 20.390
whsc1Wolf-Hirschhorn syndrome candidate 10.385
sox1aSRY-box containing gene 1a0.383
tbx1T-box 10.371
notch1bnotch homolog 1b0.359
hp1bp3heterochromatin protein 1, binding protein 30.358
pou3f2POU class 3 homeobox 20.358
zfp36l1azinc finger protein 36, C3H type-like 1a0.349
sox2SRY-box containing gene 20.349
emx1empty spiracles homeobox 10.341
gata4GATA-binding protein 40.332
hand2heart and neural crest derivatives expressed transcript 20.329
hoxb1bhomeo box B1b0.317
lef1lymphocyte enhancer binding factor 10.316
klf4Kruppel-like factor 40.312
alcambactivated leukocyte cell adhesion molecule b0.308
irx4biroquois homeobox protein 4b0.305
pcdh18aprotocadherin 18a0.298
hnrnpkheterogeneous nuclear ribonucleoprotein K0.297
foxa3forkhead box A30.294
junbjun B proto-oncogene0.292
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.289
adipoqladiponectin, C1Q and collagen domain containing, like0.286
zic2bzic family member 2 (odd-paired homolog, Drosophila) b0.286
osr1odd-skipped related 1 (Drosophila)0.276
dnmt7DNA (cytosine-5-)-methyltransferase 70.265
gbx2gastrulation brain homeo box 20.264
vsx1visual system homeobox 1 homolog, chx10-like0.263
tll1tolloid-like 10.255
suv39h1bsuppressor of variegation 3-9 homolog 1b0.254
hmgb2bhigh-mobility group box 2b0.252
gata5GATA-binding protein 50.251
dlx5adistal-less homeobox gene 5a0.250
tp53tumor protein p530.249
mecomMDS1 and EVI1 complex locus0.244
rargbretinoic acid receptor, gamma b0.244
meis3myeloid ecotropic viral integration site 30.241
odz4odd Oz/ten-m homolog 40.240
sox19bSRY-box containing gene 19b0.236
fstafollistatin a0.236
ptf1apancreas specific transcription factor, 1a0.233
gata3GATA-binding protein 30.233
ntn1bnetrin 1b0.231
fgf8afibroblast growth factor 8 a0.229
lmx1b.1LIM homeobox transcription factor 1, beta 10.229
hnf1baHNF1 homeobox Ba0.229
insrainsulin receptor a0.227
pou5f1POU domain, class 5, transcription factor 10.224
vcanaversican a0.224
nkx2.1bNK2 homeobox 1b0.217
vsx2visual system homeobox 20.216
hey1hairy/enhancer-of-split related with YRPW motif 10.214
nkx2.5NK2 transcription factor related 50.213
runx2arunt-related transcription factor 2a0.212
smosmoothened homolog (Drosophila)0.212
hmx1H6 homeo box 10.210
her1hairy-related 10.208
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PclPolycomblike0.999
E(z)Enhancer of zeste0.999
CTCFCG8591 gene product from transcript CG8591-RA0.998
PcPolycomb0.998
gppgrappa0.998
Snr1Snf5-related 10.998
MadMothers against dpp0.998
hephemipterous0.998
grogroucho0.997
shnschnurri0.996
trxtrithorax0.995
BEAF-32Boundary element-associated factor of 32kD0.994
ash1absent, small, or homeotic discs 10.993
E(spl)Enhancer of split0.989
escextra sexcombs0.988
IswiImitation SWI0.985
kaykayak0.985
panpangolin0.980
wgwingless0.978
slmbsupernumerary limbs0.978
ScmSex comb on midleg0.977
pr-set7CG3307 gene product from transcript CG3307-RC0.976
kluklumpfuss0.974
crmcramped0.974
UbxUltrabithorax0.972
E(var)3-9Enhancer of variegation 3-90.968
p53CG33336 gene product from transcript CG33336-RB0.967
bratbrain tumor0.966
TrlTrithorax-like0.964
araaraucan0.964
twstwins0.963
slp1sloppy paired 10.960
InRInsulin-like receptor0.953
CtBPC-terminal Binding Protein0.952
dcodiscs overgrown0.948
gsbgooseberry0.946
Fmr1CG6203 gene product from transcript CG6203-RC0.945
enengrailed0.944
CycBCyclin B0.944
OptixCG18455 gene product from transcript CG18455-RA0.943
cicubitus interruptus0.943
ssspineless0.942
D1D1 chromosomal protein0.942
mammastermind0.941
pbproboscipedia0.936
ykiyorkie0.934
waplwings apart-like0.933
eveeven skipped0.932
smt3CG4494 gene product from transcript CG4494-RA0.930
atoatonal0.927
hrghiiragi0.923
HLHmdeltaE(spl) region transcript mdelta0.916
osaCG7467 gene product from transcript CG7467-RD0.905
dallydivision abnormally delayed0.904
snasnail0.904
ftzfushi tarazu0.902
eygeyegone0.901
sdscalloped0.899
cnccap-n-collar0.899
ushu-shaped0.898
Su(var)3-7Suppressor of variegation 3-70.895
Su(var)205Suppressor of variegation 2050.894
stisticky0.894
nubnubbin0.893
E2f2E2F transcription factor 20.891
hthhomothorax0.890
brmbrahma0.888
NNotch0.888
tshteashirt0.887
ash2absent, small, or homeotic discs 20.883
pdm2POU domain protein 20.871
SerSerrate0.869
XNPCG4548 gene product from transcript CG4548-RA0.858
His2AvHistone H2A variant0.857
DpDP transcription factor0.845
Acf1ATP-dependent chromatin assembly factor large subunit0.842
lokloki0.837
Pp1-87BProtein phosphatase 1 at 87B0.831
SlbpStem-loop binding protein0.831
Rpd3CG7471 gene product from transcript CG7471-RA0.830
Sam-SS-adenosylmethionine Synthetase0.829
Doc2Dorsocross20.819
phylphyllopod0.816
mormoira0.816
Eip63EEcdysone-induced protein 63E0.815
Chd1Chromodomain-helicase-DNA-binding protein 10.814
reptreptin0.806
alaristaless0.803
nabCG33545 gene product from transcript CG33545-RC0.802
nkdnaked cuticle0.802
CkaConnector of kinase to AP-10.798
MaxCG9648 gene product from transcript CG9648-RA0.797
HGTXCG13475 gene product from transcript CG13475-RB0.794
bcdbicoid0.794
modmodulo0.790
crolcrooked legs0.785
piwiCG6122 gene product from transcript CG6122-RA0.785
knknot0.781
HLHm7E(spl) region transcript m70.774
sogshort gastrulation0.765
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
JunJun oncogene0.789
Tgfbr2transforming growth factor, beta receptor II0.584
Junbjun B proto-oncogene0.577
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.548
Nfianuclear factor I/A0.524
FosFBJ osteosarcoma oncogene0.509
Ahraryl hydrocarbon receptor0.497
Ier2immediate early response 20.439
Metmet proto-oncogene0.437
Hes1hairy and enhancer of split 1 (Drosophila)0.423
Creb1cAMP responsive element binding protein 10.409
Pgam1phosphoglycerate mutase 1 (brain)0.409
Sfrs1splicing factor, arginine/serine-rich 10.391
DbpD site of albumin promoter (albumin D-box) binding protein0.390
Nfibnuclear factor I/B0.388
UncxUNC homeobox0.355
Sdc3syndecan 30.342
Dusp1dual specificity phosphatase 10.333
Vimvimentin0.332
Nfyanuclear transcription factor-Y alpha0.332
Tcfe2atranscription factor E2a0.326
Ptmaprothymosin alpha0.322
Ncanneurocan0.320
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.307
Trim28tripartite motif-containing 280.304
Id1inhibitor of DNA binding 10.302
Anxa2annexin A20.301
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.299
Stip1stress-induced phosphoprotein 10.289
Ralgdsral guanine nucleotide dissociation stimulator0.285
Nr1d2nuclear receptor subfamily 1, group D, member 20.282
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.273
Arf6ADP-ribosylation factor 60.273
Adra2badrenergic, alpha-2B-, receptor0.263
Anxa5annexin A50.263
Klf4Kruppel-like factor 4 (gut)0.260
Ascl1achaete-scute complex homolog 1 (Drosophila)0.260
Tmpothymopoietin0.255
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.253
Id3inhibitor of DNA binding 30.251
Eif4heukaryotic translation initiation factor 4H0.250
Socs3suppressor of cytokine signaling 30.249
Fgfr1Fibroblast growth factor receptor 10.244
Dynll1dynein light chain LC8-type 10.244
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.239
Smad7SMAD family member 70.232
Shox2short stature homeobox 20.231
Wbp11WW domain binding protein 110.230
Mgpmatrix Gla protein0.227
Dccdeleted in colorectal carcinoma0.220
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.219
Smad6SMAD family member 60.219
Cysscystatin S0.217
Bcl2B-cell CLL/lymphoma 20.213
Pcnaproliferating cell nuclear antigen0.212
Gna12guanine nucleotide binding protein (G protein) alpha 120.201
Grk1G protein-coupled receptor kinase 10.201
Flt1FMS-related tyrosine kinase 10.201
Gata4GATA binding protein 40.200
Btg2BTG family, member 20.200
RorbRAR-related orphan receptor B0.200
S100a10S100 calcium binding protein A100.199
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.196
Hand2heart and neural crest derivatives expressed 20.196
Cnga3cyclic nucleotide gated channel alpha 30.195
Lrfn2leucine rich repeat and fibronectin type III domain containing 20.195
Hnrnprheterogeneous nuclear ribonucleoprotein R0.195
Synposynaptopodin0.193
Dusp6dual specificity phosphatase 60.192
Khdrbs1KH domain containing, RNA binding, signal transduction associated 10.191
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.190
Sf1splicing factor 10.189
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.189
Mycmyelocytomatosis oncogene0.182
FaslgFas ligand (TNF superfamily, member 6)0.182
S100a8S100 calcium binding protein A80.179
Crygbcrystallin, gamma B0.179
Ubtfupstream binding transcription factor, RNA polymerase I0.177
Il12binterleukin 12B0.176
Fgfr2fibroblast growth factor receptor 20.175
Chrna4cholinergic receptor, nicotinic, alpha 40.173
Lgals1lectin, galactoside-binding, soluble, 10.173
Neurog1neurogenin 10.171
Lzts2leucine zipper, putative tumor suppressor 20.171
Flnafilamin A, alpha0.171
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.170
Sh3bp1SH3-domain binding protein 10.169
Siah1aseven in absentia 1A0.168
Calm2calmodulin 20.168
Chrnb3cholinergic receptor, nicotinic, beta 30.167
Zfp382zinc finger protein 3820.166
Prl8a9prolactin family 8, subfamily a, member 90.162
Pip5k1cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma0.161
Pou3f2POU class 3 homeobox 20.161
Crybb3crystallin, beta B30.159
Klf2Kruppel-like factor 2 (lung)0.156
Eif4enif1eukaryotic translation initiation factor 4E nuclear import factor 10.156
Cd40lgCD40 ligand0.155
Hdac2histone deacetylase 20.152
Arpc1bactin related protein 2/3 complex, subunit 1B0.150
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RPD3Rpd3p0.999
SIN3Sin3p0.992
PHO23Pho23p0.988
SIR2Sir2p0.987
RAP1Rap1p0.980
HHF1Hhf1p0.978
HDA1Hda1p0.976
ORC2Orc2p0.964
RLF2Rlf2p0.955
HHT1Hht1p0.952
SIN4Sin4p0.945
RXT2Rxt2p0.924
SET1Set1p0.923
ORC5Orc5p0.916
CTI6Cti6p0.893
ITC1Itc1p0.892
YCS4Ycs4p0.890
HOG1Hog1p0.889
SIR4Sir4p0.879
RPN4Rpn4p0.877
DIA2Dia2p0.875
YTA7Yta7p0.863
GLN3Gln3p0.848
GAL11Gal11p0.846
GLC7Glc7p0.836
UME6Ume6p0.831
SNT1Snt1p0.825
RCO1Rco1p0.815
ORC1Orc1p0.810
SUM1Sum1p0.793
SSN3Ssn3p0.787
SDS3Sds3p0.787
CYC8Cyc8p0.777
HMO1Hmo1p0.772
VID22Vid22p0.770
MRC1Mrc1p0.764
RAD9Rad9p0.763
PGD1Pgd1p0.762
GBP2Gbp2p0.758
SLX5Slx5p0.750
ASF1Asf1p0.749
ADR1Adr1p0.748
RTT106Rtt106p0.740
MED2Med2p0.739
HTZ1Htz1p0.736
CKA2Cka2p0.700
SPT16Spt16p0.699
CDC6Cdc6p0.693
SET3Set3p0.687
DOT6Dot6p0.681
RTF1Rtf1p0.680
SAP30Sap30p0.672
UBP10Ubp10p0.668
NAT1Nat1p0.665
CDC45Cdc45p0.649
ISW2Isw2p0.647
SAS2Sas2p0.641
NRG1Nrg1p0.637
FKH1Fkh1p0.633
CTF18Ctf18p0.621
CCR4Ccr4p0.620
PHO4Pho4p0.615
SIR3Sir3p0.606
RAD6Rad6p0.605
NET1Net1p0.593
HTB1Htb1p0.585
SET2Set2p0.577
MET4Met4p0.576
ARP4Arp4p0.571
SWI4Swi4p0.567
MED6Med6p0.562
RSC2Rsc2p0.562
SPT8Spt8p0.557
SCH9Sch9p0.549
CUP9Cup9p0.546
RAD53Rad53p0.546
NUP1Nup1p0.543
FKH2Fkh2p0.541
HTA2Hta2p0.540
MCM7Mcm7p0.537
IZH4Izh4p0.536
SRM1Srm1p0.535
GCR2Gcr2p0.534
RIF1Rif1p0.532
HAT1Hat1p0.531
NST1Nst1p0.525
SPT10Spt10p0.523
HTA1Hta1p0.515
MOT1Mot1p0.514
SMC4Smc4p0.511
ESC2Esc2p0.507
SIC1Sic1p0.506
HST1Hst1p0.505
STP22Stp22p0.503
CHL1Chl1p0.498
BRE2Bre2p0.496
CMK2Cmk2p0.495
PAP2Pap2p0.494
RGR1Rgr1p0.493
RLM1Rlm1p0.483