The network for 'determination of bilateral symmetry' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

determination of bilateral symmetry

The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.

NameDescriptionProbabilityFunc Analog Organism
che-2Protein CHE-20.234
egl-18Protein EGL-180.064
glp-1Protein GLP-10.056
soc-2Protein SOC-20.055
inx-4Protein INX-40.048
che-3Protein CHE-30.040
pdfr-1Protein PDFR-10.035
unc-9Protein UNC-90.033
lin-17Protein LIN-170.032
mec-2Protein MEC-20.027
inx-13Protein INX-130.027
che-11Protein CHE-110.026
bar-1Protein BAR-10.025
hlh-1Protein HLH-10.024
vab-3Protein VAB-30.021
klp-15Protein KLP-150.021
efn-2Protein EFN-20.020
sdz-28Protein SDZ-280.020
lin-29Protein LIN-290.019
eat-4Protein EAT-40.019
bli-1Protein BLI-10.018
rig-6Protein RIG-60.017
ina-1Protein INA-10.016
che-14Protein CHE-140.016
unc-7Protein UNC-70.014
unc-53Protein UNC-530.014
unc-73Protein UNC-730.014
daf-12Protein DAF-120.013
egl-19Protein EGL-190.013
lin-11Protein LIN-110.012
inx-5Protein INX-50.012
osm-5Protein OSM-50.012
unc-52Protein UNC-520.012
unc-62Protein UNC-620.012
cam-1Protein CAM-10.012
pal-1Protein PAL-10.012
syg-2Protein SYG-20.012
unc-115Protein UNC-1150.011
mps-2Protein MPS-20.011
nphp-1Protein NPHP-10.010
ajm-1Protein AJM-10.010
sel-8Protein SEL-80.010
F49E2.5Protein F49E2.50.010
daf-10Protein DAF-100.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.996
pkd2polycystic kidney disease 20.994
aldh1a2aldehyde dehydrogenase 1 family, member A20.994
lrrc6leucine rich repeat containing 60.992
ift88intraflagellar transport 88 homolog0.990
pax2apaired box gene 2a0.988
cdh2cadherin 2, neuronal0.988
chdchordin0.976
fzd10frizzled homolog 100.973
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.972
bmp4bone morphogenetic protein 40.969
etv5bets variant 5b0.958
ntlano tail a0.954
hnf1baHNF1 homeobox Ba0.953
gata3GATA-binding protein 30.953
neurodneurogenic differentiation0.951
fgf8afibroblast growth factor 8 a0.939
zgc:100838zgc:1008380.934
wnt11rwingless-type MMTV integration site family, member 11, related0.930
tbx20T-box 200.923
smad9MAD homolog 9 (Drosophila)0.922
runx2brunt-related transcription factor 2b0.909
lhx1aLIM homeobox 1a0.903
fgf3fibroblast growth factor 30.898
twist1atwist1a0.898
flhfloating head0.898
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.893
bmp2bbone morphogenetic protein 2b0.892
wnt11wingless-type MMTV integration site family, member 110.858
cdoncell adhesion molecule-related/down-regulated by oncogenes0.851
tbx18T-box 180.847
gro1groucho 10.844
pax8paired box gene 80.841
msxcmuscle segment homeobox C0.830
lrrc50leucine rich repeat containing 500.821
gli1GLI-Kruppel family member 10.812
sulf1sulfatase 10.808
bmp2abone morphogenetic protein 2a0.808
shhbsonic hedgehog b0.804
gata4GATA-binding protein 40.774
sesn1sestrin 10.769
hspb7heat shock protein family, alpha-crystallin-related, b70.764
snai1bsnail homolog 1b (Drosophila)0.764
arl13bADP-ribosylation factor-like 13b0.760
zic4zic family member 40.752
dlddeltaD0.751
twist3twist30.749
pcsk5aproprotein convertase subtilisin/kexin type 5a0.746
itgb1bintegrin, beta 1b0.744
tbx16T-box gene 160.740
smad5MAD homolog 5 (Drosophila)0.702
fzd8afrizzled homolog 8a0.702
notch1anotch homolog 1a0.700
rfx2regulatory factor X, 2 (influences HLA class II expression)0.698
fgfrl1bfibroblast growth factor receptor-like 1b0.685
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.683
ephb4beph receptor B4b0.681
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.681
gbx2gastrulation brain homeo box 20.665
itgavintegrin, alpha V0.664
trpm7transient receptor potential cation channel, subfamily M, member 70.663
hand2heart and neural crest derivatives expressed transcript 20.663
rarabretinoic acid receptor, alpha b0.662
eya4eyes absent homolog 4 (Drosophila)0.654
gli2aGLI-Kruppel family member GLI2a0.649
emx3empty spiracles homeobox 30.638
dmrt2adoublesex and mab-3 related transcription factor 2a0.627
cdx4caudal type homeo box transcription factor 40.626
fgf4fibroblast growth factor 40.621
twist1btwist1b0.615
zic1zic family member 1 (odd-paired homolog, Drosophila)0.615
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.609
foxj1aforkhead box J1a0.608
tfap2atranscription factor AP-2 alpha0.606
lft1lefty10.602
shhasonic hedgehog a0.600
gdf6agrowth differentiation factor 6a0.585
notch1bnotch homolog 1b0.582
hey2hairy/enhancer-of-split related with YRPW motif 20.581
fgfr4fibroblast growth factor receptor 40.576
wnt4awingless-type MMTV integration site family, member 4a0.576
six4bsine oculis homeobox homolog 4b0.569
tnni1btroponin I, skeletal, slow b0.565
lft2lefty20.556
ext1aexostoses (multiple) 1a0.549
nkx2.5NK2 transcription factor related 50.547
mapk1mitogen-activated protein kinase 10.546
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.546
pcdh8protocadherin 80.541
cc2d2acoiled-coil and C2 domain containing 2A0.539
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.537
igf1rbinsulin-like growth factor 1b receptor0.534
dbx1adeveloping brain homeobox 1a0.523
pou3f2POU class 3 homeobox 20.520
ndr2nodal-related 20.519
olfm2olfactomedin 20.514
smarcd3bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b0.506
fibinfin bud initiation factor0.502
vmhcventricular myosin heavy chain0.502
robo3roundabout homolog 30.498
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
tintinman0.644
Rac1CG2248 gene product from transcript CG2248-RA0.615
twitwist0.557
mysmyospheroid0.489
dshdishevelled0.382
tkvthickveins0.371
AcslAcyl-CoA synthetase long-chain0.332
wgwingless0.275
cicubitus interruptus0.251
slouslouch0.243
emcextra macrochaetae0.227
bazbazooka0.219
stumpsCG31317 gene product from transcript CG31317-RC0.219
enengrailed0.215
htlheartless0.213
fngfringe0.211
rheaCG6831 gene product from transcript CG6831-RA0.167
roboroundabout0.159
LanB1CG7123 gene product from transcript CG7123-RA0.146
crbcrumbs0.139
ptcpatched0.126
HLH54FCG5005 gene product from transcript CG5005-RA0.120
cactcactus0.117
ifinflated0.115
shishibire0.103
Cdc42CG12530 gene product from transcript CG12530-RA0.103
enaenabled0.093
EgfrEpidermal growth factor receptor0.092
NNotch0.091
eveeven skipped0.086
PvrPDGF- and VEGF-receptor related0.083
CG14869CG14869 gene product from transcript CG14869-RB0.082
arrarrow0.079
knknot0.079
Rho1CG8416 gene product from transcript CG8416-RB0.076
midmidline0.075
srpserpent0.071
comtcomatose0.060
G-oalpha47AG protein oalpha 47A0.058
Lim1CG11354 gene product from transcript CG11354-RA0.058
gbbglass bottom boat0.054
kstkarst0.054
Ras85DRas oncogene at 85D0.051
Myo31DFMyosin 31DF0.050
ovoCG6824 gene product from transcript CG6824-RE0.049
LanB2Laminin B20.049
Tsc1CG6147 gene product from transcript CG6147-RA0.047
dppdecapentaplegic0.046
scbscab0.045
slislit0.045
kugkugelei0.044
pcxpecanex0.044
srstripe0.044
zfh1Zn finger homeodomain 10.043
bibifid0.042
TlToll0.040
apapterous0.040
CbyChibby0.036
nctnicastrin0.036
cv-ccrossveinless c0.035
naunautilus0.034
bynbrachyenteron0.034
snssticks and stones0.033
eyaeyes absent0.033
frufruitless0.032
ash2absent, small, or homeotic discs 20.031
kirrekin of irre0.031
fufused0.031
pbproboscipedia0.030
hhhedgehog0.030
WASpCG1520 gene product from transcript CG1520-RA0.030
hkbhuckebein0.029
Cul-5Cullin-50.028
wbwing blister0.028
Sema-1aCG18405 gene product from transcript CG18405-RD0.027
tumtumbleweed0.027
robo3CG5423 gene product from transcript CG5423-RA0.027
TBPHCG10327 gene product from transcript CG10327-RC0.027
kibrakibra ortholog0.027
slp1sloppy paired 10.026
unc-5CG8166 gene product from transcript CG8166-RA0.026
Wnt4Wnt oncogene analog 40.025
fjfour-jointed0.025
neuroliginCG13772 gene product from transcript CG13772-RA0.025
flwflapwing0.025
Syx1ASyntaxin 1A0.024
pnrpannier0.024
rhorhomboid0.024
Snap25Synapse protein 250.023
LanALaminin A0.023
Su(z)12CG8013 gene product from transcript CG8013-RA0.023
otkoff-track0.021
frtzfritz0.021
RhoGAP93BCG3421 gene product from transcript CG3421-RA0.020
p120ctnAdherens junction protein p1200.019
atoatonal0.019
G-salpha60AG protein salpha 60A0.019
MedMedea0.019
rempAreduced mechanoreceptor potential A0.018
invinvected0.018
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMAD3SMAD family member 30.996
RHOAras homolog gene family, member A0.977
SMURF2SMAD specific E3 ubiquitin protein ligase 20.733
SMAD7SMAD family member 70.702
TGFB1transforming growth factor, beta 10.700
BMPR1Abone morphogenetic protein receptor, type IA0.661
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.609
SMAD2SMAD family member 20.585
SMAD1SMAD family member 10.532
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.525
FSTL1follistatin-like 10.465
ATF2activating transcription factor 20.423
TBX5T-box 50.406
FKBP1AFK506 binding protein 1A, 12kDa0.403
NOTCH1notch 10.375
GSK3Bglycogen synthase kinase 3 beta0.366
SMAD4SMAD family member 40.325
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.284
SP1Sp1 transcription factor0.261
FGF10fibroblast growth factor 100.233
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.216
ARHGAP1Rho GTPase activating protein 10.214
FLNCfilamin C, gamma0.213
GATA4GATA binding protein 40.175
PBX1pre-B-cell leukemia homeobox 10.146
ENGendoglin0.136
MAP2K4mitogen-activated protein kinase kinase 40.132
EP300E1A binding protein p3000.127
BMP2bone morphogenetic protein 20.127
JAG1jagged 10.127
CHRDchordin0.121
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.108
TJP1tight junction protein 1 (zona occludens 1)0.107
TMED10transmembrane emp24-like trafficking protein 10 (yeast)0.107
MAPK8mitogen-activated protein kinase 80.085
YBX1Y box binding protein 10.081
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.081
SMAD5SMAD family member 50.080
TGFBR1transforming growth factor, beta receptor 10.079
YY1YY1 transcription factor0.079
APCadenomatous polyposis coli0.078
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.073
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.072
ARRB2arrestin, beta 20.070
SIN3ASIN3 homolog A, transcription regulator (yeast)0.065
HDAC2histone deacetylase 20.065
SIRT1sirtuin 10.062
AXIN1axin 10.061
LRP6low density lipoprotein receptor-related protein 60.060
CXXC5CXXC finger protein 50.059
CD44CD44 molecule (Indian blood group)0.050
ACVR1activin A receptor, type I0.049
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.049
SNIP1Smad nuclear interacting protein 10.047
MKL1megakaryoblastic leukemia (translocation) 10.047
HIPK2homeodomain interacting protein kinase 20.046
PKD1polycystic kidney disease 1 (autosomal dominant)0.046
PLXNB1plexin B10.046
MAPK9mitogen-activated protein kinase 90.045
CREB1cAMP responsive element binding protein 10.044
PTCH1patched 10.043
GLI1GLI family zinc finger 10.041
MAML1mastermind-like 1 (Drosophila)0.040
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.040
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.038
SENP3SUMO1/sentrin/SMT3 specific peptidase 30.037
FLNBfilamin B, beta0.037
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.036
SFPQsplicing factor proline/glutamine-rich0.035
GDF5growth differentiation factor 50.035
PMLpromyelocytic leukemia0.035
ZFYVE9zinc finger, FYVE domain containing 90.033
SMAD6SMAD family member 60.033
PCM1pericentriolar material 10.033
MARK3MAP/microtubule affinity-regulating kinase 30.032
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.030
TP53tumor protein p530.029
FGF7fibroblast growth factor 70.029
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.028
PKP4plakophilin 40.028
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.028
SMURF1SMAD specific E3 ubiquitin protein ligase 10.027
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.027
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.027
MKL2MKL/myocardin-like 20.027
ATF3activating transcription factor 30.027
FZD1frizzled homolog 1 (Drosophila)0.027
HMGA1high mobility group AT-hook 10.026
SPENspen homolog, transcriptional regulator (Drosophila)0.026
CTBP2C-terminal binding protein 20.026
CANXcalnexin0.025
BBS2Bardet-Biedl syndrome 20.025
HDAC9histone deacetylase 90.025
BMP1bone morphogenetic protein 10.024
SASS6spindle assembly 6 homolog (C. elegans)0.024
NOGnoggin0.023
ARPC4actin related protein 2/3 complex, subunit 4, 20kDa0.023
EPAS1endothelial PAS domain protein 10.023
DSPdesmoplakin0.023
MEIS2Meis homeobox 20.022
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism