The network for 'head development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

head development

The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.

NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.961
pha-4Protein PHA-40.932
che-13Protein CHE-130.927
unc-73Protein UNC-730.779
egl-46Protein EGL-460.776
unc-42Protein UNC-420.749
egl-15Protein EGL-150.720
vab-1Protein VAB-10.643
pry-1Protein PRY-10.623
egl-44Protein EGL-440.619
nhr-67Protein NHR-670.605
egl-5Protein EGL-50.600
unc-62Protein UNC-620.583
rig-6Protein RIG-60.566
vab-3Protein VAB-30.560
bar-1Protein BAR-10.557
let-60Protein LET-600.524
ldb-1Protein LDB-10.520
ten-1Protein TEN-10.516
zip-7Protein ZIP-70.499
ceh-36Protein CEH-360.485
unc-53Protein UNC-530.474
lin-36Protein LIN-360.472
zyg-9Protein ZYG-90.472
goa-1Protein GOA-10.457
R10E12.2Protein R10E12.20.456
daf-12Protein DAF-120.454
pkg-1Protein PKG-10.454
eor-2Protein EOR-20.433
elt-6Protein ELT-60.430
plc-1Protein PLC-10.419
unc-9Protein UNC-90.416
sax-3Protein SAX-30.413
sax-7Protein SAX-70.404
eor-1Protein EOR-10.404
mig-5Protein MIG-50.403
egl-30Protein EGL-300.398
flt-1Protein FLT-10.389
cat-1Protein CAT-10.376
T28F4.1Protein T28F4.10.371
mrp-4Protein MRP-40.370
hbl-1Protein HBL-10.363
R02D5.1Protein R02D5.10.361
lin-25Protein LIN-250.353
clh-5Protein CLH-50.346
ceh-27Protein CEH-270.343
unc-70Protein UNC-700.339
eya-1Protein EYA-10.338
lin-29Protein LIN-290.336
ceh-16Protein CEH-160.335
ztf-2Protein ZTF-20.334
lin-66Protein LIN-660.333
efn-4Protein EFN-40.332
ncx-3Protein NCX-30.329
spc-1Protein SPC-10.328
syg-2Protein SYG-20.327
C14F11.2Protein C14F11.20.320
cpg-3Protein CPG-30.306
lin-11Protein LIN-110.306
tbx-8Protein TBX-80.304
trim-9Protein TRIM-90.303
exc-5Protein EXC-50.302
pdfr-1Protein PDFR-10.301
T27A3.1Protein T27A3.10.300
plc-3Protein PLC-30.299
nid-1Protein NID-10.297
egl-27Protein EGL-270.295
tag-303Protein TAG-3030.294
ceh-44Protein CEH-440.292
lin-12Protein LIN-120.292
syg-1Protein SYG-10.289
atn-1Protein ATN-10.283
rpm-1Protein RPM-10.282
let-607Protein LET-6070.282
smp-1Protein SMP-10.279
unc-6Protein UNC-60.279
mac-1Protein MAC-10.279
chd-7Protein CHD-70.276
cpna-5Protein CPNA-50.274
lin-53Protein LIN-530.271
egl-13Protein EGL-130.271
che-2Protein CHE-20.269
ida-1Protein IDA-10.267
F36D4.5Protein F36D4.50.266
ina-1Protein INA-10.263
CELE_T05E11.3Protein T05E11.30.256
lin-32Protein LIN-320.256
gmeb-1Protein GMEB-10.255
hnd-1Protein HND-10.253
C16B8.3Protein C16B8.30.251
trap-1Protein TRAP-10.250
tbb-4Protein TBB-40.250
gei-18Protein GEI-180.249
sago-1Protein SAGO-10.249
nhr-34Protein NHR-340.246
apl-1Protein APL-10.245
pax-3Protein PAX-30.245
agr-1Protein AGR-10.245
cnd-1Protein CND-10.243
lam-2Protein LAM-20.241
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fgf3fibroblast growth factor 31.000
spry4sprouty (Drosophila) homolog 40.999
eya1eyes absent homolog 10.999
lhx1aLIM homeobox 1a0.998
dlx2adistal-less homeobox gene 2a0.997
tbx1T-box 10.997
lef1lymphocyte enhancer binding factor 10.997
shhbsonic hedgehog b0.996
hnf1baHNF1 homeobox Ba0.995
lmo4aLIM domain only 4a0.994
six3bsine oculis homeobox homolog 3b0.992
sema3aasemaphorin 3aa0.991
egr2bearly growth response 2b0.990
aldh1a2aldehyde dehydrogenase 1 family, member A20.990
foxd3forkhead box D30.988
gata3GATA-binding protein 30.988
jag1bjagged 1b0.985
edn1endothelin 10.985
six3asine oculis homeobox homolog 3a0.984
foxp2forkhead box P20.982
etv5bets variant 5b0.980
lmx1b.1LIM homeobox transcription factor 1, beta 10.979
rx3retinal homeobox gene 30.978
hoxb5bhomeo box B5b0.978
bmp2bbone morphogenetic protein 2b0.976
wnt11rwingless-type MMTV integration site family, member 11, related0.976
znf503zinc finger protein 5030.975
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.975
wnt5bwingless-type MMTV integration site family, member 5b0.973
rx2retinal homeobox gene 20.973
fgfr4fibroblast growth factor receptor 40.972
olig2oligodendrocyte lineage transcription factor 20.971
tal1T-cell acute lymphocytic leukemia 10.967
bmp4bone morphogenetic protein 40.964
gbx2gastrulation brain homeo box 20.961
gli1GLI-Kruppel family member 10.961
sox10SRY-box containing gene 100.959
raraaretinoic acid receptor, alpha a0.958
neo1neogenin 10.957
hey1hairy/enhancer-of-split related with YRPW motif 10.956
pax8paired box gene 80.955
fzd7afrizzled homolog 7a0.954
dlx3bdistal-less homeobox gene 3b0.953
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.953
her5hairy-related 50.952
otpborthopedia homolog b0.950
flhfloating head0.949
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.946
tp53tumor protein p530.944
prox1prospero-related homeobox gene 10.941
her9hairy-related 90.937
stmn4stathmin-like 40.936
foxa2forkhead box A20.935
pax2apaired box gene 2a0.934
hoxb3ahomeo box B3a0.933
fezf2FEZ family zinc finger 20.932
rfx2regulatory factor X, 2 (influences HLA class II expression)0.932
nr2e1nuclear receptor subfamily 2, group E, member 10.928
tbx16T-box gene 160.928
thtyrosine hydroxylase0.922
ntlano tail a0.921
shhasonic hedgehog a0.920
bdnfbrain-derived neurotrophic factor0.917
olfm2olfactomedin 20.916
kdrlkinase insert domain receptor like0.914
epb41l5erythrocyte membrane protein band 4.1 like 50.913
barhl2BarH-like 20.911
ndr2nodal-related 20.910
otx2orthodenticle homolog 20.908
sp5lSp5 transcription factor-like0.907
maflv-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein L0.905
mpzmyelin protein zero0.904
bocbrother of CDO0.902
lhx2bLIM homeobox 2b0.902
tfap2btranscription factor AP-2 beta0.901
myf5myogenic factor 50.898
neurod4neurogenic differentiation 40.897
tfap2atranscription factor AP-2 alpha0.893
axin2axin 2 (conductin, axil)0.891
sox1aSRY-box containing gene 1a0.889
arxaristaless related homeobox0.888
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.887
gbx1gastrulation brain homeobox 10.886
wnt1wingless-type MMTV integration site family, member 10.885
wnt3awingless-type MMTV integration site family, member 3A0.881
fzd7bfrizzled homolog 7b0.878
rasgef1baRasGEF domain family, member 1Ba0.876
meis3myeloid ecotropic viral integration site 30.876
traf4atnf receptor-associated factor 4a0.873
jag2jagged 20.871
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.867
sox11bSRY-box containing gene 11b0.861
lfnglunatic fringe homolog0.859
fn1fibronectin 10.856
gdf6agrowth differentiation factor 6a0.853
bhlhe22basic helix-loop-helix family, member e220.853
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Fmr1CG6203 gene product from transcript CG6203-RC0.998
E(spl)Enhancer of split0.997
lolalongitudinals lacking0.979
Rac1CG2248 gene product from transcript CG2248-RA0.977
Ten-aTenascin accessory0.972
fkhfork head0.961
slp1sloppy paired 10.952
robo3CG5423 gene product from transcript CG5423-RA0.937
slmbsupernumerary limbs0.935
Tao-1CG14217 gene product from transcript CG14217-RF0.928
Su(H)Suppressor of Hairless0.927
EgfrEpidermal growth factor receptor0.923
Ras85DRas oncogene at 85D0.923
Act5CActin 5C0.921
Exp6Exportin 60.921
ari-2ariadne 20.897
mbtmushroom bodies tiny0.865
vapvacuolar peduncle0.851
CG32810CG32810 gene product from transcript CG32810-RB0.850
pashapartner of drosha0.841
DscamDown syndrome cell adhesion molecule0.839
emsempty spiracles0.812
cicubitus interruptus0.807
jebjelly belly0.769
PtpmegCG1228 gene product from transcript CG1228-RD0.765
AlkCG8250 gene product from transcript CG8250-RA0.751
nkdnaked cuticle0.750
dlg1discs large 10.737
AtpalphaNa pump alpha subunit0.733
Ten-mTenascin major0.731
sleslender lobes0.691
wupAwings up A0.685
MadMothers against dpp0.675
toytwin of eyeless0.668
Stat92ESignal-transducer and activator of transcription protein at 92E0.665
fz2frizzled 20.659
abd-Aabdominal A0.647
Bap170Brahma associated protein 170kD0.643
par-1CG8201 gene product from transcript CG8201-RA0.625
Taf1TBP-associated factor 10.624
RhoGAPp190CG32555 gene product from transcript CG32555-RB0.618
norpAno receptor potential A0.614
G-oalpha47AG protein oalpha 47A0.602
Trim9CG31721 gene product from transcript CG31721-RB0.599
C15CG7937 gene product from transcript CG7937-RA0.595
Top2Topoisomerase 20.590
HLHm5E(spl) region transcript m50.559
stanstarry night0.558
stumpsCG31317 gene product from transcript CG31317-RC0.556
drkdownstream of receptor kinase0.552
tefutelomere fusion0.545
Hsc70-4Heat shock protein cognate 40.543
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MDM2Mdm2 p53 binding protein homolog (mouse)0.945
APCadenomatous polyposis coli0.928
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.849
ESR1estrogen receptor 10.815
FGFR2fibroblast growth factor receptor 20.794
NOTCH1notch 10.723
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.702
IGF1Rinsulin-like growth factor 1 receptor0.684
EGFRepidermal growth factor receptor0.603
FGFR1fibroblast growth factor receptor 10.600
CASP3caspase 3, apoptosis-related cysteine peptidase0.591
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.576
ARandrogen receptor0.556
SORBS3sorbin and SH3 domain containing 30.542
MYOD1myogenic differentiation 10.537
MPDZmultiple PDZ domain protein0.530
SMAD7SMAD family member 70.530
GSK3Bglycogen synthase kinase 3 beta0.526
S100BS100 calcium binding protein B0.494
ATXN1ataxin 10.486
JAG1jagged 10.467
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.453
PKM2pyruvate kinase, muscle0.431
CREBBPCREB binding protein0.421
ZNF43zinc finger protein 430.416
SMAD2SMAD family member 20.406
DAXXdeath-domain associated protein0.402
XIAPX-linked inhibitor of apoptosis0.394
PEX14peroxisomal biogenesis factor 140.388
FGF1fibroblast growth factor 1 (acidic)0.387
NR4A1nuclear receptor subfamily 4, group A, member 10.368
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.367
UBR1ubiquitin protein ligase E3 component n-recognin 10.362
NTRK3neurotrophic tyrosine kinase, receptor, type 30.361
CASP8caspase 8, apoptosis-related cysteine peptidase0.359
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.359
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.343
CASP9caspase 9, apoptosis-related cysteine peptidase0.333
TMSB4Xthymosin beta 4, X-linked0.323
PDX1pancreatic and duodenal homeobox 10.319
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.318
NR0B1nuclear receptor subfamily 0, group B, member 10.301
PAX8paired box 80.291
SOX1SRY (sex determining region Y)-box 10.290
HDAC1histone deacetylase 10.286
DLG4discs, large homolog 4 (Drosophila)0.283
SOX11SRY (sex determining region Y)-box 110.271
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.270
TP73tumor protein p730.270
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.269
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.269
BCL2L11BCL2-like 11 (apoptosis facilitator)0.257
RUNX1runt-related transcription factor 10.256
CALM1calmodulin 1 (phosphorylase kinase, delta)0.248
FGF3fibroblast growth factor 30.245
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.240
CRHR1corticotropin releasing hormone receptor 10.236
TAL1T-cell acute lymphocytic leukemia 10.230
FOXD3forkhead box D30.229
SIX6SIX homeobox 60.228
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.227
HIC1hypermethylated in cancer 10.226
S100A8S100 calcium binding protein A80.226
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.222
TCF4transcription factor 40.218
CHD3chromodomain helicase DNA binding protein 30.218
MAPK14mitogen-activated protein kinase 140.217
LBX1ladybird homeobox 10.217
LRP6low density lipoprotein receptor-related protein 60.217
WNT1wingless-type MMTV integration site family, member 10.216
LAMA4laminin, alpha 40.215
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.213
FKBP1AFK506 binding protein 1A, 12kDa0.211
FOXA2forkhead box A20.210
BMP2bone morphogenetic protein 20.210
RB1retinoblastoma 10.209
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.208
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.206
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.205
AKT1v-akt murine thymoma viral oncogene homolog 10.204
ZNF273zinc finger protein 2730.204
BBS10Bardet-Biedl syndrome 100.203
FYNFYN oncogene related to SRC, FGR, YES0.202
SFRP1secreted frizzled-related protein 10.197
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.195
POU4F2POU class 4 homeobox 20.193
HDAC2histone deacetylase 20.191
TCP1t-complex 10.189
MAP3K5mitogen-activated protein kinase kinase kinase 50.187
RAXretina and anterior neural fold homeobox0.186
TSC2tuberous sclerosis 20.181
NOTCH3notch 30.177
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.174
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.174
PBX1pre-B-cell leukemia homeobox 10.173
POU3F2POU class 3 homeobox 20.172
SC4MOLsterol-C4-methyl oxidase-like0.172
TBX5T-box 50.172
CFL1cofilin 1 (non-muscle)0.170
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.669
Hcn1hyperpolarization-activated cyclic nucleotide-gated potassium channel 10.655
Grik1glutamate receptor, ionotropic, kainate 10.642
Drd1adopamine receptor D1A0.556
Cgaglycoprotein hormones, alpha polypeptide0.553
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.543
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.538
Crhr1corticotropin releasing hormone receptor 10.529
Eporerythropoietin receptor0.525
Cntn2contactin 2 (axonal)0.469
Nrxn3neurexin 30.458
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.458
Hoxb7homeo box B70.450
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.447
Gad2glutamate decarboxylase 20.445
Ahraryl hydrocarbon receptor0.443
Arnt2aryl hydrocarbon receptor nuclear translocator 20.438
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.432
Rims1regulating synaptic membrane exocytosis 10.428
Scn10asodium channel, voltage-gated, type X, alpha subunit0.427
Myo1dmyosin ID0.418
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.414
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.403
Syt9synaptotagmin IX0.402
Aardalanine and arginine rich domain containing protein0.401
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.400
LOC246267resection-induced TPI (rs11)0.398
Cd4Cd4 molecule0.396
Crxcone-rod homeobox0.390
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.389
Gabrb1gamma-aminobutyric acid (GABA) A receptor, beta 10.387
UncxUNC homeobox0.387
Neurod1neurogenic differentiation 10.382
Prlhrprolactin releasing hormone receptor0.379
Sirpasignal-regulatory protein alpha0.378
Il12binterleukin 12B0.378
B4galnt4beta-1,4-N-acetyl-galactosaminyl transferase 40.377
Arandrogen receptor0.376
Elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.375
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.370
Mogmyelin oligodendrocyte glycoprotein0.369
Trhr2thyrotropin releasing hormone receptor 20.364
Pou3f2POU class 3 homeobox 20.358
Chrna7cholinergic receptor, nicotinic, alpha 70.358
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.356
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.352
Epha8Eph receptor A80.352
Pfn1profilin 10.351
Gria4glutamate receptor, ionotrophic, AMPA 40.349
Slco2b1solute carrier organic anion transporter family, member 2b10.340
Tpbpatrophoblast specific protein alpha0.338
Adra2cadrenergic, alpha-2C-, receptor0.336
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.333
Olr1078olfactory receptor 10780.324
St18suppression of tumorigenicity 180.324
Tacr1tachykinin receptor 10.321
Robo1roundabout homolog 1 (Drosophila)0.320
Oprk1opioid receptor, kappa 10.318
Ptprsprotein tyrosine phosphatase, receptor type, S0.317
Crhbpcorticotropin releasing hormone binding protein0.315
Marcksmyristoylated alanine rich protein kinase C substrate0.311
GperG protein-coupled estrogen receptor 10.310
St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.309
Slc9a4solute carrier family 9 (sodium/hydrogen exchanger), member 40.309
Ube2d4ubiquitin-conjugating enzyme E2D 40.307
Casp12caspase 120.302
Nrxn1neurexin 10.302
Hist1h1dhistone cluster 1, H1d0.301
Drd2dopamine receptor D20.301
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.294
Kcnk3potassium channel, subfamily K, member 30.294
Hoxc4homeo box C40.291
Ugt8UDP glycosyltransferase 80.291
Galr3galanin receptor 30.288
Mapre1microtubule-associated protein, RP/EB family, member 10.288
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.286
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.285
Ptprdprotein tyrosine phosphatase, receptor type, D0.284
Nptxrneuronal pentraxin receptor0.280
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.279
Fxyd1FXYD domain-containing ion transport regulator 10.275
Chrna2cholinergic receptor, nicotinic, alpha 2 (neuronal)0.274
Ptafrplatelet-activating factor receptor0.274
Cckbrcholecystokinin B receptor0.274
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.273
Stc1stanniocalcin 10.273
Camk2n2calcium/calmodulin-dependent protein kinase II inhibitor 20.273
Hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.269
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.268
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.267
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.264
Slc32a1solute carrier family 32 (GABA vesicular transporter), member 10.263
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.261
Nrsn2neurensin 20.259
Sstr2somatostatin receptor 20.259
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.258
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.257
Itgamintegrin, alpha M0.254
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism