The network for 'development of primary male sexual characteristics' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

development of primary male sexual characteristics

The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion.

NameDescriptionProbabilityFunc Analog Organism
pop-1Protein POP-10.223
pha-4Protein PHA-40.195
vab-3Protein VAB-30.145
hlh-1Protein HLH-10.106
fkh-2Protein FKH-20.085
K04B12.2Protein K04B12.20.080
lin-12Protein LIN-120.073
pry-1Protein PRY-10.066
fat-4Protein FAT-40.066
egl-18Protein EGL-180.062
egl-46Protein EGL-460.060
ceh-13Protein CEH-130.051
cnd-1Protein CND-10.051
Y65A5A.1Protein Y65A5A.10.049
aldo-2Protein ALDO-20.048
bar-1Protein BAR-10.047
hlh-2Protein HLH-20.046
ceh-27Protein CEH-270.045
clec-180Protein CLEC-1800.044
wrm-1Protein WRM-10.044
nhr-67Protein NHR-670.043
iff-1Protein IFF-10.042
elo-1Protein ELO-10.042
Y56A3A.6Protein Y56A3A.60.042
bli-1Protein BLI-10.041
R05G6.7Protein R05G6.70.041
W01C8.5Protein W01C8.50.040
pmk-1Protein PMK-10.037
eef-1A.1Protein EEF-1A.10.037
hbl-1Protein HBL-10.037
cec-1Protein CEC-10.037
dpy-20Protein DPY-200.036
unc-62Protein UNC-620.035
axl-1Protein AXL-10.035
sago-1Protein SAGO-10.034
hnd-1Protein HND-10.034
spd-1Protein SPD-10.034
CELE_F59A6.5Protein F59A6.50.034
uso-1Protein USO-10.031
cyp-33E2Protein CYP-33E20.031
best-7Protein BEST-70.031
arrd-4Protein ARRD-40.030
mlt-10Protein MLT-100.030
art-1Protein ART-10.030
sax-3Protein SAX-30.030
col-128Protein COL-1280.030
T25B9.9Protein T25B9.90.029
hcp-3Protein HCP-30.029
T28C6.8Protein T28C6.80.028
efl-1Protein EFL-10.028
prp-31Protein PRP-310.028
T21H3.1Protein T21H3.10.028
zip-7Protein ZIP-70.028
sfrp-1Protein SFRP-10.028
C15F1.8Protein C15F1.80.027
pal-1Protein PAL-10.027
dpy-26Protein DPY-260.027
B0336.3Protein B0336.30.027
far-2Protein FAR-20.026
ceh-16Protein CEH-160.026
igcm-3Protein IGCM-30.026
lin-29Protein LIN-290.026
F13E6.1Protein F13E6.10.025
madf-5Protein MADF-50.025
lit-1Protein LIT-10.025
F58H1.5Protein F58H1.50.024
CELE_E01G4.6Protein E01G4.60.024
lin-32Protein LIN-320.024
ntl-2Protein NTL-20.024
ten-1Protein TEN-10.024
tag-250Protein TAG-2500.024
mltn-9Protein MLTN-90.024
teg-4Protein TEG-40.024
eya-1Protein EYA-10.023
vav-1Protein VAV-10.023
C05E11.3Protein C05E11.30.023
hpo-8Protein HPO-80.023
let-60Protein LET-600.023
irx-1Protein IRX-10.023
unc-42Protein UNC-420.023
C24A3.4Protein C24A3.40.023
col-110Protein COL-1100.023
ech-8Protein ECH-80.023
him-1Protein HIM-10.023
ztf-2Protein ZTF-20.023
T16G1.2Protein T16G1.20.023
CELE_Y54G11A.11Protein Y54G11A.110.023
fat-1Protein FAT-10.023
F57F5.1Protein F57F5.10.023
ina-1Protein INA-10.022
Y44E3A.1Protein Y44E3A.10.022
C33G3.4Protein C33G3.40.022
dos-2Protein DOS-20.022
lact-9Protein LACT-90.022
tsp-17Protein TSP-170.022
CELE_ZK1025.3Protein ZK1025.30.022
sptf-1Protein SPTF-10.022
mig-13Protein MIG-130.022
C16A3.6Protein C16A3.60.022
cdc-25.2Protein CDC-25.20.022
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
linlines0.053
RASSF8CG5053 gene product from transcript CG5053-RA0.047
vgvestigial0.041
CG32711CG32711 gene product from transcript CG32711-RA0.034
pnrpannier0.029
tuptailup0.027
CG9510CG9510 gene product from transcript CG9510-RC0.024
stetstem cell tumor0.024
betaTub60Dbeta-Tubulin at 60D0.022
CG5362CG5362 gene product from transcript CG5362-RA0.021
l(2)k16918lethal (2) k169180.021
frcfringe connection0.021
vvlventral veins lacking0.020
CG10083CG10083 gene product from transcript CG10083-RA0.020
Cdk4Cyclin-dependent kinase 40.020
kl-5male fertility factor kl50.019
enengrailed0.018
shfshifted0.018
ushu-shaped0.017
cathDCG1548 gene product from transcript CG1548-RA0.017
MgstlMicrosomal glutathione S-transferase-like0.017
HopHsp70/Hsp90 organizing protein homolog0.016
Tip60CG6121 gene product from transcript CG6121-RA0.016
yip2yippee interacting protein 20.016
Gef26CG9491 gene product from transcript CG9491-RB0.015
HimHoles in muscle0.014
acachaete0.013
locolocomotion defects0.013
kluklumpfuss0.012
CG6776CG6776 gene product from transcript CG6776-RA0.012
stumpsCG31317 gene product from transcript CG31317-RC0.012
cdc14CG7134 gene product from transcript CG7134-RB0.011
CG10863CG10863 gene product from transcript CG10863-RA0.011
cuecueball0.011
nbsCG6754 gene product from transcript CG6754-RC0.011
CG4911CG4911 gene product from transcript CG4911-RA0.010
zfh1Zn finger homeodomain 10.010
abd-Aabdominal A0.010
CG11151CG11151 gene product from transcript CG11151-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.986
ESR1estrogen receptor 10.979
TAL1T-cell acute lymphocytic leukemia 10.908
PLCG1phospholipase C, gamma 10.679
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.539
ARandrogen receptor0.403
BCAR1breast cancer anti-estrogen resistance 10.377
BCL2B-cell CLL/lymphoma 20.348
MDM2Mdm2 p53 binding protein homolog (mouse)0.343
FANCD2Fanconi anemia, complementation group D20.325
PDX1pancreatic and duodenal homeobox 10.276
BCL2L1BCL2-like 10.270
HNF4Ahepatocyte nuclear factor 4, alpha0.237
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.222
TRIP6thyroid hormone receptor interactor 60.206
CREBBPCREB binding protein0.206
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.185
CASP8caspase 8, apoptosis-related cysteine peptidase0.184
EGR1early growth response 10.167
NGFnerve growth factor (beta polypeptide)0.165
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.159
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.155
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.154
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.151
VEGFAvascular endothelial growth factor A0.148
MSH6mutS homolog 6 (E. coli)0.134
EGR3early growth response 30.128
NR5A1nuclear receptor subfamily 5, group A, member 10.114
ARID4BAT rich interactive domain 4B (RBP1-like)0.105
CDH5cadherin 5, type 2 (vascular endothelium)0.102
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.101
NCOA3nuclear receptor coactivator 30.101
EGR2early growth response 20.099
FOXD3forkhead box D30.097
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.096
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.094
ARID4AAT rich interactive domain 4A (RBP1-like)0.093
UHRF2ubiquitin-like with PHD and ring finger domains 20.092
FGFR1fibroblast growth factor receptor 10.089
POU5F1POU class 5 homeobox 10.089
RORARAR-related orphan receptor A0.085
PAX8paired box 80.084
NRP1neuropilin 10.082
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.079
HDAC2histone deacetylase 20.078
PTPRBprotein tyrosine phosphatase, receptor type, B0.077
AP1M1adaptor-related protein complex 1, mu 1 subunit0.074
FZD1frizzled homolog 1 (Drosophila)0.073
NR4A1nuclear receptor subfamily 4, group A, member 10.071
SMAD7SMAD family member 70.069
PCNAproliferating cell nuclear antigen0.068
PTPRJprotein tyrosine phosphatase, receptor type, J0.067
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.065
CFLARCASP8 and FADD-like apoptosis regulator0.063
KITLGKIT ligand0.062
BAK1BCL2-antagonist/killer 10.060
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.058
SH3BP4SH3-domain binding protein 40.056
GSK3Bglycogen synthase kinase 3 beta0.055
MPDZmultiple PDZ domain protein0.055
BRCA1breast cancer 1, early onset0.054
PROX1prospero homeobox 10.051
SOX2SRY (sex determining region Y)-box 20.048
FGF18fibroblast growth factor 180.047
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.047
BAXBCL2-associated X protein0.047
RAD50RAD50 homolog (S. cerevisiae)0.046
HDAC1histone deacetylase 10.046
PGFplacental growth factor0.045
RBPMSRNA binding protein with multiple splicing0.044
GHRgrowth hormone receptor0.043
NEUROD1neurogenic differentiation 10.042
TOP2Atopoisomerase (DNA) II alpha 170kDa0.039
NR0B1nuclear receptor subfamily 0, group B, member 10.039
SMURF1SMAD specific E3 ubiquitin protein ligase 10.038
CAV1caveolin 1, caveolae protein, 22kDa0.036
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.035
FGF8fibroblast growth factor 8 (androgen-induced)0.035
GATA4GATA binding protein 40.034
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.034
WNT1wingless-type MMTV integration site family, member 10.034
SMAD4SMAD family member 40.032
SF3B4splicing factor 3b, subunit 4, 49kDa0.032
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.032
GDNFglial cell derived neurotrophic factor0.032
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.031
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.031
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.030
GFI1Bgrowth factor independent 1B transcription repressor0.030
BIDBH3 interacting domain death agonist0.029
RNR2l-rRNA0.029
NR4A2nuclear receptor subfamily 4, group A, member 20.029
CASP10caspase 10, apoptosis-related cysteine peptidase0.028
TTRtransthyretin0.028
NCOA1nuclear receptor coactivator 10.027
SPDEFSAM pointed domain containing ets transcription factor0.027
POU3F2POU class 3 homeobox 20.027
GATA5GATA binding protein 50.027
RAD23BRAD23 homolog B (S. cerevisiae)0.027
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.027
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax8paired box gene 81.000
Arandrogen receptor0.996
Pax2paired box gene 20.994
Hoxa10homeobox A100.979
Kiss1KiSS-1 metastasis-suppressor0.978
Lhcgrluteinizing hormone/choriogonadotropin receptor0.975
Nr5a1nuclear receptor subfamily 5, group A, member 10.973
Hoxd11homeobox D110.968
Esr1estrogen receptor 1 (alpha)0.953
Hoxa11homeobox A110.952
Pitx2paired-like homeodomain transcription factor 20.952
Gata4GATA binding protein 40.950
Pou3f3POU domain, class 3, transcription factor 30.908
Amhr2anti-Mullerian hormone type 2 receptor0.859
Hoxd13homeobox D130.855
Pax3paired box gene 30.846
Sall4sal-like 4 (Drosophila)0.845
Ptenphosphatase and tensin homolog0.827
Lhx3LIM homeobox protein 30.823
Dkk1dickkopf homolog 1 (Xenopus laevis)0.798
Emx2empty spiracles homolog 2 (Drosophila)0.795
Ror2receptor tyrosine kinase-like orphan receptor 20.793
Fgf8fibroblast growth factor 80.784
Gata6GATA binding protein 60.754
Lhx1LIM homeobox protein 10.719
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.716
Bcl2B-cell leukemia/lymphoma 20.715
Rargretinoic acid receptor, gamma0.707
Nr0b1nuclear receptor subfamily 0, group B, member 10.699
Rarbretinoic acid receptor, beta0.691
Hoxa9homeobox A90.681
Hoxd10homeobox D100.672
Plac1placental specific protein 10.663
Eya1eyes absent 1 homolog (Drosophila)0.652
Apcadenomatosis polyposis coli0.622
Amhanti-Mullerian hormone0.613
Isl1ISL1 transcription factor, LIM/homeodomain0.566
Kdrkinase insert domain protein receptor0.557
Gata3GATA binding protein 30.556
Fgfr2fibroblast growth factor receptor 20.553
Trp53transformation related protein 530.522
Fgf10fibroblast growth factor 100.519
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.517
Wnt6wingless-related MMTV integration site 60.507
Sema5bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B0.490
Acvr1activin A receptor, type 10.484
Pgrprogesterone receptor0.466
Hand2heart and neural crest derivatives expressed transcript 20.462
Cdkn1bcyclin-dependent kinase inhibitor 1B0.460
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.454
Pax6paired box gene 60.451
Tcf15transcription factor 150.450
Nkx6-1NK6 homeobox 10.443
Nos3nitric oxide synthase 3, endothelial cell0.441
Wt1Wilms tumor 1 homolog0.437
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.435
Barx1BarH-like homeobox 10.433
Sall3sal-like 3 (Drosophila)0.433
Dhhdesert hedgehog0.429
Smad3MAD homolog 3 (Drosophila)0.416
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.416
Hoxc9homeobox C90.396
Gdf11growth differentiation factor 110.394
Smc1astructural maintenance of chromosomes 1A0.387
Fshrfollicle stimulating hormone receptor0.385
Atoh7atonal homolog 7 (Drosophila)0.384
Sox7SRY-box containing gene 70.379
Tbx3T-box 30.368
Sgpl1sphingosine phosphate lyase 10.364
Hoxd9homeobox D90.363
Cdh5cadherin 50.360
Dmrt1doublesex and mab-3 related transcription factor 10.356
Nf1neurofibromatosis 10.354
Hoxb3homeobox B30.350
TiparpTCDD-inducible poly(ADP-ribose) polymerase0.349
Hoxc5homeobox C50.343
Tbx2T-box 20.340
Rxraretinoid X receptor alpha0.337
Kitkit oncogene0.336
Efna4ephrin A40.327
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.324
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.323
Meox2mesenchyme homeobox 20.323
Retret proto-oncogene0.311
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.310
Tcf21transcription factor 210.309
Klklotho0.307
Dlx1distal-less homeobox 10.300
Duox2dual oxidase 20.299
Wnt3awingless-related MMTV integration site 3A0.299
Tbrachyury0.298
Gfra3glial cell line derived neurotrophic factor family receptor alpha 30.296
Hoxd3homeobox D30.295
Pitx1paired-like homeodomain transcription factor 10.293
Schip1schwannomin interacting protein 10.289
Rararetinoic acid receptor, alpha0.288
Nkx2-1NK2 homeobox 10.285
Col2a1collagen, type II, alpha 10.283
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.282
Sox3SRY-box containing gene 30.280
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Apoeapolipoprotein E0.050
Prdm2PR domain containing 2, with ZNF domain0.033
Gata6GATA binding protein 60.031
Fut1fucosyltransferase 10.030
Pdynprodynorphin0.029
DbpD site of albumin promoter (albumin D-box) binding protein0.029
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.028
Nr5a2nuclear receptor subfamily 5, group A, member 20.026
Hmgn1high-mobility group nucleosome binding domain 10.026
Ppardperoxisome proliferator-activated receptor delta0.026
Bcl2B-cell CLL/lymphoma 20.025
Dbidiazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)0.024
Mcm6minichromosome maintenance complex component 60.023
Synposynaptopodin0.023
Cst12cystatin 120.023
Dnase1l3deoxyribonuclease 1-like 30.023
Rhobtb2Rho-related BTB domain containing 20.023
Sult1a1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.023
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.022
Kcng3potassium voltage-gated channel, subfamily G, member 30.022
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.022
Hlfhepatic leukemia factor0.021
Tmem158transmembrane protein 1580.021
Lamp2lysosomal-associated membrane protein 20.021
Gjb3gap junction protein, beta 30.021
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.021
Aldh3a1aldehyde dehydrogenase 3 family, member A10.021
Crybb3crystallin, beta B30.021
Dstndestrin0.020
Akr1c18aldo-keto reductase family 1, member C180.020
Unc5bunc-5 homolog B (C. elegans)0.020
Rln1relaxin 10.020
FaslgFas ligand (TNF superfamily, member 6)0.019
Nr0b2nuclear receptor subfamily 0, group B, member 20.019
Znf532zinc finger protein 5320.019
Svs5seminal vesicle secretory protein 50.019
Apobapolipoprotein B0.019
Ralav-ral simian leukemia viral oncogene homolog A (ras related)0.019
Prkceprotein kinase C, epsilon0.019
Rbp3retinol binding protein 3, interstitial0.019
C1scomplement component 1, s subcomponent0.019
Myo9amyosin IXA0.019
Pdzd2PDZ domain containing 20.019
Gfra2GDNF family receptor alpha 20.019
LOC56764dnaj-like protein0.019
Cyp17a1cytochrome P450, family 17, subfamily a, polypeptide 10.018
Slc7a10solute carrier family 7, (neutral amino acid transporter, y+ system) member 100.018
Tgfbr2transforming growth factor, beta receptor II0.018
G6pcglucose-6-phosphatase, catalytic subunit0.018
Capn1calpain 10.018
Pon1paraoxonase 10.018
Fabp6fatty acid binding protein 6, ileal0.018
Plac1placenta-specific 10.018
Irx4iroquois homeobox 40.017
Espnespin0.017
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.017
Ptprhprotein tyrosine phosphatase, receptor type, H0.017
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.017
Fbxo10F-box protein 100.017
Prlrprolactin receptor0.017
LOC257643cystatin SC0.017
Pacs1phosphofurin acidic cluster sorting protein 10.017
Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha0.017
Shc3SHC (Src homology 2 domain containing) transforming protein 30.017
Crisp2cysteine-rich secretory protein 20.017
Trhrthyrotropin releasing hormone receptor0.017
Rararetinoic acid receptor, alpha0.016
Kcnh1potassium voltage-gated channel, subfamily H (eag-related), member 10.016
Magmyelin-associated glycoprotein0.016
Renrenin0.016
Apoa2apolipoprotein A-II0.016
Pla2g1bphospholipase A2, group IB, pancreas0.016
Slc4a3solute carrier family 4 (anion exchanger), member 30.016
Acacbacetyl-Coenzyme A carboxylase beta0.016
Mamdc4MAM domain containing 40.016
Dchs1dachsous 1 (Drosophila)0.016
Dnah2dynein, axonemal, heavy chain 20.016
Eif2c2eukaryotic translation initiation factor 2C, 20.016
Fn1fibronectin 10.016
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.016
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.016
LOC246267resection-induced TPI (rs11)0.016
Ccl5chemokine (C-C motif) ligand 50.016
Adcy10adenylate cyclase 10 (soluble)0.016
Igfbp5insulin-like growth factor binding protein 50.016
PawrPRKC, apoptosis, WT1, regulator0.016
Pla2g5phospholipase A2, group V0.016
Rab20RAB20, member RAS oncogene family0.016
Ednrbendothelin receptor type B0.016
Mettl7bmethyltransferase like 7B0.015
Ptgirprostaglandin I2 (prostacyclin) receptor (IP)0.015
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.015
Prlhrprolactin releasing hormone receptor0.015
Foxp4forkhead box P40.015
C2cd4dC2 calcium-dependent domain containing 4D0.015
Stat4signal transducer and activator of transcription 40.015
Casq2calsequestrin 2 (cardiac muscle)0.015
Ftlferritin, light polypeptide0.015
Epn1Epsin 10.015
Kcnt1potassium channel, subfamily T, member 10.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism