The network for 'negative regulation of cell morphogenesis involved in differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell morphogenesis involved in differentiation

Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.

NameDescriptionProbabilityFunc Analog Organism
sel-12Protein SEL-120.082
bar-1Protein BAR-10.069
egl-18Protein EGL-180.062
pry-1Protein PRY-10.060
madf-5Protein MADF-50.056
R10E12.2Protein R10E12.20.054
sax-3Protein SAX-30.044
unc-104Protein UNC-1040.044
lir-1Protein LIR-10.041
unc-9Protein UNC-90.038
F28E10.1Protein F28E10.10.037
sur-2Protein SUR-20.036
sem-4Protein SEM-40.035
axl-1Protein AXL-10.035
tbb-4Protein TBB-40.034
lin-17Protein LIN-170.034
cdh-3Protein CDH-30.032
cam-1Protein CAM-10.029
ten-1Protein TEN-10.028
cfz-2Protein CFZ-20.027
snt-4Protein SNT-40.026
pcp-3Protein PCP-30.025
nhr-66Protein NHR-660.025
paa-1Protein PAA-10.025
set-16Protein SET-160.025
soc-2Protein SOC-20.025
B0198.3Protein B0198.30.023
ccb-1Protein CCB-10.023
hbl-1Protein HBL-10.023
pop-1Protein POP-10.023
unc-129Protein UNC-1290.023
T28B11.1Protein T28B11.10.023
unc-42Protein UNC-420.023
ptp-3Protein PTP-30.022
lin-12Protein LIN-120.022
cec-1Protein CEC-10.022
zfp-1Protein ZFP-10.022
F52D10.6Protein F52D10.60.022
xpc-1Protein XPC-10.021
smp-1Protein SMP-10.021
nhr-67Protein NHR-670.021
CELE_T13H5.1Protein T13H5.10.021
let-60Protein LET-600.021
hhat-2Protein HHAT-20.021
kal-1Protein KAL-10.020
daf-12Protein DAF-120.019
zoo-1Protein ZOO-10.019
rig-6Protein RIG-60.019
syg-2Protein SYG-20.019
W02B8.1Protein W02B8.10.019
rpy-1Protein RPY-10.019
F53B3.5Protein F53B3.50.018
F36D4.5Protein F36D4.50.018
jac-1Protein JAC-10.018
ife-4Protein IFE-40.018
dpy-19Protein DPY-190.018
hlh-30Protein HLH-300.018
hmr-1Protein HMR-10.018
DH11.5Protein DH11.50.018
fmi-1Protein FMI-10.018
ima-3Protein IMA-30.018
lit-1Protein LIT-10.018
bet-2Protein BET-20.018
cnt-2Protein CNT-20.017
lin-36Protein LIN-360.017
mrck-1Protein MRCK-10.017
pha-4Protein PHA-40.017
dhs-27Protein DHS-270.017
ceh-6Protein CEH-60.017
elt-6Protein ELT-60.017
lev-1Protein LEV-10.017
mef-2Protein MEF-20.017
B0432.8Protein B0432.80.017
exp-2Protein EXP-20.016
clh-5Protein CLH-50.016
met-1Protein MET-10.016
F09C3.2Protein F09C3.20.016
igcm-3Protein IGCM-30.016
CELE_F47G4.4Protein F47G4.40.016
jmjd-2Protein JMJD-20.015
pde-1Protein PDE-10.015
eor-2Protein EOR-20.015
cdc-42Protein CDC-420.015
hmp-1Protein HMP-10.015
F11A10.5Protein F11A10.50.015
tmc-2Protein TMC-20.015
arl-3Protein ARL-30.015
egl-30Protein EGL-300.015
dmd-9Protein DMD-90.015
plx-2Protein PLX-20.015
egl-46Protein EGL-460.015
pqn-87Protein PQN-870.015
CELE_F07A5.4Protein F07A5.40.015
inx-7Protein INX-70.015
csnk-1Protein CSNK-10.015
hrp-1Protein HRP-10.015
eor-1Protein EOR-10.015
unc-1Protein UNC-10.015
cit-1.1Protein CIT-1.10.014
rgl-1Protein RGL-10.014
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
foxa1forkhead box A10.774
fgfr3fibroblast growth factor receptor 30.409
bocbrother of CDO0.239
tfectranscription factor EC0.182
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.170
fzd7afrizzled homolog 7a0.148
notum3notum 30.111
rdh10aretinol dehydrogenase 10a0.108
lhx2bLIM homeobox 2b0.108
irx2airoquois homeobox protein 2, a0.096
robo2roundabout homolog 20.092
gro1groucho 10.086
rdh8retinol dehydrogenase 80.086
col7a1lcollagen type VII alpha 1-like0.084
efnb3bephrin B3b0.081
dtngdystrobrevin, gamma and dystrobrevin, gamma-like0.068
alcamaactivated leukocyte cell adhesion molecule a0.065
ntn2netrin 20.063
ntn1bnetrin 1b0.062
tnctenascin C0.061
epb4.1l4erythrocyte protein band 4.1-like 40.061
ntn1anetrin 1a0.060
sema3dsemaphorin 3d0.058
efnb2aephrin B2a0.054
sp8asp8 transcription factor a0.053
slit1aslit homolog 1a (Drosophila)0.051
cdh2cadherin 2, neuronal0.050
crabp1bcellular retinoic acid binding protein 1b0.050
fstl1bfollistatin-like 1b0.049
igf1rbinsulin-like growth factor 1b receptor0.048
kal1aKallmann syndrome 1a sequence0.047
irx5airoquois homeobox protein 5a0.047
igf2ainsulin-like growth factor 2a0.047
ptpraprotein tyrosine phosphatase, receptor type, A0.045
evx1even-skipped homeobox 10.041
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.040
loxl2blysyl oxidase-like 2b0.039
barhl2BarH-like 20.038
olfm2olfactomedin 20.038
esrraestrogen-related receptor alpha0.038
zdhhc8bzinc finger, DHHC-type containing 8b0.038
gsnagelsolin a0.038
foxa3forkhead box A30.037
dab1adisabled homolog 1a (Drosophila)0.036
bmp2abone morphogenetic protein 2a0.035
metmet proto-oncogene (hepatocyte growth factor receptor)0.034
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.032
irx5biroquois homeobox protein 5b0.031
ret1receptor tyrosine kinase0.031
traf4atnf receptor-associated factor 4a0.031
smoc1SPARC related modular calcium binding 10.030
sox1aSRY-box containing gene 1a0.030
gro2groucho 20.029
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.029
fzd5frizzled homolog 50.028
lama1laminin, alpha 10.028
epha7eph receptor A70.028
slit1bslit homolog 1b (Drosophila)0.028
sema3fbsemaphorin 3fb0.027
rxrgaretinoid x receptor, gamma a0.027
neurod4neurogenic differentiation 40.027
phox2apaired-like homeobox 2a0.027
tbx2aT-box gene 2a0.025
epha4aeph receptor A4a0.025
ebf3early B-cell factor 30.024
cntn2contactin 20.023
mapk14amitogen-activated protein kinase 14a0.023
nrp1aneuropilin 1a0.023
angptl2angiopoietin-like 20.022
col12a1collagen, type XII, alpha 10.021
sema3aasemaphorin 3aa0.021
nog1noggin 10.021
ascl1aachaete-scute complex-like 1a (Drosophila)0.020
slit3slit (Drosophila) homolog 30.020
unc5bunc-5 homolog B (C. elegans)0.020
sema6dlsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like0.020
frem3Fras1 related extracellular matrix 30.020
insm1ainsulinoma-associated 1a0.019
flncbfilamin C, gamma b (actin binding protein 280)0.019
pou3f3aPOU class 3 homeobox 3a0.019
hoxb2ahomeo box B2a0.019
gap43growth associated protein 430.019
nav3neuron navigator 30.018
metrnmeteorin, glial cell differentiation regulator0.018
hgfahepatocyte growth factor a0.018
nrp2aneuropilin 2a0.018
raraaretinoic acid receptor, alpha a0.018
foxi3bforkhead box I3b0.018
pea3ETS-domain transcription factor pea30.018
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.018
foxd3forkhead box D30.017
ptpn11aprotein tyrosine phosphatase, non-receptor type 11, a0.017
sfrp1asecreted frizzled-related protein 1a0.017
dbx1adeveloping brain homeobox 1a0.016
rbpjarecombination signal binding protein for immunoglobulin kappa J region a0.016
ephb4beph receptor B4b0.016
bhmtbetaine-homocysteine methyltransferase0.016
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HDAC1histone deacetylase 10.998
HDAC2histone deacetylase 20.989
FGF1fibroblast growth factor 1 (acidic)0.809
TBX5T-box 50.245
POU5F1POU class 5 homeobox 10.160
RB1CC1RB1-inducible coiled-coil 10.142
NCOA1nuclear receptor coactivator 10.139
VEGFAvascular endothelial growth factor A0.124
GRB7growth factor receptor-bound protein 70.124
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.123
PCDHA4protocadherin alpha 40.107
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.093
NEDD4neural precursor cell expressed, developmentally down-regulated 40.075
IMMTinner membrane protein, mitochondrial0.067
RBBP4retinoblastoma binding protein 40.064
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.060
GOLGA2golgin A20.052
SMN1survival of motor neuron 1, telomeric0.052
CLDN4claudin 40.051
FAF1Fas (TNFRSF6) associated factor 10.050
WDYHV1WDYHV motif containing 10.048
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.046
CDC27cell division cycle 27 homolog (S. cerevisiae)0.045
TGFB3transforming growth factor, beta 30.045
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.038
SLC25A36solute carrier family 25, member 360.037
REV3LREV3-like, catalytic subunit of DNA polymerase zeta (yeast)0.036
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.036
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.035
CHD4chromodomain helicase DNA binding protein 40.033
MTA3metastasis associated 1 family, member 30.033
COL4A3BPcollagen, type IV, alpha 3 (Goodpasture antigen) binding protein0.033
CYFIP2cytoplasmic FMR1 interacting protein 20.032
FZD1frizzled homolog 1 (Drosophila)0.031
MAP3K5mitogen-activated protein kinase kinase kinase 50.030
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.030
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.030
GABARAPGABA(A) receptor-associated protein0.028
NR4A1nuclear receptor subfamily 4, group A, member 10.027
CCT8chaperonin containing TCP1, subunit 8 (theta)0.027
RTN4reticulon 40.025
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.025
RAP1ARAP1A, member of RAS oncogene family0.025
ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific )0.024
CPEcarboxypeptidase E0.024
FAM160A2family with sequence similarity 160, member A20.024
FZD8frizzled homolog 8 (Drosophila)0.024
PAX8paired box 80.024
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.023
RXRAretinoid X receptor, alpha0.023
MMP14matrix metallopeptidase 14 (membrane-inserted)0.023
RAB2ARAB2A, member RAS oncogene family0.022
AP1M1adaptor-related protein complex 1, mu 1 subunit0.022
MBD2methyl-CpG binding domain protein 20.022
SIN3ASIN3 homolog A, transcription regulator (yeast)0.021
COL1A1collagen, type I, alpha 10.021
ARandrogen receptor0.020
SOX2SRY (sex determining region Y)-box 20.020
SCNN1Asodium channel, nonvoltage-gated 1 alpha0.020
TBK1TANK-binding kinase 10.019
LRP6low density lipoprotein receptor-related protein 60.019
NR2E3nuclear receptor subfamily 2, group E, member 30.019
MOBKL3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.019
APH1Aanterior pharynx defective 1 homolog A (C. elegans)0.018
GATA4GATA binding protein 40.018
DCCdeleted in colorectal carcinoma0.018
MTA1metastasis associated 10.018
KCNRGpotassium channel regulator0.018
CREBBPCREB binding protein0.018
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.018
CDK6cyclin-dependent kinase 60.018
ATRXalpha thalassemia/mental retardation syndrome X-linked0.017
FGF10fibroblast growth factor 100.017
LUC7L2LUC7-like 2 (S. cerevisiae)0.017
SCAMP1secretory carrier membrane protein 10.017
FXR1fragile X mental retardation, autosomal homolog 10.016
ST14suppression of tumorigenicity 14 (colon carcinoma)0.016
ATN1atrophin 10.016
GATAD2AGATA zinc finger domain containing 2A0.016
SESN2sestrin 20.015
GEMIN6gem (nuclear organelle) associated protein 60.015
FGFR1fibroblast growth factor receptor 10.015
LBX1ladybird homeobox 10.015
WFDC2WAP four-disulfide core domain 20.015
FXYD3FXYD domain containing ion transport regulator 30.015
BBS10Bardet-Biedl syndrome 100.014
MTA2metastasis associated 1 family, member 20.014
ATP8ATP synthase F0 subunit 80.014
FGF8fibroblast growth factor 8 (androgen-induced)0.014
KDM1Alysine (K)-specific demethylase 1A0.014
CYFIP1cytoplasmic FMR1 interacting protein 10.014
UBE3Aubiquitin protein ligase E3A0.013
CSNK2Bcasein kinase 2, beta polypeptide0.013
RCOR1REST corepressor 10.013
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.013
CDX2caudal type homeobox 20.013
WBP2WW domain binding protein 20.013
CDK2AP1cyclin-dependent kinase 2 associated protein 10.013
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.996
Ephb2Eph receptor B20.995
Gli3GLI-Kruppel family member GLI30.995
Epha4Eph receptor A40.993
Efnb2ephrin B20.977
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.956
Robo1roundabout homolog 1 (Drosophila)0.910
Psen1presenilin 10.905
Ctnnb1catenin (cadherin associated protein), beta 10.885
Slit3slit homolog 3 (Drosophila)0.813
Shhsonic hedgehog0.773
Ephb3Eph receptor B30.757
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.718
Wnt3awingless-related MMTV integration site 3A0.717
Tyro3TYRO3 protein tyrosine kinase 30.685
Pou3f3POU domain, class 3, transcription factor 30.679
AxlAXL receptor tyrosine kinase0.658
Ptk2PTK2 protein tyrosine kinase 20.645
Gli2GLI-Kruppel family member GLI20.635
Notch1Notch gene homolog 1 (Drosophila)0.617
Fgf8fibroblast growth factor 80.583
Ror1receptor tyrosine kinase-like orphan receptor 10.575
Fzd1frizzled homolog 1 (Drosophila)0.573
Wnt5awingless-related MMTV integration site 5A0.569
Foxa2forkhead box A20.533
Rarbretinoic acid receptor, beta0.529
Tbx3T-box 30.527
Sall4sal-like 4 (Drosophila)0.516
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.491
Gab1growth factor receptor bound protein 2-associated protein 10.481
Apc2adenomatosis polyposis coli 20.476
Zfpm2zinc finger protein, multitype 20.475
Nrp1neuropilin 10.410
Foxc1forkhead box C10.408
Rargretinoic acid receptor, gamma0.402
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.395
Plcg1phospholipase C, gamma 10.360
Ptenphosphatase and tensin homolog0.355
Axin1axin 10.354
Fgf18fibroblast growth factor 180.347
Tnks1bp1tankyrase 1 binding protein 10.334
Mmp15matrix metallopeptidase 150.334
Sfrp1secreted frizzled-related protein 10.326
Hoxd11homeobox D110.319
Sfrp2secreted frizzled-related protein 20.314
Sox2SRY-box containing gene 20.297
Pax2paired box gene 20.297
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.293
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.289
Lhx1LIM homeobox protein 10.277
Fgfr1fibroblast growth factor receptor 10.277
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.236
Dkk1dickkopf homolog 1 (Xenopus laevis)0.234
Pcdh12protocadherin 120.232
Emx1empty spiracles homolog 1 (Drosophila)0.225
Fgf3fibroblast growth factor 30.224
L1camL1 cell adhesion molecule0.220
Dll1delta-like 1 (Drosophila)0.218
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.216
Dll4delta-like 4 (Drosophila)0.215
Vangl2vang-like 2 (van gogh, Drosophila)0.213
Pax8paired box gene 80.210
Fzd8frizzled homolog 8 (Drosophila)0.208
Bmp5bone morphogenetic protein 50.196
Hoxa13homeobox A130.194
Nrp2neuropilin 20.193
Arhgef12Rho guanine nucleotide exchange factor (GEF) 120.192
Wnt3wingless-related MMTV integration site 30.187
Chd7chromodomain helicase DNA binding protein 70.187
Sall1sal-like 1 (Drosophila)0.186
Bmp1bone morphogenetic protein 10.185
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.185
Grid1glutamate receptor, ionotropic, delta 10.182
Pthlhparathyroid hormone-like peptide0.181
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.173
Mertkc-mer proto-oncogene tyrosine kinase0.171
Pbx1pre B-cell leukemia transcription factor 10.170
Hes1hairy and enhancer of split 1 (Drosophila)0.169
Pou3f2POU domain, class 3, transcription factor 20.165
Unc5cunc-5 homolog C (C. elegans)0.162
Dock1dedicator of cytokinesis 10.161
Efna2ephrin A20.160
Trp63transformation related protein 630.155
Zdhhc17zinc finger, DHHC domain containing 170.154
Wnt2bwingless related MMTV integration site 2b0.152
Dlx5distal-less homeobox 50.152
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.152
Adam11a disintegrin and metallopeptidase domain 110.150
Efsembryonal Fyn-associated substrate0.149
MagixMAGI family member, X-linked0.149
Grb10growth factor receptor bound protein 100.149
Appamyloid beta (A4) precursor protein0.148
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.146
SrcRous sarcoma oncogene0.145
Pax3paired box gene 30.141
Gli1GLI-Kruppel family member GLI10.141
Rnf208ring finger protein 2080.139
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism