The network for 'positive regulation of purine nucleotide catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of purine nucleotide catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.

NameDescriptionProbabilityFunc Analog Organism
let-60Protein LET-600.338
lag-1Protein LAG-10.227
F52G3.1Protein F52G3.10.144
rig-6Protein RIG-60.132
sem-5Protein SEM-50.127
goa-1Protein GOA-10.126
unc-79Protein UNC-790.124
C11E4.6Protein C11E4.60.118
zfp-3Protein ZFP-30.113
rpm-1Protein RPM-10.107
mpk-1Protein MPK-10.095
CELE_F47G4.4Protein F47G4.40.083
plc-3Protein PLC-30.077
flh-2Protein FLH-20.058
unc-71Protein UNC-710.056
abl-1Protein ABL-10.054
eor-2Protein EOR-20.053
egrh-1Protein EGRH-10.052
egl-18Protein EGL-180.052
coh-3Protein COH-30.052
smp-1Protein SMP-10.050
cgef-2Protein CGEF-20.049
sup-17Protein SUP-170.048
rme-4Protein RME-40.047
ptp-4Protein PTP-40.047
etr-1Protein ETR-10.046
lin-45Protein LIN-450.044
afd-1Protein AFD-10.044
cam-1Protein CAM-10.042
rgl-1Protein RGL-10.042
egl-44Protein EGL-440.042
abts-1Protein ABTS-10.040
zfp-1Protein ZFP-10.039
T23F2.2Protein T23F2.20.039
F28B3.1Protein F28B3.10.038
bet-2Protein BET-20.038
sax-3Protein SAX-30.037
aha-1Protein AHA-10.036
C53C9.2Protein C53C9.20.036
magi-1Protein MAGI-10.035
itr-1Protein ITR-10.035
egl-8Protein EGL-80.035
ykt-6Protein YKT-60.035
sto-4Protein STO-40.034
kin-25Protein KIN-250.034
snf-1Protein SNF-10.033
pkg-1Protein PKG-10.032
gar-3Protein GAR-30.032
ist-1Protein IST-10.032
mbk-1Protein MBK-10.031
cah-6Protein CAH-60.030
ddr-2Protein DDR-20.029
rpb-7Protein RPB-70.029
myo-3Protein MYO-30.028
cpt-1Protein CPT-10.028
sma-6Protein SMA-60.028
stau-1Protein STAU-10.028
pat-3Protein PAT-30.027
daf-19Protein DAF-190.027
unc-115Protein UNC-1150.027
nck-1Protein NCK-10.027
cdh-9Protein CDH-90.027
ptp-1Protein PTP-10.027
zoo-1Protein ZOO-10.027
CELE_Y60A3A.9Protein Y60A3A.90.026
par-6Protein PAR-60.026
lin-40Protein LIN-400.026
larp-5Protein LARP-50.026
exc-5Protein EXC-50.025
atg-11Protein ATG-110.025
CELE_K08E7.6Protein K08E7.60.025
ced-10Protein CED-100.025
magu-3Protein MAGU-30.025
ubr-1Protein UBR-10.025
T23F11.1Protein T23F11.10.025
pdk-1Protein PDK-10.024
C15H9.5Protein C15H9.50.024
nrx-1Protein NRX-10.024
unc-26Protein UNC-260.024
rab-5Protein RAB-50.023
sav-1Protein SAV-10.023
pak-1Protein PAK-10.023
crt-1Protein CRT-10.023
mpz-1Protein MPZ-10.023
acr-2Protein ACR-20.023
Y55B1AL.2Protein Y55B1AL.20.022
hpk-1Protein HPK-10.022
Y55F3BR.2Protein Y55F3BR.20.022
T14B1.1Protein T14B1.10.022
F13H6.1Protein F13H6.10.021
gap-2Protein GAP-20.021
lin-7Protein LIN-70.021
frm-10Protein FRM-100.021
CELE_Y43F8B.19Protein Y43F8B.190.021
sel-12Protein SEL-120.021
git-1Protein GIT-10.021
C49A1.10Protein C49A1.100.020
clr-1Protein CLR-10.020
rpn-6.1Protein RPN-6.10.020
CELE_T10D4.6Protein T10D4.60.020
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tpm4tropomyosin 40.689
hspa4aheat shock protein 4a0.378
rtcd1RNA terminal phosphate cyclase domain 10.346
bcl2B-cell leukemia/lymphoma 20.340
bidaBH3 interacting domain death agonist0.331
ppargperoxisome proliferator activated receptor gamma0.317
nf1aneurofibromin 1a0.242
dnaja1lDnaJ (Hsp40) homolog, subfamily A, member 1, like0.230
hsp90a.2heat shock protein 90-alpha 20.208
mcl1bmyeloid cell leukemia sequence 1b0.171
adrb2aadrenergic receptor, beta 2a0.167
sox4aSRY-box containing gene 4a0.166
rtn1areticulon 1a0.155
cfl2lcofilin 2, like0.149
si:ch211-232m7.1si:ch211-232m7.10.146
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.146
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.133
s1pr1sphingosine-1-phosphate receptor 10.129
icnictacalcin0.128
zgc:100838zgc:1008380.127
pdlim1PDZ and LIM domain 1 (elfin)0.119
ndel1anudE nuclear distribution gene E homolog like 1 (A. nidulans) A0.117
nf1bneurofibromin 1b0.116
baxabcl2-associated X protein, a0.115
mcl1amyeloid cell leukemia sequence 1a0.115
cnn2calponin 20.112
cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.110
krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.106
msnamoesin a0.104
pole2polymerase (DNA directed), epsilon 20.099
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.099
b3gnt5aUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a0.097
LOC565839tumor necrosis factor alpha-induced protein 2-like0.096
gna12guanine nucleotide binding protein (G protein) alpha 120.095
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.094
scinlbscinderin like b0.094
adrb2badrenergic receptor, beta 2b0.093
s100v2S100 calcium binding protein V20.093
pvalb4parvalbumin 40.092
dzip1DAZ interacting protein 10.091
pak2ap21 (CDKN1A)-activated kinase 2a0.090
phf21aPHD finger protein 21A0.090
rab5cRAB5C, member RAS oncogene family0.090
acsl4aacyl-CoA synthetase long-chain family member 4a0.089
whsc1Wolf-Hirschhorn syndrome candidate 10.089
gclcglutamate-cysteine ligase, catalytic subunit0.088
LOC567131calcitonin gene-related peptide type 1 receptor-like0.087
ywhaityrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide0.087
gro2groucho 20.086
bokaBCL2-related ovarian killer a0.085
actc1aactin, alpha, cardiac muscle 1a0.084
epb41l5erythrocyte membrane protein band 4.1 like 50.083
mcm6MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae)0.082
tomm34translocase of outer mitochondrial membrane 340.080
elf2bE74-like factor 2b (ets domain transcription factor)0.080
zgc:77517zgc:775170.080
rhoaaras homolog gene family, member Aa0.080
rcn1reticulocalbin 1, EF-hand calcium binding domain0.078
sncbsynuclein, beta0.078
zgc:73142zgc:731420.077
ilkintegrin linked kinase0.077
tpm3tropomyosin 30.076
gsnagelsolin a0.076
epha2eph receptor A20.076
mat2amethionine adenosyltransferase II, alpha0.075
depdc1aDEP domain containing 1a0.074
wu:fb39a06wu:fb39a060.074
zgc:112329zgc:1123290.071
nebnebulin0.071
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.071
tnni2a.4troponin I, skeletal, fast 2a.40.070
sox19aSRY-box containing gene 19a0.070
cldnkclaudin k0.070
s100zS100 calcium binding protein Z0.070
adrb3aadrenergic receptor, beta 3a0.069
phlda2pleckstrin homology-like domain, family A, member 20.069
mycbp2MYC binding protein 20.068
dnajb1bDnaJ (Hsp40) homolog, subfamily B, member 1b0.068
rpsaribosomal protein SA0.067
acheacetylcholinesterase0.067
gnao1aguanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a0.067
tsc22d3TSC22 domain family, member 30.066
nfe2l3nuclear factor (erythroid-derived 2)-like 30.066
wu:fc23b05wu:fc23b050.065
zgc:92851zgc:928510.065
ccnb2cyclin B20.065
ccna2cyclin A20.065
melkmaternal embryonic leucine zipper kinase0.064
rrasrelated RAS viral (r-ras) oncogene homolog0.064
chac1ChaC, cation transport regulator-like 10.064
atp6v1alATPase, H+ transporting, lysosomal V1 subunit A, like0.064
ahnakAHNAK nucleoprotein0.064
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.063
badBCL2-antagonist of cell death0.063
yap1Yes-associated protein 10.062
dnmt7DNA (cytosine-5-)-methyltransferase 70.062
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.062
hmgb3ahigh-mobility group box 3a0.062
yrkYes-related kinase0.062
junbjun B proto-oncogene0.061
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
rokRho-kinase0.626
drprdraper0.572
WnkCG7177 gene product from transcript CG7177-RA0.431
PknProtein kinase related to protein kinase N0.363
PtenCG5671 gene product from transcript CG5671-RB0.344
RhoGAP68FCG6811 gene product from transcript CG6811-RA0.331
plexBplexin B0.307
mbcmyoblast city0.283
Pi3K92ECG4141 gene product from transcript CG4141-RB0.271
pucpuckered0.260
Dap160Dynamin associated protein 1600.257
NaCP60ENa channel protein 60E0.242
staistathmin0.236
RhebCG1081 gene product from transcript CG1081-RA0.231
jumujumeau0.217
stgstring0.207
HemHEM-protein0.206
drkdownstream of receptor kinase0.184
CG7158CG7158 gene product from transcript CG7158-RA0.171
GugGrunge0.163
unc-104CG8566 gene product from transcript CG8566-RB0.158
rapsrapsynoid0.145
nwknervous wreck0.142
cnocanoe0.135
Plc21CPhospholipase C at 21C0.125
AbiAbelson interacting protein0.116
cenG1Acentaurin gamma 1A0.112
Fak56DFocal Adhesion Kinase0.112
sizschizo0.111
synjsynaptojanin0.109
SosSon of sevenless0.102
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.101
Cf2Chorion factor 20.100
Pk61CProtein kinase 61C0.098
mbtmushroom bodies tiny0.096
dysdysfusion0.088
Myo31DFMyosin 31DF0.088
Act88FActin 88F0.087
kuzkuzbanian0.087
Smg1CG32743 gene product from transcript CG32743-RA0.084
l(2)k16918lethal (2) k169180.079
Tsc1CG6147 gene product from transcript CG6147-RA0.076
CG3573CG3573 gene product from transcript CG3573-RA0.075
DAAMDishevelled Associated Activator of Morphogenesis0.075
KhcKinesin heavy chain0.074
CG8155CG8155 gene product from transcript CG8155-RA0.074
dosdaughter of sevenless0.073
RhoGAPp190CG32555 gene product from transcript CG32555-RB0.071
maskmultiple ankyrin repeats single KH domain0.070
simasimilar0.069
Mlc2Myosin light chain 20.068
pod1CG4532 gene product from transcript CG4532-RF0.067
KlcKinesin light chain0.064
MadMothers against dpp0.062
EphrinCG1862 gene product from transcript CG1862-RA0.062
flwflapwing0.060
CG9426CG9426 gene product from transcript CG9426-RA0.060
tmodtropomodulin0.059
Hnf4Hepatocyte nuclear factor 40.057
Tre1trapped in endoderm-10.054
ShawShaker cognate w0.054
Rbsn-5Rabenosyn-50.054
DabDisabled0.054
CG11033CG11033 gene product from transcript CG11033-RB0.053
Vps45Vacuolar protein sorting 450.053
neurneuralized0.053
bazbazooka0.052
Stat92ESignal-transducer and activator of transcription protein at 92E0.052
Su(H)Suppressor of Hairless0.052
CG7231CG7231 gene product from transcript CG7231-RE0.052
Dcr-2Dicer-20.052
carcarnation0.051
neuroliginCG13772 gene product from transcript CG13772-RA0.051
p120ctnAdherens junction protein p1200.051
gclgerm cell-less0.050
pcxpecanex0.049
Ced-12CG5336 gene product from transcript CG5336-RA0.048
CG17233CG17233 gene product from transcript CG17233-RA0.048
klarklarsicht0.047
trioCG18214 gene product from transcript CG18214-RA0.047
G-ialpha65AG protein alphai subunit 65A0.046
Vps35Vacuolar protein sorting 350.046
CalpBCalpain-B0.045
Su(Tpl)CG32217 gene product from transcript CG32217-RB0.045
RhoBTBCG5701 gene product from transcript CG5701-RA0.044
CG8334CG8334 gene product from transcript CG8334-RA0.044
gfAgiant fibre A0.044
UBL3CG9038 gene product from transcript CG9038-RC0.044
kenken and barbie0.043
SbfSET domain binding factor0.043
pkaapCG4132 gene product from transcript CG4132-RA0.043
CG9941CG9941 gene product from transcript CG9941-RA0.043
phlpole hole0.043
Mlp84BMuscle LIM protein at 84B0.043
DlicDynein light intermediate chain0.042
pgant3polypeptide GalNAc transferase 30.042
MtlMig-2-like0.042
piepineapple eye0.042
MbsMyosin binding subunit0.040
CG6454CG6454 gene product from transcript CG6454-RC0.040
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)1.000
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.993
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.987
SFNstratifin0.984
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.976
EGFRepidermal growth factor receptor0.969
FGFR2fibroblast growth factor receptor 20.947
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.917
PTK2PTK2 protein tyrosine kinase 20.912
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.902
LAMTOR1late endosomal/lysosomal adaptor, MAPK and MTOR activator 10.890
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.890
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.880
BCAR1breast cancer anti-estrogen resistance 10.876
GRB7growth factor receptor-bound protein 70.873
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.860
GIT1G protein-coupled receptor kinase interacting ArfGAP 10.819
OCRLoculocerebrorenal syndrome of Lowe0.817
ARRB1arrestin, beta 10.813
RIN3Ras and Rab interactor 30.810
NCF2neutrophil cytosolic factor 20.804
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.803
SNX9sorting nexin 90.790
DNM1dynamin 10.769
LAMTOR2late endosomal/lysosomal adaptor, MAPK and MTOR activator 20.766
BCL2L1BCL2-like 10.735
GSK3Bglycogen synthase kinase 3 beta0.729
PLCG1phospholipase C, gamma 10.725
BBS10Bardet-Biedl syndrome 100.725
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.707
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.703
S100A8S100 calcium binding protein A80.702
SH3RF1SH3 domain containing ring finger 10.702
EXOSC10exosome component 100.696
DOCK1dedicator of cytokinesis 10.683
GRB2growth factor receptor-bound protein 20.634
NCKAP1NCK-associated protein 10.620
ITSN1intersectin 1 (SH3 domain protein)0.613
PTPRJprotein tyrosine phosphatase, receptor type, J0.610
TSC2tuberous sclerosis 20.606
RICTORRPTOR independent companion of MTOR, complex 20.605
SH3BP2SH3-domain binding protein 20.597
FGF1fibroblast growth factor 1 (acidic)0.597
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.586
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.586
FGFR1fibroblast growth factor receptor 10.585
RGS2regulator of G-protein signaling 2, 24kDa0.585
CNKSR2connector enhancer of kinase suppressor of Ras 20.580
ILKintegrin-linked kinase0.567
RHOAras homolog gene family, member A0.554
MTORmechanistic target of rapamycin (serine/threonine kinase)0.538
S100BS100 calcium binding protein B0.538
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.529
RASSF5Ras association (RalGDS/AF-6) domain family member 50.515
VAV1vav 1 guanine nucleotide exchange factor0.505
CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.504
S100A6S100 calcium binding protein A60.503
ADRBK1adrenergic, beta, receptor kinase 10.500
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.498
S100A9S100 calcium binding protein A90.487
STAT5Asignal transducer and activator of transcription 5A0.470
PKN3protein kinase N30.467
HSPA1Bheat shock 70kDa protein 1B0.465
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.457
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.456
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.455
CCR5chemokine (C-C motif) receptor 50.449
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.447
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.443
ZYXzyxin0.431
S100A1S100 calcium binding protein A10.430
DSPdesmoplakin0.429
S100A11S100 calcium binding protein A110.414
FMNL1formin-like 10.399
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.393
EIF2B2eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa0.376
AGAP5ArfGAP with GTPase domain, ankyrin repeat and PH domain 50.371
RHOCras homolog gene family, member C0.369
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.368
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.364
AGAP7ArfGAP with GTPase domain, ankyrin repeat and PH domain 70.362
TRAF5TNF receptor-associated factor 50.358
MARK3MAP/microtubule affinity-regulating kinase 30.349
ADAM15ADAM metallopeptidase domain 150.346
PAK4p21 protein (Cdc42/Rac)-activated kinase 40.339
PNPLA6patatin-like phospholipase domain containing 60.338
SH3KBP1SH3-domain kinase binding protein 10.335
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.333
ANKRD28ankyrin repeat domain 280.333
TOR1Atorsin family 1, member A (torsin A)0.331
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.330
DDX39ADEAD (Asp-Glu-Ala-Asp) box polypeptide 39A0.330
VASPvasodilator-stimulated phosphoprotein0.322
C7orf59chromosome 7 open reading frame 590.321
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.319
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.315
LIMS1LIM and senescent cell antigen-like domains 10.314
TFGTRK-fused gene0.314
TNK2tyrosine kinase, non-receptor, 20.308
ABI1abl-interactor 10.300
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rac1RAS-related C3 botulinum substrate 10.962
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.907
Itsn1intersectin 1 (SH3 domain protein 1A)0.865
BrafBraf transforming gene0.843
Arrb2arrestin, beta 20.833
Grb2growth factor receptor bound protein 20.811
Nf1neurofibromatosis 10.735
Dnm1dynamin 10.714
Bcl2B-cell leukemia/lymphoma 20.696
Hmha1histocompatibility (minor) HA-10.690
Vav1vav 1 oncogene0.656
Chrm1cholinergic receptor, muscarinic 1, CNS0.617
Git1G protein-coupled receptor kinase-interactor 10.600
Ptk2bPTK2 protein tyrosine kinase 2 beta0.567
Klklotho0.565
Plxna1plexin A10.543
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.504
Selplgselectin, platelet (p-selectin) ligand0.471
Pde1bphosphodiesterase 1B, Ca2+-calmodulin dependent0.457
Adrbk1adrenergic receptor kinase, beta 10.452
Gnb2guanine nucleotide binding protein (G protein), beta 20.442
Sox10SRY-box containing gene 100.391
Epha4Eph receptor A40.361
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.355
Cd37CD37 antigen0.354
Arhgap21Rho GTPase activating protein 210.352
Hdac7histone deacetylase 70.324
Arrb1arrestin, beta 10.316
Tmem123transmembrane protein 1230.313
Tsc2tuberous sclerosis 20.309
BaxBCL2-associated X protein0.302
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.294
Tsc1tuberous sclerosis 10.292
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.292
Eps15epidermal growth factor receptor pathway substrate 150.291
CblCasitas B-lineage lymphoma0.289
Ltblymphotoxin B0.288
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.284
Rpgrip1lRpgrip1-like0.280
Adrb1adrenergic receptor, beta 10.278
Rasgrp1RAS guanyl releasing protein 10.278
Gpsm3G-protein signalling modulator 3 (AGS3-like, C. elegans)0.276
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.274
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.272
Stag2stromal antigen 20.270
Nrp1neuropilin 10.269
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.269
Parvaparvin, alpha0.268
Plxnb1plexin B10.268
Ntf3neurotrophin 30.261
Prkccprotein kinase C, gamma0.260
Itga3integrin alpha 30.259
Arhgef12Rho guanine nucleotide exchange factor (GEF) 120.256
Arhgap30Rho GTPase activating protein 300.256
Pafah1b1platelet-activating factor acetylhydrolase, isoform 1b, subunit 10.248
Akt1thymoma viral proto-oncogene 10.240
Prkcdprotein kinase C, delta0.234
Nrbp2nuclear receptor binding protein 20.233
Dlg4discs, large homolog 4 (Drosophila)0.232
Plxna3plexin A30.229
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.224
Elmo1engulfment and cell motility 1, ced-12 homolog (C. elegans)0.218
Rhobras homolog gene family, member B0.216
Cacnb3calcium channel, voltage-dependent, beta 3 subunit0.216
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.215
Nf2neurofibromatosis 20.211
Scn5asodium channel, voltage-gated, type V, alpha0.210
Arpc4actin related protein 2/3 complex, subunit 40.210
Actbactin, beta0.207
Rtknrhotekin0.206
Laptm5lysosomal-associated protein transmembrane 50.202
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.195
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.194
Mobpmyelin-associated oligodendrocytic basic protein0.189
Arhgef6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 60.185
Pip4k2aphosphatidylinositol-5-phosphate 4-kinase, type II, alpha0.185
Ksr1kinase suppressor of ras 10.181
Epha1Eph receptor A10.181
Cfl1cofilin 1, non-muscle0.181
Ptprcprotein tyrosine phosphatase, receptor type, C0.177
Rasgrp2RAS, guanyl releasing protein 20.176
Zfr2zinc finger RNA binding protein 20.175
Atp13a2ATPase type 13A20.174
Mast3microtubule associated serine/threonine kinase 30.171
Fmnl1formin-like 10.170
Bicd2bicaudal D homolog 2 (Drosophila)0.169
Ehmt2euchromatic histone lysine N-methyltransferase 20.165
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.165
Rasal3RAS protein activator like 30.163
Bcrbreakpoint cluster region0.162
Ccl7chemokine (C-C motif) ligand 70.161
Sirpasignal-regulatory protein alpha0.161
Phlpp1PH domain and leucine rich repeat protein phosphatase 10.160
Efna1ephrin A10.160
Tcfcp2l1transcription factor CP2-like 10.160
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.157
P2rx6purinergic receptor P2X, ligand-gated ion channel, 60.156
Sh3bp1SH3-domain binding protein 10.154
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.152
ND6NADH dehydrogenase subunit 60.152
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Copb1coatomer protein complex, subunit beta 10.234
Taglntransgelin0.156
Pja2praja 2, RING-H2 motif containing0.128
Arpc2actin related protein 2/3 complex, subunit 20.102
Epas1endothelial PAS domain protein 10.091
Ptafrplatelet-activating factor receptor0.090
Arl1ADP-ribosylation factor-like 10.088
Actg2actin, gamma 2, smooth muscle, enteric0.087
Myl9myosin, light chain 9, regulatory0.085
Adora2aadenosine A2a receptor0.083
Dgkgdiacylglycerol kinase, gamma0.083
Myo1cmyosin IC0.077
Acta2smooth muscle alpha-actin0.072
Rap1bRAP1B, member of RAS oncogene family0.071
Picalmphosphatidylinositol binding clathrin assembly protein0.068
Apcadenomatous polyposis coli0.068
Kcnab1potassium voltage-gated channel, shaker-related subfamily, beta member 10.068
Myo1dmyosin ID0.066
Chrm1cholinergic receptor, muscarinic 10.065
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.065
Gng7guanine nucleotide binding protein (G protein), gamma 70.064
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.064
Cyth1cytohesin 10.062
Copb2coatomer protein complex, subunit beta 2 (beta prime)0.062
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.061
Scn3bsodium channel, voltage-gated, type III, beta0.059
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.058
Homer1homer homolog 1 (Drosophila)0.057
Sirpasignal-regulatory protein alpha0.056
Anxa2annexin A20.056
KitlgKIT ligand0.053
Ddr1discoidin domain receptor tyrosine kinase 10.053
Serp1stress-associated endoplasmic reticulum protein 10.053
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.053
Gria2glutamate receptor, ionotropic, AMPA 20.052
Lcp2lymphocyte cytosolic protein 20.051
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.050
RfngRFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.049
Inpp5dinositol polyphosphate-5-phosphatase D0.049
Adcy5adenylate cyclase 50.049
Strnstriatin, calmodulin binding protein0.049
Itpr2inositol 1,4,5-triphosphate receptor, type 20.048
Dstndestrin0.048
Cmklr1chemokine-like receptor 10.047
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.047
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.047
Zmym4zinc finger, MYM-type 40.046
Hand2heart and neural crest derivatives expressed 20.046
Cfpcomplement factor properdin0.044
Amphamphiphysin0.043
Prkchprotein kinase C, eta0.043
Mcammelanoma cell adhesion molecule0.043
Hk1hexokinase 10.043
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.043
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.042
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.042
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.041
Sox17SRY (sex determining region Y)-box 170.041
Shank2SH3 and multiple ankyrin repeat domains 20.041
Pde1bphosphodiesterase 1B, calmodulin-dependent0.040
Fgfr1Fibroblast growth factor receptor 10.039
Camk4calcium/calmodulin-dependent protein kinase IV0.039
Pik3r2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.039
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.039
Sel1lsel-1 suppressor of lin-12-like (C. elegans)0.039
Git1G protein-coupled receptor kinase interacting ArfGAP 10.038
Kremen1kringle containing transmembrane protein 10.037
Ddndendrin0.037
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.037
Atrnattractin0.037
Clcn7chloride channel 70.035
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.035
Stk39serine/threonine kinase 39, STE20/SPS1 homolog (yeast)0.035
Hpcahippocalcin0.035
Pld2phospholipase D20.035
Adrbk1adrenergic, beta, receptor kinase 10.035
Brafv-raf murine sarcoma viral oncogene homolog B10.034
Albalbumin0.034
Sstr1somatostatin receptor 10.033
Utrnutrophin0.033
Apbb1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.033
Gpr182G protein-coupled receptor 1820.032
Plcg1phospholipase C, gamma 10.032
Rab5aRAB5A, member RAS oncogene family0.032
Sncasynuclein, alpha (non A4 component of amyloid precursor)0.032
Smg5Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)0.031
Unc5bunc-5 homolog B (C. elegans)0.031
Anxa1annexin A10.031
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.031
Arf4ADP-ribosylation factor 40.031
Btg1B-cell translocation gene 1, anti-proliferative0.030
Dlg3discs, large homolog 3 (Drosophila)0.030
LOC293989cytochrome P450-like0.029
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.029
Timp1TIMP metallopeptidase inhibitor 10.029
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.029
Gria1glutamate receptor, ionotropic, AMPA 10.029
Necap1NECAP endocytosis associated 10.029
Nr4a2nuclear receptor subfamily 4, group A, member 20.028
Stxbp5syntaxin binding protein 5 (tomosyn)0.028
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
GYL1Gyl1p0.362
MKK1Mkk1p0.354
GCD6Gcd6p0.242
STE11Ste11p0.221
PKC1Pkc1p0.155
RHO1Rho1p0.135
STE5Ste5p0.131
YPT53Ypt53p0.110
SPA2Spa2p0.110
ROM2Rom2p0.103
BEM3Bem3p0.100
VPS15Vps15p0.099
CDC24Cdc24p0.094
PTP2Ptp2p0.087
TUS1Tus1p0.078
TOM1Tom1p0.076
SAC7Sac7p0.073
PEA2Pea2p0.067
SUI3Sui3p0.066
SSA4Ssa4p0.065
SUI2Sui2p0.064
RPG1Rpg1p0.054
STE4Ste4p0.054
AVO1Avo1p0.051
YCR007Chypothetical protein0.050
CRZ1Crz1p0.048
CHS1Chs1p0.047
KEL1Kel1p0.046
SSK2Ssk2p0.044
MKK2Mkk2p0.042
CCT4Cct4p0.042
APM3Apm3p0.042
TOF2Tof2p0.041
TRR1Trr1p0.039
MNN9Mnn9p0.038
RGD1Rgd1p0.038
ACK1Ack1p0.038
KSS1Kss1p0.038
VTA1Vta1p0.037
PKH2Pkh2p0.037
SEC16Sec16p0.037
BFR1Bfr1p0.036
TSC11Tsc11p0.036
STI1Sti1p0.036
CYK3Cyk3p0.035
YDR186Chypothetical protein0.035
MDS3Mds3p0.035
GCD1Gcd1p0.034
URA4Ura4p0.034
CDC50Cdc50p0.034
MSG5Msg5p0.034
AKL1Akl1p0.033
GPB2Gpb2p0.033
SPR6Spr6p0.033
RGA2Rga2p0.032
MOB2Mob2p0.032
PRS2Prs2p0.032
GCD7Gcd7p0.032
INP52Inp52p0.032
NUP49Nup49p0.032
GGA2Gga2p0.031
YOL087Chypothetical protein0.031
CHC1Chc1p0.031
FAA2Faa2p0.030
YNL108Chypothetical protein0.030
NEO1Neo1p0.030
SET1Set1p0.030
SWC7Swc7p0.029
FKH1Fkh1p0.029
HRP1Hrp1p0.029
MRE11Mre11p0.029
NGL3Ngl3p0.029
CRG1Crg1p0.029
NVJ1Nvj1p0.029
TSC10Tsc10p0.029
YML002Whypothetical protein0.029
ATG20Atg20p0.028
STT4Stt4p0.028
CDC12Cdc12p0.028
SOG2Sog2p0.028
SLG1Slg1p0.027
YGR012Whypothetical protein0.027
URA3Ura3p0.026
PPE1Ppe1p0.026
GCD2Gcd2p0.026
CMK2Cmk2p0.026
BRN1Brn1p0.026
YGK3Ygk3p0.026
ITR2Itr2p0.026
YPR148Chypothetical protein0.026
KTR4Ktr4p0.026
FUS2Fus2p0.025
SRD1Srd1p0.025
LEU2Leu2p0.025
CUR1Cur1p0.025
BUL1Bul1p0.025
DCD1Dcd1p0.025
CUP1-1Cup1-1p0.024
PEP7Pep7p0.024
BUD2Bud2p0.024