The network for 'epithelial cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

NameDescriptionProbabilityFunc Analog Organism
pha-4Protein PHA-40.183
elt-6Protein ELT-60.179
hlh-2Protein HLH-20.170
unc-73Protein UNC-730.120
vab-3Protein VAB-30.108
nhr-67Protein NHR-670.095
egl-18Protein EGL-180.091
rig-6Protein RIG-60.090
egl-46Protein EGL-460.081
let-60Protein LET-600.068
ten-1Protein TEN-10.066
bar-1Protein BAR-10.061
mab-5Protein MAB-50.058
sup-12Protein SUP-120.054
inx-3Protein INX-30.048
cnd-1Protein CND-10.047
lin-17Protein LIN-170.042
nhr-2Protein NHR-20.036
daf-3Protein DAF-30.035
cam-1Protein CAM-10.035
pry-1Protein PRY-10.033
sma-9Protein SMA-90.032
nhr-69Protein NHR-690.029
lin-29Protein LIN-290.028
egl-27Protein EGL-270.028
set-1Protein SET-10.028
flt-1Protein FLT-10.027
Y71G12B.11Protein Y71G12B.110.026
ftt-2Protein FTT-20.025
egl-15Protein EGL-150.023
lsy-2Protein LSY-20.023
par-1Protein PAR-10.023
fasn-1Protein FASN-10.023
lin-11Protein LIN-110.022
magi-1Protein MAGI-10.022
eor-1Protein EOR-10.022
mpk-1Protein MPK-10.022
scd-1Protein SCD-10.022
mls-2Protein MLS-20.021
unc-53Protein UNC-530.021
daf-1Protein DAF-10.021
dpff-1Protein DPFF-10.020
xpo-1Protein XPO-10.020
lam-2Protein LAM-20.020
mab-31Protein MAB-310.020
apl-1Protein APL-10.020
unc-98Protein UNC-980.020
cas-1Protein CAS-10.019
unc-43Protein UNC-430.019
sma-6Protein SMA-60.019
pxf-1Protein PXF-10.018
hlh-1Protein HLH-10.018
nhr-64Protein NHR-640.018
lin-7Protein LIN-70.017
sma-1Protein SMA-10.017
C34F6.1Protein C34F6.10.017
egl-23Protein EGL-230.017
T09B4.5Protein T09B4.50.017
F31C3.6Protein F31C3.60.017
svh-2Protein SVH-20.017
sdz-28Protein SDZ-280.016
epi-1Protein EPI-10.016
imb-2Protein IMB-20.016
elt-2Protein ELT-20.016
egl-5Protein EGL-50.016
daf-4Protein DAF-40.016
bli-1Protein BLI-10.016
nhr-25Protein NHR-250.015
tra-1Protein TRA-10.015
mec-2Protein MEC-20.015
F26E4.7Protein F26E4.70.015
elc-1Protein ELC-10.015
zfp-1Protein ZFP-10.015
kin-4Protein KIN-40.015
soc-2Protein SOC-20.015
lin-15BProtein LIN-15B0.015
mig-2Protein MIG-20.015
fkh-2Protein FKH-20.015
hbl-1Protein HBL-10.014
ceh-27Protein CEH-270.014
K04B12.2Protein K04B12.20.014
end-3Protein END-30.014
ain-1Protein AIN-10.013
F21A10.2Protein F21A10.20.013
glt-1Protein GLT-10.013
daf-5Protein DAF-50.013
vab-10Protein VAB-100.013
nhr-32Protein NHR-320.013
ref-2Protein REF-20.013
cpr-4Protein CPR-40.013
C29G2.6Protein C29G2.60.013
gon-2Protein GON-20.013
sel-7Protein SEL-70.013
ajm-1Protein AJM-10.013
sfrp-1Protein SFRP-10.013
T24H10.1Protein T24H10.10.013
vab-1Protein VAB-10.013
lir-1Protein LIR-10.013
ceeh-1Protein CEEH-10.012
vpr-1Protein VPR-10.012
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mibmind bomb0.991
dlcdeltaC0.990
eya1eyes absent homolog 10.930
kitakit receptor a0.916
shhasonic hedgehog a0.889
lhx1aLIM homeobox 1a0.874
notch3notch homolog 30.871
tp63tumor protein p630.870
cdh1cadherin 1, epithelial0.862
tal1T-cell acute lymphocytic leukemia 10.851
notch1anotch homolog 1a0.837
dladeltaA0.835
irx3airoquois homeobox protein 3a0.829
tyrtyrosinase0.825
ascl1aachaete-scute complex-like 1a (Drosophila)0.811
sox3SRY-box containing gene 30.797
fzd8afrizzled homolog 8a0.786
gli2aGLI-Kruppel family member GLI2a0.784
notch1bnotch homolog 1b0.777
kdrlkinase insert domain receptor like0.771
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.755
pax6bpaired box gene 6b0.748
ikzf1IKAROS family zinc finger 1 (Ikaros)0.744
dlbdeltaB0.726
hey1hairy/enhancer-of-split related with YRPW motif 10.717
prdm1aPR domain containing 1a, with ZNF domain0.714
fzd7bfrizzled homolog 7b0.711
fstafollistatin a0.693
gdf6agrowth differentiation factor 6a0.692
wt1bwilms tumor 1b0.691
cdh23cadherin-like 230.686
otpborthopedia homolog b0.666
gli1GLI-Kruppel family member 10.660
sox19aSRY-box containing gene 19a0.656
tbx2bT-box 2b0.642
cdh6cadherin 60.626
hoxa13ahomeo box A13a0.618
sox10SRY-box containing gene 100.615
lef1lymphocyte enhancer binding factor 10.608
nr2e1nuclear receptor subfamily 2, group E, member 10.607
atoh1batonal homolog 1b0.597
rad21RAD21 homolog (S. pombe)0.589
fgf8afibroblast growth factor 8 a0.568
ocrloculocerebrorenal syndrome of Lowe0.560
hey2hairy/enhancer-of-split related with YRPW motif 20.560
foxi3aforkhead box I3a0.546
hnf1baHNF1 homeobox Ba0.543
tfap2atranscription factor AP-2 alpha0.532
hapln1ahyaluronan and proteoglycan link protein 1a0.531
gbx2gastrulation brain homeo box 20.529
neurog1neurogenin 10.519
cxcr4achemokine (C-X-C motif) receptor 4a0.518
notch2notch homolog 20.513
mitfamicrophthalmia-associated transcription factor a0.511
neurod4neurogenic differentiation 40.510
dlx5adistal-less homeobox gene 5a0.509
olig2oligodendrocyte lineage transcription factor 20.509
otx2orthodenticle homolog 20.509
sall1asal-like 1a (Drosophila)0.499
isl1islet10.496
hdac1histone deacetylase 10.490
jag1bjagged 1b0.490
shhbsonic hedgehog b0.487
trpm7transient receptor potential cation channel, subfamily M, member 70.487
mnx1motor neuron and pancreas homeobox 10.484
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.482
mecomMDS1 and EVI1 complex locus0.478
barx1BarH-like homeobox 10.473
her6hairy-related 60.470
acvr1lactivin A receptor, type I like0.466
fabp11afatty acid binding protein 11a0.460
emx2empty spiracles homeobox 20.459
olfm2olfactomedin 20.459
osr2odd-skipped related 2 (Drosophila)0.458
fabp2fatty acid binding protein 2, intestinal0.458
dachadachshund a0.444
pax2apaired box gene 2a0.438
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.438
twist1btwist1b0.437
tbx2aT-box gene 2a0.427
six4bsine oculis homeobox homolog 4b0.425
zic1zic family member 1 (odd-paired homolog, Drosophila)0.422
epcamepithelial cell adhesion molecule0.419
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.405
dlx3bdistal-less homeobox gene 3b0.404
ntlano tail a0.404
vsx2visual system homeobox 20.404
krt4keratin 40.402
cdh2cadherin 2, neuronal0.402
fgf10afibroblast growth factor 10a0.398
cldnbclaudin b0.397
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.390
ihhaIndian hedgehog homolog a0.389
vcanbversican b0.385
bocbrother of CDO0.383
alcambactivated leukocyte cell adhesion molecule b0.379
fezf2FEZ family zinc finger 20.377
hoxb5ahomeo box B5a0.375
tpm4tropomyosin 40.367
hoxa3ahomeo box A3a0.365
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
domedomeless1.000
RalaRas-related protein1.000
aopanterior open1.000
fzfrizzled1.000
par-1CG8201 gene product from transcript CG8201-RA0.999
Ced-12CG5336 gene product from transcript CG5336-RA0.999
cicubitus interruptus0.999
Rac1CG2248 gene product from transcript CG2248-RA0.999
ttktramtrack0.998
wgwingless0.998
chicchickadee0.998
alpha-Catalpha Catenin0.996
Akt1CG4006 gene product from transcript CG4006-RA0.995
edechinoid0.994
cindrCIN85 and CD2AP orthologue0.994
diadiaphanous0.994
mysmyospheroid0.994
pydpolychaetoid0.992
EgfrEpidermal growth factor receptor0.991
emcextra macrochaetae0.990
par-6CG5884 gene product from transcript CG5884-RA0.990
nmonemo0.990
oskoskar0.990
Stat92ESignal-transducer and activator of transcription protein at 92E0.986
Rho1CG8416 gene product from transcript CG8416-RB0.986
dcodiscs overgrown0.982
Lis-1Lissencephaly-10.980
VangVan Gogh0.979
SoxNSoxNeuro0.979
Dcr-2Dicer-20.978
rheaCG6831 gene product from transcript CG6831-RA0.975
hpohippo0.974
bskbasket0.974
coscosta0.971
trctricornered0.971
shnschnurri0.969
Cdc42CG12530 gene product from transcript CG12530-RA0.968
wtswarts0.968
ykiyorkie0.967
smosmoothened0.967
G-oalpha47AG protein oalpha 47A0.967
rokRho-kinase0.963
ecdecdysoneless0.963
fngfringe0.962
uspultraspiracle0.957
shgshotgun0.954
CycECyclin E0.948
panpangolin0.947
Ets97DEts at 97D0.946
escextra sexcombs0.940
vasvasa0.937
SerSerrate0.935
rlrolled0.934
hephemipterous0.932
eveeven skipped0.930
hbshibris0.929
NNotch0.927
sqhspaghetti squash0.927
osoutstretched0.926
dshdishevelled0.923
babobaboon0.921
KhcKinesin heavy chain0.919
dppdecapentaplegic0.918
pntpointed0.916
mammastermind0.916
zipzipper0.915
Fas2Fasciclin 20.914
hthhomothorax0.913
cswcorkscrew0.912
mbcmyoblast city0.903
Pvf1PDGF- and VEGF-related factor 10.901
Tm1Tropomyosin 10.901
bazbazooka0.900
lkb1CG9374 gene product from transcript CG9374-RJ0.899
dacdachshund0.898
vvlventral veins lacking0.895
jingCG9397 gene product from transcript CG9397-RI0.894
snssticks and stones0.892
kugkugelei0.891
shishibire0.890
DadDaughters against dpp0.886
taitaiman0.885
Wnt4Wnt oncogene analog 40.877
rapsrapsynoid0.873
eggeggless0.866
fs(1)M3female sterile (1) M30.865
locolocomotion defects0.864
RbfRetinoblastoma-family protein0.854
l(2)gllethal (2) giant larvae0.852
mewmultiple edematous wings0.848
shotshort stop0.844
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.843
stanstarry night0.833
kluklumpfuss0.831
msnmisshapen0.830
acachaete0.828
Dhc64CDynein heavy chain 64C0.822
Syx1ASyntaxin 1A0.822
smt3CG4494 gene product from transcript CG4494-RA0.821
E(spl)Enhancer of split0.818
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ESR1estrogen receptor 11.000
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.999
TJP1tight junction protein 1 (zona occludens 1)0.998
EGFRepidermal growth factor receptor0.997
FLNAfilamin A, alpha0.997
RARAretinoic acid receptor, alpha0.996
CDK2cyclin-dependent kinase 20.995
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.991
SFNstratifin0.986
NOTCH1notch 10.983
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.968
RUNX1runt-related transcription factor 10.968
FN1fibronectin 10.967
E2F1E2F transcription factor 10.964
GRB2growth factor receptor-bound protein 20.961
VEGFAvascular endothelial growth factor A0.956
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.924
EP300E1A binding protein p3000.924
QKIquaking homolog, KH domain RNA binding (mouse)0.921
TAL1T-cell acute lymphocytic leukemia 10.917
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.916
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.903
CREBBPCREB binding protein0.902
VIMvimentin0.895
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.890
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.889
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.879
CCNE1cyclin E10.879
PTPN1protein tyrosine phosphatase, non-receptor type 10.870
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.867
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.860
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.858
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.857
GAPDHglyceraldehyde-3-phosphate dehydrogenase0.848
NCOA3nuclear receptor coactivator 30.841
SOX2SRY (sex determining region Y)-box 20.840
KRT5keratin 50.838
NRP1neuropilin 10.838
MSNmoesin0.819
TP63tumor protein p630.817
ACTBactin, beta0.808
CAV1caveolin 1, caveolae protein, 22kDa0.804
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.794
JAG1jagged 10.792
FKBP1AFK506 binding protein 1A, 12kDa0.792
ANXA2annexin A20.792
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.788
MDM2Mdm2 p53 binding protein homolog (mouse)0.783
KRT15keratin 150.772
TRIM29tripartite motif containing 290.769
ARandrogen receptor0.765
CCND1cyclin D10.763
STK3serine/threonine kinase 30.760
IQGAP1IQ motif containing GTPase activating protein 10.759
HOXB5homeobox B50.736
KRT8keratin 80.732
FGFR1fibroblast growth factor receptor 10.728
XIAPX-linked inhibitor of apoptosis0.727
RHOAras homolog gene family, member A0.727
ITGB4integrin, beta 40.724
PAX3paired box 30.716
TJP2tight junction protein 2 (zona occludens 2)0.714
TGIF1TGFB-induced factor homeobox 10.706
SETD7SET domain containing (lysine methyltransferase) 70.701
HDAC1histone deacetylase 10.693
SPRR1Asmall proline-rich protein 1A0.689
MYH9myosin, heavy chain 9, non-muscle0.689
DNM2dynamin 20.686
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.682
NCOA1nuclear receptor coactivator 10.672
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.671
RB1retinoblastoma 10.671
LDHAlactate dehydrogenase A0.658
BCAR1breast cancer anti-estrogen resistance 10.657
ENGendoglin0.657
CTSBcathepsin B0.653
CDK6cyclin-dependent kinase 60.651
ANXA1annexin A10.650
SULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.648
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.647
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.644
PGK1phosphoglycerate kinase 10.642
KRT6Akeratin 6A0.636
BMPR1Abone morphogenetic protein receptor, type IA0.623
AHRaryl hydrocarbon receptor0.611
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.605
ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific )0.605
DCAF7DDB1 and CUL4 associated factor 70.603
CAB39calcium binding protein 390.601
STAT5Asignal transducer and activator of transcription 5A0.597
PBX1pre-B-cell leukemia homeobox 10.593
NKX3-1NK3 homeobox 10.585
HNF4Ahepatocyte nuclear factor 4, alpha0.583
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.582
APCadenomatous polyposis coli0.560
HDAC4histone deacetylase 40.559
FLNBfilamin B, beta0.558
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.558
SMAD7SMAD family member 70.554
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tgfbr2transforming growth factor, beta receptor II0.721
Id3inhibitor of DNA binding 30.264
Anxa5annexin A50.256
Il8rainterleukin 8 receptor, alpha0.247
Anxa2annexin A20.226
Hes2hairy and enhancer of split 2 (Drosophila)0.197
Itgb1integrin, beta 10.196
S100a10S100 calcium binding protein A100.194
Flt1FMS-related tyrosine kinase 10.194
Notch3Notch homolog 3 (Drosophila)0.186
Trhr2thyrotropin releasing hormone receptor 20.182
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.172
Ednrbendothelin receptor type B0.167
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.162
Myh9myosin, heavy chain 9, non-muscle0.151
Sdcbpsyndecan binding protein0.149
Cd9CD9 molecule0.148
Ehfets homologous factor0.146
Nos3nitric oxide synthase 3, endothelial cell0.144
Pdynprodynorphin0.141
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.139
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.137
Gata6GATA binding protein 60.135
Decr12,4-dienoyl CoA reductase 1, mitochondrial0.132
Lypd3Ly6/Plaur domain containing 30.132
RGD1304644similar to RIKEN cDNA 2310046K010.131
Prlrprolactin receptor0.131
Arpc1bactin related protein 2/3 complex, subunit 1B0.126
Rararetinoic acid receptor, alpha0.123
Acta2smooth muscle alpha-actin0.122
Lpar2lysophosphatidic acid receptor 20.121
Slc22a7solute carrier family 22 (organic anion transporter), member 70.118
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.118
Grik3glutamate receptor, ionotropic, kainate 30.117
Acaa2acetyl-Coenzyme A acyltransferase 20.117
Tgfbr3transforming growth factor, beta receptor III0.117
Atp7bATPase, Cu++ transporting, beta polypeptide0.114
Pde5aphosphodiesterase 5A, cGMP-specific0.113
Tln1talin 10.113
Arf6ADP-ribosylation factor 60.107
Elf1E74-like factor 10.107
Il1r1interleukin 1 receptor, type I0.107
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.103
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.102
Dmkndermokine0.102
Agtr1bangiotensin II receptor, type 1b0.101
Onecut1one cut homeobox 10.100
Litaflipopolysaccharide-induced TNF factor0.099
Ednraendothelin receptor type A0.099
Smad7SMAD family member 70.096
Tpm4tropomyosin 40.094
Ifitm3interferon induced transmembrane protein 30.094
Myl9myosin, light chain 9, regulatory0.092
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.090
Myadmmyeloid-associated differentiation marker0.089
Dio3deiodinase, iodothyronine, type III0.089
Itgb4integrin, beta 40.089
Klf6Kruppel-like factor 60.087
Nr5a2nuclear receptor subfamily 5, group A, member 20.087
Lims1LIM and senescent cell antigen-like domains 10.087
Trim29tripartite motif-containing 290.087
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.086
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.085
Lim2lens intrinsic membrane protein 20.085
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.082
Ghrhrgrowth hormone releasing hormone receptor0.082
Sox17SRY (sex determining region Y)-box 170.081
Il12binterleukin 12B0.081
MdficMyoD family inhibitor domain containing0.078
Tff2trefoil factor 20.077
Fgfr2fibroblast growth factor receptor 20.077
Chadchondroadherin0.077
Adrb1adrenergic, beta-1-, receptor0.076
Arhgap4Rho GTPase activating protein 40.075
Lmnalamin A0.075
Twist2twist homolog 2 (Drosophila)0.075
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.074
Slc14a2solute carrier family 14 (urea transporter), member 20.073
Platplasminogen activator, tissue0.073
Foxe1forkhead box E1 (thyroid transcription factor 2)0.071
Acvr1activin A receptor, type I0.070
Cald1caldesmon 10.070
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.069
Cacna1gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.068
Itga6integrin, alpha 60.068
Bcanbrevican0.068
Gata3GATA binding protein 30.067
Sp4Sp4 transcription factor0.067
Smad1SMAD family member 10.067
Slit1slit homolog 1 (Drosophila)0.067
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.067
Kcng3potassium voltage-gated channel, subfamily G, member 30.067
Fut1fucosyltransferase 10.067
Phox2apaired-like homeobox 2a0.066
Bcl2B-cell CLL/lymphoma 20.066
Krt15keratin 150.066
Rasa1RAS p21 protein activator (GTPase activating protein) 10.066
Hes5hairy and enhancer of split 5 (Drosophila)0.065
Slco2a1solute carrier organic anion transporter family, member 2a10.065
Pdpnpodoplanin0.065
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism