The network for 'male sex differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

male sex differentiation

The establishment of the sex of a male organism by physical differentiation.

NameDescriptionProbabilityFunc Analog Organism
egl-46Protein EGL-460.706
dpy-13Protein DPY-130.661
egl-18Protein EGL-180.560
col-157Protein COL-1570.542
rol-6Protein ROL-60.433
col-17Protein COL-170.429
col-144Protein COL-1440.395
lin-29Protein LIN-290.392
let-60Protein LET-600.385
egl-15Protein EGL-150.359
col-34Protein COL-340.355
col-104Protein COL-1040.351
pry-1Protein PRY-10.344
pha-4Protein PHA-40.329
nhr-67Protein NHR-670.317
ten-1Protein TEN-10.296
col-154Protein COL-1540.295
nep-21Protein NEP-210.290
ina-1Protein INA-10.289
col-93Protein COL-930.287
dpy-4Protein DPY-40.283
sma-4Protein SMA-40.279
hbl-1Protein HBL-10.279
daf-1Protein DAF-10.278
trim-9Protein TRIM-90.277
lin-17Protein LIN-170.268
eff-1Protein EFF-10.259
col-2Protein COL-20.255
mab-5Protein MAB-50.250
col-125Protein COL-1250.248
col-146Protein COL-1460.244
col-98Protein COL-980.239
hlh-1Protein HLH-10.226
sur-2Protein SUR-20.224
col-73Protein COL-730.220
CELE_Y57A10A.23Protein Y57A10A.230.209
R10E12.2Protein R10E12.20.206
ceh-20Protein CEH-200.201
col-92Protein COL-920.196
col-119Protein COL-1190.194
col-109Protein COL-1090.194
cki-1Protein CKI-10.190
pop-1Protein POP-10.185
col-90Protein COL-900.182
rnt-1Protein RNT-10.181
hnd-1Protein HND-10.180
lin-32Protein LIN-320.178
col-167Protein COL-1670.171
rol-8Protein ROL-80.170
plc-3Protein PLC-30.169
C14H10.2Protein C14H10.20.168
F58H1.5Protein F58H1.50.168
col-173Protein COL-1730.168
nhr-25Protein NHR-250.165
col-143Protein COL-1430.161
unc-73Protein UNC-730.159
fkh-2Protein FKH-20.158
wrt-6Protein WRT-60.156
col-133Protein COL-1330.155
lin-12Protein LIN-120.153
elt-6Protein ELT-60.151
ceh-18Protein CEH-180.148
col-13Protein COL-130.147
hlh-2Protein HLH-20.145
col-107Protein COL-1070.143
col-80Protein COL-800.142
mep-1Protein MEP-10.141
spt-5Protein SPT-50.138
col-159Protein COL-1590.138
W02C12.1Protein W02C12.10.137
apl-1Protein APL-10.133
hcp-3Protein HCP-30.125
ZK84.1Protein ZK84.10.125
mig-2Protein MIG-20.121
igcm-3Protein IGCM-30.121
col-94Protein COL-940.120
col-79Protein COL-790.119
grld-1Protein GRLD-10.118
uso-1Protein USO-10.118
eor-1Protein EOR-10.118
col-156Protein COL-1560.116
col-43Protein COL-430.116
ltd-1Protein LTD-10.114
C17E7.9Protein C17E7.90.113
soc-2Protein SOC-20.110
lag-1Protein LAG-10.109
cye-1Protein CYE-10.108
col-114Protein COL-1140.108
daf-4Protein DAF-40.107
dnj-19Protein DNJ-190.106
crt-1Protein CRT-10.105
ced-10Protein CED-100.103
col-49Protein COL-490.098
dpy-7Protein DPY-70.098
asp-3Protein ASP-30.097
ceh-27Protein CEH-270.096
flt-1Protein FLT-10.096
col-71Protein COL-710.096
col-145Protein COL-1450.095
asb-2Protein ASB-20.094
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Myo31DFMyosin 31DF0.420
EcREcdysone receptor0.341
e(y)3enhancer of yellow 30.263
Stat92ESignal-transducer and activator of transcription protein at 92E0.196
Btk29ABtk family kinase at 29A0.176
MadMothers against dpp0.149
l(2)gllethal (2) giant larvae0.120
cicubitus interruptus0.115
Cpr67Fa2Cuticular protein 67Fa20.106
EndoGIEndonuclease G inhibitor0.071
cv-ccrossveinless c0.060
dallydivision abnormally delayed0.047
mxcmulti sex combs0.045
Rac1CG2248 gene product from transcript CG2248-RA0.045
argosCG4531 gene product from transcript CG4531-RA0.043
locolocomotion defects0.038
mei-9meiotic 90.037
emcextra macrochaetae0.035
CG1927CG1927 gene product from transcript CG1927-RA0.035
wdnwings down0.034
CG32711CG32711 gene product from transcript CG32711-RA0.033
bowlbrother of odd with entrails limited0.032
eyaeyes absent0.031
phlpole hole0.031
Wnt4Wnt oncogene analog 40.031
yip2yippee interacting protein 20.030
sosine oculis0.030
cortoCG2530 gene product from transcript CG2530-RA0.028
PargPoly(ADP-ribose) glycohydrolase0.028
CG6776CG6776 gene product from transcript CG6776-RA0.026
vvlventral veins lacking0.026
NFATNFAT homolog0.026
Abd-BAbdominal B0.024
cathDCG1548 gene product from transcript CG1548-RA0.023
wbwing blister0.023
Taf4TBP-associated factor 40.022
CG34449CG34449 gene product from transcript CG34449-RB0.022
mus201mutagen-sensitive 2010.022
Wnt2Wnt oncogene analog 20.022
RpS15AaRibosomal protein S15Aa0.022
Nup153Nucleoporin 1530.021
hydhyperplastic discs0.021
CG13862CG13862 gene product from transcript CG13862-RA0.021
CG11151CG11151 gene product from transcript CG11151-RA0.020
sogshort gastrulation0.019
CG17018CG17018 gene product from transcript CG17018-RC0.018
debcldeath executioner Bcl-2 homologue0.018
bab1bric a brac 10.018
CycBCyclin B0.017
CG17508CG17508 gene product from transcript CG17508-RA0.017
UnrUpstream of N-ras0.017
cdicenter divider0.016
kl-5male fertility factor kl50.016
HopHsp70/Hsp90 organizing protein homolog0.016
CG11347CG11347 gene product from transcript CG11347-RE0.016
CBPsarcoplasmic calcium-binding protein0.016
Sin3ACG8815 gene product from transcript CG8815-RC0.016
bip1CG7574 gene product from transcript CG7574-RA0.016
Atg1Autophagy-specific gene 10.016
Su(Tpl)CG32217 gene product from transcript CG32217-RB0.016
Taf1TBP-associated factor 10.016
p53CG33336 gene product from transcript CG33336-RB0.016
EndoGEndonuclease G0.016
RASSF8CG5053 gene product from transcript CG5053-RA0.016
zfh1Zn finger homeodomain 10.015
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ESR1estrogen receptor 11.000
FGFR2fibroblast growth factor receptor 20.976
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.921
EP300E1A binding protein p3000.885
TAL1T-cell acute lymphocytic leukemia 10.831
EGFRepidermal growth factor receptor0.774
NCOA3nuclear receptor coactivator 30.757
RBM8ARNA binding motif protein 8A0.717
BCAR1breast cancer anti-estrogen resistance 10.711
PAX3paired box 30.689
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.682
BCL2B-cell CLL/lymphoma 20.624
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.622
FGF10fibroblast growth factor 100.618
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.602
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.597
NCOA2nuclear receptor coactivator 20.569
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.555
CREBBPCREB binding protein0.551
SMAD7SMAD family member 70.512
BCL2L1BCL2-like 10.480
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.467
PTPN1protein tyrosine phosphatase, non-receptor type 10.432
MDM2Mdm2 p53 binding protein homolog (mouse)0.406
UPF2UPF2 regulator of nonsense transcripts homolog (yeast)0.393
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.381
INSRinsulin receptor0.369
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.361
STAT5Asignal transducer and activator of transcription 5A0.345
JAK2Janus kinase 20.338
POU3F2POU class 3 homeobox 20.313
POU5F1POU class 5 homeobox 10.311
BMP2bone morphogenetic protein 20.280
EGR1early growth response 10.271
CDH5cadherin 5, type 2 (vascular endothelium)0.264
KCNE1potassium voltage-gated channel, Isk-related family, member 10.256
NCOA1nuclear receptor coactivator 10.230
PDX1pancreatic and duodenal homeobox 10.229
RORARAR-related orphan receptor A0.226
TRIP6thyroid hormone receptor interactor 60.213
GFI1Bgrowth factor independent 1B transcription repressor0.205
LDLRlow density lipoprotein receptor0.200
MSH6mutS homolog 6 (E. coli)0.200
MPDZmultiple PDZ domain protein0.195
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.185
PGFplacental growth factor0.183
FOXD3forkhead box D30.183
UHRF2ubiquitin-like with PHD and ring finger domains 20.180
PPP5Cprotein phosphatase 5, catalytic subunit0.179
NRP1neuropilin 10.171
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.164
LATlinker for activation of T cells0.159
IRS1insulin receptor substrate 10.159
FGFR1fibroblast growth factor receptor 10.157
FYNFYN oncogene related to SRC, FGR, YES0.157
NGFnerve growth factor (beta polypeptide)0.156
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.154
CAV1caveolin 1, caveolae protein, 22kDa0.153
FDFT1farnesyl-diphosphate farnesyltransferase 10.153
ARandrogen receptor0.147
VEGFAvascular endothelial growth factor A0.138
SOX2SRY (sex determining region Y)-box 20.134
BAXBCL2-associated X protein0.129
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.125
EGR2early growth response 20.125
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.119
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.116
RXRAretinoid X receptor, alpha0.114
EGR3early growth response 30.111
FGF8fibroblast growth factor 8 (androgen-induced)0.109
PAX8paired box 80.109
HIPK2homeodomain interacting protein kinase 20.106
IGF1Rinsulin-like growth factor 1 receptor0.105
NR5A1nuclear receptor subfamily 5, group A, member 10.105
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.103
ARID4AAT rich interactive domain 4A (RBP1-like)0.099
SC4MOLsterol-C4-methyl oxidase-like0.091
KITLGKIT ligand0.085
HBP1HMG-box transcription factor 10.081
SH3BP4SH3-domain binding protein 40.077
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.077
UPF3BUPF3 regulator of nonsense transcripts homolog B (yeast)0.075
SHC2SHC (Src homology 2 domain containing) transforming protein 20.074
NAV1neuron navigator 10.072
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.069
CTNND1catenin (cadherin-associated protein), delta 10.069
GSK3Bglycogen synthase kinase 3 beta0.068
RETret proto-oncogene0.065
EIF4G2eukaryotic translation initiation factor 4 gamma, 20.065
GAB1GRB2-associated binding protein 10.065
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.064
GATA4GATA binding protein 40.061
PLCG1phospholipase C, gamma 10.058
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.057
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.056
BAK1BCL2-antagonist/killer 10.056
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.055
FANCD2Fanconi anemia, complementation group D20.054
MEOX2mesenchyme homeobox 20.053
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax2paired box gene 20.999
Nr5a1nuclear receptor subfamily 5, group A, member 10.997
Pax8paired box gene 80.996
Fgf8fibroblast growth factor 80.981
Pax3paired box gene 30.979
Hoxd13homeobox D130.978
Tbx3T-box 30.978
Hoxd11homeobox D110.978
Hoxa13homeobox A130.978
Fgfr2fibroblast growth factor receptor 20.968
Apcadenomatosis polyposis coli0.958
Arandrogen receptor0.947
Hand2heart and neural crest derivatives expressed transcript 20.942
Gdnfglial cell line derived neurotrophic factor0.933
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.921
Trp63transformation related protein 630.919
Esr1estrogen receptor 1 (alpha)0.917
Gli3GLI-Kruppel family member GLI30.916
Hoxa10homeobox A100.916
Ror2receptor tyrosine kinase-like orphan receptor 20.907
Lhcgrluteinizing hormone/choriogonadotropin receptor0.900
Hoxa11homeobox A110.882
Shhsonic hedgehog0.875
Kitkit oncogene0.864
Retret proto-oncogene0.856
Msx2homeobox, msh-like 20.847
Fgf18fibroblast growth factor 180.841
Pgrprogesterone receptor0.826
Smosmoothened homolog (Drosophila)0.826
Amhanti-Mullerian hormone0.825
Rargretinoic acid receptor, gamma0.805
Nos3nitric oxide synthase 3, endothelial cell0.799
Ntf3neurotrophin 30.792
Fgf9fibroblast growth factor 90.784
Gata4GATA binding protein 40.775
Emx2empty spiracles homolog 2 (Drosophila)0.774
Pitx2paired-like homeodomain transcription factor 20.774
Ptenphosphatase and tensin homolog0.773
Hoxd9homeobox D90.766
Gata6GATA binding protein 60.760
Trp53transformation related protein 530.757
Fgfr3fibroblast growth factor receptor 30.750
Acvr1activin A receptor, type 10.749
Smad3MAD homolog 3 (Drosophila)0.729
Hoxd10homeobox D100.725
Pitx1paired-like homeodomain transcription factor 10.719
Sall4sal-like 4 (Drosophila)0.719
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.705
Lhx1LIM homeobox protein 10.704
Nr0b1nuclear receptor subfamily 0, group B, member 10.702
Fshrfollicle stimulating hormone receptor0.700
Sox9SRY-box containing gene 90.698
Hoxc9homeobox C90.679
Bcl2B-cell leukemia/lymphoma 20.673
Lhx9LIM homeobox protein 90.672
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.672
Isl1ISL1 transcription factor, LIM/homeodomain0.662
Wnt4wingless-related MMTV integration site 40.650
Gli2GLI-Kruppel family member GLI20.639
Lhx3LIM homeobox protein 30.637
Pou3f3POU domain, class 3, transcription factor 30.631
Stat5bsignal transducer and activator of transcription 5B0.623
Hoxa9homeobox A90.590
Pbx1pre B-cell leukemia transcription factor 10.578
Hspg2perlecan (heparan sulfate proteoglycan 2)0.575
Bmp4bone morphogenetic protein 40.567
Sfrp2secreted frizzled-related protein 20.565
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.559
Bmpr1abone morphogenetic protein receptor, type 1A0.546
Ptpn11protein tyrosine phosphatase, non-receptor type 110.539
Leprleptin receptor0.532
Efna4ephrin A40.527
Kiss1KiSS-1 metastasis-suppressor0.515
Col2a1collagen, type II, alpha 10.514
Ascl1achaete-scute complex homolog 1 (Drosophila)0.513
Meox2mesenchyme homeobox 20.509
Vegfavascular endothelial growth factor A0.505
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.490
Amhr2anti-Mullerian hormone type 2 receptor0.483
Pax6paired box gene 60.475
Sox2SRY-box containing gene 20.457
Rararetinoic acid receptor, alpha0.457
Foxc1forkhead box C10.452
Esrrbestrogen related receptor, beta0.450
Rxraretinoid X receptor alpha0.447
Dkk1dickkopf homolog 1 (Xenopus laevis)0.442
Nkx6-1NK6 homeobox 10.441
Ctsbcathepsin B0.441
Gdf5growth differentiation factor 50.439
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.437
Sall3sal-like 3 (Drosophila)0.436
Npr3natriuretic peptide receptor 30.433
Barx1BarH-like homeobox 10.432
Foxf1aforkhead box F1a0.430
Wnt6wingless-related MMTV integration site 60.424
Arid4aAT rich interactive domain 4A (RBP1-like)0.417
Sgpl1sphingosine phosphate lyase 10.411
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.408
Fgf15fibroblast growth factor 150.405
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Bcl2B-cell CLL/lymphoma 20.248
Fut1fucosyltransferase 10.233
Nr5a2nuclear receptor subfamily 5, group A, member 20.158
Fabp6fatty acid binding protein 6, ileal0.129
Gjb3gap junction protein, beta 30.122
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.108
Prdm2PR domain containing 2, with ZNF domain0.108
Gata6GATA binding protein 60.101
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.097
Tgfbr3transforming growth factor, beta receptor III0.089
Trim29tripartite motif-containing 290.089
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.084
DbpD site of albumin promoter (albumin D-box) binding protein0.082
G6pcglucose-6-phosphatase, catalytic subunit0.081
Shc3SHC (Src homology 2 domain containing) transforming protein 30.081
Wt1Wilms tumor 10.079
Apoeapolipoprotein E0.068
Crybb3crystallin, beta B30.068
Ppardperoxisome proliferator-activated receptor delta0.064
Tcf21transcription factor 210.062
Creb1cAMP responsive element binding protein 10.059
Sfrp4secreted frizzled-related protein 40.058
Rararetinoic acid receptor, alpha0.056
Notch3Notch homolog 3 (Drosophila)0.055
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.054
Bmp7bone morphogenetic protein 70.053
Aldh3a1aldehyde dehydrogenase 3 family, member A10.053
Psen1presenilin 10.053
Hlfhepatic leukemia factor0.052
Nr1d2nuclear receptor subfamily 1, group D, member 20.052
LOC246267resection-induced TPI (rs11)0.052
Apohapolipoprotein H (beta-2-glycoprotein I)0.051
Efnb1ephrin B10.050
Bmp15bone morphogenetic protein 150.048
Msx2msh homeobox 20.047
Kcnt1potassium channel, subfamily T, member 10.047
Padi1peptidyl arginine deiminase, type I0.047
Slc14a2solute carrier family 14 (urea transporter), member 20.046
Rln1relaxin 10.046
Ftlferritin, light polypeptide0.046
Crisp2cysteine-rich secretory protein 20.046
Ctrcchymotrypsin C (caldecrin)0.045
Pdzd2PDZ domain containing 20.045
Casp3caspase 30.045
Ptpn14protein tyrosine phosphatase, non-receptor type 140.045
Fgf1fibroblast growth factor 10.044
Prl7a4prolactin family 7, subfamily a, member 40.044
Adfpadipose differentiation related protein0.044
Cckbrcholecystokinin B receptor0.044
Igfbp5insulin-like growth factor binding protein 50.044
Gja3gap junction protein, alpha 30.044
Foxd4forkhead box D40.043
Gse1genetic suppressor element 10.043
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive0.043
PawrPRKC, apoptosis, WT1, regulator0.043
Slco2a1solute carrier organic anion transporter family, member 2a10.043
Kcnmb1potassium large conductance calcium-activated channel, subfamily M, beta member 10.042
Il13ra1interleukin 13 receptor, alpha 10.041
Arandrogen receptor0.041
Kcng3potassium voltage-gated channel, subfamily G, member 30.040
Starsteroidogenic acute regulatory protein0.040
Foxd1forkhead box D10.040
Ednraendothelin receptor type A0.040
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.040
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.040
TekTEK tyrosine kinase, endothelial0.039
Begainbrain-enriched guanylate kinase-associated0.039
Id3inhibitor of DNA binding 30.039
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.039
Fam65afamily with sequence similarity 65, member A0.039
Lhx1LIM homeobox 10.039
Chrnb4cholinergic receptor, nicotinic, beta 40.038
Apoa2apolipoprotein A-II0.038
Rab20RAB20, member RAS oncogene family0.038
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.038
Scnn1bsodium channel, nonvoltage-gated 1, beta0.037
Atxn1ataxin 10.037
Ubdubiquitin D0.037
Mettl7bmethyltransferase like 7B0.037
Mamdc4MAM domain containing 40.037
Gata3GATA binding protein 30.037
Klf13Kruppel-like factor 130.037
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.037
Pla2g5phospholipase A2, group V0.036
Gata1GATA binding protein 10.036
Dbidiazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)0.036
Adcy10adenylate cyclase 10 (soluble)0.036
Ceacam3carcinoembryonic antigen-related cell adhesion molecule 30.036
Cyp17a1cytochrome P450, family 17, subfamily a, polypeptide 10.036
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.036
Smad4SMAD family member 40.035
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.035
Tpt1tumor protein, translationally-controlled 10.035
Sult5a1sulfotransferase family 5A, member 10.035
Prdx1peroxiredoxin 10.035
Strnstriatin, calmodulin binding protein0.035
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism