The network for 'positive regulation of molecular function' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of molecular function

Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.

NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.443
vav-1Protein VAV-10.246
bar-1Protein BAR-10.242
let-60Protein LET-600.229
sma-6Protein SMA-60.206
atg-2Protein ATG-20.177
imb-2Protein IMB-20.173
sta-1Protein STA-10.173
nhr-6Protein NHR-60.157
mpk-1Protein MPK-10.153
sli-1Protein SLI-10.152
ceh-20Protein CEH-200.151
itr-1Protein ITR-10.150
rig-6Protein RIG-60.146
CELE_F47G4.4Protein F47G4.40.145
smp-1Protein SMP-10.143
sem-5Protein SEM-50.127
unc-73Protein UNC-730.124
atp-2Protein ATP-20.124
plk-1Protein PLK-10.119
hsr-9Protein HSR-90.117
cks-1Protein CKS-10.116
par-5Protein PAR-50.114
afd-1Protein AFD-10.112
hgrs-1Protein HGRS-10.104
unc-26Protein UNC-260.103
sur-2Protein SUR-20.103
unc-40Protein UNC-400.102
mig-15Protein MIG-150.102
C11E4.6Protein C11E4.60.098
R90.1Protein R90.10.098
ceh-34Protein CEH-340.097
Y54E5A.7Protein Y54E5A.70.094
gei-17Protein GEI-170.091
vab-10Protein VAB-100.090
wrm-1Protein WRM-10.090
ajm-1Protein AJM-10.085
rpm-1Protein RPM-10.084
unc-71Protein UNC-710.083
sqv-8Protein SQV-80.083
nurf-1Protein NURF-10.082
K10D6.4Protein K10D6.40.079
gap-2Protein GAP-20.078
unc-10Protein UNC-100.077
pqe-1Protein PQE-10.077
lin-36Protein LIN-360.077
C34F6.10Protein C34F6.100.076
zyg-1Protein ZYG-10.076
pas-7Protein PAS-70.076
max-2Protein MAX-20.075
lmp-2Protein LMP-20.074
rgl-1Protein RGL-10.074
kin-20Protein KIN-200.073
Y95B8A.12Protein Y95B8A.120.071
mat-3Protein MAT-30.071
T23F11.1Protein T23F11.10.070
spk-1Protein SPK-10.069
tmc-2Protein TMC-20.068
aak-2Protein AAK-20.067
eor-2Protein EOR-20.067
let-756Protein LET-7560.066
dars-1Protein DARS-10.066
T28C6.7Protein T28C6.70.066
F54E4.3Protein F54E4.30.066
spc-1Protein SPC-10.065
srgp-1Protein SRGP-10.065
daf-21Protein DAF-210.064
lam-2Protein LAM-20.063
ttx-1Protein TTX-10.063
ham-1Protein HAM-10.062
goa-1Protein GOA-10.059
egl-8Protein EGL-80.059
cst-1Protein CST-10.059
lag-1Protein LAG-10.059
mtm-3Protein MTM-30.059
glp-1Protein GLP-10.059
abl-1Protein ABL-10.058
gsy-1Protein GSY-10.057
sym-4Protein SYM-40.057
ergo-1Protein ERGO-10.057
pmk-1Protein PMK-10.057
unc-6Protein UNC-60.057
eat-6Protein EAT-60.056
mes-3Protein MES-30.056
dpy-21Protein DPY-210.055
dpy-22Protein DPY-220.055
plc-1Protein PLC-10.055
scd-1Protein SCD-10.054
gei-8Protein GEI-80.054
Y77E11A.1Protein Y77E11A.10.054
F29B9.11Protein F29B9.110.054
CELE_F43G6.4Protein F43G6.40.054
cdc-48.2Protein CDC-48.20.054
gei-18Protein GEI-180.054
lin-66Protein LIN-660.054
rsp-2Protein RSP-20.053
eef-1A.1Protein EEF-1A.10.053
uaf-1Protein UAF-10.053
elt-6Protein ELT-60.053
W05F2.6Protein W05F2.60.053
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tpm4tropomyosin 40.535
fgfr1afibroblast growth factor receptor 1a0.307
fn1fibronectin 10.258
gata5GATA-binding protein 50.253
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.244
lef1lymphocyte enhancer binding factor 10.222
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.217
socs3asuppressor of cytokine signaling 3a0.209
id1inhibitor of DNA binding 10.197
efnb2aephrin B2a0.180
ppargperoxisome proliferator activated receptor gamma0.167
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.167
per3period homolog 3 (Drosophila)0.162
baxabcl2-associated X protein, a0.158
tlr3toll-like receptor 30.152
wnt2bbwingless-type MMTV integration site family, member 2Bb0.147
tgfb3transforming growth factor, beta 30.146
cmybtranscription factor cmyb0.144
stc1lstanniocalcin 1, like0.137
robo3roundabout homolog 30.137
hmgb1ahigh-mobility group box 1a0.134
appbamyloid beta (A4) precursor protein b0.127
sparcsecreted acidic cysteine rich glycoprotein0.124
pkd2polycystic kidney disease 20.122
ventventral expressed homeobox0.121
notch3notch homolog 30.118
bmp2abone morphogenetic protein 2a0.115
ascl1aachaete-scute complex-like 1a (Drosophila)0.114
wt1bwilms tumor 1b0.113
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.113
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.111
fgfr3fibroblast growth factor receptor 30.107
ptk2.1protein tyrosine kinase 2a0.106
cx43connexin 430.106
bidaBH3 interacting domain death agonist0.100
pitx3paired-like homeodomain transcription factor 30.100
runx2brunt-related transcription factor 2b0.098
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.097
sox7SRY-box containing gene 70.095
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.091
ncor1nuclear receptor co-repressor 10.091
her15.1hairy and enhancer of split-related 15.10.090
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.089
adrb2aadrenergic receptor, beta 2a0.088
dladeltaA0.084
gata2aGATA-binding protein 2a0.083
fzd7afrizzled homolog 7a0.082
pycardPYD and CARD domain containing0.081
gro1groucho 10.081
gata1aGATA binding protein 1a0.079
sox11aSRY-box containing gene 11a0.079
hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.079
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.078
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.077
crabp2acellular retinoic acid binding protein 2, a0.077
id3inhibitor of DNA binding 30.076
evx1even-skipped homeobox 10.076
sox19aSRY-box containing gene 19a0.075
flhfloating head0.075
hmga1ahigh mobility group AT-hook 1a0.074
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.074
si:dkeyp-50f5.1si:dkeyp-50f5.10.072
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.071
yrkYes-related kinase0.070
kdrlkinase insert domain receptor like0.070
zbtb4zinc finger and BTB domain containing 40.069
opn1mw2opsin 1 (cone pigments), medium-wave-sensitive, 20.068
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.067
egr2bearly growth response 2b0.067
msi1musashi homolog 1 (Drosophila)0.066
axin1axin 10.066
bmperBMP binding endothelial regulator0.064
cldngclaudin g0.064
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.064
clppClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)0.063
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.062
adipoqladiponectin, C1Q and collagen domain containing, like0.062
psen1presenilin 10.061
wnt3wingless-type MMTV integration site family, member 30.061
ctgfconnective tissue growth factor0.061
hsp90a.2heat shock protein 90-alpha 20.060
foxh1forkhead box H10.059
tp53tumor protein p530.058
furinafurin (paired basic amino acid cleaving enzyme) a0.055
ttnatitin a0.055
wnt10awingless-type MMTV integration site family, member 10a0.055
zgc:85866zgc:858660.054
si:dkey-228g21.4si:dkey-228g21.40.054
mycamyelocytomatosis oncogene a0.054
kiss1rbKISS1 receptor b0.054
smad2MAD homolog 2 (Drosophila)0.054
rdh10bretinol dehydrogenase 10b0.054
il6rinterleukin 6 receptor0.053
LOC559201similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3)0.053
puf60apoly-U binding splicing factor a0.052
il6stinterleukin 6 signal transducer0.051
wif1wnt inhibitory factor 10.050
spry2sprouty homolog 20.050
mcl1amyeloid cell leukemia sequence 1a0.050
igf1rainsulin-like growth factor 1a receptor0.049
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rac1CG2248 gene product from transcript CG2248-RA0.983
bskbasket0.979
wgwingless0.835
kaykayak0.802
neurneuralized0.796
shnschnurri0.795
PakPAK-kinase0.744
SmoxSmad on X0.723
Stat92ESignal-transducer and activator of transcription protein at 92E0.716
htlheartless0.696
flwflapwing0.694
pucpuckered0.683
AlkCG8250 gene product from transcript CG8250-RA0.634
eyaeyes absent0.605
ShawShaker cognate w0.552
Sin3ACG8815 gene product from transcript CG8815-RC0.530
Akt1CG4006 gene product from transcript CG4006-RA0.516
Pi3K92ECG4141 gene product from transcript CG4141-RB0.506
trioCG18214 gene product from transcript CG18214-RA0.466
MerMerlin0.461
dmdiminutive0.461
wtswarts0.457
ttvtout-velu0.450
nmonemo0.434
HLHm7E(spl) region transcript m70.434
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.428
tsrtwinstar0.427
Fmr1CG6203 gene product from transcript CG6203-RC0.424
dapdacapo0.416
hipkhomeodomain interacting protein kinase0.411
PtenCG5671 gene product from transcript CG5671-RB0.410
AbiAbelson interacting protein0.399
LanB2Laminin B20.386
ik2IkappaB kinase-like 20.378
chicchickadee0.372
sggshaggy0.367
drkdownstream of receptor kinase0.367
numbCG3779 gene product from transcript CG3779-RB0.367
CycECyclin E0.364
smosmoothened0.364
kstkarst0.360
phlpole hole0.357
cicubitus interruptus0.353
MarfMitochondrial assembly regulatory factor0.345
Tab2TAK1-associated binding protein 20.340
rokRho-kinase0.332
eIF-4EEukaryotic initiation factor 4E0.331
HopHsp70/Hsp90 organizing protein homolog0.327
Gyc76CGuanylyl cyclase at 76C0.326
fzfrizzled0.325
rapretina aberrant in pattern0.324
Pk61CProtein kinase 61C0.323
Rac2CG8556 gene product from transcript CG8556-RA0.323
cactcactus0.323
E(spl)Enhancer of split0.317
jarjaguar0.316
Atg1Autophagy-specific gene 10.311
MadMothers against dpp0.292
inscinscuteable0.291
Dcp-1Death caspase-10.282
p120ctnAdherens junction protein p1200.276
lealeak0.274
G-oalpha47AG protein oalpha 47A0.271
maskmultiple ankyrin repeats single KH domain0.270
Pp2B-14DProtein phosphatase 2B at 14D0.264
dikdiskette0.261
CkIIalphaCasein kinase II alpha subunit0.258
nejnejire0.257
auxauxillin0.257
sdscalloped0.255
RASSF8CG5053 gene product from transcript CG5053-RA0.254
Lis-1Lissencephaly-10.253
Cip4CG15015 gene product from transcript CG15015-RA0.253
kuzkuzbanian0.252
mysmyospheroid0.251
Pros54Proteasome 54kD subunit0.247
panpangolin0.247
Dsor1Downstream of raf10.246
AceAcetylcholine esterase0.246
zfh1Zn finger homeodomain 10.245
shishibire0.238
Dhc64CDynein heavy chain 64C0.237
Socs36ESuppressor of cytokine signaling at 36E0.234
dncdunce0.234
Bap60Brahma associated protein 60kD0.230
G-salpha60AG protein salpha 60A0.226
mbcmyoblast city0.223
LLobe0.222
prosprospero0.222
CadNCadherin-N0.220
egreiger0.219
SMC1CG6057 gene product from transcript CG6057-RA0.217
linlines0.217
HLHm3E(spl) region transcript m30.215
cnocanoe0.213
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.208
PknProtein kinase related to protein kinase N0.207
babobaboon0.207
rprreaper0.201
WASpCG1520 gene product from transcript CG1520-RA0.198
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.516
Calcrlcalcitonin receptor-like0.469
Sellselectin L0.466
Accn2amiloride-sensitive cation channel 2, neuronal0.410
Bcl2B-cell CLL/lymphoma 20.323
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.322
Myo1bmyosin Ib0.321
Anxa2annexin A20.317
Agtr1aangiotensin II receptor, type 1a0.308
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.288
Ube2l3ubiquitin-conjugating enzyme E2L 30.288
Grb2growth factor receptor bound protein 20.286
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.285
Trhrthyrotropin releasing hormone receptor0.278
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.273
Clpscolipase, pancreatic0.269
JunJun oncogene0.266
Fkbp1aFK506 binding protein 1a0.266
Leprleptin receptor0.266
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.263
Slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.249
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.246
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.246
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.240
Adora2aadenosine A2a receptor0.227
Fgfr1Fibroblast growth factor receptor 10.221
Cd4Cd4 molecule0.220
LOC100363783rCG53773-like0.214
Ptafrplatelet-activating factor receptor0.213
Inpp5dinositol polyphosphate-5-phosphatase D0.213
Cdc42cell division cycle 42 (GTP binding protein)0.210
Gja1gap junction protein, alpha 10.209
Hspa8heat shock protein 80.206
Pou2f2POU class 2 homeobox 20.204
Dynll1dynein light chain LC8-type 10.201
Casp2caspase 20.200
Sirpasignal-regulatory protein alpha0.200
Il1rl1interleukin 1 receptor-like 10.199
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.198
Sox17SRY (sex determining region Y)-box 170.196
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.194
Necab1N-terminal EF-hand calcium binding protein 10.192
Htr75-hydroxytryptamine (serotonin) receptor 70.191
Tmem59transmembrane protein 590.189
Slc25a5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.187
Dact3dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)0.185
Folh1folate hydrolase 10.185
Nrp2neuropilin 20.185
Castcalpastatin0.183
Jtbjumping translocation breakpoint0.182
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.181
Tmod3tropomodulin 30.180
Impdh2IMP (inosine monophosphate) dehydrogenase 20.179
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.179
CblCas-Br-M (murine) ecotropic retroviral transforming sequence0.177
Rims1regulating synaptic membrane exocytosis 10.177
Hsp90b1heat shock protein 90, beta, member 10.173
Marcksmyristoylated alanine rich protein kinase C substrate0.172
Crisp2cysteine-rich secretory protein 20.172
Prkcgprotein kinase C, gamma0.171
Ncr1natural cytotoxicity triggering receptor 10.171
Oxtroxytocin receptor0.169
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.168
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.168
Phkg1phosphorylase kinase, gamma 10.166
Jak1Janus kinase 10.164
Robo1roundabout homolog 1 (Drosophila)0.164
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.163
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.161
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.160
Cd247Cd247 molecule0.160
Plekpleckstrin0.159
Mpeg1macrophage expressed 10.158
Syt8synaptotagmin VIII0.158
Ccr5chemokine (C-C motif) receptor 50.158
Egr3early growth response 30.158
Slc15a3solute carrier family 15, member 30.158
Tacr1tachykinin receptor 10.157
Rgs12regulator of G-protein signaling 120.157
Ptprcprotein tyrosine phosphatase, receptor type, C0.156
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.155
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.154
Ece1endothelin converting enzyme 10.154
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.154
Albalbumin0.153
Ube2d4ubiquitin-conjugating enzyme E2D 40.152
Cfpcomplement factor properdin0.148
Tlr7toll-like receptor 70.148
Cd40lgCD40 ligand0.147
Atf3activating transcription factor 30.147
Gng7guanine nucleotide binding protein (G protein), gamma 70.145
Cav3caveolin 30.144
Shox2short stature homeobox 20.143
Prdm2PR domain containing 2, with ZNF domain0.142
Lnpepleucyl/cystinyl aminopeptidase0.142
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.141
Hspd1heat shock protein 1 (chaperonin)0.141
Cald1caldesmon 10.141
Atxn1ataxin 10.140
LOC60591calcium-activated potassium channel beta subunit0.139
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC12Cdc12p0.298
CKA2Cka2p0.264
NBP2Nbp2p0.260
SPA2Spa2p0.183
RAD52Rad52p0.176
STE11Ste11p0.172
TPS1Tps1p0.165
RAS2Ras2p0.160
STI1Sti1p0.145
YME1Yme1p0.143
GYL1Gyl1p0.138
HSL1Hsl1p0.137
PBS2Pbs2p0.131
SSK1Ssk1p0.118
TPK1Tpk1p0.117
GGA1Gga1p0.116
NET1Net1p0.114
MSN5Msn5p0.110
ALO1Alo1p0.109
HSC82Hsc82p0.107
FAB1Fab1p0.103
TSR1Tsr1p0.103
SIP1Sip1p0.102
SWD3Swd3p0.099
ROM2Rom2p0.097
RHO1Rho1p0.096
CDC50Cdc50p0.096
CLB3Clb3p0.096
ENT1Ent1p0.095
STE20Ste20p0.093
CCP1Ccp1p0.092
SPT15Spt15p0.090
REG1Reg1p0.089
RPP1BRpp1bp0.087
TPK2Tpk2p0.084
PSK1Psk1p0.081
TSC11Tsc11p0.080
CYR1Cyr1p0.078
SSA4Ssa4p0.078
SSK2Ssk2p0.078
RIM21Rim21p0.078
MKK1Mkk1p0.077
ATG21Atg21p0.077
PRE3Pre3p0.075
SAC7Sac7p0.075
MSH2Msh2p0.074
GAL83Gal83p0.074
SDS22Sds22p0.073
CRN1Crn1p0.073
MYO2Myo2p0.071
MSN2Msn2p0.071
RPP0Rpp0p0.070
NUP157Nup157p0.070
CDC10Cdc10p0.069
EXO1Exo1p0.068
ECM29Ecm29p0.068
SCH9Sch9p0.068
RPT3Rpt3p0.068
CDC23Cdc23p0.068
STE12Ste12p0.067
DBF2Dbf2p0.067
GDS1Gds1p0.066
AHP1Ahp1p0.066
SUI3Sui3p0.066
CLN3Cln3p0.066
CHS1Chs1p0.066
MET4Met4p0.066
PUB1Pub1p0.066
ATG26Atg26p0.065
YIP4Yip4p0.064
BMH1Bmh1p0.064
CKS1Cks1p0.064
HYP2Hyp2p0.064
CRZ1Crz1p0.062
PTP2Ptp2p0.062
TOR1Tor1p0.062
SLT2Slt2p0.062
SSK22Ssk22p0.062
ROT1Rot1p0.062
SUS1Sus1p0.061
CDC16Cdc16p0.060
AXL2Axl2p0.060
SEC53Sec53p0.060
ORC2Orc2p0.060
STE4Ste4p0.059
VAM3Vam3p0.059
NDE1Nde1p0.058
HSP82Hsp82p0.057
SCJ1Scj1p0.057
SWI1Swi1p0.056
YAP1801hypothetical protein0.056
YGK3Ygk3p0.056
PEA2Pea2p0.056
MSG5Msg5p0.056
GIC2Gic2p0.055
CHC1Chc1p0.055
VPS60Vps60p0.055
SIT4Sit4p0.055
MON2Mon2p0.055
STV1Stv1p0.055