The network for 'myofibril assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

myofibril assembly

Formation of myofibrils, the repeating units of striated muscle.

NameDescriptionProbabilityFunc Analog Organism
twk-18Protein TWK-180.426
his-64Protein HIS-640.414
gei-4Protein GEI-40.391
act-4Protein ACT-40.366
unc-15Protein UNC-150.352
cysl-1Protein CYSL-10.326
deb-1Protein DEB-10.264
unc-98Protein UNC-980.253
pfn-3Protein PFN-30.252
pat-2Protein PAT-20.229
his-46Protein HIS-460.222
ketn-1Protein KETN-10.211
mlc-2Protein MLC-20.210
T28B4.1Protein T28B4.10.206
F39G3.5Protein F39G3.50.200
vha-8Protein VHA-80.199
pat-10Protein PAT-100.197
F35A5.1Protein F35A5.10.183
his-1Protein HIS-10.183
vha-14Protein VHA-140.180
dyb-1Protein DYB-10.180
inx-5Protein INX-50.179
his-68Protein HIS-680.177
his-5Protein HIS-50.166
eat-18Protein EAT-180.158
gst-7Protein GST-70.157
plp-1Protein PLP-10.156
myo-3Protein MYO-30.147
mpk-1Protein MPK-10.147
ZC449.5Protein ZC449.50.145
act-2Protein ACT-20.141
unc-27Protein UNC-270.141
mlc-1Protein MLC-10.138
pat-6Protein PAT-60.137
fog-2Protein FOG-20.137
dim-1Protein DIM-10.134
F47B7.1Protein F47B7.10.133
CELE_ZC204.12Protein ZC204.120.132
lec-3Protein LEC-30.130
unc-87Protein UNC-870.129
F42C5.9Protein F42C5.90.127
dyc-1Protein DYC-10.124
sqt-1Protein SQT-10.124
Y17G7B.12Protein Y17G7B.120.120
CELE_M03A8.3Protein M03A8.30.120
nhr-111Protein NHR-1110.118
F42H10.3Protein F42H10.30.116
che-3Protein CHE-30.115
unc-45Protein UNC-450.114
C46A5.6Protein C46A5.60.114
nhr-2Protein NHR-20.114
C06G3.6Protein C06G3.60.113
lam-2Protein LAM-20.112
T09F3.2Protein T09F3.20.112
zyx-1Protein ZYX-10.111
CELE_C17H12.13Protein C17H12.130.111
col-34Protein COL-340.111
lig-4Protein LIG-40.111
pat-4Protein PAT-40.111
unc-68Protein UNC-680.110
unc-36Protein UNC-360.109
Y110A7A.6Protein Y110A7A.60.108
ace-3Protein ACE-30.108
pdl-1Protein PDL-10.107
col-7Protein COL-70.107
inx-12Protein INX-120.106
CELE_F39H2.3Protein F39H2.30.106
R107.5Protein R107.50.105
aqp-4Protein AQP-40.104
tni-1Protein TNI-10.104
K09G1.1Protein K09G1.10.103
col-147Protein COL-1470.103
vab-3Protein VAB-30.102
rab-14Protein RAB-140.102
dys-1Protein DYS-10.101
mup-4Protein MUP-40.100
C14A4.6Protein C14A4.60.100
ifb-1Protein IFB-10.100
ajm-1Protein AJM-10.100
C53C9.2Protein C53C9.20.100
CELE_Y51A2D.14Protein Y51A2D.140.099
tnt-2Protein TNT-20.099
insc-1Protein INSC-10.099
CELE_C01G10.8Protein C01G10.80.099
suro-1Protein SURO-10.098
his-16Protein HIS-160.098
M02D8.1Protein M02D8.10.098
tag-232Protein TAG-2320.097
col-141Protein COL-1410.097
unc-112Protein UNC-1120.096
inx-15Protein INX-150.095
emb-9Protein EMB-90.093
evl-20Protein EVL-200.092
his-31Protein HIS-310.091
K06A9.1Protein K06A9.10.091
T23F2.5Protein T23F2.50.091
unc-37Protein UNC-370.091
cnd-1Protein CND-10.091
K03E5.2Protein K03E5.20.091
egl-44Protein EGL-440.090
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ttnatitin a0.999
tnnc1btroponin C type 1b (slow)0.999
smyd1bSET and MYND domain containing 1b0.996
unc45bunc-45 homolog B (C. elegans)0.994
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.990
smyhc1slow myosin heavy chain 10.990
vmhcventricular myosin heavy chain0.987
myhz2myosin, heavy polypeptide 2, fast muscle specific0.974
tnni2a.4troponin I, skeletal, fast 2a.40.962
tnni1altroponin I, skeletal, slow like0.959
pdlim7PDZ and LIM domain 70.956
actn3bactinin alpha 3b0.950
smyhc2slow myosin heavy chain 20.946
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.945
zgc:66286zgc:662860.937
myogmyogenin0.932
mylz2myosin, light polypeptide 2, skeletal muscle0.924
pdlim5PDZ and LIM domain 50.922
actn3aactinin alpha 3a0.920
dmddystrophin0.900
dag1dystroglycan 10.898
actc1bactin, alpha, cardiac muscle 1b0.886
tnnt3btroponin T3b, skeletal, fast0.878
smyd1aSET and MYND domain containing 1a0.835
nebnebulin0.825
hsp90a.1heat shock protein 90-alpha 10.810
tpm3tropomyosin 30.787
actn2actinin, alpha 20.777
itgb1b.2integrin, beta 1b.20.756
cmlc1cardiac myosin light chain-10.745
desmadesmin a0.742
atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.681
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.674
myod1myogenic differentiation 10.630
myl1myosin, light chain 1, alkali; skeletal, fast0.607
tpmaalpha-tropomyosin0.605
tpm4tropomyosin 40.603
tmem38atransmembrane protein 38A0.598
wnt11rwingless-type MMTV integration site family, member 11, related0.596
srlsarcalumenin0.570
atp2a2aATPase, Ca++ transporting, cardiac muscle, slow twitch 2a0.545
ilkintegrin linked kinase0.525
gapdhglyceraldehyde-3-phosphate dehydrogenase0.515
limk2LIM domain kinase 20.515
stac3SH3 and cysteine rich domain 30.499
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.479
myf6myogenic factor 60.476
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.459
xirp2axin actin-binding repeat containing 2a0.454
xirp1xin actin-binding repeat containing 10.450
mef2cbmyocyte enhancer factor 2cb0.435
tpm2tropomyosin 2 (beta)0.432
tnni1btroponin I, skeletal, slow b0.419
hspb1heat shock protein, alpha-crystallin-related, 10.384
tnnc2troponin C type 2 (fast)0.381
actc1aactin, alpha, cardiac muscle 1a0.379
hspg2heparan sulfate proteoglycan 20.374
limk1LIM domain kinase 10.366
ckmacreatine kinase, muscle a0.352
lamb2laminin, beta 2 (laminin S)0.352
col15a1bcollagen, type XV, alpha 1b0.350
cx39.9connexin 39.90.345
flncbfilamin C, gamma b (actin binding protein 280)0.344
mybpc3myosin binding protein C, cardiac0.341
ttnbtitin b0.337
pdlim2PDZ and LIM domain 2 (mystique)0.319
lamb1alaminin, beta 1a0.311
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.305
atp1a2aATPase, Na+/K+ transporting, alpha 2a polypeptide0.296
mnx1motor neuron and pancreas homeobox 10.286
tnnt1troponin T1, skeletal, slow0.278
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.276
tnnc1atroponin C type 1a (slow)0.275
tnnt2atroponin T2a, cardiac0.268
pdlim4PDZ and LIM domain 40.263
ldb3bLIM domain binding 3b0.255
pdlim3aPDZ and LIM domain 3a0.253
kbtbd10bkelch repeat and BTB (POZ) domain containing 10b0.249
chrndcholinergic receptor, nicotinic, delta polypeptide0.245
acheacetylcholinesterase0.236
aldocbaldolase C, fructose-bisphosphate, b0.231
krt8keratin 80.227
smyhc1lslow myosin heavy chain 1, like0.210
lamc1laminin, gamma 10.206
mef2camyocyte enhancer factor 2ca0.203
six1bsine oculis homeobox homolog 1b0.202
plod3procollagen-lysine, 2-oxoglutarate 5-dioxygenase 30.197
pvalb4parvalbumin 40.189
tnnt3atroponin T3a, skeletal, fast0.180
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.163
perpPERP, TP53 apoptosis effector0.160
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.153
si:dkey-261h17.1si:dkey-261h17.10.151
scn1basodium channel, voltage-gated, type I, beta a0.147
eno3enolase 3, (beta, muscle)0.143
ryr1bryanodine receptor 1b (skeletal)0.142
mfn2mitofusin 20.139
myf5myogenic factor 50.139
pabpc4poly(A) binding protein, cytoplasmic 4 (inducible form)0.138
scn4absodium channel, voltage-gated, type IV, alpha, b0.136
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mysmyospheroid0.998
Actnalpha actinin0.998
wupAwings up A0.994
Zasp52Z band alternatively spliced PDZ-motif protein 520.994
slssallimus0.983
ifinflated0.983
MhcMyosin heavy chain0.976
Zasp66Z band alternatively spliced PDZ-motif protein 660.974
upupheld0.973
Act88FActin 88F0.971
tmodtropomodulin0.962
flwflapwing0.948
Mlc2Myosin light chain 20.945
Tm2Tropomyosin 20.942
PrmParamyosin0.932
CanB2Calcineurin B20.929
howheld out wings0.870
Cf2Chorion factor 20.856
AtpalphaNa pump alpha subunit0.841
BicDBicaudal D0.662
Rac1CG2248 gene product from transcript CG2248-RA0.651
rheaCG6831 gene product from transcript CG6831-RA0.602
Rho1CG8416 gene product from transcript CG8416-RB0.572
MicalMolecule interacting with CasL0.560
mblmuscleblind0.555
CG11299CG11299 gene product from transcript CG11299-RA0.550
coracoracle0.528
salssarcomere length short0.527
flnflightin0.515
sesBstress-sensitive B0.501
Dcr-2Dicer-20.433
zipzipper0.403
Rya-r44FRyanodine receptor 44F0.402
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.398
twProtein O-mannosyltransferase 20.369
TspThrombospondin0.252
AmphAmphiphysin0.251
MoeMoesin0.241
bsblistered0.239
stmAstambha A0.223
Mef2Myocyte enhancer factor 20.220
Rab11Rab-protein 110.217
konkon-tiki0.210
coroCG9446 gene product from transcript CG9446-RC0.185
Vap-33-1CG5014 gene product from transcript CG5014-RB0.177
Ca-P60ACalcium ATPase at 60A0.173
eIF-4EEukaryotic initiation factor 4E0.165
DAAMDishevelled Associated Activator of Morphogenesis0.160
flrflare0.144
Act57BActin 57B0.134
Cdc42CG12530 gene product from transcript CG12530-RA0.117
GpdhGlycerol 3 phosphate dehydrogenase0.116
ewgerect wing0.114
shotshort stop0.112
srstripe0.107
poloCG12306 gene product from transcript CG12306-RA0.106
CG13366CG13366 gene product from transcript CG13366-RA0.090
me31Bmaternal expression at 31B0.089
Ca-alpha1DCa[2+]-channel protein alpha[[1]] subunit D0.086
LanALaminin A0.085
staistathmin0.084
LaspCG3849 gene product from transcript CG3849-RB0.083
EnoEnolase0.081
e(y)3enhancer of yellow 30.078
Act79BActin 79B0.077
RalaRas-related protein0.075
Trxr-1Thioredoxin reductase-10.074
klarklarsicht0.073
chicchickadee0.072
mbcmyoblast city0.072
uspultraspiracle0.071
Kr-h1Kruppel homolog 10.071
PgkPhosphoglycerate kinase0.065
DdcDopa decarboxylase0.065
LamCLamin C0.064
sloslowpoke0.063
pUf68poly U binding factor 68kD0.063
Gpo-1Glycerophosphate oxidase-10.062
Akap200A kinase anchor protein 2000.061
twitwist0.060
snssticks and stones0.060
otuovarian tumor0.060
Fs(2)KetFemale sterile (2) Ketel0.059
VangVan Gogh0.059
Mlp84BMuscle LIM protein at 84B0.057
Mp20Muscle protein 200.057
rtrotated abdomen0.056
htlheartless0.055
dsxdoublesex0.055
Act5CActin 5C0.055
effeffete0.053
Pros26Proteasome 26kD subunit0.052
AcslAcyl-CoA synthetase long-chain0.052
htshu li tai shao0.050
ArgkArginine kinase0.050
Pink1PTEN-induced putative kinase 10.049
stnAstoned A0.049
shgshotgun0.048
Mlc1Myosin alkali light chain 10.047
dcodiscs overgrown0.046
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TRIM63tripartite motif containing 630.926
TTNtitin0.869
FLNAfilamin A, alpha0.521
ACTN1actinin, alpha 10.456
ZYXzyxin0.386
FN1fibronectin 10.315
TPM1tropomyosin 1 (alpha)0.196
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.186
ACTN4actinin, alpha 40.185
NEBnebulin0.174
KRT15keratin 150.146
MYH9myosin, heavy chain 9, non-muscle0.132
ACTBactin, beta0.061
VCLvinculin0.060
KRT6Bkeratin 6B0.053
TNNI1troponin I type 1 (skeletal, slow)0.049
PDLIM7PDZ and LIM domain 7 (enigma)0.049
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.038
HDAC4histone deacetylase 40.035
TBX5T-box 50.034
ANK1ankyrin 1, erythrocytic0.031
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.031
KRT8keratin 80.028
CFL1cofilin 1 (non-muscle)0.024
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.023
TPM2tropomyosin 2 (beta)0.023
CALD1caldesmon 10.021
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.021
MYL9myosin, light chain 9, regulatory0.020
ACTA2actin, alpha 2, smooth muscle, aorta0.018
GEMIN7gem (nuclear organelle) associated protein 70.018
CNN2calponin 20.018
GPIglucose-6-phosphate isomerase0.018
MYOZ1myozenin 10.017
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.015
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.015
HAP1huntingtin-associated protein 10.015
ACTN2actinin, alpha 20.014
ATXN1ataxin 10.013
PXNpaxillin0.013
FLNBfilamin B, beta0.012
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.012
MYOGmyogenin (myogenic factor 4)0.012
ACTC1actin, alpha, cardiac muscle 10.012
TMPOthymopoietin0.012
PRRC2Aproline-rich coiled-coil 2A0.012
TAGLNtransgelin0.011
MYOD1myogenic differentiation 10.011
PICALMphosphatidylinositol binding clathrin assembly protein0.011
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.011
TJP1tight junction protein 1 (zona occludens 1)0.011
NDUFS7NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)0.011
FLNCfilamin C, gamma0.011
TCF4transcription factor 40.010
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ttntitin0.999
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.997
Ilkintegrin linked kinase0.984
Dmddystrophin, muscular dystrophy0.967
Tgfb2transforming growth factor, beta 20.935
Actn2actinin alpha 20.922
Inpp5dinositol polyphosphate-5-phosphatase D0.917
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.890
Lmnalamin A0.887
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.865
Actc1actin, alpha, cardiac muscle 10.861
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.828
Hrchistidine rich calcium binding protein0.794
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.793
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.793
Ldb3LIM domain binding 30.791
Sox9SRY-box containing gene 90.790
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.765
Vegfavascular endothelial growth factor A0.758
Itgb1integrin beta 1 (fibronectin receptor beta)0.728
Vclvinculin0.709
Actn1actinin, alpha 10.664
Gja1gap junction protein, alpha 10.662
Hand2heart and neural crest derivatives expressed transcript 20.639
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.632
Taglntransgelin0.596
Gli2GLI-Kruppel family member GLI20.569
Aldoaaldolase A, fructose-bisphosphate0.561
Tpm2tropomyosin 2, beta0.541
Msx1homeobox, msh-like 10.537
Myom2myomesin 20.511
Csf1colony stimulating factor 1 (macrophage)0.504
Vaspvasodilator-stimulated phosphoprotein0.503
Tln1talin 10.493
Rac1RAS-related C3 botulinum substrate 10.493
Tnnt3troponin T3, skeletal, fast0.487
Tgfb1transforming growth factor, beta 10.487
Tgfbr2transforming growth factor, beta receptor II0.486
Tnnt2troponin T2, cardiac0.459
Actg2actin, gamma 2, smooth muscle, enteric0.405
Myh9myosin, heavy polypeptide 9, non-muscle0.404
Cnn1calponin 10.392
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.389
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.381
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.379
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.367
Myl9myosin, light polypeptide 9, regulatory0.358
Tnnc1troponin C, cardiac/slow skeletal0.350
Eya1eyes absent 1 homolog (Drosophila)0.344
Acta2actin, alpha 2, smooth muscle, aorta0.342
TapbpTAP binding protein0.330
Desdesmin0.320
Gpi1glucose phosphate isomerase 10.305
Trp53transformation related protein 530.304
Tnnc2troponin C2, fast0.303
Tnni1troponin I, skeletal, slow 10.286
Nrapnebulin-related anchoring protein0.281
Myl3myosin, light polypeptide 30.278
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.272
Csrp3cysteine and glycine-rich protein 30.261
Lims1LIM and senescent cell antigen-like domains 10.254
Ednrbendothelin receptor type B0.253
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.251
Nos3nitric oxide synthase 3, endothelial cell0.244
Myo1cmyosin IC0.239
Ctnnb1catenin (cadherin associated protein), beta 10.237
Cnn2calponin 20.231
Mybpc3myosin binding protein C, cardiac0.216
Tnni2troponin I, skeletal, fast 20.215
Shhsonic hedgehog0.213
Myl1myosin, light polypeptide 10.202
Hdac4histone deacetylase 40.196
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.196
Ikzf1IKAROS family zinc finger 10.193
Tagln2transgelin 20.186
Plecplectin0.184
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.183
Myom1myomesin 10.183
Pthlhparathyroid hormone-like peptide0.182
Pfn1profilin 10.182
Col1a1collagen, type I, alpha 10.181
Tcte3t-complex-associated testis expressed 30.181
Actn3actinin alpha 30.174
Nrp1neuropilin 10.173
Plxnd1plexin D10.171
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.167
Itgb3integrin beta 30.166
Ptpn11protein tyrosine phosphatase, non-receptor type 110.164
Prrx1paired related homeobox 10.164
Gata6GATA binding protein 60.159
Capzbcapping protein (actin filament) muscle Z-line, beta0.159
Myh7myosin, heavy polypeptide 7, cardiac muscle, beta0.157
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.156
Hand1heart and neural crest derivatives expressed transcript 10.154
Casq2calsequestrin 20.148
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.148
Fli1Friend leukemia integration 10.146
Engendoglin0.140
Wdr1WD repeat domain 10.139
Ckmt2creatine kinase, mitochondrial 20.139
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Myh7myosin, heavy chain 7, cardiac muscle, beta0.060
Myh9myosin, heavy chain 9, non-muscle0.056
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.047
Mbmyoglobin0.029
Krt18keratin 180.027
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.020
Ckmcreatine kinase, muscle0.019
Actbactin, beta0.017
Myl1myosin, light chain 10.015
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.015
Myoz2myozenin 20.015
Tnni2troponin I type 2 (skeletal, fast)0.015
Flnafilamin A, alpha0.014
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.014
Actc1actin, alpha, cardiac muscle 10.012
Lmnalamin A0.012
Csrp3cysteine and glycine-rich protein 30.011
Pgam2phosphoglycerate mutase 2 (muscle)0.010
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.010
Tagln2transgelin 20.010
Actn2actinin alpha 20.010
Mybpc1myosin binding protein C, slow type0.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism