The network for 'sphingolipid biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

sphingolipid biosynthetic process

The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

NameDescriptionProbabilityFunc Analog Organism
T22D1.3Protein T22D1.30.038
elo-2Protein ELO-20.022
pmp-1Protein PMP-10.019
tbc-3Protein TBC-30.017
F53E4.1Protein F53E4.10.016
sur-5Protein SUR-50.016
aagr-2Protein AAGR-20.015
mlc-4Protein MLC-40.014
cdc-37Protein CDC-370.014
CELE_C27A7.1Protein C27A7.10.014
abts-3Protein ABTS-30.014
cki-2Protein CKI-20.012
fln-1Protein FLN-10.012
gob-1Protein GOB-10.011
hmgs-1Protein HMGS-10.011
mrp-5Protein MRP-50.011
tre-3Protein TRE-30.011
sptl-1Protein SPTL-10.011
gspd-1Protein GSPD-10.011
dph-2Protein DPH-20.011
best-7Protein BEST-70.011
T10B5.7Protein T10B5.70.011
elt-2Protein ELT-20.010
hpo-19Protein HPO-190.010
mboa-3Protein MBOA-30.010
pcyt-1Protein PCYT-10.010
Y25C1A.7Protein Y25C1A.70.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
st8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.306
st8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.256
st8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.252
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.249
slc9a3r1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.233
lppLIM domain containing preferred translocation partner in lipoma0.232
vtg7vitellogenin 70.201
pitpnaphosphatidylinositol transfer protein, alpha0.134
fa2hfatty acid 2-hydroxylase0.118
lass5LAG1 homolog, ceramide synthase 5 (S. cerevisiae)0.118
vtg6vitellogenin 60.118
LOC564867novel protein similar to LAG1 homolog, ceramide synthase family0.113
rnf128aring finger protein 128a0.108
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.093
elovl7bELOVL family member 7, elongation of long chain fatty acids (yeast) b0.091
rplp1ribosomal protein, large, P10.090
renrenin0.084
ucp2uncoupling protein 20.083
atp6v0d1ATPase, H+ transporting, V0 subunit D isoform 10.083
lndc1ly6/neurotoxin domain containing 10.080
stk10serine/threonine kinase 100.076
cotl1coactosin-like 1 (Dictyostelium)0.076
vtg1vitellogenin 10.067
gperG protein-coupled estrogen receptor 10.063
mapk1mitogen-activated protein kinase 10.061
fkbp10FK506 binding protein 100.058
pfn1profilin 10.055
csnk1dbcasein kinase 1, delta b0.054
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.052
sass6spindle assembly 6 homolog (C. elegans)0.048
fam49bafamily with sequence similarity 49, member Ba0.046
eomesaeomesodermin homolog a0.043
st8sia5ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 50.043
c1galt1bcore 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b0.042
anxa3bannexin A3b0.042
lrmplymphoid-restricted membrane protein0.041
spg11spastic paraplegia 110.041
zgc:56419zgc:564190.040
grhl3grainyhead-like 30.040
tob1atransducer of ERBB2, 1a0.038
sh3gl1aSH3-domain GRB2-like 1a0.038
si:ch211-284e13.2si:ch211-284e13.20.037
ugp2bUDP-glucose pyrophosphorylase 2b0.037
slc39a7solute carrier family 39 (zinc transporter), member 70.035
atp6v1hATPase, H+ transporting, lysosomal, V1 subunit H0.035
ppp1r14aaprotein phosphatase 1, regulatory (inhibitor) subunit 14Aa0.034
foxo3aforkhead box O3A0.034
arpc1bactin related protein 2/3 complex, subunit 1B0.034
fzd5frizzled homolog 50.034
ckmt2creatine kinase, mitochondrial 2 (sarcomeric)0.033
dusp1dual specificity phosphatase 10.033
si:dkey-49m19.7si:dkey-49m19.70.032
ctszcathepsin Z0.031
si:ch73-178d14.1si:ch73-178d14.10.031
zgc:56280zgc:562800.030
btg2B-cell translocation gene 20.030
ehd2EH-domain containing 20.029
cldn15aclaudin 15a0.029
gulp1GULP, engulfment adaptor PTB domain containing 10.029
aqp7aquaporin 70.029
manfmesencephalic astrocyte-derived neurotrophic factor0.029
rock2brho-associated, coiled-coil containing protein kinase 2b0.029
pgrprogesterone receptor0.028
trpc6transient receptor potential cation channel, subfamily C, member 60.028
pomt1protein-O-mannosyltransferase 10.027
ctsdcathepsin D0.027
mllt10myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 100.027
etv5aets variant 5a0.027
baiap2l1aBAI1-associated protein 2-like 1a0.027
clicachloride intracellular channel a0.027
plxnb2bplexin b2b0.026
gna12guanine nucleotide binding protein (G protein) alpha 120.026
zgc:64098zgc:640980.026
rtn4areticulon 4a0.025
junbjun B proto-oncogene0.025
anxa5bannexin A5b0.025
pglyrp2peptidoglycan recognition protein 20.024
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.024
alas1aminolevulinate, delta-, synthetase 10.023
mmp15amatrix metallopeptidase 15a0.023
igfbp1ainsulin-like growth factor binding protein 1a0.023
lass2LAG1 homolog, ceramide synthase 2 (S. cerevisiae)0.023
rab13RAB13, member RAS oncogene family0.023
sgtasmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha0.023
gria1bglutamate receptor, ionotropic, AMPA 1b0.023
cldn2claudin 20.022
cyp2y3cytochrome P450, family 2, subfamily Y, polypeptide 30.022
plk3polo-like kinase 3 (Drosophila)0.022
ndel1bnudE nuclear distribution gene E homolog like 1 (A. nidulans) B0.022
hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase0.021
srpxsushi-repeat-containing protein0.021
sult3st2sulfotransferase family 3, cytosolic sulfotransferase 20.021
homezhomeodomain leucine zipper gene0.021
trim71tripartite motif-containing 710.021
LOC569642hypothetical protein LOC5696420.021
ca8carbonic anhydrase VIII0.021
gpx7glutathione peroxidase 70.021
slc25a14solute carrier family 25 (mitochondrial carrier, brain), member 140.020
far1fatty acyl CoA reductase 10.020
th2tyrosine hydroxylase 20.020
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG16904CG16904 gene product from transcript CG16904-RA0.028
CG30008CG30008 gene product from transcript CG30008-RA0.022
CG33129CG33129 gene product from transcript CG33129-RE0.011
CG9459CG9459 gene product from transcript CG9459-RA0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.379
PDPK13-phosphoinositide dependent protein kinase-10.092
LAMP1lysosomal-associated membrane protein 10.075
NOXA1NADPH oxidase activator 10.065
TMBIM6transmembrane BAX inhibitor motif containing 60.050
SURF4surfeit 40.039
ANXA4annexin A40.039
NUMBnumb homolog (Drosophila)0.038
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.034
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.033
PICK1protein interacting with PRKCA 10.033
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.031
SH3RF1SH3 domain containing ring finger 10.029
MAPKAP1mitogen-activated protein kinase associated protein 10.027
CDC37cell division cycle 37 homolog (S. cerevisiae)0.027
MAPTmicrotubule-associated protein tau0.026
RICTORRPTOR independent companion of MTOR, complex 20.025
RARAretinoic acid receptor, alpha0.025
CTGFconnective tissue growth factor0.024
SLC39A1solute carrier family 39 (zinc transporter), member 10.024
DUSP23dual specificity phosphatase 230.023
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.023
LRRK2leucine-rich repeat kinase 20.022
ZNF71zinc finger protein 710.021
CCDC115coiled-coil domain containing 1150.018
DCTN1dynactin 10.017
CDCP1CUB domain containing protein 10.017
BRF2BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like0.016
PREX1phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 10.016
RPTORregulatory associated protein of MTOR, complex 10.016
CASP7caspase 7, apoptosis-related cysteine peptidase0.015
LASS2LAG1 homolog, ceramide synthase 20.014
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.013
CASP3caspase 3, apoptosis-related cysteine peptidase0.013
FYNFYN oncogene related to SRC, FGR, YES0.012
NR1H2nuclear receptor subfamily 1, group H, member 20.012
RHEBRas homolog enriched in brain0.012
NEDD9neural precursor cell expressed, developmentally down-regulated 90.011
DEPTORDEP domain containing MTOR-interacting protein0.011
PDK1pyruvate dehydrogenase kinase, isozyme 10.010
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.010
NPTNneuroplastin0.010
NMT2N-myristoyltransferase 20.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Elovl1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 10.976
Mapkap1mitogen-activated protein kinase associated protein 10.863
Ctgfconnective tissue growth factor0.704
Sptlc2serine palmitoyltransferase, long chain base subunit 20.685
Rptorregulatory associated protein of MTOR, complex 10.583
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.581
Ebpphenylalkylamine Ca2+ antagonist (emopamil) binding protein0.570
Mlst8MTOR associated protein, LST8 homolog (S. cerevisiae)0.537
RictorRPTOR independent companion of MTOR, complex 20.495
Thbs1thrombospondin 10.494
FosFBJ osteosarcoma oncogene0.488
Bcap31B-cell receptor-associated protein 310.458
Spcs2signal peptidase complex subunit 2 homolog (S. cerevisiae)0.450
Cyr61cysteine rich protein 610.420
Ptgesprostaglandin E synthase0.376
Mfsd1major facilitator superfamily domain containing 10.357
CdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.289
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.271
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 10.259
Asah1N-acylsphingosine amidohydrolase 10.227
Serpine1serine (or cysteine) peptidase inhibitor, clade E, member 10.220
Mybphmyosin binding protein H0.219
Gaaglucosidase, alpha, acid0.198
Scarb2scavenger receptor class B, member 20.188
Tmem9bTMEM9 domain family, member B0.185
Ighimmunoglobulin heavy chain complex0.180
Pttg1ippituitary tumor-transforming 1 interacting protein0.179
Errfi1ERBB receptor feedback inhibitor 10.177
Inpp5jinositol polyphosphate 5-phosphatase J0.170
Tmem33transmembrane protein 330.161
0610007P14RikRIKEN cDNA 0610007P14 gene0.157
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.147
Acsl5acyl-CoA synthetase long-chain family member 50.141
Tnctenascin C0.138
Dpp7dipeptidylpeptidase 70.133
Rnh1ribonuclease/angiogenin inhibitor 10.132
Orai1ORAI calcium release-activated calcium modulator 10.131
Derl2Der1-like domain family, member 20.128
AclyATP citrate lyase0.126
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.126
Cd9CD9 antigen0.120
Capn2calpain 20.116
Syt3synaptotagmin III0.115
Scamp2secretory carrier membrane protein 20.111
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.111
Txndc12thioredoxin domain containing 12 (endoplasmic reticulum)0.110
Ptgirprostaglandin I receptor (IP)0.108
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.106
Anxa4annexin A40.104
Pthlhparathyroid hormone-like peptide0.104
Rpa3replication protein A30.103
Soat1sterol O-acyltransferase 10.101
BtkBruton agammaglobulinemia tyrosine kinase0.100
Rab25RAB25, member RAS oncogene family0.098
Mgat2mannoside acetylglucosaminyltransferase 20.098
Hsd17b12hydroxysteroid (17-beta) dehydrogenase 120.094
Hrh1histamine receptor H10.090
RragcRas-related GTP binding C0.088
BlnkB-cell linker0.088
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.085
Nrcamneuron-glia-CAM-related cell adhesion molecule0.084
F3coagulation factor III0.081
D15Ertd621eDNA segment, Chr 15, ERATO Doi 621, expressed0.080
Sc4molsterol-C4-methyl oxidase-like0.078
Tll1tolloid-like0.078
Zfp36zinc finger protein 360.077
Cstbcystatin B0.076
Anxa5annexin A50.076
Serp1stress-associated endoplasmic reticulum protein 10.076
Sft2d1SFT2 domain containing 10.076
Magmyelin-associated glycoprotein0.075
Hrhairless0.072
Cln5ceroid-lipofuscinosis, neuronal 50.072
Cd40CD40 antigen0.072
Dusp1dual specificity phosphatase 10.072
Pdcd6programmed cell death 60.071
Col8a1collagen, type VIII, alpha 10.067
Rnase1ribonuclease, RNase A family, 1 (pancreatic)0.065
Tnfrsf12atumor necrosis factor receptor superfamily, member 12a0.063
Slc31a1solute carrier family 31, member 10.063
Cdh13cadherin 130.062
Tpp1tripeptidyl peptidase I0.062
Fgf7fibroblast growth factor 70.061
LitafLPS-induced TN factor0.061
Tspan31tetraspanin 310.061
Lgmnlegumain0.058
Plekhg6pleckstrin homology domain containing, family G (with RhoGef domain) member 60.057
Klf6Kruppel-like factor 60.057
Man2a1mannosidase 2, alpha 10.056
Degs1degenerative spermatocyte homolog 1 (Drosophila)0.054
Adam9a disintegrin and metallopeptidase domain 9 (meltrin gamma)0.053
Pla2g10phospholipase A2, group X0.053
Slc2a5solute carrier family 2 (facilitated glucose transporter), member 50.053
1600012H06RikRIKEN cDNA 1600012H06 gene0.052
Lgals2lectin, galactose-binding, soluble 20.052
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.051
Syt5synaptotagmin V0.050
Loxlysyl oxidase0.049
Tmem19transmembrane protein 190.049
Mslnmesothelin0.049
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tspan31tetraspanin 310.034
RGD1303130kidney predominant protein NCU-G10.024
Errfi1ERBB receptor feedback inhibitor 10.024
Slc25a5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.016
Lass2LAG1 homolog, ceramide synthase 20.015
Gltpglycolipid transfer protein0.015
Elovl1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 10.015
Agaaspartylglucosaminidase0.014
FosFBJ osteosarcoma oncogene0.014
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.013
Sdc1syndecan 10.013
Fgl2fibrinogen-like 20.013
Scamp3secretory carrier membrane protein 30.013
Dio1deiodinase, iodothyronine, type I0.012
Khkketohexokinase0.012
Rpn1ribophorin I0.012
Efhd2EF-hand domain family, member D20.012
Slc48a1solute carrier family 48 (heme transporter), member 10.012
Upb1ureidopropionase, beta0.012
Tmbim1transmembrane BAX inhibitor motif containing 10.012
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.012
Bpnt13'(2'), 5'-bisphosphate nucleotidase 10.011
Egr1early growth response 10.011
RGD1311307similar to 1300014I06Rik protein0.011
Hyal3hyaluronoglucosaminidase 30.011
Zfp36zinc finger protein 360.010
Acat3acetyl-Coenzyme A acetyltransferase 30.010
Rassf4Ras association (RalGDS/AF-6) domain family member 40.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
LCB2Lcb2p0.897
TOR2Tor2p0.875
LAG1Lag1p0.874
TOR1Tor1p0.787
LCB1Lcb1p0.510
MDS3Mds3p0.446
BMH1Bmh1p0.400
SCS7Scs7p0.320
PTK2Ptk2p0.304
YPK1Ypk1p0.286
TSC3Tsc3p0.244
CMK2Cmk2p0.235
SLM1Slm1p0.232
GSF2Gsf2p0.208
LAC1Lac1p0.207
VMA11Vma11p0.203
CSG2Csg2p0.193
IFA38Ifa38p0.184
FPK1Fpk1p0.157
LCB3Lcb3p0.152
ELO1Elo1p0.141
RIM101Rim101p0.128
SVP26Svp26p0.110
TCO89Tco89p0.109
SIA1Sia1p0.100
SUR2Sur2p0.098
LIP1Lip1p0.096
KSP1Ksp1p0.092
GCS1Gcs1p0.085
IPT1Ipt1p0.080
YJL193Whypothetical protein0.080
SAK1Sak1p0.080
NPR1Npr1p0.079
YPL260Whypothetical protein0.077
YLR257Whypothetical protein0.076
TAX4Tax4p0.075
SUR1Sur1p0.072
IZH3Izh3p0.072
PPQ1Ppq1p0.071
NUR1Nur1p0.070
AVT1Avt1p0.069
SSK1Ssk1p0.069
ISC1Isc1p0.066
RTS1Rts1p0.064
YLR177Whypothetical protein0.063
PLB2Plb2p0.062
FMP48Fmp48p0.060
CTR2Ctr2p0.060
ERG11Erg11p0.059
OSH3Osh3p0.058
TOS1Tos1p0.058
MBF1Mbf1p0.055
LST4Lst4p0.052
YLR162Whypothetical protein0.050
YPL014Whypothetical protein0.050
FKS1Fks1p0.049
MRS3Mrs3p0.049
AGP1Agp1p0.046
YGR016Whypothetical protein0.043
PAM1Pam1p0.043
GPI2Gpi2p0.043
YNL144Chypothetical protein0.043
SRD1Srd1p0.042
YAR028Whypothetical protein0.042
YLR264C-Ahypothetical protein0.041
SKS1Sks1p0.041
OST1Ost1p0.041
PMC1Pmc1p0.041
ATO3Ato3p0.041
PMT6Pmt6p0.040
AZF1Azf1p0.040
VMA16Vma16p0.039
ATF2Atf2p0.039
LEU2Leu2p0.038
CSH1Csh1p0.038
PRR2Prr2p0.038
PSD1Psd1p0.037
PHD1Phd1p0.037
SHR3Shr3p0.037
YOL038C-Ahypothetical protein0.037
ERD2Erd2p0.037
YMR102Chypothetical protein0.036
VHR1Vhr1p0.035
VHS1Vhs1p0.035
HAL5Hal5p0.035
KIN82Kin82p0.034
YOR390Whypothetical protein0.034
YPS1Yps1p0.034
OPY1Opy1p0.033
SEF1Sef1p0.033
MF(ALPHA)2Mf(alpha)2p0.033
CHS1Chs1p0.033
LDB16Ldb16p0.032
YPR063Chypothetical protein0.032
HRK1Hrk1p0.032
SPL2Spl2p0.031
YAR068Whypothetical protein0.031
RPS14BRps14bp0.031
ARP10Arp10p0.031
SPC25Spc25p0.031