The network for 'regulation of cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cell fate specification

Any process that mediates the adoption of a specific fate by a cell.

NameDescriptionProbabilityFunc Analog Organism
lin-17Protein LIN-170.887
sel-8Protein SEL-80.745
lin-29Protein LIN-290.673
egl-18Protein EGL-180.658
bar-1Protein BAR-10.601
pha-4Protein PHA-40.580
let-60Protein LET-600.531
mig-5Protein MIG-50.444
egl-30Protein EGL-300.347
nhr-25Protein NHR-250.346
pry-1Protein PRY-10.327
elt-6Protein ELT-60.321
sdc-1Protein SDC-10.293
daf-3Protein DAF-30.254
ten-1Protein TEN-10.248
egl-36Protein EGL-360.240
pop-1Protein POP-10.194
hlh-1Protein HLH-10.175
tam-1Protein TAM-10.169
eya-1Protein EYA-10.166
lin-36Protein LIN-360.155
eor-2Protein EOR-20.150
asd-1Protein ASD-10.134
hbl-1Protein HBL-10.129
nhr-67Protein NHR-670.122
unc-53Protein UNC-530.121
cki-1Protein CKI-10.114
set-16Protein SET-160.111
flh-1Protein FLH-10.109
sem-5Protein SEM-50.109
eor-1Protein EOR-10.100
lit-1Protein LIT-10.092
sos-1Protein SOS-10.091
CELE_F47G4.4Protein F47G4.40.085
lag-1Protein LAG-10.082
fkh-2Protein FKH-20.082
vab-3Protein VAB-30.081
B0205.9Protein B0205.90.081
CELE_Y57G11C.22Protein Y57G11C.220.076
psa-3Protein PSA-30.074
dpy-22Protein DPY-220.074
sys-1Protein SYS-10.074
R02D5.1Protein R02D5.10.073
egl-5Protein EGL-50.068
ing-3Protein ING-30.067
F41H10.3Protein F41H10.30.065
fox-1Protein FOX-10.064
cec-6Protein CEC-60.063
ain-1Protein AIN-10.059
panl-3Protein PANL-30.054
unc-73Protein UNC-730.049
vab-1Protein VAB-10.047
cam-1Protein CAM-10.047
dsh-2Protein DSH-20.045
ceh-32Protein CEH-320.045
his-24Protein HIS-240.044
wrm-1Protein WRM-10.044
B0454.9Protein B0454.90.039
vang-1Protein VANG-10.039
let-756Protein LET-7560.039
pes-1Protein PES-10.039
lin-40Protein LIN-400.037
hlh-2Protein HLH-20.036
wdr-5.3Protein WDR-5.30.036
lin-48Protein LIN-480.035
camt-1Protein CAMT-10.034
unc-62Protein UNC-620.034
T02E9.5Protein T02E9.50.033
rgs-7Protein RGS-70.033
trim-9Protein TRIM-90.032
ztf-22Protein ZTF-220.031
agt-2Protein AGT-20.031
math-26Protein MATH-260.031
dpy-21Protein DPY-210.031
egl-15Protein EGL-150.031
lag-2Protein LAG-20.030
wapl-1Protein WAPL-10.030
unc-54Protein UNC-540.030
tbx-8Protein TBX-80.030
cfim-2Protein CFIM-20.030
CELE_W04E12.2Protein W04E12.20.030
dhs-14Protein DHS-140.030
fbxb-40Protein FBXB-400.030
axl-1Protein AXL-10.029
ceh-6Protein CEH-60.029
R151.8Protein R151.80.029
ceh-20Protein CEH-200.029
lsd-1Protein LSD-10.028
CELE_Y105C5A.24Protein Y105C5A.240.028
ZK177.1Protein ZK177.10.028
lin-12Protein LIN-120.027
unc-40Protein UNC-400.027
Y56A3A.6Protein Y56A3A.60.027
klf-2Protein KLF-20.027
ceh-16Protein CEH-160.026
crm-1Protein CRM-10.026
C49H3.6Protein C49H3.60.026
zip-7Protein ZIP-70.026
mpk-1Protein MPK-10.026
W02B8.1Protein W02B8.10.025
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ventventral expressed homeobox0.841
fgfr1afibroblast growth factor receptor 1a0.795
gata3GATA-binding protein 30.742
bmp4bone morphogenetic protein 40.648
bmp2bbone morphogenetic protein 2b0.596
sox9bSRY-box containing gene 9b0.544
hoxb2ahomeo box B2a0.491
sox1aSRY-box containing gene 1a0.465
vsx2visual system homeobox 20.457
msxcmuscle segment homeobox C0.453
hmx4H6 family homeobox 40.416
tbx1T-box 10.384
dusp6dual specificity phosphatase 60.373
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.360
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.342
dhrs3adehydrogenase/reductase (SDR family) member 3a0.327
eya1eyes absent homolog 10.327
dkk1bdickkopf 1b0.305
wnt1wingless-type MMTV integration site family, member 10.299
atoh1aatonal homolog 1a0.293
foxg1aforkhead box G1a0.263
pcdh8protocadherin 80.262
jag1ajagged 1a0.238
flhfloating head0.235
nkx2.2aNK2 transcription factor related 2a0.232
notch2notch homolog 20.219
jag2jagged 20.213
six4bsine oculis homeobox homolog 4b0.212
pitx3paired-like homeodomain transcription factor 30.208
hey1hairy/enhancer-of-split related with YRPW motif 10.208
meis3myeloid ecotropic viral integration site 30.205
gbx2gastrulation brain homeo box 20.183
ndr2nodal-related 20.181
evx1even-skipped homeobox 10.166
hoxa11ahomeo box A11a0.162
hmx3homeo box (H6 family) 30.149
alas2aminolevulinate, delta-, synthetase 20.147
fgf3fibroblast growth factor 30.143
hoxd11ahomeo box D11a0.141
hoxb5ahomeo box B5a0.140
vsx1visual system homeobox 1 homolog, chx10-like0.136
tcf7l1btranscription factor 7-like 1b (T-cell specific, HMG-box)0.116
neo1neogenin 10.110
otpborthopedia homolog b0.109
hhiphedgehog interacting protein0.106
fgf10afibroblast growth factor 10a0.101
hoxa9ahomeo box A9a0.101
tbx6T-box gene 60.096
col14a1collagen, type XIV, alpha 10.095
gata4GATA-binding protein 40.094
notch1anotch homolog 1a0.092
spry4sprouty (Drosophila) homolog 40.091
gli1GLI-Kruppel family member 10.091
hoxb8ahomeo box B8a0.090
rereaarginine-glutamic acid dipeptide (RE) repeats a0.089
lhx1aLIM homeobox 1a0.088
gro2groucho 20.087
rarabretinoic acid receptor, alpha b0.086
ndr1nodal-related 10.083
hoxa10bhomeo box A10b0.082
aldh1a3aldehyde dehydrogenase 1 family, member A30.081
wnt8bwingless-type MMTV integration site family, member 8b0.081
notch3notch homolog 30.080
ascl1aachaete-scute complex-like 1a (Drosophila)0.076
restRE1-silencing transcription factor0.073
acvr1bactivin A receptor, type IB0.071
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.069
tp73tumor protein p730.068
wt1awilms tumor 1a0.067
sox32SRY-box containing gene 320.066
bocbrother of CDO0.066
ascl1bachaete-scute complex-like 1b (Drosophila)0.066
tp63tumor protein p630.065
pax8paired box gene 80.065
rorbRAR-related orphan receptor B0.062
her5hairy-related 50.058
mespamesoderm posterior a0.058
tbx2bT-box 2b0.058
cdh2cadherin 2, neuronal0.057
dlx5adistal-less homeobox gene 5a0.056
tll1tolloid-like 10.056
lhx1bLIM homeobox 1b0.056
evx2even-skipped homeobox 20.055
notum3notum 30.055
neurod4neurogenic differentiation 40.054
fzd5frizzled homolog 50.054
sox11bSRY-box containing gene 11b0.053
wnt10awingless-type MMTV integration site family, member 10a0.053
runx2brunt-related transcription factor 2b0.052
eng1aengrailed 1a0.052
wnt3wingless-type MMTV integration site family, member 30.051
tshbthyroid stimulating hormone, beta subunit0.051
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.884
EgfrEpidermal growth factor receptor0.824
cicubitus interruptus0.724
MadMothers against dpp0.430
eyaeyes absent0.358
ftzfushi tarazu0.315
stumpsCG31317 gene product from transcript CG31317-RC0.220
foxoforkhead box, sub-group O0.207
snssticks and stones0.195
vvlventral veins lacking0.187
mxcmulti sex combs0.180
slp1sloppy paired 10.180
Abd-BAbdominal B0.175
phlpole hole0.155
Gap1GTPase-activating protein 10.153
Lim1CG11354 gene product from transcript CG11354-RA0.151
rapretina aberrant in pattern0.125
mewmultiple edematous wings0.121
C15CG7937 gene product from transcript CG7937-RA0.116
kirrekin of irre0.113
toytwin of eyeless0.112
E(spl)Enhancer of split0.108
sobsister of odd and bowl0.104
amosabsent MD neurons and olfactory sensilla0.093
eveeven skipped0.092
bab1bric a brac 10.090
slmbsupernumerary limbs0.088
argosCG4531 gene product from transcript CG4531-RA0.085
NotumCG13076 gene product from transcript CG13076-RB0.085
CG4328CG4328 gene product from transcript CG4328-RB0.082
gcmglial cells missing0.077
fkhfork head0.072
CTCFCG8591 gene product from transcript CG8591-RA0.067
stanstarry night0.067
par-1CG8201 gene product from transcript CG8201-RA0.065
abd-Aabdominal A0.063
InRInsulin-like receptor0.058
Dip3Dorsal interacting protein 30.055
tsgtwisted gastrulation0.055
Mef2Myocyte enhancer factor 20.054
bab2CG9102 gene product from transcript CG9102-RA0.053
emcextra macrochaetae0.052
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.998
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.997
FGF1fibroblast growth factor 1 (acidic)0.897
JAG1jagged 10.896
BMP2bone morphogenetic protein 20.567
BMPR1Abone morphogenetic protein receptor, type IA0.455
DAXXdeath-domain associated protein0.421
CSNK1Ecasein kinase 1, epsilon0.363
DVL1dishevelled, dsh homolog 1 (Drosophila)0.237
LRP6low density lipoprotein receptor-related protein 60.221
PAX3paired box 30.214
NKX2-1NK2 homeobox 10.209
ARandrogen receptor0.197
MEIS1Meis homeobox 10.195
FOXD3forkhead box D30.177
E2F4E2F transcription factor 4, p107/p130-binding0.154
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.134
SOX10SRY (sex determining region Y)-box 100.127
DVL3dishevelled, dsh homolog 3 (Drosophila)0.123
APCadenomatous polyposis coli0.103
E2F6E2F transcription factor 60.095
AXIN1axin 10.089
FGF10fibroblast growth factor 100.083
CREBBPCREB binding protein0.071
SOX2SRY (sex determining region Y)-box 20.070
FZD1frizzled homolog 1 (Drosophila)0.057
SMAD1SMAD family member 10.055
MEIS2Meis homeobox 20.051
WNT3Awingless-type MMTV integration site family, member 3A0.051
NCOA2nuclear receptor coactivator 20.048
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.044
CTNNBIP1catenin, beta interacting protein 10.041
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.039
NUP62nucleoporin 62kDa0.037
FGFR1fibroblast growth factor receptor 10.029
SP1Sp1 transcription factor0.028
HCFC1host cell factor C1 (VP16-accessory protein)0.026
BMP7bone morphogenetic protein 70.026
NEDD4neural precursor cell expressed, developmentally down-regulated 40.025
RAXretina and anterior neural fold homeobox0.022
TNFSF11tumor necrosis factor (ligand) superfamily, member 110.020
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.019
MSX1msh homeobox 10.019
MYST2MYST histone acetyltransferase 20.018
BBS10Bardet-Biedl syndrome 100.017
ZFYVE9zinc finger, FYVE domain containing 90.017
RASSF1Ras association (RalGDS/AF-6) domain family member 10.017
DLL1delta-like 1 (Drosophila)0.016
WT1Wilms tumor 10.015
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.014
FGF8fibroblast growth factor 8 (androgen-induced)0.014
GSK3Bglycogen synthase kinase 3 beta0.014
SFRP1secreted frizzled-related protein 10.014
WDYHV1WDYHV motif containing 10.013
FGFR3fibroblast growth factor receptor 30.013
FGF7fibroblast growth factor 70.013
HNF1AHNF1 homeobox A0.013
MAPK1mitogen-activated protein kinase 10.013
LDB1LIM domain binding 10.012
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.012
FRS2fibroblast growth factor receptor substrate 20.012
CDK11Bcyclin-dependent kinase 11B0.012
MAPK14mitogen-activated protein kinase 140.012
RFWD2ring finger and WD repeat domain 20.012
SMURF1SMAD specific E3 ubiquitin protein ligase 10.012
ETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.011
FOXO1forkhead box O10.011
WNT5Awingless-type MMTV integration site family, member 5A0.011
OTPorthopedia homeobox0.011
SIM2single-minded homolog 2 (Drosophila)0.011
KLF6Kruppel-like factor 60.010
ERGv-ets erythroblastosis virus E26 oncogene homolog (avian)0.010
LIN54lin-54 homolog (C. elegans)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 10.999
Shhsonic hedgehog0.989
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.959
Fgfr2fibroblast growth factor receptor 20.949
Fgf8fibroblast growth factor 80.939
Vangl2vang-like 2 (van gogh, Drosophila)0.909
Otx2orthodenticle homolog 2 (Drosophila)0.862
Pax3paired box gene 30.852
Fgfr1fibroblast growth factor receptor 10.845
Gli3GLI-Kruppel family member GLI30.827
Bmp4bone morphogenetic protein 40.827
Lef1lymphoid enhancer binding factor 10.804
Foxc1forkhead box C10.729
Tgfbr2transforming growth factor, beta receptor II0.699
Rargretinoic acid receptor, gamma0.684
Dvl3dishevelled 3, dsh homolog (Drosophila)0.645
Jag1jagged 10.629
Hes1hairy and enhancer of split 1 (Drosophila)0.626
Tcfap2atranscription factor AP-2, alpha0.592
Alx4aristaless-like homeobox 40.486
Hand2heart and neural crest derivatives expressed transcript 20.435
Notch1Notch gene homolog 1 (Drosophila)0.434
Isl1ISL1 transcription factor, LIM/homeodomain0.421
Nf1neurofibromatosis 10.393
Chd7chromodomain helicase DNA binding protein 70.392
Psen1presenilin 10.375
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.364
Sox2SRY-box containing gene 20.356
Apcadenomatosis polyposis coli0.343
Smad3MAD homolog 3 (Drosophila)0.315
Fgf10fibroblast growth factor 100.307
Pbx1pre B-cell leukemia transcription factor 10.302
Ptpn11protein tyrosine phosphatase, non-receptor type 110.296
Dvl2dishevelled 2, dsh homolog (Drosophila)0.286
Sox9SRY-box containing gene 90.265
Foxg1forkhead box G10.264
Hoxd13homeobox D130.264
Hand1heart and neural crest derivatives expressed transcript 10.255
Smosmoothened homolog (Drosophila)0.254
Dlx5distal-less homeobox 50.252
Hoxa3homeobox A30.246
Dll1delta-like 1 (Drosophila)0.240
Tbx1T-box 10.236
Wnt3awingless-related MMTV integration site 3A0.235
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.234
Smad6MAD homolog 6 (Drosophila)0.223
Gbx2gastrulation brain homeobox 20.223
Prrx1paired related homeobox 10.222
Hoxa1homeobox A10.212
Foxc2forkhead box C20.204
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.195
Acvr1activin A receptor, type 10.195
Gli2GLI-Kruppel family member GLI20.194
Tgfb2transforming growth factor, beta 20.189
Smad7MAD homolog 7 (Drosophila)0.188
Nos3nitric oxide synthase 3, endothelial cell0.185
Eya1eyes absent 1 homolog (Drosophila)0.181
Nkx2-1NK2 homeobox 10.180
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.171
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.171
Sfrp2secreted frizzled-related protein 20.168
Pax2paired box gene 20.166
Ush1gUsher syndrome 1G homolog (human)0.153
Rararetinoic acid receptor, alpha0.149
Vegfavascular endothelial growth factor A0.126
Ptenphosphatase and tensin homolog0.120
Cdh23cadherin 23 (otocadherin)0.120
Rarbretinoic acid receptor, beta0.105
Gata3GATA binding protein 30.105
Zeb1zinc finger E-box binding homeobox 10.105
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.105
Vangl1vang-like 1 (van gogh, Drosophila)0.102
Pax6paired box gene 60.101
Notch2Notch gene homolog 2 (Drosophila)0.098
Gata4GATA binding protein 40.097
S1pr3sphingosine-1-phosphate receptor 30.094
Pou4f3POU domain, class 4, transcription factor 30.092
Foxd2forkhead box D20.087
Rb1retinoblastoma 10.086
Esr1estrogen receptor 1 (alpha)0.085
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.080
Aplnrapelin receptor0.079
Emx1empty spiracles homolog 1 (Drosophila)0.078
Tcf15transcription factor 150.078
Ptch1patched homolog 10.075
Pitx2paired-like homeodomain transcription factor 20.073
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.072
Egfrepidermal growth factor receptor0.071
Pax9paired box gene 90.070
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.069
Rxraretinoid X receptor alpha0.067
Tgfbr1transforming growth factor, beta receptor I0.066
Epas1endothelial PAS domain protein 10.058
Ptpn14protein tyrosine phosphatase, non-receptor type 140.058
Cdkn1bcyclin-dependent kinase inhibitor 1B0.057
Prrx2paired related homeobox 20.056
Hoxa2homeobox A20.055
Lrp6low density lipoprotein receptor-related protein 60.054
Ebf3early B-cell factor 30.054
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Timp3TIMP metallopeptidase inhibitor 30.044
Flt1FMS-related tyrosine kinase 10.021
Unc5bunc-5 homolog B (C. elegans)0.019
Lamc1laminin, gamma 10.017
Fgfr2fibroblast growth factor receptor 20.016
Axin1axin 10.016
Itpr2inositol 1,4,5-triphosphate receptor, type 20.015
Igfbp5insulin-like growth factor binding protein 50.015
Mcammelanoma cell adhesion molecule0.015
Adam7ADAM metallopeptidase domain 70.014
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.013
Sod3superoxide dismutase 3, extracellular0.013
Adora1adenosine A1 receptor0.012
Prdm2PR domain containing 2, with ZNF domain0.012
Prkd3protein kinase D30.011
Dchs1dachsous 1 (Drosophila)0.011
Wipf1WAS/WASL interacting protein family, member 10.011
Ednrbendothelin receptor type B0.011
Myo1cmyosin IC0.010
Glra1glycine receptor, alpha 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism