The network for 'striated muscle cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

striated muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.

NameDescriptionProbabilityFunc Analog Organism
twk-18Protein TWK-180.668
act-4Protein ACT-40.562
pat-10Protein PAT-100.512
unc-43Protein UNC-430.449
myo-3Protein MYO-30.439
atn-1Protein ATN-10.432
his-1Protein HIS-10.337
his-64Protein HIS-640.329
ace-3Protein ACE-30.314
inx-5Protein INX-50.304
T28B4.1Protein T28B4.10.296
F42C5.9Protein F42C5.90.286
D1044.2Protein D1044.20.280
R107.5Protein R107.50.280
sqt-1Protein SQT-10.279
col-146Protein COL-1460.271
cka-2Protein CKA-20.264
ketn-1Protein KETN-10.248
abts-1Protein ABTS-10.243
prp-8Protein PRP-80.194
unc-112Protein UNC-1120.191
col-34Protein COL-340.191
hlh-1Protein HLH-10.189
cysl-1Protein CYSL-10.189
unc-60Protein UNC-600.189
dys-1Protein DYS-10.188
pat-4Protein PAT-40.188
tag-345Protein TAG-3450.186
pfn-3Protein PFN-30.185
lin-11Protein LIN-110.184
act-2Protein ACT-20.184
F46C8.3Protein F46C8.30.183
set-18Protein SET-180.182
fog-2Protein FOG-20.177
F47B7.1Protein F47B7.10.174
col-92Protein COL-920.173
unc-15Protein UNC-150.173
vha-1Protein VHA-10.172
F14B8.6Protein F14B8.60.172
F32B5.1Protein F32B5.10.171
vab-3Protein VAB-30.171
eat-6Protein EAT-60.169
C26B9.3Protein C26B9.30.168
ret-1Protein RET-10.166
sem-5Protein SEM-50.162
his-5Protein HIS-50.160
R90.1Protein R90.10.159
vha-13Protein VHA-130.158
slo-1Protein SLO-10.157
hlh-2Protein HLH-20.157
his-31Protein HIS-310.156
csq-1Protein CSQ-10.155
pha-4Protein PHA-40.154
his-46Protein HIS-460.152
plp-1Protein PLP-10.150
CELE_Y51A2D.14Protein Y51A2D.140.149
kin-2Protein KIN-20.148
emb-9Protein EMB-90.148
vha-14Protein VHA-140.148
C13C4.5Protein C13C4.50.145
CELE_M03A8.3Protein M03A8.30.145
mlc-1Protein MLC-10.144
unc-45Protein UNC-450.143
his-38Protein HIS-380.143
tag-260Protein TAG-2600.140
tag-232Protein TAG-2320.138
F25G6.9Protein F25G6.90.138
ost-1Protein OST-10.138
T05G5.1Protein T05G5.10.135
mig-6Protein MIG-60.135
ttm-4Protein TTM-40.135
F35A5.1Protein F35A5.10.133
dim-1Protein DIM-10.132
ZK632.9Protein ZK632.90.132
inx-15Protein INX-150.132
tag-163Protein TAG-1630.130
CELE_F18A11.3Protein F18A11.30.130
epi-1Protein EPI-10.129
lev-11Protein LEV-110.129
insc-1Protein INSC-10.127
ceh-22Protein CEH-220.127
vha-8Protein VHA-80.123
col-160Protein COL-1600.122
syg-1Protein SYG-10.122
frm-1Protein FRM-10.121
F39G3.5Protein F39G3.50.120
mlc-2Protein MLC-20.120
egl-19Protein EGL-190.118
let-268Protein LET-2680.117
snf-11Protein SNF-110.117
col-93Protein COL-930.117
C46A5.6Protein C46A5.60.117
ttm-5Protein TTM-50.116
unc-82Protein UNC-820.115
let-2Protein LET-20.115
M02D8.1Protein M02D8.10.114
CELE_C01G6.5Protein C01G6.50.113
unc-89Protein UNC-890.112
vab-10Protein VAB-100.112
cwn-2Protein CWN-20.111
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ttnatitin a1.000
myod1myogenic differentiation 11.000
smyd1bSET and MYND domain containing 1b1.000
cdh2cadherin 2, neuronal1.000
unc45bunc-45 homolog B (C. elegans)0.998
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.995
vmhcventricular myosin heavy chain0.992
myhz2myosin, heavy polypeptide 2, fast muscle specific0.992
pdlim7PDZ and LIM domain 70.991
myf5myogenic factor 50.990
ilkintegrin linked kinase0.989
dag1dystroglycan 10.987
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.981
bmp4bone morphogenetic protein 40.979
actn2actinin, alpha 20.973
tnnc1btroponin C type 1b (slow)0.973
hspb1heat shock protein, alpha-crystallin-related, 10.973
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.972
hsp90a.1heat shock protein 90-alpha 10.969
xirp1xin actin-binding repeat containing 10.961
gli1GLI-Kruppel family member 10.955
six1bsine oculis homeobox homolog 1b0.951
desmadesmin a0.943
sox9aSRY-box containing gene 9a0.933
tpm4tropomyosin 40.928
tnni1altroponin I, skeletal, slow like0.916
bmp2bbone morphogenetic protein 2b0.912
mef2camyocyte enhancer factor 2ca0.911
gapdhglyceraldehyde-3-phosphate dehydrogenase0.911
tbx1T-box 10.910
ckmacreatine kinase, muscle a0.892
tnni2a.4troponin I, skeletal, fast 2a.40.887
actn3bactinin alpha 3b0.886
mef2cbmyocyte enhancer factor 2cb0.879
smyhc1slow myosin heavy chain 10.863
rx3retinal homeobox gene 30.859
nkx2.5NK2 transcription factor related 50.855
mylz2myosin, light polypeptide 2, skeletal muscle0.852
wnt5bwingless-type MMTV integration site family, member 5b0.844
tnnt3btroponin T3b, skeletal, fast0.843
pax2apaired box gene 2a0.814
fstl1bfollistatin-like 1b0.806
ldb3bLIM domain binding 3b0.801
aldh1a2aldehyde dehydrogenase 1 family, member A20.800
tnni1btroponin I, skeletal, slow b0.797
srfserum response factor0.794
tnnc2troponin C type 2 (fast)0.767
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.762
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.760
wt1awilms tumor 1a0.760
muskmuscle, skeletal, receptor tyrosine kinase0.759
gdf6agrowth differentiation factor 6a0.750
pdlim3bPDZ and LIM domain 3b0.750
lama2laminin, alpha 20.741
ndr2nodal-related 20.730
ttnbtitin b0.730
ryr1bryanodine receptor 1b (skeletal)0.721
fn1fibronectin 10.714
smyd1aSET and MYND domain containing 1a0.714
sox9bSRY-box containing gene 9b0.707
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.699
kirrel3lkin of IRRE like 3 like0.697
myf6myogenic factor 60.689
tbx24T-box 240.687
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.682
smyhc2slow myosin heavy chain 20.681
cxcr4achemokine (C-X-C motif) receptor 4a0.678
mstnbmyostatin b0.674
shhasonic hedgehog a0.662
mbnl2muscleblind-like 2 (Drosophila)0.656
tbx2aT-box gene 2a0.644
prdm1aPR domain containing 1a, with ZNF domain0.644
foxa2forkhead box A20.642
spry4sprouty (Drosophila) homolog 40.637
cacnb4acalcium channel, voltage-dependent, beta 4a subunit0.633
wt1bwilms tumor 1b0.632
cx27.5connexin 27.50.626
ldb3aLIM-domain binding factor 3a0.610
acta1aactin, alpha 1a, skeletal muscle0.607
tp73tumor protein p730.603
actc1aactin, alpha, cardiac muscle 1a0.601
pitx3paired-like homeodomain transcription factor 30.593
lama4laminin, alpha 40.590
cav3caveolin 30.585
gpiaglucose phosphate isomerase a0.582
tbx18T-box 180.569
cx39.9connexin 39.90.564
actn3aactinin alpha 3a0.563
nme2b.2non-metastatic cells 2b.2, protein (NM23B) expressed in0.563
atp2a2aATPase, Ca++ transporting, cardiac muscle, slow twitch 2a0.560
kdrlkinase insert domain receptor like0.558
crabp2acellular retinoic acid binding protein 2, a0.558
flncbfilamin C, gamma b (actin binding protein 280)0.537
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
snssticks and stones1.000
Rac1CG2248 gene product from transcript CG2248-RA0.999
Rho1CG8416 gene product from transcript CG8416-RB0.999
mbcmyoblast city0.999
Zasp52Z band alternatively spliced PDZ-motif protein 520.998
Actnalpha actinin0.994
Atg1Autophagy-specific gene 10.993
Rac2CG8556 gene product from transcript CG8556-RA0.986
MhcMyosin heavy chain0.977
Mef2Myocyte enhancer factor 20.977
Rya-r44FRyanodine receptor 44F0.970
Mlp84BMuscle LIM protein at 84B0.961
PvrPDGF- and VEGF-receptor related0.958
AtpalphaNa pump alpha subunit0.948
EgfrEpidermal growth factor receptor0.948
MadMothers against dpp0.941
wupAwings up A0.939
Vrp1Verprolin 10.939
lbeladybird early0.929
Act87EActin 87E0.917
PyKPyruvate kinase0.903
foxoforkhead box, sub-group O0.900
LanB2Laminin B20.900
mewmultiple edematous wings0.889
CG11299CG11299 gene product from transcript CG11299-RA0.878
Cg25CCollagen type IV0.876
shotshort stop0.864
sosine oculis0.858
rolsrolling pebbles0.858
WASpCG1520 gene product from transcript CG1520-RA0.830
blowblown fuse0.822
CanB2Calcineurin B20.821
Act57BActin 57B0.817
DadDaughters against dpp0.811
BicDBicaudal D0.811
ThorCG8846 gene product from transcript CG8846-RA0.793
Act88FActin 88F0.785
RalaRas-related protein0.716
LanALaminin A0.695
Mlc1Myosin alkali light chain 10.692
Tm2Tropomyosin 20.688
S6kRPS6-p70-protein kinase0.687
htshu li tai shao0.684
Act5CActin 5C0.682
Tsc1CG6147 gene product from transcript CG6147-RA0.668
Arp66BActin-related protein 66B0.653
myoglianinCG1838 gene product from transcript CG1838-RD0.646
MicalMolecule interacting with CasL0.625
NeurochondrinCG2330 gene product from transcript CG2330-RA0.619
elavembryonic lethal abnormal vision0.586
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.579
cicubitus interruptus0.549
salssarcomere length short0.548
howheld out wings0.534
Mlc2Myosin light chain 20.534
JIL-1CG6297 gene product from transcript CG6297-RA0.524
stcksteamer duck0.520
Arf79FADP ribosylation factor 79F0.511
GripGlutamate receptor binding protein0.476
Cdc42CG12530 gene product from transcript CG12530-RA0.476
stmAstambha A0.470
LamCLamin C0.469
kirrekin of irre0.455
mib2mind bomb 20.432
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.999
FN1fibronectin 10.999
TRIM63tripartite motif containing 630.997
EGFRepidermal growth factor receptor0.986
FLNAfilamin A, alpha0.961
GRB2growth factor receptor-bound protein 20.960
ACTN1actinin, alpha 10.945
SRFserum response factor (c-fos serum response element-binding transcription factor)0.920
NOTCH1notch 10.920
SHC1SHC (Src homology 2 domain containing) transforming protein 10.899
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.878
JAG1jagged 10.877
TPM1tropomyosin 1 (alpha)0.862
CTGFconnective tissue growth factor0.804
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.771
QKIquaking homolog, KH domain RNA binding (mouse)0.768
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)0.742
SQSTM1sequestosome 10.733
ACTBactin, beta0.687
CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.685
COL4A2collagen, type IV, alpha 20.670
FYNFYN oncogene related to SRC, FGR, YES0.666
CAV1caveolin 1, caveolae protein, 22kDa0.641
PTRFpolymerase I and transcript release factor0.640
KRT8keratin 80.627
CREBBPCREB binding protein0.578
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.558
MYH9myosin, heavy chain 9, non-muscle0.538
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.536
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.529
NCK2NCK adaptor protein 20.521
NCOR2nuclear receptor corepressor 20.503
CFL1cofilin 1 (non-muscle)0.498
ACTN4actinin, alpha 40.486
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.458
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.455
KRT15keratin 150.436
TNNI1troponin I type 1 (skeletal, slow)0.433
MYOZ1myozenin 10.430
FKBP4FK506 binding protein 4, 59kDa0.414
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.410
ARandrogen receptor0.409
BMP2bone morphogenetic protein 20.403
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.395
ACTN2actinin, alpha 20.381
FGF1fibroblast growth factor 1 (acidic)0.368
ILKintegrin-linked kinase0.367
RARAretinoic acid receptor, alpha0.367
ACTA1actin, alpha 1, skeletal muscle0.367
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.363
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.351
JUNjun proto-oncogene0.346
CASP8caspase 8, apoptosis-related cysteine peptidase0.339
NCOR1nuclear receptor corepressor 10.335
MYH7Bmyosin, heavy chain 7B, cardiac muscle, beta0.321
GEMIN7gem (nuclear organelle) associated protein 70.313
TCAPtitin-cap (telethonin)0.311
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.308
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.306
LATlinker for activation of T cells0.306
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.303
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.302
FKBP1AFK506 binding protein 1A, 12kDa0.302
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.301
PRKD2protein kinase D20.301
ESR1estrogen receptor 10.297
FGFR1fibroblast growth factor receptor 10.297
ALDOAaldolase A, fructose-bisphosphate0.296
RBPMSRNA binding protein with multiple splicing0.285
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.285
FHL2four and a half LIM domains 20.285
BMPR1Abone morphogenetic protein receptor, type IA0.283
KRT6Bkeratin 6B0.265
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.261
FSTL1follistatin-like 10.260
MYL9myosin, light chain 9, regulatory0.247
PKM2pyruvate kinase, muscle0.239
TBX5T-box 50.229
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.226
CALD1caldesmon 10.224
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.221
THBS1thrombospondin 10.219
SF3B4splicing factor 3b, subunit 4, 49kDa0.218
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.207
PLCG1phospholipase C, gamma 10.207
TGFB1transforming growth factor, beta 10.206
IQGAP1IQ motif containing GTPase activating protein 10.201
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.198
DTNAdystrobrevin, alpha0.197
ACTA2actin, alpha 2, smooth muscle, aorta0.193
TOP1topoisomerase (DNA) I0.191
LIMS1LIM and senescent cell antigen-like domains 10.185
YAP1Yes-associated protein 10.181
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Myh9myosin, heavy chain 9, non-muscle0.037
Myl1myosin, light chain 10.036
Emp1epithelial membrane protein 10.034
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.033
Pfn1profilin 10.030
Tagln2transgelin 20.030
Acta2smooth muscle alpha-actin0.029
Cav1caveolin 1, caveolae protein0.028
Actc1actin, alpha, cardiac muscle 10.028
Tubb5tubulin, beta 50.024
Gnai3guanine nucleotide binding protein (G protein), alpha inhibiting 30.023
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.022
Ckmcreatine kinase, muscle0.022
Acvr1activin A receptor, type I0.022
Ccnd3cyclin D30.022
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.022
Krt18keratin 180.021
Irs1insulin receptor substrate 10.021
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.021
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.021
Smad7SMAD family member 70.021
Tpm4tropomyosin 40.021
Chordc1cysteine and histidine-rich domain (CHORD)-containing 10.020
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.020
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.020
Myo1bmyosin Ib0.019
Rap1bRAP1B, member of RAS oncogene family0.019
S100a11S100 calcium binding protein A11 (calizzarin)0.018
Actbactin, beta0.018
LOC100362824caveolin 2-like0.017
Adora2aadenosine A2a receptor0.017
Pkm2pyruvate kinase, muscle0.016
Tmsb4xthymosin beta 4, X-linked0.015
Agtr1aangiotensin II receptor, type 1a0.015
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.015
Cfl1cofilin 1, non-muscle0.015
Rhoaras homolog gene family, member A0.015
Trhrthyrotropin releasing hormone receptor0.015
Prss2protease, serine, 20.015
Ptmaprothymosin alpha0.015
Casq2calsequestrin 2 (cardiac muscle)0.015
Csnk1g2casein kinase 1, gamma 20.015
Ctsccathepsin C0.014
Tcf4transcription factor 40.014
Dchs1dachsous 1 (Drosophila)0.014
Myadmmyeloid-associated differentiation marker0.014
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.014
Cdk2cyclin dependent kinase 20.014
Arl5aADP-ribosylation factor-like 5A0.014
Cacng1calcium channel, voltage-dependent, gamma subunit 10.014
Cd9CD9 molecule0.014
Rasa1RAS p21 protein activator (GTPase activating protein) 10.014
Actn3actinin alpha 30.014
Hoxb7homeo box B70.014
Clic4chloride intracellular channel 40.014
Myo1cmyosin IC0.014
Tgfbr2transforming growth factor, beta receptor II0.014
Bdkrb2bradykinin receptor B20.014
Chrnb4cholinergic receptor, nicotinic, beta 40.013
Casp2caspase 20.013
Fgfr2fibroblast growth factor receptor 20.013
Calcrlcalcitonin receptor-like0.013
Tpm3tropomyosin 3, gamma0.013
Tnni1troponin I type 1 (skeletal, slow)0.013
Tpm1tropomyosin 1, alpha0.013
Tgfb2transforming growth factor, beta 20.013
Ube2cubiquitin-conjugating enzyme E2C0.013
Nr2f2nuclear receptor subfamily 2, group F, member 20.013
Nos3nitric oxide synthase 3, endothelial cell0.013
Cnn1calponin 1, basic, smooth muscle0.013
Scarb1scavenger receptor class B, member 10.013
Irs3insulin receptor substrate 30.013
Shisa5shisa homolog 5 (Xenopus laevis)0.013
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.013
Mcammelanoma cell adhesion molecule0.013
Pcnxl3pecanex-like 3 (Drosophila)0.012
Tnni2troponin I type 2 (skeletal, fast)0.012
Lbrlamin B receptor0.012
Tnp2transition protein 20.012
Ptprcprotein tyrosine phosphatase, receptor type, C0.012
Apoa5apolipoprotein A-V0.012
Marcksmyristoylated alanine rich protein kinase C substrate0.012
Igfbp3insulin-like growth factor binding protein 30.012
Cald1caldesmon 10.012
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.012
Id2inhibitor of DNA binding 20.012
Chrna6cholinergic receptor, nicotinic, alpha 60.012
Sod3superoxide dismutase 3, extracellular0.012
Slc12a4solute carrier family 12 (potassium/chloride transporters), member 40.012
Anxa4annexin A40.012
Skap2src kinase associated phosphoprotein 20.012
LOC683626similar to limb-bud and heart0.012
Id1inhibitor of DNA binding 10.012
Stat5bsignal transducer and activator of transcription 5B0.012
Rup2urinary protein 20.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism