The network for 'positive regulation of ligase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of ligase activity

Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.

Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
tag-72Protein TAG-720.034
flad-1Protein FLAD-10.018
cdc-48.2Protein CDC-48.20.018
CELE_F19F10.9Protein F19F10.90.016
set-1Protein SET-10.016
B0001.3Protein B0001.30.016
nath-10Protein NATH-100.016
F33G12.3Protein F33G12.30.015
F13G3.6Protein F13G3.60.015
ZK792.5Protein ZK792.50.015
tufm-2Protein TUFM-20.015
npp-5Protein NPP-50.015
C37H5.5Protein C37H5.50.014
spt-5Protein SPT-50.013
atad-3Protein ATAD-30.013
F57C9.7Protein F57C9.70.013
thoc-1Protein THOC-10.013
nud-1Protein NUD-10.013
dom-3Protein DOM-30.013
ttll-4Protein TTLL-40.012
M03C11.8Protein M03C11.80.012
CELE_F14D7.2Protein F14D7.20.012
C30B5.4Protein C30B5.40.011
exos-7Protein EXOS-70.011
CELE_T02G6.5Protein T02G6.50.011
F26F4.6Protein F26F4.60.011
T14B4.1Protein T14B4.10.011
ndc-80Protein NDC-800.011
mdt-18Protein MDT-180.011
CELE_C53D6.4Protein C53D6.40.011
wdr-46Protein WDR-460.010
T11G6.5Protein T11G6.50.010
tag-124Protein TAG-1240.010
CELE_JC8.5Protein JC8.50.010
mdt-30Protein MDT-300.010
glh-4Protein GLH-40.010
msp-55Protein MSP-550.010
B0035.15Protein B0035.150.010
C16C8.4Protein C16C8.40.010
hmp-2Protein HMP-20.010
mog-5Protein MOG-50.010
ucp-4Protein UCP-40.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RING1ring finger protein 10.958
RNF2ring finger protein 20.910
CBX8chromobox homolog 80.875
BMI1BMI1 polycomb ring finger oncogene0.828
CDC27cell division cycle 27 homolog (S. cerevisiae)0.729
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.673
CBX7chromobox homolog 70.589
SIRT2sirtuin 20.448
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.390
ARIH2ariadne homolog 2 (Drosophila)0.341
CTAG1Bcancer/testis antigen 1B0.259
NAP1L5nucleosome assembly protein 1-like 50.205
TEKT4tektin 40.180
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.178
CBX6chromobox homolog 60.163
RNF144Bring finger protein 144B0.159
PJA1praja ring finger 10.140
EID2EP300 interacting inhibitor of differentiation 20.139
PLK1polo-like kinase 10.124
FHL1four and a half LIM domains 10.123
UBE3Aubiquitin protein ligase E3A0.119
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.101
CBX4chromobox homolog 40.097
USP11ubiquitin specific peptidase 110.091
GSK3Bglycogen synthase kinase 3 beta0.083
NEDD4neural precursor cell expressed, developmentally down-regulated 40.082
EID2BEP300 interacting inhibitor of differentiation 2B0.079
MAGEA1melanoma antigen family A, 1 (directs expression of antigen MZ2-E)0.071
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.061
RYBPRING1 and YY1 binding protein0.061
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.060
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.060
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.059
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.058
MAGEA12melanoma antigen family A, 120.058
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.056
ATF5activating transcription factor 50.048
ADRB2adrenergic, beta-2-, receptor, surface0.048
RNF11ring finger protein 110.046
MAGEA3melanoma antigen family A, 30.045
LNX1ligand of numb-protein X 10.044
MAGEA6melanoma antigen family A, 60.044
BCORBCL6 corepressor0.043
GCLCglutamate-cysteine ligase, catalytic subunit0.042
BIRC3baculoviral IAP repeat containing 30.039
MYST1MYST histone acetyltransferase 10.037
PRNPprion protein0.037
APLFaprataxin and PNKP like factor0.037
CCDC6coiled-coil domain containing 60.036
MAGEA5melanoma antigen family A, 50.036
BAXBCL2-associated X protein0.035
EID3EP300 interacting inhibitor of differentiation 30.035
UBE2Mubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)0.033
LIG4ligase IV, DNA, ATP-dependent0.031
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.031
PCGF1polycomb group ring finger 10.030
CLSPNclaspin0.030
DAXXdeath-domain associated protein0.030
TRIM69tripartite motif containing 690.029
KAT5K(lysine) acetyltransferase 50.029
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.028
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.026
PCGF5polycomb group ring finger 50.025
NRIP1nuclear receptor interacting protein 10.025
TUBB2Ctubulin, beta 2C0.025
SUFUsuppressor of fused homolog (Drosophila)0.024
PMLpromyelocytic leukemia0.022
PHC2polyhomeotic homolog 2 (Drosophila)0.022
TNIP1TNFAIP3 interacting protein 10.022
TRIM28tripartite motif containing 280.022
MOAP1modulator of apoptosis 10.020
MAGEA2melanoma antigen family A, 20.020
MAKmale germ cell-associated kinase0.020
MAGEC1melanoma antigen family C, 10.020
EID1EP300 interacting inhibitor of differentiation 10.019
PCGF3polycomb group ring finger 30.019
PCGF2polycomb group ring finger 20.018
EIF2S2eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa0.018
POLR2Cpolymerase (RNA) II (DNA directed) polypeptide C, 33kDa0.017
PSMA3proteasome (prosome, macropain) subunit, alpha type, 30.017
WWP2WW domain containing E3 ubiquitin protein ligase 20.017
UBE2L3ubiquitin-conjugating enzyme E2L 30.016
YAF2YY1 associated factor 20.016
DDIT4DNA-damage-inducible transcript 40.016
GET4golgi to ER traffic protein 4 homolog (S. cerevisiae)0.015
BIRC2baculoviral IAP repeat containing 20.015
ERHenhancer of rudimentary homolog (Drosophila)0.015
RBX1ring-box 1, E3 ubiquitin protein ligase0.015
SYVN1synovial apoptosis inhibitor 1, synoviolin0.015
CSNK2Bcasein kinase 2, beta polypeptide0.015
RANGAP1Ran GTPase activating protein 10.014
EIF4Eeukaryotic translation initiation factor 4E0.014
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.014
NHEJ1nonhomologous end-joining factor 10.014
HSPA1Lheat shock 70kDa protein 1-like0.014
TUBG1tubulin, gamma 10.014
MAGEA4melanoma antigen family A, 40.013
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.013
PTTG1pituitary tumor-transforming 10.013
MAGEB2melanoma antigen family B, 20.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ccnb1cyclin B10.037
Pttg1pituitary tumor-transforming 10.020
Plaurplasminogen activator, urokinase receptor0.019
March5membrane-associated ring finger (C3HC4) 50.019
Kifc1kinesin family member C10.017
Troaptrophinin associated protein0.016
Kif22kinesin family member 220.016
Gclcglutamate-cysteine ligase, catalytic subunit0.015
Birc5baculoviral IAP repeat-containing 50.015
LOC689399hypothetical protein LOC6893990.014
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.013
Cdca3cell division cycle associated 30.013
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.012
PVRpoliovirus receptor0.011
Ptbp1polypyrimidine tract binding protein 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism