The network for 'negative regulation of transcription dna templated' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of transcription dna templated

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.998
pha-4Protein PHA-40.983
elt-6Protein ELT-60.902
hlh-2Protein HLH-20.849
his-1Protein HIS-10.699
zip-7Protein ZIP-70.685
his-16Protein HIS-160.641
unc-62Protein UNC-620.626
his-64Protein HIS-640.589
nhr-67Protein NHR-670.526
pry-1Protein PRY-10.515
his-50Protein HIS-500.472
his-5Protein HIS-50.446
egl-46Protein EGL-460.432
let-502Protein LET-5020.426
his-61Protein HIS-610.391
his-3Protein HIS-30.390
ceh-27Protein CEH-270.371
eya-1Protein EYA-10.360
his-46Protein HIS-460.353
nhr-2Protein NHR-20.346
mix-1Protein MIX-10.338
sur-2Protein SUR-20.336
wrm-1Protein WRM-10.332
cnd-1Protein CND-10.330
his-52Protein HIS-520.307
mls-2Protein MLS-20.288
hcp-3Protein HCP-30.278
F10D7.5Protein F10D7.50.277
daf-1Protein DAF-10.273
CELE_F19F10.9Protein F19F10.90.273
cam-1Protein CAM-10.257
mab-5Protein MAB-50.256
lin-17Protein LIN-170.252
F39B2.1Protein F39B2.10.251
hbl-1Protein HBL-10.248
rad-26Protein RAD-260.248
inx-3Protein INX-30.242
orc-1Protein ORC-10.242
his-51Protein HIS-510.239
ztf-2Protein ZTF-20.238
ran-1Protein RAN-10.235
tam-1Protein TAM-10.235
his-31Protein HIS-310.235
zyg-1Protein ZYG-10.234
hda-1Protein HDA-10.229
his-38Protein HIS-380.229
his-68Protein HIS-680.225
mat-3Protein MAT-30.225
peb-1Protein PEB-10.224
his-29Protein HIS-290.221
tbx-8Protein TBX-80.218
pop-1Protein POP-10.215
shn-1Protein SHN-10.214
lin-53Protein LIN-530.213
mcm-2Protein MCM-20.202
nhr-25Protein NHR-250.199
his-45Protein HIS-450.190
zfp-1Protein ZFP-10.186
drap-1Protein DRAP-10.183
sel-7Protein SEL-70.182
mep-1Protein MEP-10.181
ceh-16Protein CEH-160.181
pes-1Protein PES-10.179
his-42Protein HIS-420.172
efl-1Protein EFL-10.171
mes-4Protein MES-40.165
eor-1Protein EOR-10.164
fkh-2Protein FKH-20.163
D1081.8Protein D1081.80.160
daf-12Protein DAF-120.160
cfim-2Protein CFIM-20.158
egl-38Protein EGL-380.153
prp-8Protein PRP-80.152
his-47Protein HIS-470.148
ceh-34Protein CEH-340.147
his-14Protein HIS-140.145
unc-42Protein UNC-420.142
daf-21Protein DAF-210.139
R07E4.5Protein R07E4.50.135
mom-4Protein MOM-40.135
attf-2Protein ATTF-20.133
bar-1Protein BAR-10.133
hlh-1Protein HLH-10.131
flt-1Protein FLT-10.129
lsy-2Protein LSY-20.128
lin-40Protein LIN-400.127
npp-21Protein NPP-210.127
npp-22Protein NPP-220.127
fozi-1Protein FOZI-10.126
Y82E9BR.13Protein Y82E9BR.130.126
deb-1Protein DEB-10.125
dpy-22Protein DPY-220.122
hlh-14Protein HLH-140.121
htz-1Protein HTZ-10.119
CELE_T26A8.4Protein T26A8.40.118
patr-1Protein PATR-10.117
R05H5.5Protein R05H5.50.114
pax-3Protein PAX-30.113
cdt-2Protein CDT-20.112
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chdchordin0.872
bocbrother of CDO0.830
jag2jagged 20.746
pax2apaired box gene 2a0.720
pcnaproliferating cell nuclear antigen0.700
snai1bsnail homolog 1b (Drosophila)0.692
gata6GATA-binding protein 60.672
dlx2adistal-less homeobox gene 2a0.643
dlx5adistal-less homeobox gene 5a0.573
zic1zic family member 1 (odd-paired homolog, Drosophila)0.557
six3bsine oculis homeobox homolog 3b0.546
rarabretinoic acid receptor, alpha b0.532
pitx2paired-like homeodomain transcription factor 20.499
ndr2nodal-related 20.492
tbx1T-box 10.489
mab21l2mab-21-like 20.480
spry4sprouty (Drosophila) homolog 40.461
fgf3fibroblast growth factor 30.459
whsc1Wolf-Hirschhorn syndrome candidate 10.454
bmp2bbone morphogenetic protein 2b0.439
sox32SRY-box containing gene 320.437
tp53tumor protein p530.415
dlx3bdistal-less homeobox gene 3b0.414
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.402
otx1borthodenticle homolog 1b0.394
runx2brunt-related transcription factor 2b0.393
grem2gremlin 2, cysteine knot superfamily0.391
hoxd4ahomeo box D4a0.385
nr2e1nuclear receptor subfamily 2, group E, member 10.384
gli1GLI-Kruppel family member 10.373
shhbsonic hedgehog b0.370
nkx1.2laNK1 transcription factor related 2-like,a0.365
tbx5aT-box 5a0.359
meis2.1myeloid ecotropic viral integration site 2.10.353
twist3twist30.346
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.345
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.338
ccnd1cyclin D10.321
ascl1aachaete-scute complex-like 1a (Drosophila)0.315
dlcdeltaC0.314
hmgb1ahigh-mobility group box 1a0.314
ptf1apancreas specific transcription factor, 1a0.307
gbx2gastrulation brain homeo box 20.295
sesn1sestrin 10.293
irx7iroquois homeobox protein 70.282
tfap2atranscription factor AP-2 alpha0.278
flhfloating head0.274
hp1bp3heterochromatin protein 1, binding protein 30.273
gata4GATA-binding protein 40.268
foxa3forkhead box A30.264
sox10SRY-box containing gene 100.261
emx1empty spiracles homeobox 10.261
notch1anotch homolog 1a0.256
neurog1neurogenin 10.252
sox9aSRY-box containing gene 9a0.241
ripply1ripply10.233
runx1runt-related transcription factor 10.231
fgf19fibroblast growth factor 190.220
hoxb1bhomeo box B1b0.217
foxi1forkhead box I10.215
spawsouthpaw0.212
sox19aSRY-box containing gene 19a0.211
nkx2.2aNK2 transcription factor related 2a0.206
gata5GATA-binding protein 50.205
dlx6adistal-less homeobox gene 6a0.203
nkx2.5NK2 transcription factor related 50.201
axin2axin 2 (conductin, axil)0.201
fezf2FEZ family zinc finger 20.200
tll1tolloid-like 10.199
msxcmuscle segment homeobox C0.196
hoxc4ahomeo box C4a0.196
vsx1visual system homeobox 1 homolog, chx10-like0.195
eomesaeomesodermin homolog a0.190
hand2heart and neural crest derivatives expressed transcript 20.190
pcdh18bprotocadherin 18b0.186
olig3oligodendrocyte transcription factor 30.185
emx3empty spiracles homeobox 30.184
dusp6dual specificity phosphatase 60.184
gscgoosecoid0.179
gbx1gastrulation brain homeobox 10.178
lhx1aLIM homeobox 1a0.177
dctdopachrome tautomerase0.176
hmx1H6 homeo box 10.175
dlx1adistal-less homeobox gene 1a0.174
pou3f2POU class 3 homeobox 20.174
dlx4adistal-less homeobox gene 4a0.174
irx4biroquois homeobox protein 4b0.167
pax6apaired box gene 6a0.167
pax8paired box gene 80.166
sox19bSRY-box containing gene 19b0.165
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.163
egr1early growth response 10.162
neo1neogenin 10.162
junbjun B proto-oncogene0.159
meis3myeloid ecotropic viral integration site 30.157
lhx5LIM homeobox 50.155
etv2ets variant gene 20.154
per2period homolog 2 (Drosophila)0.153
zfp36l1azinc finger protein 36, C3H type-like 1a0.153
pou3f3bPOU class 3 homeobox 3b0.153
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Snr1Snf5-related 11.000
hephemipterous1.000
CTCFCG8591 gene product from transcript CG8591-RA0.999
PclPolycomblike0.999
mammastermind0.998
kaykayak0.998
tlltailless0.997
hthhomothorax0.997
Su(var)205Suppressor of variegation 2050.997
shnschnurri0.994
atoatonal0.993
araaraucan0.993
slp1sloppy paired 10.992
gppgrappa0.991
bowlbrother of odd with entrails limited0.991
PcPolycomb0.991
Rpd3CG7471 gene product from transcript CG7471-RA0.991
brkbrinker0.989
IswiImitation SWI0.988
cicubitus interruptus0.988
His2AvHistone H2A variant0.986
salmspalt major0.986
nubnubbin0.986
gsbgooseberry0.984
p53CG33336 gene product from transcript CG33336-RB0.984
D1D1 chromosomal protein0.983
HLHm7E(spl) region transcript m70.981
knknot0.979
E(spl)Enhancer of split0.978
trxtrithorax0.976
dcodiscs overgrown0.975
Su(H)Suppressor of Hairless0.974
eveeven skipped0.973
UbxUltrabithorax0.973
hhairy0.972
smt3CG4494 gene product from transcript CG4494-RA0.972
ftzfushi tarazu0.972
tintinman0.972
abd-Aabdominal A0.968
cnccap-n-collar0.966
lwrlesswright0.966
KrKruppel0.965
lidlittle imaginal discs0.964
ykiyorkie0.962
ash1absent, small, or homeotic discs 10.958
ScmSex comb on midleg0.957
E(var)3-9Enhancer of variegation 3-90.957
Nf-YCNuclear factor Y-box C0.957
Abd-BAbdominal B0.956
tuptailup0.956
hkbhuckebein0.954
nabCG33545 gene product from transcript CG33545-RC0.950
CtBPC-terminal Binding Protein0.949
prdpaired0.947
grogroucho0.947
runrunt0.942
sosine oculis0.938
pbproboscipedia0.938
eyaeyes absent0.935
ph-ppolyhomeotic proximal0.934
tshteashirt0.933
slislit0.933
rprreaper0.930
emsempty spiracles0.930
polybromoCG11375 gene product from transcript CG11375-RA0.929
Spt5CG7626 gene product from transcript CG7626-RA0.927
BEAF-32Boundary element-associated factor of 32kD0.926
eggeggless0.924
osaCG7467 gene product from transcript CG7467-RD0.922
mirrmirror0.919
kniknirps0.918
SerSerrate0.909
mus209mutagen-sensitive 2090.907
svpseven up0.904
MadMothers against dpp0.902
rhorhomboid0.896
alaristaless0.895
Akt1CG4006 gene product from transcript CG4006-RA0.893
prosprospero0.892
E2f2E2F transcription factor 20.889
binbiniou0.882
HGTXCG13475 gene product from transcript CG13475-RB0.880
dacdachshund0.879
ushu-shaped0.876
btlbreathless0.869
domedomeless0.866
eygeyegone0.857
pdm2POU domain protein 20.852
Uba2Smt3 activating enzyme 20.850
panpangolin0.848
EcREcdysone receptor0.842
Sir2CG5216 gene product from transcript CG5216-RA0.839
slp2sloppy paired 20.837
gcmglial cells missing0.835
Hel25EHelicase at 25E0.834
Tip60CG6121 gene product from transcript CG6121-RA0.833
MEP-1CG1244 gene product from transcript CG1244-RG0.829
senssenseless0.827
hhhedgehog0.827
dpndeadpan0.823
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
JunJun oncogene0.945
Junbjun B proto-oncogene0.825
Dusp1dual specificity phosphatase 10.788
FosFBJ osteosarcoma oncogene0.713
Btg2BTG family, member 20.634
Smad7SMAD family member 70.588
Nfibnuclear factor I/B0.543
DbpD site of albumin promoter (albumin D-box) binding protein0.488
Tcfe2atranscription factor E2a0.400
Tgfbr2transforming growth factor, beta receptor II0.374
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.360
Rhobras homolog gene family, member B0.352
Klf6Kruppel-like factor 60.350
Ubtfupstream binding transcription factor, RNA polymerase I0.325
Nr1d2nuclear receptor subfamily 1, group D, member 20.308
Ahraryl hydrocarbon receptor0.305
Pou3f2POU class 3 homeobox 20.302
S100a8S100 calcium binding protein A80.299
Trim28tripartite motif-containing 280.294
Id1inhibitor of DNA binding 10.292
Metmet proto-oncogene0.288
Grk1G protein-coupled receptor kinase 10.276
Hoxb7homeo box B70.269
Ier2immediate early response 20.261
Myh9myosin, heavy chain 9, non-muscle0.260
Vimvimentin0.248
S100a10S100 calcium binding protein A100.245
Klf9Kruppel-like factor 90.245
Tcf4transcription factor 40.242
Ripk3receptor-interacting serine-threonine kinase 30.236
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.235
S100a9S100 calcium binding protein A90.233
Rararetinoic acid receptor, alpha0.230
Atf3activating transcription factor 30.222
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.218
Bmp7bone morphogenetic protein 70.212
Hoxc4homeo box C40.211
Hes1hairy and enhancer of split 1 (Drosophila)0.211
Slc4a1solute carrier family 4 (anion exchanger), member 10.206
Jak2Janus kinase 20.196
Kdm6blysine (K)-specific demethylase 6B0.196
Foxi2forkhead box I20.195
Mycmyelocytomatosis oncogene0.192
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.186
Tcp11t-complex protein 110.185
Palmparalemmin0.183
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.182
Neurog1neurogenin 10.178
Pcnaproliferating cell nuclear antigen0.178
Lpllipoprotein lipase0.177
Smad1SMAD family member 10.173
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.170
Siah1aseven in absentia 1A0.167
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.166
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.166
Sp1Sp1 transcription factor0.166
Axin1axin 10.163
Defb1defensin beta 10.163
Errfi1ERBB receptor feedback inhibitor 10.162
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.161
Cntn4contactin 40.161
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.160
Otx1orthodenticle homeobox 10.160
Dab2disabled homolog 2 (Drosophila)0.159
Ptbp1polypyrimidine tract binding protein 10.158
Eif4heukaryotic translation initiation factor 4H0.155
Nedd4neural precursor cell expressed, developmentally down-regulated 40.155
Gastgastrin0.154
Grin2dglutamate receptor, ionotropic, N-methyl D-aspartate 2D0.154
Egr1early growth response 10.150
Socs7suppressor of cytokine signaling 70.149
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.149
Anxa2annexin A20.148
Flt1FMS-related tyrosine kinase 10.147
Sorbs3sorbin and SH3 domain containing 30.145
Klf4Kruppel-like factor 4 (gut)0.144
Pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.143
Adra2badrenergic, alpha-2B-, receptor0.141
Nr4a3nuclear receptor subfamily 4, group A, member 30.141
Klf2Kruppel-like factor 2 (lung)0.139
Mapk9mitogen-activated protein kinase 90.139
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.138
Dchs1dachsous 1 (Drosophila)0.138
Jundjun D proto-oncogene0.138
Msl1male-specific lethal 1 homolog (Drosophila)0.137
Foxe3forkhead box E30.137
Nfyanuclear transcription factor-Y alpha0.136
Synposynaptopodin0.135
Thbdthrombomodulin0.134
A4galtalpha 1,4-galactosyltransferase0.133
Zfp36l2zinc finger protein 36, C3H type-like 20.133
Abcc1ATP-binding cassette, subfamily C (CFTR/MRP), member 10.132
Shox2short stature homeobox 20.131
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.130
Lphn2latrophilin 20.129
Lhx5LIM homeobox 50.127
Pgam1phosphoglycerate mutase 1 (brain)0.127
Dlg1discs, large homolog 1 (Drosophila)0.127
Alx1ALX homeobox 10.126
Uts2rurotensin 2 receptor0.126
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RPD3Rpd3p0.999
RLF2Rlf2p0.998
SIR2Sir2p0.997
HDA1Hda1p0.994
RAP1Rap1p0.993
SIN3Sin3p0.991
HHT1Hht1p0.988
RCO1Rco1p0.978
RXT2Rxt2p0.976
HHF1Hhf1p0.975
SET1Set1p0.959
SDS3Sds3p0.957
PHO23Pho23p0.956
SUM1Sum1p0.951
HAT1Hat1p0.944
SIR4Sir4p0.927
ORC5Orc5p0.925
SET2Set2p0.923
CYC8Cyc8p0.920
CTI6Cti6p0.910
HDA3Hda3p0.890
SET3Set3p0.882
RIF1Rif1p0.881
NAT1Nat1p0.872
SPT16Spt16p0.870
PAP2Pap2p0.865
ADR1Adr1p0.859
GAL11Gal11p0.841
RPN4Rpn4p0.836
HTB1Htb1p0.819
HFI1Hfi1p0.809
ORC2Orc2p0.805
MED2Med2p0.792
HCM1Hcm1p0.790
RIM101Rim101p0.775
EAF3Eaf3p0.772
RSC2Rsc2p0.767
UME1Ume1p0.756
CHD1Chd1p0.751
GCR2Gcr2p0.745
FKH2Fkh2p0.740
SWD1Swd1p0.730
BDF1Bdf1p0.718
GCN5Gcn5p0.706
SIR3Sir3p0.703
SNT1Snt1p0.702
HSP82Hsp82p0.695
ISW2Isw2p0.695
PGD1Pgd1p0.694
DOA1Doa1p0.685
RTT106Rtt106p0.683
SPT10Spt10p0.681
NUP133Nup133p0.671
ADA2Ada2p0.667
YAK1Yak1p0.659
UBP8Ubp8p0.656
IES3Ies3p0.655
STP22Stp22p0.650
NHP6ANhp6ap0.645
SPP1Spp1p0.632
ORC6Orc6p0.630
SIN4Sin4p0.624
UME6Ume6p0.622
RPB2Rpb2p0.607
SWI4Swi4p0.601
DEP1Dep1p0.598
NRG1Nrg1p0.597
LGE1Lge1p0.588
YTA7Yta7p0.580
FOB1Fob1p0.577
DOT6Dot6p0.575
ASF1Asf1p0.570
RSC4Rsc4p0.570
SSN3Ssn3p0.563
TAF5Taf5p0.560
PHO4Pho4p0.558
ROX3Rox3p0.555
URE2Ure2p0.555
HMO1Hmo1p0.553
GLN3Gln3p0.549
CDC6Cdc6p0.538
PBS2Pbs2p0.533
STE7Ste7p0.531
CSE2Cse2p0.519
HAA1Haa1p0.514
MSN2Msn2p0.510
RGT1Rgt1p0.507
ISW1Isw1p0.503
HIR1Hir1p0.501
CTK1Ctk1p0.501
HTB2Htb2p0.500
MMS22Mms22p0.491
IXR1Ixr1p0.488
SDC1Sdc1p0.485
IZH4Izh4p0.484
HAT2Hat2p0.484
CTF18Ctf18p0.484
SCH9Sch9p0.479
HOS4Hos4p0.471
MCM2Mcm2p0.469