The network for 'germ cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

germ cell development

The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.

NameDescriptionProbabilityFunc Analog Organism
par-5Protein PAR-50.986
npp-1Protein NPP-10.984
goa-1Protein GOA-10.965
gld-1Protein GLD-10.956
vab-3Protein VAB-30.924
rpa-2Protein RPA-20.916
cye-1Protein CYE-10.903
cgh-1Protein CGH-10.884
glp-1Protein GLP-10.882
cin-4Protein CIN-40.875
npp-7Protein NPP-70.873
egg-6Protein EGG-60.860
lag-1Protein LAG-10.860
mat-3Protein MAT-30.858
mex-5Protein MEX-50.843
rsp-7Protein RSP-70.839
let-858Protein LET-8580.834
gls-1Protein GLS-10.833
lmn-1Protein LMN-10.810
C14C10.5Protein C14C10.50.806
mut-16Protein MUT-160.789
F33D11.10Protein F33D11.100.784
unc-60Protein UNC-600.769
spdl-1Protein SPDL-10.760
CELE_C47E8.4Protein C47E8.40.745
cdc-37Protein CDC-370.742
dao-5Protein DAO-50.738
gpd-4Protein GPD-40.727
lin-53Protein LIN-530.726
rpb-2Protein RPB-20.723
prp-8Protein PRP-80.719
hil-2Protein HIL-20.714
oma-2Protein OMA-20.713
yif-1Protein YIF-10.710
hda-1Protein HDA-10.710
eef-1A.1Protein EEF-1A.10.709
snr-4Protein SNR-40.702
ptc-1Protein PTC-10.693
attf-2Protein ATTF-20.684
unc-32Protein UNC-320.683
aos-1Protein AOS-10.683
msp-77Protein MSP-770.678
klp-16Protein KLP-160.678
lin-13Protein LIN-130.674
rpl-3Protein RPL-30.672
klp-15Protein KLP-150.665
mom-2Protein MOM-20.663
gpr-1Protein GPR-10.662
msp-78Protein MSP-780.661
prmt-1Protein PRMT-10.655
F42G9.1Protein F42G9.10.652
let-99Protein LET-990.652
F43G9.12Protein F43G9.120.650
B0464.2Protein B0464.20.645
sma-6Protein SMA-60.644
xpo-1Protein XPO-10.644
scc-1Protein SCC-10.643
mcm-7Protein MCM-70.643
ruvb-1Protein RUVB-10.642
gpr-2Protein GPR-20.637
CELE_C12D8.1Protein C12D8.10.635
csn-1Protein CSN-10.634
wrm-1Protein WRM-10.634
nap-1Protein NAP-10.633
hcp-3Protein HCP-30.625
W05F2.3Protein W05F2.30.622
teg-4Protein TEG-40.621
zif-1Protein ZIF-10.620
dsh-2Protein DSH-20.620
prp-3Protein PRP-30.620
ztf-7Protein ZTF-70.613
gsp-1Protein GSP-10.613
msp-36Protein MSP-360.612
Y65B4BR.5Protein Y65B4BR.50.611
rsa-1Protein RSA-10.608
let-502Protein LET-5020.604
snr-6Protein SNR-60.603
E02H1.1Protein E02H1.10.600
C48B6.2Protein C48B6.20.600
klp-18Protein KLP-180.598
eftu-2Protein EFTU-20.598
puf-5Protein PUF-50.596
immt-2Protein IMMT-20.595
spr-5Protein SPR-50.586
npp-15Protein NPP-150.578
retr-1Protein RETR-10.573
rpa-1Protein RPA-10.564
spn-4Protein SPN-40.559
mex-6Protein MEX-60.556
prp-31Protein PRP-310.556
zyg-11Protein ZYG-110.554
htz-1Protein HTZ-10.553
tct-1Protein TCT-10.548
CELE_C16C10.4Protein C16C10.40.548
pabp-2Protein PABP-20.547
glh-1Protein GLH-10.545
puf-3Protein PUF-30.545
tag-170Protein TAG-1700.538
sem-5Protein SEM-50.536
paa-1Protein PAA-10.535
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tp53tumor protein p530.624
piwil1piwi-like 1 (Drosophila)0.570
brca2breast cancer 2, early onset0.567
axin1axin 10.554
nanos3nanos homolog 30.483
bmp2bbone morphogenetic protein 2b0.436
e2f5E2F transcription factor 50.377
piwil2piwi-like 2 (Drosophila)0.374
lamc1laminin, gamma 10.308
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.281
tbpl2TATA box binding protein like 20.276
sox9bSRY-box containing gene 9b0.268
mmp9matrix metalloproteinase 90.260
odc1ornithine decarboxylase 10.251
tbx16T-box gene 160.211
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.207
apoebapolipoprotein Eb0.201
gli1GLI-Kruppel family member 10.184
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.182
egr1early growth response 10.180
sap18sin3-associated polypeptide0.175
cxcr4bchemokine (C-X-C motif), receptor 4b0.172
ptch2patched 20.171
snrpcsmall nuclear ribonucleoprotein polypeptide C0.161
sf1splicing factor 10.153
ybx1Y box binding protein 10.152
plcg1phospholipase C, gamma 10.150
neurog1neurogenin 10.148
alcambactivated leukocyte cell adhesion molecule b0.142
sart3squamous cell carcinoma antigen recognised by T cells 30.142
tll1tolloid-like 10.133
igf1rbinsulin-like growth factor 1b receptor0.128
pbx4pre-B-cell leukemia transcription factor 40.126
nacanascent polypeptide-associated complex alpha polypeptide0.124
lama1laminin, alpha 10.122
hmgb2bhigh-mobility group box 2b0.121
cct7chaperonin containing TCP1, subunit 7 (eta)0.116
notch1anotch homolog 1a0.114
elavl2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)0.111
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.110
gro2groucho 20.108
mybl2myeloblastosis oncogene-like 20.107
rpsaribosomal protein SA0.106
flot1bflotillin 1b0.099
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.099
foxh1forkhead box H10.097
pabpc1apoly A binding protein, cytoplasmic 1 a0.096
mobkl3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.096
prnprs3prion protein, related sequence 30.095
brd2abromodomain-containing 2a0.095
smad1MAD homolog 1 (Drosophila)0.095
snrpd3lsmall nuclear ribonucleoprotein D3 polypeptide, like0.094
dlx3bdistal-less homeobox gene 3b0.091
chd7chromodomain helicase DNA binding protein 70.091
sycp3lsynaptonemal complex protein 3 like0.090
ncor1nuclear receptor co-repressor 10.088
hsp90a.1heat shock protein 90-alpha 10.088
rpl7aribosomal protein L7a0.087
mespbmesoderm posterior b0.086
alcamaactivated leukocyte cell adhesion molecule a0.085
lama5laminin, alpha 50.085
mespamesoderm posterior a0.081
col8a1acollagen, type VIII, alpha 1a0.081
hhiphedgehog interacting protein0.080
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.078
pou5f1POU domain, class 5, transcription factor 10.078
neo1neogenin 10.078
laptm4alysosomal-associated protein transmembrane 4 alpha0.077
scribscribbled homolog (Drosophila)0.077
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.076
lamb1alaminin, beta 1a0.076
otx1borthodenticle homolog 1b0.075
supt5hsuppressor of Ty 5 homolog (S. cerevisiae)0.073
dldhdihydrolipoamide dehydrogenase0.072
eif3beukaryotic translation initiation factor 3, subunit B0.072
msnamoesin a0.072
efnb2aephrin B2a0.071
tdrd1tudor domain containing 10.071
mef2dmyocyte enhancer factor 2d0.071
pdha1apyruvate dehydrogenase (lipoamide) alpha 1a0.071
ccnb1cyclin B10.071
wnt11rwingless-type MMTV integration site family, member 11, related0.071
cct8chaperonin containing TCP1, subunit 8 (theta)0.070
rplp0ribosomal protein, large, P00.069
egr2bearly growth response 2b0.068
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.067
her6hairy-related 60.067
pax8paired box gene 80.065
orgoogenesis-related gene0.065
dusp6dual specificity phosphatase 60.065
vegfaavascular endothelial growth factor Aa0.064
polr2bpolymerase (RNA) II (DNA directed) polypeptide B0.064
elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.064
bmp4bone morphogenetic protein 40.064
atp2b4ATPase, Ca++ transporting, plasma membrane 40.063
foxi1forkhead box I10.062
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.242
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.127
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.108
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.097
CDK2cyclin-dependent kinase 20.092
EGFRepidermal growth factor receptor0.077
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.071
CSNK2A1casein kinase 2, alpha 1 polypeptide0.063
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.062
MAGOHmago-nashi homolog, proliferation-associated (Drosophila)0.052
QKIquaking homolog, KH domain RNA binding (mouse)0.052
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.048
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.048
SF3A2splicing factor 3a, subunit 2, 66kDa0.038
CREBBPCREB binding protein0.038
TP53tumor protein p530.036
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.032
SNRPD1small nuclear ribonucleoprotein D1 polypeptide 16kDa0.031
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.029
U2AF1U2 small nuclear RNA auxiliary factor 10.028
HNRNPUheterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)0.027
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.027
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.026
HNRNPKheterogeneous nuclear ribonucleoprotein K0.025
BRCA2breast cancer 2, early onset0.024
SNRPBsmall nuclear ribonucleoprotein polypeptides B and B10.021
CALM1calmodulin 1 (phosphorylase kinase, delta)0.020
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.020
SMAD4SMAD family member 40.020
PRPF3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)0.018
PRPF19PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)0.018
EIF3Heukaryotic translation initiation factor 3, subunit H0.017
EIF4A3eukaryotic translation initiation factor 4A30.017
CCNB1cyclin B10.017
SNRPD3small nuclear ribonucleoprotein D3 polypeptide 18kDa0.016
GRB2growth factor receptor-bound protein 20.016
DVL3dishevelled, dsh homolog 3 (Drosophila)0.016
PTBP1polypyrimidine tract binding protein 10.015
TARDBPTAR DNA binding protein0.014
SRSF1serine/arginine-rich splicing factor 10.014
KPNA2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.014
SNW1SNW domain containing 10.014
MCM7minichromosome maintenance complex component 70.013
CDC27cell division cycle 27 homolog (S. cerevisiae)0.013
HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)0.013
SP1Sp1 transcription factor0.013
PTPN1protein tyrosine phosphatase, non-receptor type 10.013
SF3B1splicing factor 3b, subunit 1, 155kDa0.013
CCT3chaperonin containing TCP1, subunit 3 (gamma)0.013
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.013
DHX15DEAH (Asp-Glu-Ala-His) box polypeptide 150.013
RPA1replication protein A1, 70kDa0.013
RBM39RNA binding motif protein 390.012
EP300E1A binding protein p3000.012
PNNpinin, desmosome associated protein0.012
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.012
RB1retinoblastoma 10.012
SRSF3serine/arginine-rich splicing factor 30.012
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.012
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.012
INSRinsulin receptor0.012
SRSF2serine/arginine-rich splicing factor 20.012
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.011
WIPF1WAS/WASL interacting protein family, member 10.011
SNRPEsmall nuclear ribonucleoprotein polypeptide E0.011
TCP1t-complex 10.011
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.011
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.011
SNRPFsmall nuclear ribonucleoprotein polypeptide F0.011
ATF2activating transcription factor 20.011
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.010
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.010
CCNA2cyclin A20.010
ESR1estrogen receptor 10.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 11.000
Ptenphosphatase and tensin homolog0.999
Apcadenomatosis polyposis coli0.993
Bcl2B-cell leukemia/lymphoma 20.987
Amhr2anti-Mullerian hormone type 2 receptor0.987
Itgb1integrin beta 1 (fibronectin receptor beta)0.985
Trp53transformation related protein 530.981
Smad4MAD homolog 4 (Drosophila)0.979
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.974
Gli3GLI-Kruppel family member GLI30.970
Fgfr1fibroblast growth factor receptor 10.970
Csf1colony stimulating factor 1 (macrophage)0.967
Ptpn11protein tyrosine phosphatase, non-receptor type 110.954
Fgf8fibroblast growth factor 80.951
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.931
Sox9SRY-box containing gene 90.927
Nf1neurofibromatosis 10.924
Hif1ahypoxia inducible factor 1, alpha subunit0.924
Psen1presenilin 10.921
CblCasitas B-lineage lymphoma0.916
Cdkn1bcyclin-dependent kinase inhibitor 1B0.899
Tgfb2transforming growth factor, beta 20.899
Fgfr2fibroblast growth factor receptor 20.890
Shhsonic hedgehog0.872
Gli2GLI-Kruppel family member GLI20.866
Nos3nitric oxide synthase 3, endothelial cell0.850
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.846
Efnb2ephrin B20.832
Pax8paired box gene 80.821
Rararetinoic acid receptor, alpha0.821
Foxc1forkhead box C10.805
Hnrnpuheterogeneous nuclear ribonucleoprotein U0.802
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.798
Cdk1cyclin-dependent kinase 10.792
Bmpr1abone morphogenetic protein receptor, type 1A0.787
Leprleptin receptor0.784
Nr3c1nuclear receptor subfamily 3, group C, member 10.782
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.779
Msx2homeobox, msh-like 20.771
Gsk3bglycogen synthase kinase 3 beta0.755
Fshrfollicle stimulating hormone receptor0.749
Pbx1pre B-cell leukemia transcription factor 10.741
Ndel1nuclear distribution gene E-like homolog 1 (A. nidulans)0.738
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.738
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.737
Smad1MAD homolog 1 (Drosophila)0.734
Pitx2paired-like homeodomain transcription factor 20.722
Thrbthyroid hormone receptor beta0.720
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.718
TardbpTAR DNA binding protein0.714
Foxh1forkhead box H10.711
Lmx1bLIM homeobox transcription factor 1 beta0.708
Ptch1patched homolog 10.707
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.707
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.699
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.698
SrcRous sarcoma oncogene0.698
Atf2activating transcription factor 20.698
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.695
Gata5GATA binding protein 50.693
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.684
Stat3signal transducer and activator of transcription 30.683
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.683
Mtormechanistic target of rapamycin (serine/threonine kinase)0.676
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.670
Smad3MAD homolog 3 (Drosophila)0.667
Gna13guanine nucleotide binding protein, alpha 130.664
Rxraretinoid X receptor alpha0.659
Ddx5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.656
Vhlvon Hippel-Lindau tumor suppressor0.653
Ccna2cyclin A20.651
Cdk2cyclin-dependent kinase 20.651
Brca1breast cancer 10.648
Rb1retinoblastoma 10.641
Hoxa2homeobox A20.635
Ptk7PTK7 protein tyrosine kinase 70.632
Vegfavascular endothelial growth factor A0.631
Gata4GATA binding protein 40.630
Bbs4Bardet-Biedl syndrome 4 (human)0.629
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.626
Tgfb1transforming growth factor, beta 10.622
Npm1nucleophosmin 10.621
Eya1eyes absent 1 homolog (Drosophila)0.621
Vangl2vang-like 2 (van gogh, Drosophila)0.619
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.606
Stx1asyntaxin 1A (brain)0.593
Ccnb1cyclin B10.589
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.588
Mdm2transformed mouse 3T3 cell double minute 20.587
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.584
Msx1homeobox, msh-like 10.583
Arid1aAT rich interactive domain 1A (SWI-like)0.572
Runx2runt related transcription factor 20.567
Retret proto-oncogene0.554
Notch1Notch gene homolog 1 (Drosophila)0.548
Adam17a disintegrin and metallopeptidase domain 170.547
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ptprcprotein tyrosine phosphatase, receptor type, C0.019
Sept7septin 70.019
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.016
Anp32eacidic (leucine-rich) nuclear phosphoprotein 32 family, member E0.015
Mapk3mitogen activated protein kinase 30.013
Acvr1activin A receptor, type I0.013
Rac1ras-related C3 botulinum toxin substrate 10.013
Nedd4neural precursor cell expressed, developmentally down-regulated 40.013
Ctxn1cortexin 10.013
Ednrbendothelin receptor type B0.013
Myh9myosin, heavy chain 9, non-muscle0.013
Id3inhibitor of DNA binding 30.013
Ccl3chemokine (C-C motif) ligand 30.012
Rap1bRAP1B, member of RAS oncogene family0.012
Sfrs2splicing factor, arginine/serine-rich 20.012
Atp5bATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.012
Sorbs1sorbin and SH3 domain containing 10.011
Pcnaproliferating cell nuclear antigen0.011
Sirpasignal-regulatory protein alpha0.011
Uqcrc1ubiquinol-cytochrome c reductase core protein I0.011
Actbactin, beta0.011
Mapre1microtubule-associated protein, RP/EB family, member 10.011
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.011
Gata6GATA binding protein 60.011
Slc25a4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 40.011
Zfp36zinc finger protein 360.011
Pebp1phosphatidylethanolamine binding protein 10.011
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.011
Lbrlamin B receptor0.011
Fkbp1aFK506 binding protein 1a0.010
Taok1TAO kinase 10.010
Fusfusion (involved in t(12;16) in malignant liposarcoma) (human)0.010
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.010
Btg2BTG family, member 20.010
Fgfr1Fibroblast growth factor receptor 10.010
Snap25synaptosomal-associated protein 250.010
Atp5dATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism