The network for 'cellular response to metal ion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to metal ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.

NameDescriptionProbabilityFunc Analog Organism
cyp-35C1Protein CYP-35C10.197
cyp-35A2Protein CYP-35A20.143
egl-18Protein EGL-180.104
cyp-35A4Protein CYP-35A40.095
cdf-1Protein CDF-10.082
ugt-22Protein UGT-220.054
ptc-1Protein PTC-10.052
flt-1Protein FLT-10.046
elt-6Protein ELT-60.043
rpn-1Protein RPN-10.042
pry-1Protein PRY-10.041
F13H6.3Protein F13H6.30.041
cyp-35A3Protein CYP-35A30.039
mek-2Protein MEK-20.039
Y65A5A.1Protein Y65A5A.10.039
daf-12Protein DAF-120.036
F01G4.4Protein F01G4.40.035
uba-1Protein UBA-10.034
eat-6Protein EAT-60.034
lbp-7Protein LBP-70.033
cyp-35A5Protein CYP-35A50.032
CELE_ZK1025.3Protein ZK1025.30.032
F48E8.6Protein F48E8.60.030
ten-1Protein TEN-10.030
col-111Protein COL-1110.029
ddr-2Protein DDR-20.028
syd-2Protein SYD-20.027
ugt-17Protein UGT-170.026
axl-1Protein AXL-10.025
R10E4.1Protein R10E4.10.025
W01A11.1Protein W01A11.10.025
rgl-1Protein RGL-10.024
C52E12.1Protein C52E12.10.024
F13B6.1Protein F13B6.10.024
CELE_T04A8.7Protein T04A8.70.023
ptr-8Protein PTR-80.023
mab-31Protein MAB-310.023
cct-2Protein CCT-20.022
catp-5Protein CATP-50.022
cdc-48.2Protein CDC-48.20.022
best-3Protein BEST-30.022
scl-2Protein SCL-20.022
nhr-67Protein NHR-670.022
oac-30Protein OAC-300.022
F45E4.5Protein F45E4.50.022
bah-1Protein BAH-10.021
CELE_C17F4.2Protein C17F4.20.021
CELE_T23F6.5Protein T23F6.50.021
lin-25Protein LIN-250.021
CELE_C29F7.2Protein C29F7.20.021
cwn-1Protein CWN-10.020
lin-17Protein LIN-170.020
tsr-1Protein TSR-10.020
dab-1Protein DAB-10.019
rpt-1Protein RPT-10.019
osm-8Protein OSM-80.019
cec-1Protein CEC-10.019
dos-2Protein DOS-20.019
cyp-35B2Protein CYP-35B20.019
CELE_Y46G5A.29Protein Y46G5A.290.019
bli-1Protein BLI-10.018
pam-1Protein PAM-10.018
K08E3.5Protein K08E3.50.018
eor-2Protein EOR-20.018
ztf-26Protein ZTF-260.018
meg-2Protein MEG-20.018
dpy-22Protein DPY-220.018
T16G1.2Protein T16G1.20.018
F35D2.2Protein F35D2.20.018
T08G11.1Protein T08G11.10.018
nhr-178Protein NHR-1780.018
tbb-1Protein TBB-10.017
F42H10.3Protein F42H10.30.017
lin-12Protein LIN-120.017
acy-1Protein ACY-10.017
C34D10.2Protein C34D10.20.017
CELE_T06G6.6Protein T06G6.60.017
obr-3Protein OBR-30.017
CELE_Y11D7A.5Protein Y11D7A.50.017
lipl-2Protein LIPL-20.017
C05D10.4Protein C05D10.40.017
lbp-5Protein LBP-50.017
rpn-2Protein RPN-20.017
pitp-1Protein PITP-10.017
C15F1.1Protein C15F1.10.017
dod-3Protein DOD-30.017
F22E12.1Protein F22E12.10.017
F35H12.1Protein F35H12.10.017
C11E4.1Protein C11E4.10.016
pbs-2Protein PBS-20.016
fkh-2Protein FKH-20.016
nhr-3Protein NHR-30.016
ogt-1Protein OGT-10.016
F35G2.5Protein F35G2.50.016
dpy-20Protein DPY-200.016
egl-44Protein EGL-440.016
CELE_F28G4.4Protein F28G4.40.016
T27A3.2Protein T27A3.20.016
F58E6.13Protein F58E6.130.016
act-3Protein ACT-30.016
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG9510CG9510 gene product from transcript CG9510-RC0.169
Rho1CG8416 gene product from transcript CG8416-RB0.108
Chd64CG14996 gene product from transcript CG14996-RB0.066
aopanterior open0.060
dupdouble parked0.045
Rab7Rab-protein 70.042
TpiTriose phosphate isomerase0.039
CG10638CG10638 gene product from transcript CG10638-RA0.038
yip2yippee interacting protein 20.023
Jafrac1thioredoxin peroxidase 10.023
Rac1CG2248 gene product from transcript CG2248-RA0.022
NPFR1neuropeptide F receptor0.019
Mt2Methyltransferase 20.019
CG11594CG11594 gene product from transcript CG11594-RB0.018
CG8446CG8446 gene product from transcript CG8446-RC0.018
CG14545CG14545 gene product from transcript CG14545-RA0.017
MTF-1Metal response element-binding Transcription Factor-10.017
Spf45CG17540 gene product from transcript CG17540-RB0.016
PHGPxCG12013 gene product from transcript CG12013-RC0.016
CG2118CG2118 gene product from transcript CG2118-RB0.015
jebjelly belly0.015
PargPoly(ADP-ribose) glycohydrolase0.015
HopHsp70/Hsp90 organizing protein homolog0.014
CG11151CG11151 gene product from transcript CG11151-RA0.013
eveeven skipped0.013
Stat92ESignal-transducer and activator of transcription protein at 92E0.012
beat-IVCG10152 gene product from transcript CG10152-RA0.012
Gs1Glutamine synthetase 10.012
kl-5male fertility factor kl50.011
CG9139CG9139 gene product from transcript CG9139-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MT1Emetallothionein 1E1.000
MT1Xmetallothionein 1X1.000
MT1Fmetallothionein 1F0.998
MT1Hmetallothionein 1H0.997
JUNjun proto-oncogene0.996
MT2Ametallothionein 2A0.958
MAPK8mitogen-activated protein kinase 80.909
MT1Gmetallothionein 1G0.899
MAPK1mitogen-activated protein kinase 10.762
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.737
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.719
ATF2activating transcription factor 20.668
NOSTRINnitric oxide synthase trafficker0.626
HDAC4histone deacetylase 40.581
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.549
APPamyloid beta (A4) precursor protein0.524
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.509
CTLA4cytotoxic T-lymphocyte-associated protein 40.503
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.423
MAP2K1mitogen-activated protein kinase kinase 10.421
MAPK14mitogen-activated protein kinase 140.420
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.417
COTL1coactosin-like 1 (Dictyostelium)0.385
MAP2K4mitogen-activated protein kinase kinase 40.381
ATF3activating transcription factor 30.369
BRAFv-raf murine sarcoma viral oncogene homolog B10.363
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.295
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.293
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.289
LRRK2leucine-rich repeat kinase 20.283
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.257
MAP3K1mitogen-activated protein kinase kinase kinase 10.242
CDK2cyclin-dependent kinase 20.234
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.211
DSG2desmoglein 20.192
GADD45Bgrowth arrest and DNA-damage-inducible, beta0.183
ARRB1arrestin, beta 10.182
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.179
NCOA1nuclear receptor coactivator 10.172
CASP8caspase 8, apoptosis-related cysteine peptidase0.171
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.156
BCL2B-cell CLL/lymphoma 20.155
DUSP1dual specificity phosphatase 10.131
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.123
CFLARCASP8 and FADD-like apoptosis regulator0.121
HDAC9histone deacetylase 90.119
PLATplasminogen activator, tissue0.118
PLAUplasminogen activator, urokinase0.116
CD80CD80 molecule0.108
ARRB2arrestin, beta 20.104
FKBP4FK506 binding protein 4, 59kDa0.103
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.099
CASP10caspase 10, apoptosis-related cysteine peptidase0.098
SOCS3suppressor of cytokine signaling 30.093
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 50.091
MT1Mmetallothionein 1M0.089
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.088
LRP6low density lipoprotein receptor-related protein 60.087
GPR50G protein-coupled receptor 500.086
MAP3K7mitogen-activated protein kinase kinase kinase 70.085
HSPA1Bheat shock 70kDa protein 1B0.085
MAPK15mitogen-activated protein kinase 150.082
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.080
FZD1frizzled homolog 1 (Drosophila)0.077
CTNND1catenin (cadherin-associated protein), delta 10.076
FADDFas (TNFRSF6)-associated via death domain0.076
MAPTmicrotubule-associated protein tau0.074
SNTG2syntrophin, gamma 20.073
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.067
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.066
KAT2BK(lysine) acetyltransferase 2B0.062
MT1Bmetallothionein 1B0.061
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.061
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.061
BIDBH3 interacting domain death agonist0.060
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.060
GRPEL1GrpE-like 1, mitochondrial (E. coli)0.056
PTENphosphatase and tensin homolog0.056
CPNE6copine VI (neuronal)0.055
SH3BP4SH3-domain binding protein 40.053
GSK3Bglycogen synthase kinase 3 beta0.052
SPTBN1spectrin, beta, non-erythrocytic 10.052
ADAMTSL4ADAMTS-like 40.051
TCF4transcription factor 40.051
CAV1caveolin 1, caveolae protein, 22kDa0.051
EP300E1A binding protein p3000.050
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.050
KCTD17potassium channel tetramerisation domain containing 170.048
PTCHD2patched domain containing 20.048
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.047
FOSL1FOS-like antigen 10.047
BAI1brain-specific angiogenesis inhibitor 10.047
KSR1kinase suppressor of ras 10.045
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.044
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.044
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.044
DCTN1dynactin 10.041
KRT5keratin 50.040
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
FosFBJ osteosarcoma oncogene0.889
Mapk14mitogen-activated protein kinase 140.775
Cps1carbamoyl-phosphate synthetase 10.720
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.573
Id3inhibitor of DNA binding 30.529
Mt2metallothionein 20.525
Mt1metallothionein 10.517
Stat3signal transducer and activator of transcription 30.508
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.502
JunJun oncogene0.438
Ascl1achaete-scute complex homolog 1 (Drosophila)0.390
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.381
Ptgs2prostaglandin-endoperoxide synthase 20.355
Neurod1neurogenic differentiation 10.338
Neurod4neurogenic differentiation 40.331
Apoeapolipoprotein E0.306
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.295
Myod1myogenic differentiation 10.293
Apcadenomatosis polyposis coli0.285
Id1inhibitor of DNA binding 10.276
Dlg4discs, large homolog 4 (Drosophila)0.274
Nfe2l2nuclear factor, erythroid derived 2, like 20.267
Rb1retinoblastoma 10.261
Tgfb1transforming growth factor, beta 10.258
Aadacarylacetamide deacetylase (esterase)0.256
Egfrepidermal growth factor receptor0.232
Nr1i3nuclear receptor subfamily 1, group I, member 30.230
Krt8keratin 80.222
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.219
Atoh7atonal homolog 7 (Drosophila)0.214
Bdkrb2bradykinin receptor, beta 20.208
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.188
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.169
Akr1c6aldo-keto reductase family 1, member C60.168
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.163
Nhlh1nescient helix loop helix 10.162
MecomMDS1 and EVI1 complex locus0.158
Onecut1one cut domain, family member 10.146
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.144
Nr4a1nuclear receptor subfamily 4, group A, member 10.139
Zfp36zinc finger protein 360.137
Dckdeoxycytidine kinase0.127
Hdac4histone deacetylase 40.126
Notch2Notch gene homolog 2 (Drosophila)0.120
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.119
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.117
Cd44CD44 antigen0.113
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.112
Krt5keratin 50.111
Nos1nitric oxide synthase 1, neuronal0.108
Ppargperoxisome proliferator activated receptor gamma0.107
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.106
Slc2a5solute carrier family 2 (facilitated glucose transporter), member 50.102
Prph2peripherin 20.101
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.099
Ror2receptor tyrosine kinase-like orphan receptor 20.097
Rdh7retinol dehydrogenase 70.096
Pthlhparathyroid hormone-like peptide0.096
Tcf3transcription factor 30.095
Krt14keratin 140.095
Krt72-pskeratin 72, pseudogene0.093
Leprleptin receptor0.093
Krt34keratin 340.091
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.091
Lect2leukocyte cell-derived chemotaxin 20.090
Epha2Eph receptor A20.088
Runx2runt related transcription factor 20.086
Pitx1paired-like homeodomain transcription factor 10.085
Ptpn11protein tyrosine phosphatase, non-receptor type 110.084
Cdh3cadherin 30.084
Pitx2paired-like homeodomain transcription factor 20.084
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.083
Dmgdhdimethylglycine dehydrogenase precursor0.082
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.082
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.081
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.080
Clpscolipase, pancreatic0.080
Olfr155olfactory receptor 1550.079
Csf1colony stimulating factor 1 (macrophage)0.078
Dctdopachrome tautomerase0.078
Hbb-bh1hemoglobin Z, beta-like embryonic chain0.077
Psapl1prosaposin-like 10.077
Uoxurate oxidase0.075
Psen1presenilin 10.074
Mep1ameprin 1 alpha0.074
Atf3activating transcription factor 30.074
Nr3c1nuclear receptor subfamily 3, group C, member 10.074
Mup5major urinary protein 50.073
Upp2uridine phosphorylase 20.072
Isl1ISL1 transcription factor, LIM/homeodomain0.072
Nr5a2nuclear receptor subfamily 5, group A, member 20.071
Nfil3nuclear factor, interleukin 3, regulated0.070
Hif3ahypoxia inducible factor 3, alpha subunit0.070
Nf1neurofibromatosis 10.069
Egr1early growth response 10.068
Gata1GATA binding protein 10.066
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd14CD14 molecule0.114
Ephx1epoxide hydrolase 1, microsomal0.109
Egr1early growth response 10.108
Akr1c18aldo-keto reductase family 1, member C180.107
Mgst1microsomal glutathione S-transferase 10.103
Plaurplasminogen activator, urokinase receptor0.101
LOC100364265ribosomal protein L19-like0.100
Olfml2bolfactomedin-like 2B0.077
Gstm1glutathione S-transferase mu 10.077
Starsteroidogenic acute regulatory protein0.072
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.070
Timp1TIMP metallopeptidase inhibitor 10.070
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.066
Clcn5chloride channel 50.065
Prss1protease, serine, 1 (trypsin 1)0.064
Cd80Cd80 molecule0.063
Clcnkachloride channel Ka0.060
Atf3activating transcription factor 30.059
Sisucrase-isomaltase (alpha-glucosidase)0.058
Pipprolactin induced protein0.056
Col1a2collagen, type I, alpha 20.054
Nrxn3neurexin 30.053
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.052
Syt4synaptotagmin IV0.051
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.050
Foxi2forkhead box I20.049
Klf6Kruppel-like factor 60.047
Vegfavascular endothelial growth factor A0.047
Timp2TIMP metallopeptidase inhibitor 20.044
Atxn1ataxin 10.043
Plauplasminogen activator, urokinase0.043
Sstr1somatostatin receptor 10.043
JunJun oncogene0.043
Pitx3paired-like homeodomain 30.042
F2rl1coagulation factor II (thrombin) receptor-like 10.042
Ece1endothelin converting enzyme 10.041
Mmp10matrix metallopeptidase 100.041
Shbgsex hormone binding globulin0.041
Cd46CD46 molecule, complement regulatory protein0.041
Dnase1l3deoxyribonuclease 1-like 30.040
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.039
Mmp12matrix metallopeptidase 120.039
Mcpt3mast cell peptidase 30.039
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.039
Aqp8aquaporin 80.038
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.038
Gsta4glutathione S-transferase alpha 40.038
Acaa1bacetyl-Coenzyme A acyltransferase 1B0.038
Gjb3gap junction protein, beta 30.037
RGD1562344similar to Gm566 protein0.037
Prok2prokineticin 20.036
Gja3gap junction protein, alpha 30.036
Vom1r101vomeronasal 1 receptor 1010.036
Adrb1adrenergic, beta-1-, receptor0.036
Dusp1dual specificity phosphatase 10.036
Znf532zinc finger protein 5320.035
Cybbcytochrome b-245, beta polypeptide0.035
Thrathyroid hormone receptor alpha0.035
Mybphmyosin binding protein H0.035
Gja1gap junction protein, alpha 10.034
Anxa5annexin A50.034
Dmbt1deleted in malignant brain tumors 10.034
Il6interleukin 60.034
Klk8kallikrein related-peptidase 80.034
RorbRAR-related orphan receptor B0.033
Slc6a17solute carrier family 6 (neurotransmitter transporter), member 170.033
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.033
Svs1seminal vesicle secretory protein 10.032
Fosl1fos-like antigen 10.032
Gsta3glutathione S-transferase A30.032
Cdkn3cyclin-dependent kinase inhibitor 30.032
Klkb1kallikrein B, plasma 10.032
Drd3dopamine receptor D30.032
Cacnb4calcium channel, voltage-dependent, beta 4 subunit0.032
Calcacalcitonin-related polypeptide alpha0.032
Mmp8matrix metallopeptidase 80.032
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.031
Shox2short stature homeobox 20.031
Ehd2EH-domain containing 20.031
Ctrcchymotrypsin C (caldecrin)0.031
Bcl2l2Bcl2-like 20.031
Cspg4chondroitin sulfate proteoglycan 40.031
Gpx1glutathione peroxidase 10.031
Dmrta1DMRT-like family A10.030
Mgst2microsomal glutathione S-transferase 20.030
Pcolceprocollagen C-endopeptidase enhancer0.030
Gstt1glutathione S-transferase theta 10.030
Tagln2transgelin 20.030
C1rcomplement component 1, r subcomponent0.030
Olr1280olfactory receptor 12800.030
Drd1adopamine receptor D1A0.029
Serpina5serine (or cysteine) peptidase inhibitor, clade A, member 50.029
Mgat3mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase0.029
Pdia4protein disulfide isomerase family A, member 40.029
RY2G5potential ligand-binding protein0.029
Grin3aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A0.029
Dlg4discs, large homolog 4 (Drosophila)0.029
Cntn2contactin 2 (axonal)0.028
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism