The network for 'negative regulation of mitochondrion organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of mitochondrion organization

Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.

NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pink1PTEN-induced putative kinase 10.016
S6kRPS6-p70-protein kinase0.014
parkparkin0.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.677
BCL2L11BCL2-like 11 (apoptosis facilitator)0.542
BCL2L1BCL2-like 10.508
BCL2B-cell CLL/lymphoma 20.428
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.312
BIDBH3 interacting domain death agonist0.158
PPP2R5Bprotein phosphatase 2, regulatory subunit B', beta0.143
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.140
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.127
BADBCL2-associated agonist of cell death0.062
FBXO7F-box protein 70.062
PLAURplasminogen activator, urokinase receptor0.061
TKTtransketolase0.054
ZNF746zinc finger protein 7460.048
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.042
VDAC1voltage-dependent anion channel 10.040
RNF144Bring finger protein 144B0.036
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.032
RHOAras homolog gene family, member A0.029
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.028
MS4A7membrane-spanning 4-domains, subfamily A, member 70.027
METmet proto-oncogene (hepatocyte growth factor receptor)0.027
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.025
GRPEL1GrpE-like 1, mitochondrial (E. coli)0.022
QARSglutaminyl-tRNA synthetase0.022
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.021
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.020
TSPOtranslocator protein (18kDa)0.019
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.018
ACAT1acetyl-CoA acetyltransferase 10.017
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.017
DBN1drebrin 10.016
GABARAPGABA(A) receptor-associated protein0.016
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.016
CFL1cofilin 1 (non-muscle)0.015
PINK1PTEN induced putative kinase 10.015
ICT1immature colon carcinoma transcript 10.015
EEF2eukaryotic translation elongation factor 20.015
TMEM11transmembrane protein 110.015
SDHBsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)0.015
TAGLN2transgelin 20.014
UCK2uridine-cytidine kinase 20.013
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.013
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.013
MAP2K6mitogen-activated protein kinase kinase 60.013
FLNBfilamin B, beta0.013
GRSF1G-rich RNA sequence binding factor 10.013
MAP1Bmicrotubule-associated protein 1B0.013
LRP6low density lipoprotein receptor-related protein 60.012
AGLamylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase0.012
RAB5CRAB5C, member RAS oncogene family0.012
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.012
MRPL14mitochondrial ribosomal protein L140.012
VDAC2voltage-dependent anion channel 20.012
PDCD2programmed cell death 20.012
RAB5BRAB5B, member RAS oncogene family0.012
IL8interleukin 80.012
RNR2l-rRNA0.011
USP14ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)0.011
RARAretinoic acid receptor, alpha0.011
CLTAclathrin, light chain A0.011
ATG4CATG4 autophagy related 4 homolog C (S. cerevisiae)0.010
FLNAfilamin A, alpha0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.331
Rpgrip1lRpgrip1-like0.211
Grb10growth factor receptor bound protein 100.194
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.172
Egfrepidermal growth factor receptor0.172
Ptpn11protein tyrosine phosphatase, non-receptor type 110.160
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.101
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.085
Leprleptin receptor0.083
Insrinsulin receptor0.082
Ppargperoxisome proliferator activated receptor gamma0.079
Ldb3LIM domain binding 30.074
Igf1rinsulin-like growth factor I receptor0.063
Akt1thymoma viral proto-oncogene 10.057
Akt2thymoma viral proto-oncogene 20.057
Ghrgrowth hormone receptor0.055
Psma4proteasome (prosome, macropain) subunit, alpha type 40.050
Smn1survival motor neuron 10.047
Itgb1integrin beta 1 (fibronectin receptor beta)0.046
Cav1caveolin 1, caveolae protein0.045
Stim2stromal interaction molecule 20.036
Bcl2B-cell leukemia/lymphoma 20.035
Bhlhe40basic helix-loop-helix family, member e400.032
Ins2insulin II0.032
Ighimmunoglobulin heavy chain complex0.032
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.031
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.027
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.027
Lmnalamin A0.026
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.025
Ins1insulin I0.023
Myh9myosin, heavy polypeptide 9, non-muscle0.023
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.023
Rcc2regulator of chromosome condensation 20.023
Nos1nitric oxide synthase 1, neuronal0.022
Wdr1WD repeat domain 10.022
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.022
Parlpresenilin associated, rhomboid-like0.022
C1qbpcomplement component 1, q subcomponent binding protein0.021
Ech1enoyl coenzyme A hydratase 1, peroxisomal0.020
Myo1cmyosin IC0.018
Mapkap1mitogen-activated protein kinase associated protein 10.018
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.018
Actn2actinin alpha 20.018
Tomm40translocase of outer mitochondrial membrane 40 homolog (yeast)0.018
Lepleptin0.017
Cd28CD28 antigen0.016
Psmd3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.016
Cd40CD40 antigen0.016
Timm23translocase of inner mitochondrial membrane 23 homolog (yeast)0.016
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.016
Ufc1ubiquitin-fold modifier conjugating enzyme 10.016
Tagln2transgelin 20.016
Acadmacyl-Coenzyme A dehydrogenase, medium chain0.015
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.015
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.015
Galnt2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20.015
BC031181cDNA sequence BC0311810.015
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.015
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)0.014
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.014
Namptnicotinamide phosphoribosyltransferase0.013
Vegfavascular endothelial growth factor A0.013
Mrps23mitochondrial ribosomal protein S230.013
Fnip1folliculin interacting protein 10.013
Apoeapolipoprotein E0.013
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.013
Hnrnpfheterogeneous nuclear ribonucleoprotein F0.013
Commd6COMM domain containing 60.013
Gtf2f2general transcription factor IIF, polypeptide 20.012
Lpin1lipin 10.012
Uroduroporphyrinogen decarboxylase0.012
Itga1integrin alpha 10.012
BlnkB-cell linker0.012
Mceemethylmalonyl CoA epimerase0.012
Pxnpaxillin0.012
Cd151CD151 antigen0.011
Immtinner membrane protein, mitochondrial0.011
0610007C21RikRIKEN cDNA 0610007C21 gene0.011
Rfc3replication factor C (activator 1) 30.011
Hsd17b10hydroxysteroid (17-beta) dehydrogenase 100.011
Wdr45WD repeat domain 450.010
Prkceprotein kinase C, epsilon0.010
AxlAXL receptor tyrosine kinase0.010
Arpc4actin related protein 2/3 complex, subunit 40.010
Dctn1dynactin 10.010
Mrpl9mitochondrial ribosomal protein L90.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.022
Grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.016
Hspd1heat shock protein 1 (chaperonin)0.013
Cycscytochrome c, somatic0.013
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.013
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.012
Acadlacyl-Coenzyme A dehydrogenase, long-chain0.011
Pgam1phosphoglycerate mutase 1 (brain)0.011
Mdh1malate dehydrogenase 1, NAD (soluble)0.011
Cotl1coactosin-like 1 (Dictyostelium)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism