The network for 'peptidyl lysine trimethylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

peptidyl lysine trimethylation

The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine.

NameDescriptionProbabilityFunc Analog Organism
prpf-4Protein PRPF-40.022
unc-44Protein UNC-440.020
C09E8.1Protein C09E8.10.017
fbxa-170Protein FBXA-1700.017
K09A9.6Protein K09A9.60.014
W06D11.1Protein W06D11.10.014
CELE_F13E9.1Protein F13E9.10.013
pat-2Protein PAT-20.013
lin-3Protein LIN-30.013
C09D4.3Protein C09D4.30.013
rpn-2Protein RPN-20.013
rskd-1Protein RSKD-10.012
C14C11.1Protein C14C11.10.012
suca-1Protein SUCA-10.012
F56B3.6Protein F56B3.60.012
retr-1Protein RETR-10.012
Y71F9AR.3Protein Y71F9AR.30.012
CELE_C15H7.3Protein C15H7.30.012
pgrn-1Protein PGRN-10.011
inx-5Protein INX-50.011
F56D1.2Protein F56D1.20.011
CELE_Y45F10B.13Protein Y45F10B.130.011
Y71F9AL.1Protein Y71F9AL.10.011
C04F5.9Protein C04F5.90.011
met-2Protein MET-20.010
ost-1Protein OST-10.010
C50D2.9Protein C50D2.90.010
dlat-1Protein DLAT-10.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mll4bmyeloid/lymphoid or mixed-lineage leukemia 4b0.454
whsc1l1Wolf-Hirschhorn syndrome candidate 1-like 10.204
whsc1Wolf-Hirschhorn syndrome candidate 10.180
prdm11PR domain containing 110.149
ehmt2euchromatic histone-lysine N-methyltransferase 20.140
setd2SET domain containing 20.111
suv420h2suppressor of variegation 4-20 homolog 2 (Drosophila)0.110
ehmt1aeuchromatic histone-lysine N-methyltransferase 1a0.109
nsd1bnuclear receptor binding SET domain protein 1b0.096
rif1RAP1 interacting factor homolog (yeast)0.096
setdb1aSET domain, bifurcated 1a0.095
mll2myeloid/lymphoid or mixed-lineage leukemia 20.094
si:dkey-181m9.9si:dkey-181m9.90.093
prdm2bPR domain containing 2, with ZNF domain b0.089
ehmt1beuchromatic histone-lysine N-methyltransferase 1b0.086
lmnb1lamin B10.085
smyd5SMYD family member 50.077
prdm9PR domain containing 90.075
cbx1achromobox homolog 1a (HP1 beta homolog Drosophila)0.065
smyd3SET and MYND domain containing 30.060
mll4amyeloid/lymphoid or mixed-lineage leukemia 4a0.059
ezh2enhancer of zeste homolog 2 (Drosophila)0.056
si:dkey-21n12.1si:dkey-21n12.10.055
usp1ubiquitin specific protease 10.054
setdb1bSET domain, bifurcated 1b0.048
setd8bSET domain containing (lysine methyltransferase) 8b0.047
fip1l1FIP1 like 1 (S. cerevisiae)0.041
tra2btransformer 2 beta homolog (Drosophila)0.040
prdm8bPR domain containing 8b0.037
setd5SET domain containing 50.034
prdm1bPR domain containing 1b, with ZNF domain0.029
si:ch211-57k11.10si:ch211-57k11.100.028
setd8aSET domain containing (lysine methyltransferase) 8a0.028
wdr18WD repeat domain 180.025
nktrnatural killer-tumor recognition sequence0.024
tubg1tubulin, gamma 10.023
apex1APEX nuclease (multifunctional DNA repair enzyme) 10.022
ilf3ainterleukin enhancer binding factor 3a0.022
arid4aAT rich interactive domain 4A (RBP1-like)0.022
ep300bE1A binding protein p300 b0.021
cnn3bcalponin 3, acidic b0.020
gata1aGATA binding protein 1a0.020
lsm14abLSM14 homolog Ab (SCD6, S. cerevisiae)0.020
zgc:158604zgc:1586040.019
nop16NOP16 nucleolar protein homolog (yeast)0.019
ap1s2adaptor-related protein complex 1, sigma 2 subunit0.019
zcchc8zinc finger, CCHC domain containing 80.018
hcfc1ahost cell factor C1a0.018
LOC100331798histone H3.3-like0.018
suv420h1suppressor of variegation 4-20 homolog 1 (Drosophila)0.018
si:ch211-51m24.3si:ch211-51m24.30.018
mtmr1bmyotubularin related protein 1b0.016
mycbp2MYC binding protein 20.016
pcdh2acprotocadherin 2 alpha c0.015
runx2arunt-related transcription factor 2a0.015
zgc:65979zgc:659790.014
csf3rcolony stimulating factor 3 receptor (granulocyte)0.014
acat1acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)0.014
smyd2aSET and MYND domain containing 2a0.014
zgc:73269zgc:732690.014
sephs1selenophosphate synthetase 10.014
zgc:66100zgc:661000.014
snapc1asmall nuclear RNA activating complex, polypeptide 1a0.014
rbbp6retinoblastoma binding protein 60.013
gpatch8G patch domain containing 80.013
hp1bp3heterochromatin protein 1, binding protein 30.013
myst2MYST histone acetyltransferase 20.013
LOC100333021cohesin subunit SA-1-like0.013
atp2b4ATPase, Ca++ transporting, plasma membrane 40.013
wu:fi04c06wu:fi04c060.012
pth2parathyroid hormone 20.012
srrm2serine/arginine repetitive matrix 20.012
tcea1transcription elongation factor A (SII), 10.012
arglu1aarginine and glutamate rich 1a0.012
zgc:73111zgc:731110.012
LOC567638hypothetical LOC5676380.012
zc3h13zinc finger CCCH-type containing 130.012
phaxphosphorylated adaptor for RNA export0.012
ptpn11bprotein tyrosine phosphatase, non-receptor type 11, b0.012
papolgpoly(A) polymerase gamma0.012
ublcp1ubiquitin-like domain containing CTD phosphatase 10.012
zgc:101080zgc:1010800.011
si:dkey-97o5.1si:dkey-97o5.10.011
akap8lA kinase (PRKA) anchor protein 8-like0.011
tfr1atransferrin receptor 1a0.011
mbd3amethyl-CpG binding domain protein 3a0.011
neil3nei endonuclease VIII-like 3 (E. coli)0.011
asz1ankyrin repeat, SAM and basic leucine zipper domain containing 10.011
cpsf6cleavage and polyadenylation specific factor 60.011
LOC795535hypothetical protein LOC7955350.011
sept2septin 20.011
rbbp9retinoblastoma binding protein 90.011
msh2mutS homolog 2 (E. coli)0.011
LOC100151531zinc finger protein Gfi-1b-like0.011
serhlserine hydrolase-like0.010
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.010
pias4aprotein inhibitor of activated STAT, 4a0.010
rap1aRAP1A, member of RAS oncogene family0.010
ubxn7UBX domain protein 70.010
zgc:112071zgc:1120710.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Snr1Snf5-related 10.427
BEAF-32Boundary element-associated factor of 32kD0.398
Su(var)3-7Suppressor of variegation 3-70.103
mormoira0.090
pzgputzig0.078
snfsans fille0.066
Spt5CG7626 gene product from transcript CG7626-RA0.066
ash1absent, small, or homeotic discs 10.054
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.049
cgcombgap0.047
tsutsunagi0.043
CG5591CG5591 gene product from transcript CG5591-RA0.042
MRG15CG6363 gene product from transcript CG6363-RA0.040
snamasomething that sticks like glue0.038
Moca-cypCG1866 gene product from transcript CG1866-RA0.034
Hel25EHelicase at 25E0.032
IswiImitation SWI0.031
CG2091CG2091 gene product from transcript CG2091-RA0.030
Cap-GCG34438 gene product from transcript CG34438-RF0.029
Bap170Brahma associated protein 170kD0.028
PcPolycomb0.028
pds5CG17509 gene product from transcript CG17509-RA0.027
wocwithout children0.027
hklhook-like0.027
Caf1Chromatin assembly factor 1 subunit0.026
mib1mind bomb 10.025
linlines0.025
XNPCG4548 gene product from transcript CG4548-RA0.025
CG3909CG3909 gene product from transcript CG3909-RA0.022
AtuAnother transcription unit0.021
pUf68poly U binding factor 68kD0.021
kiskismet0.019
MED24Mediator complex subunit 240.018
Smnsurvival motor neuron0.018
gatAglutamyl-tRNA amidotransferase subunit A0.018
gppgrappa0.018
atmsantimeros0.016
bonbonus0.015
D1D1 chromosomal protein0.015
barrbarren0.014
CG6695CG6695 gene product from transcript CG6695-RA0.014
captcapulet0.014
pr-set7CG3307 gene product from transcript CG3307-RC0.013
Mi-2CG8103 gene product from transcript CG8103-RA0.012
CSN4COP9 complex homolog subunit 40.012
enokenoki mushroom0.012
polybromoCG11375 gene product from transcript CG11375-RA0.012
His2AvHistone H2A variant0.011
Saf-BScaffold attachment factor B0.011
Bap55Brahma associated protein 55kD0.011
eIF3-S10CG9805 gene product from transcript CG9805-RA0.011
CG5013CG5013 gene product from transcript CG5013-RA0.011
ph-ppolyhomeotic proximal0.011
CG11266CG11266 gene product from transcript CG11266-RD0.011
CG1646CG1646 gene product from transcript CG1646-RH0.011
MBD-likeCG8208 gene product from transcript CG8208-RA0.010
CG11242CG11242 gene product from transcript CG11242-RA0.010
msl-3male-specific lethal 30.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.831
CBX5chromobox homolog 50.713
WDR5WD repeat domain 50.629
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.409
HIST1H3Bhistone cluster 1, H3b0.294
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.246
LRIF1ligand dependent nuclear receptor interacting factor 10.177
NCOA6nuclear receptor coactivator 60.169
RBBP5retinoblastoma binding protein 50.113
TSC22D1TSC22 domain family, member 10.110
CBX3chromobox homolog 30.107
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.089
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.084
MBD1methyl-CpG binding domain protein 10.061
RSBN1round spermatid basic protein 10.052
MYST3MYST histone acetyltransferase (monocytic leukemia) 30.046
POGZpogo transposable element with ZNF domain0.044
ARID4AAT rich interactive domain 4A (RBP1-like)0.044
ADNPactivity-dependent neuroprotector homeobox0.041
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.039
CBX1chromobox homolog 10.034
RANBP2RAN binding protein 20.031
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.026
CTR9Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.023
NIPBLNipped-B homolog (Drosophila)0.022
CHD8chromodomain helicase DNA binding protein 80.020
LBRlamin B receptor0.019
PAN3PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)0.018
ARID4BAT rich interactive domain 4B (RBP1-like)0.018
MEN1multiple endocrine neoplasia I0.018
WDR61WD repeat domain 610.017
HCFC1host cell factor C1 (VP16-accessory protein)0.016
KDM6Alysine (K)-specific demethylase 6A0.016
CUL4Acullin 4A0.016
NSL1NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)0.016
PHF19PHD finger protein 190.014
KDM1Alysine (K)-specific demethylase 1A0.014
USP47ubiquitin specific peptidase 470.014
SETD1ASET domain containing 1A0.013
ANKRD12ankyrin repeat domain 120.012
TOP2Btopoisomerase (DNA) II beta 180kDa0.011
MLL5myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)0.011
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Arid4bAT rich interactive domain 4B (RBP1-like)0.781
Arid1aAT rich interactive domain 1A (SWI-like)0.608
Arid4aAT rich interactive domain 4A (RBP1-like)0.512
Trim24tripartite motif-containing 240.482
Hdac2histone deacetylase 20.170
Rnf2ring finger protein 20.124
Cbx5chromobox homolog 5 (Drosophila HP1a)0.117
RictorRPTOR independent companion of MTOR, complex 20.115
Tnrc6ctrinucleotide repeat containing 6C0.112
Sin3atranscriptional regulator, SIN3A (yeast)0.098
Sfswapsplicing factor, suppressor of white-apricot homolog (Drosophila)0.096
Trraptransformation/transcription domain-associated protein0.087
Kdm2blysine (K)-specific demethylase 2B0.080
Tnrc6btrinucleotide repeat containing 6b0.064
Rsf1remodeling and spacing factor 10.059
Hcfc1host cell factor C10.055
Ccnt2cyclin T20.052
Bptfbromodomain PHD finger transcription factor0.047
CrebbpCREB binding protein0.044
Sufusuppressor of fused homolog (Drosophila)0.043
Rbm5RNA binding motif protein 50.042
Pias1protein inhibitor of activated STAT 10.042
Ncoa6nuclear receptor coactivator 60.041
Med13lmediator complex subunit 13-like0.040
Fam48afamily with sequence similarity 48, member A0.037
Ankrd16ankyrin repeat domain 160.037
Brd4bromodomain containing 40.032
Hdac1histone deacetylase 10.032
Rnf111ring finger 1110.031
4921513D23RikRIKEN cDNA 4921513D23 gene0.031
1700081L11RikRIKEN cDNA 1700081L11 gene0.031
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.029
Chd2chromodomain helicase DNA binding protein 20.027
Smg1SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)0.026
Brwd1bromodomain and WD repeat domain containing 10.026
Rfx7regulatory factor X, 70.025
Zfc3h1zinc finger, C3H1-type containing0.025
Zmym2zinc finger, MYM-type 20.024
NanogNanog homeobox0.023
Srsf1serine/arginine-rich splicing factor 10.022
Wbp7WW domain binding protein 70.022
Zc3h13zinc finger CCCH type containing 130.022
Ncoa3nuclear receptor coactivator 30.021
Sfrs18serine/arginine-rich splicing factor 180.021
Trim28tripartite motif-containing 280.020
2810046L04RikRIKEN cDNA 2810046L04 gene0.020
Nfyanuclear transcription factor-Y alpha0.018
Atmataxia telangiectasia mutated homolog (human)0.018
Ncbp2nuclear cap binding protein subunit 20.018
Zfp445zinc finger protein 4450.018
Sae1SUMO1 activating enzyme subunit 10.017
Top2btopoisomerase (DNA) II beta0.017
Safb2scaffold attachment factor B20.017
Helzhelicase with zinc finger domain0.017
Arglu1arginine and glutamate rich 10.017
Ddx17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.017
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.017
Rbl2retinoblastoma-like 20.016
Ep300E1A binding protein p3000.016
Msl1male-specific lethal 1 homolog (Drosophila)0.016
Dgcr8DiGeorge syndrome critical region gene 80.016
Rerearginine glutamic acid dipeptide (RE) repeats0.016
Fam193bfamily with sequence similarity 193, member B0.015
CtcfCCCTC-binding factor0.015
4933411K20RikRIKEN cDNA 4933411K20 gene0.015
Casc3cancer susceptibility candidate 30.015
Mll5myeloid/lymphoid or mixed-lineage leukemia 50.015
Ehmt1euchromatic histone methyltransferase 10.015
Pogzpogo transposable element with ZNF domain0.015
SpenSPEN homolog, transcriptional regulator (Drosophila)0.015
Pou2f1POU domain, class 2, transcription factor 10.014
Rbbp7retinoblastoma binding protein 70.014
Ergavian erythroblastosis virus E-26 (v-ets) oncogene related0.014
Nononon-POU-domain-containing, octamer binding protein0.014
Hnrnph1heterogeneous nuclear ribonucleoprotein H10.014
Mastlmicrotubule associated serine/threonine kinase-like0.014
Scaf4SR-related CTD-associated factor 40.013
Exo1exonuclease 10.013
D030056L22RikRIKEN cDNA D030056L22 gene0.013
Vezf1vascular endothelial zinc finger 10.013
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.013
Rnf44ring finger protein 440.013
Ino80dINO80 complex subunit D0.013
MgaMAX gene associated0.013
Mbtd1mbt domain containing 10.012
Zfp592zinc finger protein 5920.012
Baz2abromodomain adjacent to zinc finger domain, 2A0.012
Atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.012
Dync1h1dynein cytoplasmic 1 heavy chain 10.012
Macf1microtubule-actin crosslinking factor 10.012
Ncor1nuclear receptor co-repressor 10.012
Elp2elongation protein 2 homolog (S. cerevisiae)0.011
Morc2amicrorchidia 2A0.011
Phf12PHD finger protein 120.011
Leo1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.011
Aqraquarius0.011
D4Wsu53eDNA segment, Chr 4, Wayne State University 53, expressed0.011
Ankrd12ankyrin repeat domain 120.011
Chaf1achromatin assembly factor 1, subunit A (p150)0.011
BcorBCL6 interacting corepressor0.011
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RTF1Rtf1p0.178
SWD3Swd3p0.123
CTR9Ctr9p0.051
SDC1Sdc1p0.028
LEO1Leo1p0.017
SPP1Spp1p0.016
SUB1Sub1p0.011