The network for 'positive regulation of stress activated protein kinase signaling cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of stress activated protein kinase signaling cascade

Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.

NameDescriptionProbabilityFunc Analog Organism
F21A10.2Protein F21A10.20.385
chd-7Protein CHD-70.372
cst-1Protein CST-10.361
eor-2Protein EOR-20.338
cst-2Protein CST-20.233
lin-36Protein LIN-360.226
egl-18Protein EGL-180.157
zyg-11Protein ZYG-110.142
nhr-6Protein NHR-60.128
K10D6.4Protein K10D6.40.123
skn-1Protein SKN-10.122
clh-5Protein CLH-50.104
gap-2Protein GAP-20.103
let-19Protein LET-190.090
mig-5Protein MIG-50.090
lin-25Protein LIN-250.090
cdf-1Protein CDF-10.084
dpy-22Protein DPY-220.078
CELE_H28G03.2Protein H28G03.20.078
nhr-34Protein NHR-340.077
glit-1Protein GLIT-10.072
cnt-2Protein CNT-20.068
sur-2Protein SUR-20.065
imb-2Protein IMB-20.064
unc-5Protein UNC-50.061
bar-1Protein BAR-10.059
madf-2Protein MADF-20.059
lin-17Protein LIN-170.059
daf-3Protein DAF-30.057
CELE_T04H1.2Protein T04H1.20.057
pmk-3Protein PMK-30.055
hsf-1Protein HSF-10.055
lat-1Protein LAT-10.052
ceh-13Protein CEH-130.052
hsr-9Protein HSR-90.052
sym-4Protein SYM-40.051
sax-3Protein SAX-30.050
zoo-1Protein ZOO-10.050
ksr-1Protein KSR-10.049
ceh-20Protein CEH-200.048
trim-9Protein TRIM-90.048
unc-129Protein UNC-1290.046
obr-3Protein OBR-30.046
nipi-3Protein NIPI-30.045
oga-1Protein OGA-10.045
C32D5.10Protein C32D5.100.044
axl-1Protein AXL-10.044
pmk-2Protein PMK-20.043
dsh-1Protein DSH-10.043
hid-1Protein HID-10.042
daf-19Protein DAF-190.042
K09F5.6Protein K09F5.60.041
tps-1Protein TPS-10.040
lin-12Protein LIN-120.039
C44C1.2Protein C44C1.20.039
ldb-1Protein LDB-10.038
CELE_F52A8.6Protein F52A8.60.038
tag-304Protein TAG-3040.038
M02E1.1Protein M02E1.10.038
CELE_C17E4.10Protein C17E4.100.038
rgs-6Protein RGS-60.037
C52E12.4Protein C52E12.40.037
F28B3.1Protein F28B3.10.036
hbl-1Protein HBL-10.036
syd-2Protein SYD-20.035
F10G8.8Protein F10G8.80.035
aak-2Protein AAK-20.035
elt-6Protein ELT-60.035
CELE_W05H9.2Protein W05H9.20.035
C27C12.1Protein C27C12.10.035
F59A3.4Protein F59A3.40.035
unc-18Protein UNC-180.035
zyg-8Protein ZYG-80.034
F28C6.1Protein F28C6.10.034
pmp-3Protein PMP-30.034
pkc-3Protein PKC-30.033
acl-4Protein ACL-40.033
hpo-22Protein HPO-220.033
daf-5Protein DAF-50.033
dkf-1Protein DKF-10.033
nhr-10Protein NHR-100.032
vab-1Protein VAB-10.032
ham-1Protein HAM-10.032
alg-1Protein ALG-10.031
nlr-1Protein NLR-10.030
ceh-44Protein CEH-440.029
nck-1Protein NCK-10.029
sel-2Protein SEL-20.029
cogc-2Protein COGC-20.027
unc-71Protein UNC-710.027
F47G3.3Protein F47G3.30.026
pak-2Protein PAK-20.026
mek-2Protein MEK-20.026
eri-9Protein ERI-90.026
F22D3.6Protein F22D3.60.026
patr-1Protein PATR-10.026
ztf-22Protein ZTF-220.026
F57A8.1Protein F57A8.10.025
F53B3.5Protein F53B3.50.025
mek-1Protein MEK-10.025
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nod1nucleotide-binding oligomerization domain containing 10.738
LOC557072caspase recruitment domain-containing protein 11-like0.733
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.642
dvl2dishevelled, dsh homolog 2 (Drosophila)0.606
osr1odd-skipped related 1 (Drosophila)0.577
tlr3toll-like receptor 30.577
twist1atwist1a0.500
zbtb4zinc finger and BTB domain containing 40.465
dkk1bdickkopf 1b0.453
fzd7afrizzled homolog 7a0.416
ephb4beph receptor B4b0.380
tnfatumor necrosis factor a (TNF superfamily, member 2)0.374
nod2nucleotide-binding oligomerization domain containing 20.360
phf8PHD finger protein 80.353
wnt3wingless-type MMTV integration site family, member 30.312
eporerythropoietin receptor0.311
ctnnb1catenin (cadherin-associated protein), beta 10.274
igf1rbinsulin-like growth factor 1b receptor0.265
card9caspase recruitment domain family, member 90.245
si:dkey-273o13.1si:dkey-273o13.10.240
ifnphi1interferon phi 10.226
frzbfrizzled-related protein0.209
comtacatechol-O-methyltransferase a0.203
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.202
irak4interleukin-1 receptor-associated kinase 40.195
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.191
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.184
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.180
kopaskopos0.180
zgc:56010zgc:560100.175
cdh17cadherin 17, LI cadherin (liver-intestine)0.172
map2k4bmitogen-activated protein kinase kinase 4b0.170
wnt7bbwingless-type MMTV integration site family, member 7Bb0.170
rnd3aRho family GTPase 3a0.160
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.159
wt1bwilms tumor 1b0.159
lyzlysozyme0.159
il8interleukin 80.155
dvl3dishevelled, dsh homolog 3 (Drosophila)0.154
wnt16wingless-type MMTV integration site family, member 160.153
stc1lstanniocalcin 1, like0.152
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.149
fzd5frizzled homolog 50.148
numblnumb homolog (Drosophila)-like0.147
crip2cysteine-rich protein 20.145
csnk1g2acasein kinase 1, gamma 2a0.142
otx1borthodenticle homolog 1b0.141
trim71tripartite motif-containing 710.140
gna13aguanine nucleotide binding protein (G protein), alpha 13a0.137
wnt4awingless-type MMTV integration site family, member 4a0.136
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.133
hesx1homeo box (expressed in ES cells) 10.132
gro2groucho 20.131
il1binterleukin 1, beta and interleukin 1, beta0.129
fgfrl1bfibroblast growth factor receptor-like 1b0.127
wacaWW domain containing adaptor with coiled-coil a0.126
acvr1lactivin A receptor, type I like0.123
fgfr1bfibroblast growth factor receptor 1b0.121
tcf7transcription factor 7 (T-cell specific, HMG-box)0.120
fzd9bfrizzled homolog 9b0.120
si:rp71-39b20.7si:rp71-39b20.70.118
slc3a2solute carrier family 3, member 20.116
tmpoathymopoietin a0.115
ctsdcathepsin D0.115
si:dkey-8l13.4si:dkey-8l13.40.115
lndc1ly6/neurotoxin domain containing 10.115
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.114
sp2sp2 transcription factor0.114
pkd2polycystic kidney disease 20.112
gli3GLI-Kruppel family member GLI30.111
insrbinsulin receptor b0.111
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.111
gab1GRB2-associated binding protein 10.110
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.110
notch2notch homolog 20.109
jag2jagged 20.104
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.104
dock1dedicator of cytokinesis 10.103
fbxl14bF-box and leucine-rich repeat protein 14b0.103
card14caspase recruitment domain family, member 140.103
c1qccomplement component 1, q subcomponent, C chain0.102
wtipWilms tumor 1 interacting protein0.102
bnip3lbBCL2/adenovirus E1B interacting protein 3-like b0.098
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.097
si:ch211-195h23.3si:ch211-195h23.30.097
ckap5cytoskeleton associated protein 50.096
csf3rcolony stimulating factor 3 receptor (granulocyte)0.095
faddFas (tnfrsf6)-associated via death domain0.095
notch3notch homolog 30.094
sox7SRY-box containing gene 70.093
zgc:110340zgc:1103400.092
cdk8cyclin-dependent kinase 80.092
ctsl1bcathepsin L, 1 b0.090
tlr22toll-like receptor 220.089
wnt5awingless-type MMTV integration site family, member 5a0.086
plekhh1pleckstrin homology domain containing, family H (with MyTH4 domain) member 10.086
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.086
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.085
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.085
mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.085
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.999
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.997
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.997
BIRC3baculoviral IAP repeat containing 30.997
RIPK2receptor-interacting serine-threonine kinase 20.996
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.992
TRAF1TNF receptor-associated factor 10.991
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.972
EGFRepidermal growth factor receptor0.963
TRAF2TNF receptor-associated factor 20.948
TRAF3TNF receptor-associated factor 30.925
MAP3K7mitogen-activated protein kinase kinase kinase 70.921
MAP3K11mitogen-activated protein kinase kinase kinase 110.905
SH3KBP1SH3-domain kinase binding protein 10.903
FYNFYN oncogene related to SRC, FGR, YES0.896
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.859
TRADDTNFRSF1A-associated via death domain0.854
CSNK1Ecasein kinase 1, epsilon0.851
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.840
NRP1neuropilin 10.816
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.798
MAPK8mitogen-activated protein kinase 80.787
MYD88myeloid differentiation primary response gene (88)0.778
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.771
BCAR1breast cancer anti-estrogen resistance 10.771
SMAD2SMAD family member 20.763
TRAF5TNF receptor-associated factor 50.751
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.751
IRAK2interleukin-1 receptor-associated kinase 20.704
BBS10Bardet-Biedl syndrome 100.669
GRB2growth factor receptor-bound protein 20.669
PTK2PTK2 protein tyrosine kinase 20.651
SOS1son of sevenless homolog 1 (Drosophila)0.633
CD40CD40 molecule, TNF receptor superfamily member 50.628
IL1R1interleukin 1 receptor, type I0.627
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.612
FN1fibronectin 10.603
CCR5chemokine (C-C motif) receptor 50.602
IL1Binterleukin 1, beta0.587
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.575
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.566
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.550
SMAD3SMAD family member 30.546
CALM1calmodulin 1 (phosphorylase kinase, delta)0.540
CCL4chemokine (C-C motif) ligand 40.537
RASSF5Ras association (RalGDS/AF-6) domain family member 50.523
CAV1caveolin 1, caveolae protein, 22kDa0.523
TNFAIP3tumor necrosis factor, alpha-induced protein 30.518
CYR61cysteine-rich, angiogenic inducer, 610.499
BLNKB-cell linker0.478
BMPR1Abone morphogenetic protein receptor, type IA0.472
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.468
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.463
GADD45GIP1growth arrest and DNA-damage-inducible, gamma interacting protein 10.459
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.418
SH3RF1SH3 domain containing ring finger 10.413
TNFtumor necrosis factor0.410
IRAK1interleukin-1 receptor-associated kinase 10.390
SMURF1SMAD specific E3 ubiquitin protein ligase 10.386
AXLAXL receptor tyrosine kinase0.368
FSTL1follistatin-like 10.348
VAV1vav 1 guanine nucleotide exchange factor0.340
MAP3K1mitogen-activated protein kinase kinase kinase 10.335
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.305
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.303
LATlinker for activation of T cells0.299
PTENphosphatase and tensin homolog0.298
FBLN1fibulin 10.285
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.276
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.269
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.261
IL8interleukin 80.260
BIRC2baculoviral IAP repeat containing 20.245
ZMYND11zinc finger, MYND-type containing 110.244
TICAM2toll-like receptor adaptor molecule 20.235
GADD45Bgrowth arrest and DNA-damage-inducible, beta0.234
SH3BP2SH3-domain binding protein 20.232
IRS1insulin receptor substrate 10.230
MAL2mal, T-cell differentiation protein 2 (gene/pseudogene)0.226
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.223
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.210
CTGFconnective tissue growth factor0.207
CXCL9chemokine (C-X-C motif) ligand 90.206
TNFRSF9tumor necrosis factor receptor superfamily, member 90.197
RALBP1ralA binding protein 10.195
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.189
CXCL2chemokine (C-X-C motif) ligand 20.187
CCL2chemokine (C-C motif) ligand 20.185
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.182
LRRK2leucine-rich repeat kinase 20.178
ENGendoglin0.165
SFNstratifin0.159
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.159
GBP3guanylate binding protein 30.159
STK4serine/threonine kinase 40.157
CCL22chemokine (C-C motif) ligand 220.156
RASA1RAS p21 protein activator (GTPase activating protein) 10.153
LRP6low density lipoprotein receptor-related protein 60.150
SMAD7SMAD family member 70.150
ZNF512Bzinc finger protein 512B0.146
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loxlysyl oxidase0.099
Dact3dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)0.090
Myd88myeloid differentiation primary response gene 880.077
Adora2aadenosine A2a receptor0.066
Notch3Notch homolog 3 (Drosophila)0.061
Clic4chloride intracellular channel 40.057
Il1ainterleukin 1 alpha0.054
Ccl4chemokine (C-C motif) ligand 40.051
Npffr2neuropeptide FF receptor 20.049
Pspparotid secretory protein0.049
Prkg2protein kinase, cGMP-dependent, type II0.048
Dctn4dynactin 40.045
Stat3signal transducer and activator of transcription 30.045
Nudt3nudix (nucleoside diphosphate linked moiety X)-type motif 30.041
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.038
LOC56764dnaj-like protein0.037
Grm7glutamate receptor, metabotropic 70.034
Hoxa2homeo box A20.034
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.034
Hbe1hemoglobin, epsilon 10.033
Sh3bp1SH3-domain binding protein 10.033
RhdRh blood group, D antigen0.032
Mca32mast cell antigen 320.032
Grk1G protein-coupled receptor kinase 10.030
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.028
Cyp51cytochrome P450, family 510.028
Utrnutrophin0.028
Il9rinterleukin 9 receptor0.025
Lcklymphocyte-specific protein tyrosine kinase0.025
Il1binterleukin 1 beta0.025
Eif4heukaryotic translation initiation factor 4H0.024
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.024
Gpr4G protein-coupled receptor 40.024
Itgamintegrin, alpha M0.023
LOC286960preprotrypsinogen IV0.023
RGD1561143similar to cell surface receptor FDFACT0.022
F2rcoagulation factor II (thrombin) receptor0.022
Neurl3neuralized homolog 3 (Drosophila)0.021
Gja6gap junction protein, alpha 60.021
Nckap1NCK-associated protein 10.021
SlkSTE20-like kinase (yeast)0.021
Dlg1discs, large homolog 1 (Drosophila)0.021
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.020
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.020
Ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.020
Csf1colony stimulating factor 1 (macrophage)0.020
Ifit1interferon-induced protein with tetratricopeptide repeats 10.020
Mapk9mitogen-activated protein kinase 90.019
Fam108a1family with sequence similarity 108, member A10.019
Adamts1ADAM metallopeptidase with thrombospondin type 1 motif, 10.019
Paqr5progestin and adipoQ receptor family member V0.018
Il13ra1interleukin 13 receptor, alpha 10.018
RGD1305793similar to hypothetical protein FLJ201540.018
NrarpNotch-regulated ankyrin repeat protein0.018
Gltpglycolipid transfer protein0.018
Arf6ADP-ribosylation factor 60.018
Ccl3chemokine (C-C motif) ligand 30.017
Il6interleukin 60.017
Slc4a1solute carrier family 4 (anion exchanger), member 10.016
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.016
Fkbp4FK506 binding protein 40.016
Mapk1mitogen activated protein kinase 10.016
Syt2synaptotagmin II0.016
Jtbjumping translocation breakpoint0.016
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.015
Sellselectin L0.015
Padi3peptidyl arginine deiminase, type III0.015
Ggngametogenetin0.015
Laptm5lysosomal protein transmembrane 50.015
Pxnpaxillin0.015
Chrna10cholinergic receptor, nicotinic, alpha 100.015
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.015
Jak1Janus kinase 10.015
Lhfpl4lipoma HMGIC fusion partner-like 40.014
Prlhrprolactin releasing hormone receptor0.014
Arrdc1arrestin domain containing 10.014
Rhogras homolog gene family, member G (rho G)0.014
Ccr5chemokine (C-C motif) receptor 50.013
Wdr26WD repeat domain 260.013
Akap12A kinase (PRKA) anchor protein 120.013
St6galnac3ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 30.013
Gzmkgranzyme K0.013
Vipr2vasoactive intestinal peptide receptor 20.013
Il2rginterleukin 2 receptor, gamma0.013
Ednraendothelin receptor type A0.013
Fkbp1aFK506 binding protein 1a0.012
Pga5pepsinogen 5, group I0.012
Magmyelin-associated glycoprotein0.012
LOC686326similar to Interferon-alpha/beta receptor beta chain precursor (IFN-alpha-REC) (Type I interferon receptor) (IFN-R) (Interferon alpha/beta receptor-2)0.012
Ptpn7protein tyrosine phosphatase, non-receptor type 70.012
Ankrd13aankyrin repeat domain 13a0.012
Bap1BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)0.012
Bmp6bone morphogenetic protein 60.012
Ube2subiquitin-conjugating enzyme E2S0.012
C5ar1complement component 5a receptor 10.012
Adam2ADAM metallopeptidase domain 20.012
Testintestin gene0.012
Chrna7cholinergic receptor, nicotinic, alpha 70.012
Bcl2l2Bcl2-like 20.012
RGD1310262hypothetical LOC3046500.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism