The network for 'neuron differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron.

NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.991
vab-3Protein VAB-30.971
pha-4Protein PHA-40.873
pry-1Protein PRY-10.856
unc-73Protein UNC-730.856
syg-1Protein SYG-10.813
egl-46Protein EGL-460.808
unc-9Protein UNC-90.794
unc-53Protein UNC-530.772
hbl-1Protein HBL-10.726
T28F4.1Protein T28F4.10.724
ceh-20Protein CEH-200.718
sem-5Protein SEM-50.692
nhr-67Protein NHR-670.683
egl-44Protein EGL-440.643
daf-11Protein DAF-110.639
hlh-2Protein HLH-20.637
ten-1Protein TEN-10.594
sli-1Protein SLI-10.587
unc-52Protein UNC-520.576
egl-13Protein EGL-130.563
rig-6Protein RIG-60.561
ain-1Protein AIN-10.558
unc-42Protein UNC-420.556
C11E4.6Protein C11E4.60.552
ida-1Protein IDA-10.550
egl-8Protein EGL-80.538
dnc-2Protein DNC-20.531
sma-6Protein SMA-60.529
cam-1Protein CAM-10.501
nhr-34Protein NHR-340.499
glp-1Protein GLP-10.489
sax-3Protein SAX-30.477
lin-11Protein LIN-110.472
pxf-1Protein PXF-10.451
sad-1Protein SAD-10.450
elt-6Protein ELT-60.446
osm-3Protein OSM-30.445
sdz-28Protein SDZ-280.444
C54E4.2Protein C54E4.20.431
unc-62Protein UNC-620.417
sup-12Protein SUP-120.413
pal-1Protein PAL-10.413
swah-1Protein SWAH-10.411
epi-1Protein EPI-10.405
hlh-1Protein HLH-10.399
nhr-6Protein NHR-60.396
fkh-2Protein FKH-20.391
goa-1Protein GOA-10.390
rsd-2Protein RSD-20.388
mab-5Protein MAB-50.380
let-60Protein LET-600.373
gld-1Protein GLD-10.367
K10D6.4Protein K10D6.40.363
pan-1Protein PAN-10.362
ceh-48Protein CEH-480.356
let-607Protein LET-6070.355
pdfr-1Protein PDFR-10.353
F33H2.3Protein F33H2.30.351
dsh-1Protein DSH-10.350
ace-3Protein ACE-30.350
adr-1Protein ADR-10.346
aap-1Protein AAP-10.344
mpk-1Protein MPK-10.344
egl-5Protein EGL-50.342
cye-1Protein CYE-10.340
sorb-1Protein SORB-10.337
egl-15Protein EGL-150.337
bar-1Protein BAR-10.334
lin-23Protein LIN-230.333
ttx-1Protein TTX-10.325
wrk-1Protein WRK-10.325
CELE_Y41E3.7Protein Y41E3.70.325
cec-4Protein CEC-40.325
ppfr-2Protein PPFR-20.324
pkg-1Protein PKG-10.321
lin-17Protein LIN-170.319
unc-70Protein UNC-700.319
lin-12Protein LIN-120.319
let-2Protein LET-20.318
T26A5.6Protein T26A5.60.317
apb-1Protein APB-10.310
T27A3.1Protein T27A3.10.305
npp-1Protein NPP-10.303
che-2Protein CHE-20.302
hmp-1Protein HMP-10.301
CELE_C23G10.8Protein C23G10.80.299
hda-3Protein HDA-30.297
F28E10.1Protein F28E10.10.296
shn-1Protein SHN-10.292
unc-6Protein UNC-60.290
clh-5Protein CLH-50.289
dpy-22Protein DPY-220.288
pmk-1Protein PMK-10.287
unc-104Protein UNC-1040.285
che-13Protein CHE-130.285
vhp-1Protein VHP-10.278
mig-2Protein MIG-20.277
egl-27Protein EGL-270.277
eor-1Protein EOR-10.276
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
rx3retinal homeobox gene 31.000
kdrlkinase insert domain receptor like0.999
tbx1T-box 10.999
fgf3fibroblast growth factor 30.998
pax2apaired box gene 2a0.997
lhx2bLIM homeobox 2b0.997
sox2SRY-box containing gene 20.995
otx2orthodenticle homolog 20.994
pax6bpaired box gene 6b0.993
ndr2nodal-related 20.993
foxi1forkhead box I10.993
neurog1neurogenin 10.991
dladeltaA0.986
six3bsine oculis homeobox homolog 3b0.984
isl1islet10.983
epb41l5erythrocyte membrane protein band 4.1 like 50.981
fezf2FEZ family zinc finger 20.977
pax6apaired box gene 6a0.977
gbx2gastrulation brain homeo box 20.972
alcambactivated leukocyte cell adhesion molecule b0.972
wnt11rwingless-type MMTV integration site family, member 11, related0.972
neurodneurogenic differentiation0.971
fstafollistatin a0.968
cdh2cadherin 2, neuronal0.967
otx1aorthodenticle homolog 1a0.964
ptf1apancreas specific transcription factor, 1a0.963
crb2acrumbs homolog 2a0.962
ttnatitin a0.961
tfap2atranscription factor AP-2 alpha0.958
fli1afriend leukemia integration 1a0.955
gli2aGLI-Kruppel family member GLI2a0.954
stmn2bstathmin-like 2b0.947
hoxd4ahomeo box D4a0.947
robo2roundabout homolog 20.946
rargaretinoic acid receptor gamma a0.945
six3asine oculis homeobox homolog 3a0.944
gli1GLI-Kruppel family member 10.943
flhfloating head0.941
ift88intraflagellar transport 88 homolog0.939
otpborthopedia homolog b0.939
ptch2patched 20.938
her4.2hairy-related 4.20.938
sox1aSRY-box containing gene 1a0.937
atoh7atonal homolog 70.935
pcdh19protocadherin 190.934
egr2bearly growth response 2b0.932
dlx2adistal-less homeobox gene 2a0.932
traf4atnf receptor-associated factor 4a0.930
pou3f1POU class 3 homeobox 10.929
epha4aeph receptor A4a0.928
notch2notch homolog 20.923
irx3airoquois homeobox protein 3a0.923
ncam1aneural cell adhesion molecule 1a0.922
dmbx1adiencephalon/mesencephalon homeobox 1a0.921
olfm2olfactomedin 20.921
gdf6agrowth differentiation factor 6a0.920
kif17kinesin family member 170.915
dlcdeltaC0.915
bhlhe22basic helix-loop-helix family, member e220.914
dctn1adynactin 1a0.914
st8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.913
apcadenomatosis polyposis coli0.906
dlx5adistal-less homeobox gene 5a0.906
ankrd6ankyrin repeat domain 60.905
otx1borthodenticle homolog 1b0.901
slc1a2bsolute carrier family 1 (glial high affinity glutamate transporter), member 2b0.900
sema3aasemaphorin 3aa0.900
wnt11wingless-type MMTV integration site family, member 110.897
fstl1bfollistatin-like 1b0.897
jag2jagged 20.896
otx5orthodenticle homolog 50.889
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.888
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.887
irx4biroquois homeobox protein 4b0.886
eomesaeomesodermin homolog a0.886
neo1neogenin 10.884
nesnestin0.883
fn1fibronectin 10.875
scn1labsodium channel, voltage-gated, type I like, alpha b0.873
bocbrother of CDO0.872
rx2retinal homeobox gene 20.870
unc45bunc-45 homolog B (C. elegans)0.869
eng2aengrailed 2a0.869
slit3slit (Drosophila) homolog 30.864
tp53tumor protein p530.863
esrrgaestrogen-related receptor gamma a0.862
sox9aSRY-box containing gene 9a0.861
myod1myogenic differentiation 10.860
stmn2astathmin-like 2a0.858
fgfr4fibroblast growth factor receptor 40.857
cntn2contactin 20.855
shhbsonic hedgehog b0.854
spry2sprouty homolog 20.852
atoh1aatonal homolog 1a0.845
sox17SRY-box containing gene 170.843
tgfb3transforming growth factor, beta 30.841
scn8aasodium channel, voltage-gated, type VIII, alpha a0.836
plod3procollagen-lysine, 2-oxoglutarate 5-dioxygenase 30.836
prdm16PR domain containing 160.834
drd2adopamine receptor D2a0.829
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide1.000
CDC42cell division cycle 42 (GTP binding protein, 25kDa)1.000
EGFRepidermal growth factor receptor1.000
CREBBPCREB binding protein1.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence1.000
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.999
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.999
QKIquaking homolog, KH domain RNA binding (mouse)0.998
FYNFYN oncogene related to SRC, FGR, YES0.998
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.998
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.998
ATXN1ataxin 10.998
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.996
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.995
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.994
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.993
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.993
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.993
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.987
MAPTmicrotubule-associated protein tau0.980
SMURF2SMAD specific E3 ubiquitin protein ligase 20.975
RB1retinoblastoma 10.975
HDAC4histone deacetylase 40.970
FN1fibronectin 10.969
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.966
SMAD2SMAD family member 20.964
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.963
GRB2growth factor receptor-bound protein 20.957
CSNK2A1casein kinase 2, alpha 1 polypeptide0.954
HNRNPKheterogeneous nuclear ribonucleoprotein K0.954
LCKlymphocyte-specific protein tyrosine kinase0.953
ARandrogen receptor0.947
NCOR1nuclear receptor corepressor 10.946
SMN1survival of motor neuron 1, telomeric0.946
APCadenomatous polyposis coli0.944
EP300E1A binding protein p3000.944
SFNstratifin0.943
RUNX1runt-related transcription factor 10.941
CFL1cofilin 1 (non-muscle)0.934
TUBBtubulin, beta0.932
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.927
SHC1SHC (Src homology 2 domain containing) transforming protein 10.927
ATN1atrophin 10.923
TP53tumor protein p530.916
IGF1Rinsulin-like growth factor 1 receptor0.912
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.907
JUNjun proto-oncogene0.902
ACTBactin, beta0.902
SMAD4SMAD family member 40.900
FLNAfilamin A, alpha0.899
MAPK1mitogen-activated protein kinase 10.886
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.882
TAL1T-cell acute lymphocytic leukemia 10.881
GSK3Bglycogen synthase kinase 3 beta0.880
TUBB2Ctubulin, beta 2C0.877
DNMT1DNA (cytosine-5-)-methyltransferase 10.875
YAP1Yes-associated protein 10.872
APPamyloid beta (A4) precursor protein0.872
ESR1estrogen receptor 10.864
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.863
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.832
RARAretinoic acid receptor, alpha0.827
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.820
STRN3striatin, calmodulin binding protein 30.818
TUBA1Atubulin, alpha 1a0.805
TUBB3tubulin, beta 30.803
TRRAPtransformation/transcription domain-associated protein0.800
LRRK2leucine-rich repeat kinase 20.797
PKM2pyruvate kinase, muscle0.795
PCGF2polycomb group ring finger 20.793
PTPN11protein tyrosine phosphatase, non-receptor type 110.786
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.775
FHL2four and a half LIM domains 20.774
RXRAretinoid X receptor, alpha0.774
SMAD3SMAD family member 30.768
RPA1replication protein A1, 70kDa0.759
SPTBN1spectrin, beta, non-erythrocytic 10.758
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.757
HDAC2histone deacetylase 20.752
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.742
NCK1NCK adaptor protein 10.740
TUBA1Btubulin, alpha 1b0.737
SIN3ASIN3 homolog A, transcription regulator (yeast)0.736
MAPK8mitogen-activated protein kinase 80.736
HSPG2heparan sulfate proteoglycan 20.725
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.717
TUBA1Ctubulin, alpha 1c0.708
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.706
CBX5chromobox homolog 50.695
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.695
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.694
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.691
TCF4transcription factor 40.688
BMI1BMI1 polycomb ring finger oncogene0.683
MPRIPmyosin phosphatase Rho interacting protein0.683
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.680
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.678
KHDRBS1KH domain containing, RNA binding, signal transduction associated 10.672
AKT1v-akt murine thymoma viral oncogene homolog 10.671
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.919
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.794
Nrxn1neurexin 10.764
Lin7blin-7 homolog b (C. elegans)0.759
Dlgap1discs, large (Drosophila) homolog-associated protein 10.746
Pfn1profilin 10.669
Atf3activating transcription factor 30.658
Nedd4neural precursor cell expressed, developmentally down-regulated 40.652
Anxa2annexin A20.645
Grm7glutamate receptor, metabotropic 70.641
Slc1a1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 10.626
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.624
Sptan1spectrin, alpha, non-erythrocytic 10.616
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.606
Ifitm3interferon induced transmembrane protein 30.600
Calcrlcalcitonin receptor-like0.598
Gabrb1gamma-aminobutyric acid (GABA) A receptor, beta 10.598
Itgb1integrin, beta 10.595
Adrb1adrenergic, beta-1-, receptor0.584
Grm5glutamate receptor, metabotropic 50.577
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.576
Dlg4discs, large homolog 4 (Drosophila)0.575
Notch1Notch homolog 1, translocation-associated (Drosophila)0.563
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.558
Tpm3tropomyosin 3, gamma0.555
Cugbp2CUG triplet repeat, RNA binding protein 20.555
Actbactin, beta0.555
Adam17ADAM metallopeptidase domain 170.552
Atp2b3ATPase, Ca++ transporting, plasma membrane 30.547
Jak1Janus kinase 10.544
Cd9CD9 molecule0.543
Acvr1activin A receptor, type I0.542
Pls3plastin 3 (T-isoform)0.541
Gria4glutamate receptor, ionotrophic, AMPA 40.536
Gria2glutamate receptor, ionotropic, AMPA 20.526
Tgfbr2transforming growth factor, beta receptor II0.523
Acta2smooth muscle alpha-actin0.517
Dgkgdiacylglycerol kinase, gamma0.514
Dab2disabled homolog 2 (Drosophila)0.501
Nrxn3neurexin 30.501
Ednrbendothelin receptor type B0.497
Prkcgprotein kinase C, gamma0.493
Gnao1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.490
Map2microtubule-associated protein 20.479
Dlgap3discs, large (Drosophila) homolog-associated protein 30.476
Ccl2chemokine (C-C motif) ligand 20.472
Galr3galanin receptor 30.453
Aqp4aquaporin 40.452
Rab11aRAB11a, member RAS oncogene family0.449
Sncbsynuclein, beta0.448
Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.440
Metmet proto-oncogene0.439
Foxd3forkhead box D30.438
Nek9NIMA (never in mitosis gene a)- related kinase 90.436
Lphn2latrophilin 20.428
Jak2Janus kinase 20.428
Nckap1NCK-associated protein 10.428
Hoxa2homeo box A20.427
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.426
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.425
Itgamintegrin, alpha M0.424
Kcnd2potassium voltage-gated channel, Shal-related subfamily, member 20.423
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.422
Syngap1synaptic Ras GTPase activating protein 1 homolog (rat)0.421
Nrcamneuronal cell adhesion molecule0.421
Mpripmyosin phosphatase Rho interacting protein0.412
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.409
Rap1bRAP1B, member of RAS oncogene family0.408
Sypsynaptophysin0.407
Astn1astrotactin 10.404
Clic4chloride intracellular channel 40.403
Gas7growth arrest specific 70.403
Neurod2neurogenic differentiation 20.403
Tacr3tachykinin receptor 30.400
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.399
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.395
Apba3amyloid beta (A4) precursor protein-binding, family A, member 30.392
Map1amicrotubule-associated protein 1A0.392
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.390
Scn3asodium channel, voltage-gated, type III, alpha0.390
Prrx1paired related homeobox 10.389
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.386
Camk4calcium/calmodulin-dependent protein kinase IV0.381
Lgals9lectin, galactoside-binding, soluble, 90.378
Nell1NEL-like 1 (chicken)0.377
WaslWiskott-Aldrich syndrome-like0.370
Ptprsprotein tyrosine phosphatase, receptor type, S0.366
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.363
Nefhneurofilament, heavy polypeptide0.363
Nell2NEL-like 2 (chicken)0.363
Ier3immediate early response 30.357
Ppap2bphosphatidic acid phosphatase type 2B0.355
Cadm1cell adhesion molecule 10.354
Robo1roundabout homolog 1 (Drosophila)0.353
Strnstriatin, calmodulin binding protein0.352
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.352
Tmod2tropomodulin 20.351
Adcy6adenylate cyclase 60.351
Tcf4transcription factor 40.350
Sirpasignal-regulatory protein alpha0.346
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism