The network for 'thioester biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

thioester biosynthetic process

The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol.

NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
pdha1apyruvate dehydrogenase (lipoamide) alpha 1a0.518
aco2aconitase 2, mitochondrial0.298
dlstdihydrolipoamide S-succinyltransferase0.207
sucla2succinate-CoA ligase, ADP-forming, beta subunit0.207
cyc1cytochrome c-10.187
sdhbsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)0.135
dldhdihydrolipoamide dehydrogenase0.103
ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.070
brp44brain protein 440.058
slc25a11solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 110.047
ogdhoxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)0.035
ppm1aaprotein phosphatase, Mg2+/Mn2+ dependent, 1Aa0.034
capzbcapping protein (actin filament) muscle Z-line, beta0.029
ddx1DEAD (Asp-Glu-Ala-Asp) box polypeptide 10.025
ndufa10NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 100.024
got2bglutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)0.017
uqcrc1ubiquinol-cytochrome c reductase core protein I0.016
arf2ADP-ribosylation factor 20.015
rcn1reticulocalbin 1, EF-hand calcium binding domain0.014
papolbpoly(A) polymerase beta (testis specific)0.013
pmpcapeptidase (mitochondrial processing) alpha0.013
pccbpropionyl Coenzyme A carboxylase, beta polypeptide0.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
l(1)G0334lethal (1) G03340.496
CG1640CG1640 gene product from transcript CG1640-RB0.192
PyKPyruvate kinase0.153
CG8036CG8036 gene product from transcript CG8036-RB0.144
CG5261CG5261 gene product from transcript CG5261-RB0.077
PgiPhosphoglucose isomerase0.062
CG3731CG3731 gene product from transcript CG3731-RA0.058
CG10639CG10639 gene product from transcript CG10639-RA0.057
CG3523CG3523 gene product from transcript CG3523-RA0.053
CG7430CG7430 gene product from transcript CG7430-RA0.044
CG5214CG5214 gene product from transcript CG5214-RA0.042
CG7920CG7920 gene product from transcript CG7920-RA0.036
CG11198CG11198 gene product from transcript CG11198-RB0.023
CG17896CG17896 gene product from transcript CG17896-RB0.021
CG3902CG3902 gene product from transcript CG3902-RA0.020
CG5028CG5028 gene product from transcript CG5028-RB0.019
ND75NADH:ubiquinone reductase 75kD subunit precursor0.018
CG10863CG10863 gene product from transcript CG10863-RA0.017
IdeInsulin degrading metalloproteinase0.016
CG12030CG12030 gene product from transcript CG12030-RA0.014
CG12203CG12203 gene product from transcript CG12203-RA0.013
MdhCG5889 gene product from transcript CG5889-RC0.012
CG9140CG9140 gene product from transcript CG9140-RA0.012
CG6439CG6439 gene product from transcript CG6439-RA0.012
CG12703CG12703 gene product from transcript CG12703-RA0.012
Got2Glutamate oxaloacetate transaminase 20.012
CG8199CG8199 gene product from transcript CG8199-RA0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PDHXpyruvate dehydrogenase complex, component X1.000
DLATdihydrolipoamide S-acetyltransferase0.976
PDHBpyruvate dehydrogenase (lipoamide) beta0.824
DLDdihydrolipoamide dehydrogenase0.639
NDUFS1NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)0.531
PDHA1pyruvate dehydrogenase (lipoamide) alpha 10.403
IDH3Aisocitrate dehydrogenase 3 (NAD+) alpha0.140
PFDN1prefoldin subunit 10.133
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.042
SUCLA2succinate-CoA ligase, ADP-forming, beta subunit0.028
MAPTmicrotubule-associated protein tau0.028
AIFM1apoptosis-inducing factor, mitochondrion-associated, 10.023
SGK3serum/glucocorticoid regulated kinase family, member 30.021
SNCAIPsynuclein, alpha interacting protein0.020
ANXA7annexin A70.018
FDX1ferredoxin 10.012
MCCC1methylcrotonoyl-CoA carboxylase 1 (alpha)0.011
C21orf33chromosome 21 open reading frame 330.010
PDE4DIPphosphodiesterase 4D interacting protein0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.922
Idh3aisocitrate dehydrogenase 3 (NAD+) alpha0.367
Vdac2voltage-dependent anion channel 20.296
Mvdmevalonate (diphospho) decarboxylase0.190
Hbb-b2hemoglobin, beta adult minor chain0.141
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.135
Hba-a2hemoglobin alpha, adult chain 20.106
Alas2aminolevulinic acid synthase 2, erythroid0.087
Gpd1glycerol-3-phosphate dehydrogenase 1 (soluble)0.085
AclyATP citrate lyase0.076
Slc4a1solute carrier family 4 (anion exchanger), member 10.074
Gfm1G elongation factor, mitochondrial 10.073
Macrod1MACRO domain containing 10.067
Sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.065
Adck3aarF domain containing kinase 30.064
Etfdhelectron transferring flavoprotein, dehydrogenase0.063
Elovl6ELOVL family member 6, elongation of long chain fatty acids (yeast)0.061
Lsslanosterol synthase0.060
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.059
Beta-shemoglobin subunit beta-1-like0.058
Entpd5ectonucleoside triphosphate diphosphohydrolase 50.056
Aifm1apoptosis-inducing factor, mitochondrion-associated 10.053
Bnip3BCL2/adenovirus E1B interacting protein 30.053
Scd1stearoyl-Coenzyme A desaturase 10.052
Pcxpyruvate carboxylase0.050
Sqlesqualene epoxidase0.049
Dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.048
Uqcrc2ubiquinol cytochrome c reductase core protein 20.048
Pdha1pyruvate dehydrogenase E1 alpha 10.047
Grsf1G-rich RNA sequence binding factor 10.045
Lpin1lipin 10.038
NsdhlNAD(P) dependent steroid dehydrogenase-like0.036
Ndrg2N-myc downstream regulated gene 20.034
Iars2isoleucine-tRNA synthetase 2, mitochondrial0.031
Pmvkphosphomevalonate kinase0.030
Ahspalpha hemoglobin stabilizing protein0.030
Cscitrate synthase0.030
G6pdxglucose-6-phosphate dehydrogenase X-linked0.029
Plin4perilipin 40.029
Mmachcmethylmalonic aciduria cblC type, with homocystinuria0.028
Pink1PTEN induced putative kinase 10.028
Acsl1acyl-CoA synthetase long-chain family member 10.027
Inpp5jinositol polyphosphate 5-phosphatase J0.027
Mrpl39mitochondrial ribosomal protein L390.026
Pygmmuscle glycogen phosphorylase0.025
Afg3l2AFG3(ATPase family gene 3)-like 2 (yeast)0.025
Acat2acetyl-Coenzyme A acetyltransferase 20.025
Lrrk2leucine-rich repeat kinase 20.025
Echdc1enoyl Coenzyme A hydratase domain containing 10.025
1300010F03RikRIKEN cDNA 1300010F03 gene0.025
Elmod3ELMO/CED-12 domain containing 30.025
Fasnfatty acid synthase0.024
Plin5perilipin 50.024
Hadhbhydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit0.024
Hibch3-hydroxyisobutyryl-Coenzyme A hydrolase0.023
Srebf1sterol regulatory element binding transcription factor 10.022
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.021
Stard7START domain containing 70.021
Thrspthyroid hormone responsive SPOT14 homolog (Rattus)0.021
Osbpl1aoxysterol binding protein-like 1A0.020
Eef1a2eukaryotic translation elongation factor 1 alpha 20.019
Dhcr77-dehydrocholesterol reductase0.019
Cyp51cytochrome P450, family 510.018
Tmem70transmembrane protein 700.018
Cycscytochrome c, somatic0.017
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.016
Dhrs11dehydrogenase/reductase (SDR family) member 110.016
Vdac1voltage-dependent anion channel 10.016
Isca1iron-sulfur cluster assembly 1 homolog (S. cerevisiae)0.015
Slc27a1solute carrier family 27 (fatty acid transporter), member 10.015
Ephx2epoxide hydrolase 2, cytoplasmic0.015
Pfkmphosphofructokinase, muscle0.015
Acad11acyl-Coenzyme A dehydrogenase family, member 110.015
Cideacell death-inducing DNA fragmentation factor, alpha subunit-like effector A0.015
Mutmethylmalonyl-Coenzyme A mutase0.014
Mlycdmalonyl-CoA decarboxylase0.014
Fbxo41F-box protein 410.014
Tcea3transcription elongation factor A (SII), 30.013
Acss2acyl-CoA synthetase short-chain family member 20.013
Opa1optic atrophy 1 homolog (human)0.013
Mccc1methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)0.013
Mfn1mitofusin 10.013
Abcb10ATP-binding cassette, sub-family B (MDR/TAP), member 100.013
Dhcr2424-dehydrocholesterol reductase0.013
Syn1synapsin I0.013
Coq3coenzyme Q3 homolog, methyltransferase (yeast)0.013
Mbpmyelin basic protein0.012
RorcRAR-related orphan receptor gamma0.012
Nwd1NACHT and WD repeat domain containing 10.012
Wdtc1WD and tetratricopeptide repeats 10.012
Hibadh3-hydroxyisobutyrate dehydrogenase0.012
Dlddihydrolipoamide dehydrogenase0.012
Pex19peroxisomal biogenesis factor 190.011
St8sia6ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 60.011
Epb4.1erythrocyte protein band 4.10.011
Slc25a23solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 230.011
Gmprguanosine monophosphate reductase0.011
Sdhdsuccinate dehydrogenase complex, subunit D, integral membrane protein0.011
Fitm2fat storage-inducing transmembrane protein 20.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.553
Atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B10.404
Sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.138
Dlatdihydrolipoamide S-acetyltransferase0.053
Hibadh3-hydroxyisobutyrate dehydrogenase0.052
Uqcrc2ubiquinol cytochrome c reductase core protein 20.041
Pink1PTEN induced putative kinase 10.039
Pxmp2peroxisomal membrane protein 20.038
Aldh2aldehyde dehydrogenase 2 family (mitochondrial)0.037
Pdha1pyruvate dehydrogenase (lipoamide) alpha 10.031
Me1malic enzyme 1, NADP(+)-dependent, cytosolic0.028
Dlddihydrolipoamide dehydrogenase0.027
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.025
Ube2bubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)0.024
Ivdisovaleryl coenzyme A dehydrogenase0.020
RGD1565095similar to hypothetical protein MGC521100.019
Pdhxpyruvate dehydrogenase complex, component X0.018
Pfkmphosphofructokinase, muscle0.015
Slc25a5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.015
Acadsacyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain0.014
Bpnt13'(2'), 5'-bisphosphate nucleotidase 10.014
Bckdhabranched chain ketoacid dehydrogenase E1, alpha polypeptide0.014
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.013
Dynlt3dynein light chain Tctex-type 30.012
Slc25a42solute carrier family 25, member 420.012
Pcpyruvate carboxylase0.012
Pgk1phosphoglycerate kinase 10.012
Pygmphosphorylase, glycogen, muscle0.011
Pmpcapeptidase (mitochondrial processing) alpha0.011
Trappc6btrafficking protein particle complex 6B0.011
Oplah5-oxoprolinase (ATP-hydrolysing)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism