The network for 'mitotic g2 m transition checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitotic g2 m transition checkpoint

A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle.

NameDescriptionProbabilityFunc Analog Organism
set-1Protein SET-10.085
npp-15Protein NPP-150.054
hcf-1Protein HCF-10.043
B0205.1Protein B0205.10.042
D1081.8Protein D1081.80.040
T05E8.3Protein T05E8.30.038
emb-5Protein EMB-50.035
F36D4.2Protein F36D4.20.033
sas-5Protein SAS-50.032
hcp-1Protein HCP-10.032
rnr-1Protein RNR-10.032
CELE_C24H12.5Protein C24H12.50.031
C05C10.2Protein C05C10.20.031
spd-5Protein SPD-50.030
pcn-1Protein PCN-10.030
rpn-6.1Protein RPN-6.10.030
snr-3Protein SNR-30.029
D1081.7Protein D1081.70.029
aspm-1Protein ASPM-10.029
snr-1Protein SNR-10.028
cyk-4Protein CYK-40.028
elb-1Protein ELB-10.027
klp-19Protein KLP-190.027
mel-28Protein MEL-280.027
npp-21Protein NPP-210.026
isw-1Protein ISW-10.026
F56A8.5Protein F56A8.50.026
ran-1Protein RAN-10.025
lin-5Protein LIN-50.025
orc-2Protein ORC-20.025
mcm-7Protein MCM-70.025
C49H3.9Protein C49H3.90.025
C50F2.3Protein C50F2.30.024
C27A12.7Protein C27A12.70.024
rpa-1Protein RPA-10.024
T19H12.2Protein T19H12.20.024
him-10Protein HIM-100.024
lmn-1Protein LMN-10.024
dpy-30Protein DPY-300.024
csn-3Protein CSN-30.024
csn-2Protein CSN-20.024
eif-3.BProtein EIF-3.B0.023
T28A8.3Protein T28A8.30.023
C02B10.4Protein C02B10.40.023
bub-1Protein BUB-10.023
brc-1Protein BRC-10.022
rod-1Protein ROD-10.022
F20A1.9Protein F20A1.90.022
cin-4Protein CIN-40.022
CELE_C34D4.4Protein C34D4.40.022
rsp-1Protein RSP-10.022
rae-1Protein RAE-10.022
F09G2.8Protein F09G2.80.022
C56G2.7Protein C56G2.70.022
nra-1Protein NRA-10.022
baf-1Protein BAF-10.021
mcm-3Protein MCM-30.021
cls-2Protein CLS-20.021
rev-1Protein REV-10.021
F45F2.10Protein F45F2.100.021
npp-16Protein NPP-160.021
F58E10.3Protein F58E10.30.021
eftu-2Protein EFTU-20.020
T07A9.8Protein T07A9.80.020
ess-2Protein ESS-20.020
cash-1Protein CASH-10.020
srgp-1Protein SRGP-10.020
lin-9Protein LIN-90.020
pri-2Protein PRI-20.020
cdc-6Protein CDC-60.020
K04G2.6Protein K04G2.60.019
B0001.7Protein B0001.70.019
zyg-9Protein ZYG-90.019
emb-27Protein EMB-270.019
edc-3Protein EDC-30.019
D1043.1Protein D1043.10.019
dna-2Protein DNA-20.019
CELE_T05H4.11Protein T05H4.110.019
CELE_R09B3.2Protein R09B3.20.019
cogc-2Protein COGC-20.019
dnj-13Protein DNJ-130.018
CELE_K08F4.1Protein K08F4.10.018
T12E12.3Protein T12E12.30.018
CELE_F17C11.7Protein F17C11.70.018
nmy-2Protein NMY-20.018
sqv-4Protein SQV-40.018
mcm-5Protein MCM-50.018
bath-42Protein BATH-420.018
F55A3.3Protein F55A3.30.018
egl-18Protein EGL-180.018
pme-3Protein PME-30.018
CELE_Y41E3.11Protein Y41E3.110.018
fic-1Protein FIC-10.018
ruvb-1Protein RUVB-10.018
F19B6.1Protein F19B6.10.018
F59E10.3Protein F59E10.30.018
CELE_C39E9.11Protein C39E9.110.018
top-2Protein TOP-20.018
kin-10Protein KIN-100.017
klp-16Protein KLP-160.017
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
stilTAL1 (SCL) interrupting locus0.706
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.519
zff9zinc finger protein 90.481
caprin1acell cycle associated protein 1a0.333
rad21RAD21 homolog (S. pombe)0.272
brd2abromodomain-containing 2a0.243
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.230
naa15bN(alpha)-acetyltransferase 15, NatA auxiliary subunit b0.205
tfamtranscription factor A, mitochondrial0.195
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.190
cand1cullin-associated and neddylation-dissociated 10.175
ywhabatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a0.173
kpna3karyopherin (importin) alpha 30.169
trip13thyroid hormone receptor interactor 130.165
hspa4bheat shock protein 4b0.146
unguracil-DNA glycosylase0.145
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.144
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.132
cul3acullin 3a0.130
ywhaqatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a0.124
ctcfCCCTC-binding factor (zinc finger protein)0.112
chaf1bchromatin assembly factor 1, subunit B0.109
scube2signal peptide, CUB domain, EGF-like 20.102
lin52lin-52 homolog (C. elegans)0.102
usp4ubiquitin specific protease 4 (proto-oncogene)0.099
dgcr8DiGeorge syndrome critical region gene 80.097
arhgap11aRho GTPase activating protein 11A0.095
ap1g1adaptor-related protein complex 1, gamma 1 subunit0.092
fanciFanconi anemia, complementation group I0.092
ccna2cyclin A20.089
faf1Fas associated factor 10.088
dzip1DAZ interacting protein 10.081
cdk8cyclin-dependent kinase 80.080
csnk1g2bcasein kinase 1, gamma 2b0.077
hellshelicase, lymphoid-specific0.077
mesp2mesoderm posterior 2 homolog (mouse)0.076
eif2deukaryotic translation initiation factor 2D0.075
ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.075
dus1ldihydrouridine synthase 1-like (S. cerevisiae)0.074
chek1CHK1 checkpoint homolog (S. pombe)0.074
smc1alstructural maintenance of chromosomes 1A, like0.073
wdhd1WD repeat and HMG-box DNA binding protein 10.072
orc1origin recognition complex, subunit 10.070
cops3COP9 constitutive photomorphogenic homolog subunit 30.067
pld1aphospholipase D1a0.066
htatsf1HIV TAT specific factor 10.066
ncbp2nuclear cap binding protein subunit 20.066
g2e3G2/M-phase specific E3 ubiquitin ligase0.066
rmnd5brequired for meiotic nuclear division 5 homolog B (S. cerevisiae)0.066
LOC557062hypothetical protein LOC5570620.064
map2k6mitogen-activated protein kinase kinase 60.064
ppp2r5ebprotein phosphatase 2, regulatory subunit B', epsilon isoform b0.064
LOC553505hypothetical protein LOC5535050.062
mmgt1membrane magnesium transporter 10.062
pknox1.1pbx/knotted 1 homeobox 1.10.061
tbc1d23TBC1 domain family, member 230.061
ppp4caprotein phosphatase 4 (formerly X), catalytic subunit a0.059
senp3aSUMO1/sentrin/SMT3 specific peptidase 3a0.059
aurkbaurora kinase B0.058
arfgef1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.057
tubgcp2tubulin, gamma complex associated protein 20.057
ccdc94coiled-coil domain containing 940.057
brd2bbromodomain containing 2b0.055
morf4l1mortality factor 4 like 10.055
wacaWW domain containing adaptor with coiled-coil a0.054
pola1polymerase (DNA directed), alpha 10.054
zc3h13zinc finger CCCH-type containing 130.054
eif2b4eukaryotic translation initiation factor 2B, subunit 4 delta0.053
rtkn2rhotekin 20.053
oxsr1aoxidative-stress responsive 1a0.052
krcpkelch repeat-containing protein0.051
mycl1av-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) a0.050
skp2S-phase kinase-associated protein 2 (p45)0.050
xrcc6X-ray repair complementing defective repair in Chinese hamster cells 60.049
celsr3cadherin, EGF LAG seven-pass G-type receptor 30.049
smarcb1aSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a0.049
mobkl3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.047
slc17a6bsolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b0.047
csnk1g2acasein kinase 1, gamma 2a0.047
rqcd1RCD1 required for cell differentiation1 homolog (S. pombe)0.046
pak2bp21 (CDKN1A)-activated kinase 2b0.045
cops5COP9 constitutive photomorphogenic homolog subunit 50.045
ubinataxin-1 ubiquitin-like interacting protein0.044
ube2i2ubiquitin-conjugating enzyme E2I20.044
ppigpeptidyl-prolyl isomerase G (cyclophilin G)0.043
fbxw2F-box and WD repeat domain containing 20.042
ppp2r2dprotein phosphatase 2, regulatory subunit B, delta isoform0.042
ppil4peptidylprolyl isomerase (cyclophilin)-like 40.042
pfdn6prefoldin subunit 60.042
lama1laminin, alpha 10.042
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
BRWD3CG31132 gene product from transcript CG31132-RA0.971
His2AvHistone H2A variant0.948
IswiImitation SWI0.945
Cdk4Cyclin-dependent kinase 40.931
CSN5COP9 complex homolog subunit 50.928
MED6Mediator complex subunit 60.867
Caf1Chromatin assembly factor 1 subunit0.857
CSN3COP9 complex homolog subunit 30.856
MED17Mediator complex subunit 170.847
Brca2Breast cancer 2, early onset homolog0.837
Rpd3CG7471 gene product from transcript CG7471-RA0.830
CG10414CG10414 gene product from transcript CG10414-RA0.804
U2af50U2 small nuclear riboprotein auxiliary factor 500.794
mus312mutagen-sensitive 3120.750
l(2)NC136lethal (2) NC1360.738
Bap55Brahma associated protein 55kD0.730
CG5524CG5524 gene product from transcript CG5524-RA0.713
CDC45LCG3658 gene product from transcript CG3658-RA0.702
mus309mutagen-sensitive 3090.688
mus205mutagen-sensitive 2050.685
rad50CG6339 gene product from transcript CG6339-RD0.677
CSN4COP9 complex homolog subunit 40.674
mus101mutagen-sensitive 1010.657
DNApol-etaCG7143 gene product from transcript CG7143-RA0.656
Rcd1Reduction in Cnn dots 10.655
Cdc37CG12019 gene product from transcript CG12019-RA0.642
RecQ4CG7487 gene product from transcript CG7487-RA0.598
pashapartner of drosha0.557
cdc2cCG10498 gene product from transcript CG10498-RC0.553
polyCG9829 gene product from transcript CG9829-RB0.548
Klp3AKinesin-like protein at 3A0.540
CycKCyclin K0.527
CSN6COP9 complex homolog subunit 60.504
mei-9meiotic 90.499
CG7386CG7386 gene product from transcript CG7386-RA0.457
RanGapRan GTPase activating protein0.451
mus304mutagen-sensitive 3040.449
Caf1-180CG12109 gene product from transcript CG12109-RB0.425
Mes2CG11100 gene product from transcript CG11100-RB0.411
Ge-1CG6181 gene product from transcript CG6181-RA0.409
CG6066CG6066 gene product from transcript CG6066-RA0.407
MED20Mediator complex subunit 200.399
mbomembers only0.389
NmtN-myristoyl transferase0.386
sxcsuper sex combs0.377
mus201mutagen-sensitive 2010.369
Vps35Vacuolar protein sorting 350.358
Mob4CG3403 gene product from transcript CG3403-RA0.323
CSN7COP9 complex homolog subunit 70.319
Tip60CG6121 gene product from transcript CG6121-RA0.292
fl(2)dfemale lethal d0.278
CG5543CG5543 gene product from transcript CG5543-RA0.277
Art1Arginine methyltransferase 10.270
DNApol-alpha73DNA polymerase alpha 73kD0.253
CG10981CG10981 gene product from transcript CG10981-RA0.250
Nipped-ACG33554 gene product from transcript CG33554-RE0.249
CG10139CG10139 gene product from transcript CG10139-RA0.242
ebiCG4063 gene product from transcript CG4063-RA0.236
Mcm7Minichromosome maintenance 70.235
sec10CG6159 gene product from transcript CG6159-RA0.229
CG34415CG34415 gene product from transcript CG34415-RC0.222
CG8928CG8928 gene product from transcript CG8928-RA0.218
dahdiscontinuous actin hexagon0.216
eEF1deltaCG4912 gene product from transcript CG4912-RB0.216
CG6654CG6654 gene product from transcript CG6654-RA0.207
CragCalmodulin-binding protein related to a Rab3 GDP/GTP exchange protein0.206
CSN8COP9 complex homolog subunit 80.205
Pp2A-29BProtein phosphatase 2A at 29B0.200
SF2CG6987 gene product from transcript CG6987-RA0.199
mus308mutagen-sensitive 3080.198
Pp1-87BProtein phosphatase 1 at 87B0.193
sec15CG7034 gene product from transcript CG7034-RA0.189
Vap-33-1CG5014 gene product from transcript CG5014-RB0.187
BEAF-32Boundary element-associated factor of 32kD0.185
4EHPCG33100 gene product from transcript CG33100-RA0.180
SuURSuppressor of Under-Replication0.178
spn-Bspindle B0.177
CstF-64Cleavage stimulation factor 64 kilodalton subunit0.176
Caf1-105CG12892 gene product from transcript CG12892-RA0.173
Fs(2)KetFemale sterile (2) Ketel0.173
CG14937CG14937 gene product from transcript CG14937-RA0.169
Rev1CG12189 gene product from transcript CG12189-RA0.168
CG13298CG13298 gene product from transcript CG13298-RA0.168
Fcp1CG12252 gene product from transcript CG12252-RA0.166
Nup50Nucleoporin 500.166
eIF4AIIICG7483 gene product from transcript CG7483-RA0.157
CkIIbetaCasein kinase II beta subunit0.155
wdawill decrease acetylation0.155
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PCNAproliferating cell nuclear antigen0.892
RB1retinoblastoma 10.693
CUL1cullin 10.489
BRCA1breast cancer 1, early onset0.439
CDK2cyclin-dependent kinase 20.429
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.360
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.341
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.294
E2F1E2F transcription factor 10.288
COPS6COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)0.238
COPS4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)0.231
TP53tumor protein p530.179
COPS3COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)0.163
RAD50RAD50 homolog (S. cerevisiae)0.153
CUL2cullin 20.126
HDAC1histone deacetylase 10.109
CHEK1CHK1 checkpoint homolog (S. pombe)0.102
PARP1poly (ADP-ribose) polymerase 10.095
RBBP8retinoblastoma binding protein 80.090
ATRataxia telangiectasia and Rad3 related0.090
CDK8cyclin-dependent kinase 80.080
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.078
TOPBP1topoisomerase (DNA) II binding protein 10.075
CNOT6CCR4-NOT transcription complex, subunit 60.067
MDC1mediator of DNA-damage checkpoint 10.066
COPS8COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)0.060
MCM7minichromosome maintenance complex component 70.053
RFWD2ring finger and WD repeat domain 20.052
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.052
UBA1ubiquitin-like modifier activating enzyme 10.047
RBL1retinoblastoma-like 1 (p107)0.046
MCM2minichromosome maintenance complex component 20.041
CUL4Acullin 4A0.038
EME1essential meiotic endonuclease 1 homolog 1 (S. pombe)0.036
MSH6mutS homolog 6 (E. coli)0.036
DDB1damage-specific DNA binding protein 1, 127kDa0.034
PKM2pyruvate kinase, muscle0.033
COPS2COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)0.030
MED10mediator complex subunit 100.030
ATRXalpha thalassemia/mental retardation syndrome X-linked0.026
BTG1B-cell translocation gene 1, anti-proliferative0.026
ATMataxia telangiectasia mutated0.024
UBXN7UBX domain protein 70.024
PPP2R5Bprotein phosphatase 2, regulatory subunit B', beta0.023
H2AFXH2A histone family, member X0.023
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.022
CCNA2cyclin A20.021
FANCD2Fanconi anemia, complementation group D20.021
FANCAFanconi anemia, complementation group A0.021
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.021
MCM6minichromosome maintenance complex component 60.020
SKP2S-phase kinase-associated protein 2 (p45)0.020
RPL39ribosomal protein L390.020
MED13mediator complex subunit 130.020
CDC6cell division cycle 6 homolog (S. cerevisiae)0.019
CNOT1CCR4-NOT transcription complex, subunit 10.019
CDT1chromatin licensing and DNA replication factor 10.019
GPS1G protein pathway suppressor 10.018
TFDP1transcription factor Dp-10.017
CAND1cullin-associated and neddylation-dissociated 10.017
COPS7ACOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.017
CNOT3CCR4-NOT transcription complex, subunit 30.016
UBE2Mubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)0.016
TNRC6Btrinucleotide repeat containing 6B0.015
RPA2replication protein A2, 32kDa0.015
ORC1origin recognition complex, subunit 10.015
CUL3cullin 30.015
GFERgrowth factor, augmenter of liver regeneration0.015
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.013
E2F4E2F transcription factor 4, p107/p130-binding0.013
NEDD8neural precursor cell expressed, developmentally down-regulated 80.013
FBXO11F-box protein 110.013
CNOT8CCR4-NOT transcription complex, subunit 80.013
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.013
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.013
C19orf2chromosome 19 open reading frame 20.012
CHAF1Achromatin assembly factor 1, subunit A (p150)0.012
RBX1ring-box 1, E3 ubiquitin protein ligase0.012
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.012
ENO1enolase 1, (alpha)0.012
MED29mediator complex subunit 290.012
GTF2H1general transcription factor IIH, polypeptide 1, 62kDa0.011
RECQLRecQ protein-like (DNA helicase Q1-like)0.011
CDC45cell division cycle 45 homolog (S. cerevisiae)0.011
MED28mediator complex subunit 280.011
CUL4Bcullin 4B0.011
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.010
CNOT6LCCR4-NOT transcription complex, subunit 6-like0.010
CCNE1cyclin E10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.017
Pkm2pyruvate kinase, muscle0.013
Eno1enolase 1, (alpha)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism