The network for 'regulation of synapse structure and activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of synapse structure and activity

Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

NameDescriptionProbabilityFunc Analog Organism
unc-9Protein UNC-90.100
spc-1Protein SPC-10.043
clh-5Protein CLH-50.030
ace-3Protein ACE-30.027
ncam-1Protein NCAM-10.025
ZC449.5Protein ZC449.50.025
rig-6Protein RIG-60.020
ace-1Protein ACE-10.020
mig-15Protein MIG-150.019
plp-1Protein PLP-10.018
mec-4Protein MEC-40.017
pha-4Protein PHA-40.016
ain-1Protein AIN-10.016
unc-32Protein UNC-320.015
egl-44Protein EGL-440.015
elt-6Protein ELT-60.014
pdfr-1Protein PDFR-10.014
clic-1Protein CLIC-10.013
ceh-13Protein CEH-130.013
syd-9Protein SYD-90.012
ace-2Protein ACE-20.012
ina-1Protein INA-10.012
mep-1Protein MEP-10.012
unc-108Protein UNC-1080.012
hlh-30Protein HLH-300.012
CELE_T04H1.2Protein T04H1.20.012
C11E4.6Protein C11E4.60.012
egl-18Protein EGL-180.012
R90.1Protein R90.10.012
ceh-20Protein CEH-200.011
lgc-55Protein LGC-550.011
glr-5Protein GLR-50.011
sek-1Protein SEK-10.011
ceh-34Protein CEH-340.011
mig-5Protein MIG-50.011
chd-7Protein CHD-70.011
islo-1Protein ISLO-10.010
mig-2Protein MIG-20.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bocbrother of CDO0.715
robo2roundabout homolog 20.375
slc17a6bsolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b0.343
nf1aneurofibromin 1a0.219
nlgn4bneuroligin 4b0.169
nlgn2bneuroligin 2b0.118
smosmoothened homolog (Drosophila)0.104
thsd7athrombospondin, type I, domain containing 7A0.094
spsb4asplA/ryanodine receptor domain and SOCS box containing 4a0.090
scn8aasodium channel, voltage-gated, type VIII, alpha a0.081
flot1flotillin 10.079
nxph1neurexophilin 10.078
fbn2bfibrillin 2b0.076
cacna1dacalcium channel, voltage-dependent, L type, alpha 1D subunit, a0.069
drd2bdopamine receptor D2b0.067
ephb4beph receptor B4b0.065
gro2groucho 20.065
roraaRAR-related orphan receptor A, paralog a0.061
olfm2olfactomedin 20.057
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.056
rnd3aRho family GTPase 3a0.055
lhx2bLIM homeobox 2b0.052
sema3aasemaphorin 3aa0.050
kal1aKallmann syndrome 1a sequence0.049
lef1lymphocyte enhancer binding factor 10.046
sh3gl1bSH3-domain GRB2-like 1b0.046
dlg2discs, large (Drosophila) homolog 20.043
arnt2aryl hydrocarbon receptor nuclear translocator 20.043
ikzf5IKAROS family zinc finger 50.043
unc45bunc-45 homolog B (C. elegans)0.041
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.040
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.040
hmcn2hemicentin 20.040
s1pr2sphingosine-1-phosphate receptor 20.040
bmpr2bbone morphogenetic protein receptor, type II b (serine/threonine kinase)0.039
frem3Fras1 related extracellular matrix 30.037
ptpraprotein tyrosine phosphatase, receptor type, A0.037
pax8paired box gene 80.036
cntn1acontactin 1a0.035
nkd1naked cuticle homolog 1 (Drosophila)0.035
nog2noggin 20.034
unc5bunc-5 homolog B (C. elegans)0.033
aurkaaurora kinase A0.033
si:dkeyp-104h9.6si:dkeyp-104h9.60.033
dlg1discs, large (Drosophila) homolog 10.033
lims1LIM and senescent cell antigen-like domains 10.032
fstl1bfollistatin-like 1b0.031
nlgn2aneuroligin 2a0.031
ptk2.1protein tyrosine kinase 2a0.031
lama2laminin, alpha 20.030
gli2aGLI-Kruppel family member GLI2a0.029
ptprkprotein tyrosine phosphatase, receptor type, K0.029
gli1GLI-Kruppel family member 10.029
nrg2aneuregulin 2a0.029
nrp2bneuropilin 2b0.028
efnb2aephrin B2a0.026
six3bsine oculis homeobox homolog 3b0.026
pacsin3protein kinase C and casein kinase substrate in neurons 30.025
gad2glutamate decarboxylase 20.025
dmddystrophin0.024
barhl1.2BarH-like 1.20.024
trim33tripartite motif-containing 330.024
tjp2atight junction protein 2a (zona occludens 2)0.022
cdh23cadherin-like 230.022
wnt10awingless-type MMTV integration site family, member 10a0.022
rargbretinoic acid receptor, gamma b0.021
im:7137555im:71375550.021
szlsizzled0.021
sncbsynuclein, beta0.020
snap25asynaptosome-associated protein 25a0.020
nlgn3aneuroligin 3a0.019
zgc:86759zgc:867590.019
robo1roundabout homolog 10.019
wnt5awingless-type MMTV integration site family, member 5a0.019
ldb2aLIM-domain binding factor 2a0.019
cntn2contactin 20.019
phox2apaired-like homeobox 2a0.018
ttnatitin a0.018
lama4laminin, alpha 40.018
six1asine oculis homeobox homolog 1a0.018
zgc:85975zgc:859750.017
chrndcholinergic receptor, nicotinic, delta polypeptide0.017
akt2v-akt murine thymoma viral oncogene homolog 20.017
foxp2forkhead box P20.017
pcdh15aprotocadherin 15a0.016
stac3SH3 and cysteine rich domain 30.016
mmp9matrix metalloproteinase 90.016
igfbp3insulin-like growth factor binding protein 30.015
psen1presenilin 10.015
pbx4pre-B-cell leukemia transcription factor 40.015
zgc:112072zgc:1120720.015
myo6bmyosin VIb0.014
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.014
hspg2heparan sulfate proteoglycan 20.014
atp6v0cbATPase, H+ transporting, lysosomal, V0 subunit c, b0.014
kif5aakinesin family member 5A, a0.014
coro1acoronin, actin binding protein, 1A0.014
disc1disrupted in schizophrenia 10.014
dpysl4dihydropyrimidinase-like 40.014
ndrg4N-myc downstream regulated gene 40.013
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CaMKIICalcium/calmodulin-dependent protein kinase II1.000
neuroliginCG13772 gene product from transcript CG13772-RA1.000
witwishful thinking1.000
cazcabeza0.993
Dap160Dynamin associated protein 1600.991
roboroundabout0.989
Fmr1CG6203 gene product from transcript CG6203-RC0.984
DadDaughters against dpp0.976
GluRIIAGlutamate receptor IIA0.970
CG32635CG32635 gene product from transcript CG32635-RA0.963
cv-ccrossveinless c0.962
G-oalpha47AG protein oalpha 47A0.961
Cip4CG15015 gene product from transcript CG15015-RA0.949
CG31146CG31146 gene product from transcript CG31146-RD0.948
Vap-33-1CG5014 gene product from transcript CG5014-RB0.940
RhoGAP92BCG4755 gene product from transcript CG4755-RA0.933
hiwhighwire0.922
caccacophony0.918
fz2frizzled 20.915
PakPAK-kinase0.903
brpbruchpilot0.902
rutrutabaga0.899
Arp66BActin-related protein 66B0.891
SaraSmad anchor for receptor activation0.881
jebjelly belly0.877
AlkCG8250 gene product from transcript CG8250-RA0.850
endoAendophilin A0.844
stnBstoned B0.840
AcslAcyl-CoA synthetase long-chain0.836
WASpCG1520 gene product from transcript CG1520-RA0.833
Ank2Ankyrin 20.825
Mob4CG3403 gene product from transcript CG3403-RA0.823
nwknervous wreck0.820
Arp14DActin-related protein 14D0.794
AmphAmphiphysin0.792
Nrx-1Neurexin 10.791
miltmilton0.789
Cdc42CG12530 gene product from transcript CG12530-RA0.781
S6kIIRPS6-protein kinase-II0.768
Frq1Frequenin 10.746
Rab5Rab-protein 50.745
Nrx-IVNeurexin IV0.742
cicubitus interruptus0.739
hpohippo0.730
bskbasket0.730
MadMothers against dpp0.721
nmonemo0.702
enaenabled0.695
htshu li tai shao0.695
tkvthickveins0.690
HemHEM-protein0.686
Pak3CG14895 gene product from transcript CG14895-RA0.683
cpxcomplexin0.677
sggshaggy0.676
fd85Eforkhead domain 85E0.668
stanstarry night0.661
shotshort stop0.648
Eaat1Excitatory amino acid transporter 10.630
Snap25Synapse protein 250.626
pAbppolyA-binding protein0.624
KaiRIACG18039 gene product from transcript CG18039-RA0.619
katanin-60katanin 600.612
Ras85DRas oncogene at 85D0.599
PP2A-B'CG7913 gene product from transcript CG7913-RK0.598
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.587
wndwallenda0.587
spasspastin0.584
mysmyospheroid0.582
Src64BSrc oncogene at 64B0.578
BicDBicaudal D0.554
unc-104CG8566 gene product from transcript CG8566-RB0.554
PknProtein kinase related to protein kinase N0.550
Fak56DFocal Adhesion Kinase0.548
Applbeta amyloid protein precursor-like0.546
MicalMolecule interacting with CasL0.545
Cul-2Cullin-20.540
egreiger0.539
bazbazooka0.535
elavembryonic lethal abnormal vision0.527
Nf1Neurofibromin 10.519
CspCysteine string protein0.518
beta4GalNAcTACG8536 gene product from transcript CG8536-RA0.512
CG12187CG12187 gene product from transcript CG12187-RA0.512
scbscab0.498
dlpdally-like0.496
hipkhomeodomain interacting protein kinase0.488
dncdunce0.488
TbhTyramine beta hydroxylase0.477
Ca-betaCa2+-channel-protein-beta-subunit0.476
trioCG18214 gene product from transcript CG18214-RA0.471
kstkarst0.469
Aplip1APP-like protein interacting protein 10.463
Akt1CG4006 gene product from transcript CG4006-RA0.456
chbchromosome bows0.451
TBPHCG10327 gene product from transcript CG10327-RC0.446
Sema-1aCG18405 gene product from transcript CG18405-RD0.445
oa2octopamine receptor 20.440
spdosanpodo0.439
synaptogyrinCG10808 gene product from transcript CG10808-RA0.438
stjstraightjacket0.432
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DLG4discs, large homolog 4 (Drosophila)0.844
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.219
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.132
ITSN1intersectin 1 (SH3 domain protein)0.098
FYNFYN oncogene related to SRC, FGR, YES0.078
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.058
NEDD4neural precursor cell expressed, developmentally down-regulated 40.036
ACTN2actinin, alpha 20.035
MAPK8mitogen-activated protein kinase 80.031
CUL3cullin 30.031
PRMT1protein arginine methyltransferase 10.024
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.023
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.023
SH3GL2SH3-domain GRB2-like 20.022
NCK1NCK adaptor protein 10.021
SH3KBP1SH3-domain kinase binding protein 10.020
DNM1dynamin 10.018
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.017
CUL1cullin 10.017
GDAguanine deaminase0.017
GAS7growth arrest-specific 70.015
PTPRCprotein tyrosine phosphatase, receptor type, C0.014
MAP2K7mitogen-activated protein kinase kinase 70.014
PRKCZprotein kinase C, zeta0.014
BMP2bone morphogenetic protein 20.014
VAV1vav 1 guanine nucleotide exchange factor0.013
SH3GL3SH3-domain GRB2-like 30.013
AMPHamphiphysin0.013
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.012
WIPF1WAS/WASL interacting protein family, member 10.012
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.012
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.012
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.012
TSC22D1TSC22 domain family, member 10.012
DAAM1dishevelled associated activator of morphogenesis 10.012
RNF11ring finger protein 110.012
CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.011
SPRR2Asmall proline-rich protein 2A0.011
SMAD1SMAD family member 10.011
APBA1amyloid beta (A4) precursor protein-binding, family A, member 10.011
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.011
SMAD2SMAD family member 20.011
TSC1tuberous sclerosis 10.011
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.011
LRRK2leucine-rich repeat kinase 20.011
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.010
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.010
ARPC3actin related protein 2/3 complex, subunit 3, 21kDa0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Dlg4discs, large homolog 4 (Drosophila)0.249
Map2microtubule-associated protein 20.149
Tcof1Treacher Collins-Franceschetti syndrome 1 homolog (human)0.120
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.118
Dlgap3discs, large (Drosophila) homolog-associated protein 30.109
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.107
Syn1synapsin I0.086
Gria2glutamate receptor, ionotropic, AMPA 20.086
Sh3gl2SH3-domain GRB2-like 20.078
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.075
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.063
Hpcal4hippocalcin-like 40.063
Nrxn1neurexin 10.063
Dgkzdiacylglycerol kinase zeta0.060
Nfascneurofascin0.052
Gria1glutamate receptor, ionotropic, AMPA 10.050
Myt1lmyelin transcription factor 1-like0.050
Ptpn18protein tyrosine phosphatase, non-receptor type 180.050
Dlg1discs, large homolog 1 (Drosophila)0.048
Adap1ArfGAP with dual PH domains 10.046
Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha0.046
Chrm3cholinergic receptor, muscarinic 30.044
Slc12a5solute carrier family 12 (potassium-chloride transporter), member 50.044
Slc1a1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 10.042
Syn2synapsin II0.040
Ppp2r2cprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform0.040
Slc13a2solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 20.036
Amphamphiphysin0.035
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.035
Rims1regulating synaptic membrane exocytosis 10.034
Rgs9regulator of G-protein signaling 90.034
Gnao1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.034
Shank1SH3 and multiple ankyrin repeat domains 10.033
Syt4synaptotagmin IV0.033
Mpripmyosin phosphatase Rho interacting protein0.032
Adrbk1adrenergic, beta, receptor kinase 10.031
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.030
Sorbs2sorbin and SH3 domain containing 20.030
Dlgap1discs, large (Drosophila) homolog-associated protein 10.030
Grik1glutamate receptor, ionotropic, kainate 10.030
Epha5EphA50.029
Dlg3discs, large homolog 3 (Drosophila)0.028
RT1-DMbRT1 class II, locus DMb0.027
Hpcahippocalcin0.027
Ppp1r9bprotein phosphatase 1, regulatory subunit 9B0.026
Baiap2BAI1-associated protein 20.026
Ptprsprotein tyrosine phosphatase, receptor type, S0.025
Glg1golgi apparatus protein 10.025
Prkcdprotein kinase C, delta0.025
CamkvCaM kinase-like vesicle-associated0.025
Bin1bridging integrator 10.025
Pak3p21 protein (Cdc42/Rac)-activated kinase 30.024
Sypsynaptophysin0.023
Nlgn2neuroligin 20.023
Atp2b3ATPase, Ca++ transporting, plasma membrane 30.023
Vcsa1variable coding sequence A10.023
SvopSV2 related protein0.023
Fgfr2fibroblast growth factor receptor 20.023
Nrxn3neurexin 30.022
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.022
Mc4rmelanocortin 4 receptor0.022
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.021
Zc3h7bzinc finger CCCH-type containing 7B0.021
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.021
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.020
Cadm1cell adhesion molecule 10.020
Coro1bcoronin, actin-binding protein, 1B0.019
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.019
Caskin1CASK interacting protein 10.019
ArhgdibRho, GDP dissociation inhibitor (GDI) beta0.019
Arpc5actin related protein 2/3 complex, subunit 50.019
Cplx1complexin 10.019
Stk10serine/threonine kinase 100.019
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.018
Sirpasignal-regulatory protein alpha0.018
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.018
Nischnischarin0.018
Gas7growth arrest specific 70.018
Alcamactivated leukocyte cell adhesion molecule0.018
Nrxn2neurexin 20.017
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.017
Mgat3mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase0.017
Tmod2tropomodulin 20.017
Mmp2matrix metallopeptidase 20.017
Flnbfilamin, beta0.017
Cdh4cadherin 40.016
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.016
Tcf4transcription factor 40.016
Kcnc1potassium voltage gated channel, Shaw-related subfamily, member 10.016
Exoc7exocyst complex component 70.016
Itgamintegrin, alpha M0.016
Cdcp1CUB domain containing protein 10.016
Opn1swopsin 1 (cone pigments), short-wave-sensitive0.016
Plcg2phospholipase C, gamma 20.015
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.015
Ntf4neurotrophin 40.015
Sptbn1spectrin, beta, non-erythrocytic 10.015
Camk4calcium/calmodulin-dependent protein kinase IV0.015
Stxbp5syntaxin binding protein 5 (tomosyn)0.015
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.015
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism