The network for 'negative regulation of developmental process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of developmental process

Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.982
vab-3Protein VAB-30.936
mes-3Protein MES-30.709
pha-4Protein PHA-40.675
hmp-1Protein HMP-10.559
dpy-22Protein DPY-220.520
egl-46Protein EGL-460.496
attf-2Protein ATTF-20.475
pry-1Protein PRY-10.459
mes-4Protein MES-40.449
unc-73Protein UNC-730.442
snr-6Protein SNR-60.426
R11A8.7Protein R11A8.70.400
rsp-5Protein RSP-50.388
cfim-2Protein CFIM-20.381
egl-5Protein EGL-50.376
abl-1Protein ABL-10.358
gex-2Protein GEX-20.353
hlh-2Protein HLH-20.349
lin-36Protein LIN-360.347
R10E12.2Protein R10E12.20.344
lin-25Protein LIN-250.344
gex-3Protein GEX-30.336
spr-5Protein SPR-50.333
lin-66Protein LIN-660.325
nrde-3Protein NRDE-30.320
CELE_Y54G11A.11Protein Y54G11A.110.317
elt-6Protein ELT-60.305
mat-3Protein MAT-30.305
glp-1Protein GLP-10.294
emb-5Protein EMB-50.291
mep-1Protein MEP-10.285
npp-4Protein NPP-40.284
mab-5Protein MAB-50.282
par-5Protein PAR-50.276
T02E1.2Protein T02E1.20.273
wrm-1Protein WRM-10.267
hcp-3Protein HCP-30.263
lin-17Protein LIN-170.257
dsh-2Protein DSH-20.252
ina-1Protein INA-10.252
sdz-28Protein SDZ-280.243
htp-3Protein HTP-30.240
T09B4.5Protein T09B4.50.238
lin-12Protein LIN-120.237
patr-1Protein PATR-10.236
flt-1Protein FLT-10.236
hbl-1Protein HBL-10.235
unc-62Protein UNC-620.230
lrp-2Protein LRP-20.226
cks-1Protein CKS-10.225
sas-5Protein SAS-50.224
ten-1Protein TEN-10.223
CELE_Y41E3.11Protein Y41E3.110.217
apr-1Protein APR-10.214
lin-11Protein LIN-110.213
nhr-34Protein NHR-340.210
crn-1Protein CRN-10.210
hda-3Protein HDA-30.209
zfp-1Protein ZFP-10.204
fkh-2Protein FKH-20.202
gck-2Protein GCK-20.202
eef-1A.1Protein EEF-1A.10.200
CELE_C12D8.1Protein C12D8.10.199
ZK1098.2Protein ZK1098.20.198
mom-2Protein MOM-20.198
hlh-30Protein HLH-300.197
etr-1Protein ETR-10.197
CELE_C23G10.8Protein C23G10.80.196
wrk-1Protein WRK-10.195
cam-1Protein CAM-10.195
tsp-12Protein TSP-120.195
cpb-1Protein CPB-10.193
egl-8Protein EGL-80.193
daf-12Protein DAF-120.191
eor-2Protein EOR-20.191
unc-37Protein UNC-370.191
inx-3Protein INX-30.190
lin-35Protein LIN-350.186
egl-27Protein EGL-270.184
ida-1Protein IDA-10.184
mig-6Protein MIG-60.183
ceh-32Protein CEH-320.182
lag-1Protein LAG-10.181
egl-44Protein EGL-440.181
ceh-20Protein CEH-200.181
rsbp-1Protein RSBP-10.179
nhr-67Protein NHR-670.179
sma-6Protein SMA-60.179
F10E7.11Protein F10E7.110.177
nhr-2Protein NHR-20.177
nhr-25Protein NHR-250.176
pde-4Protein PDE-40.176
cdc-26Protein CDC-260.176
ain-1Protein AIN-10.175
rpa-1Protein RPA-10.175
spc-1Protein SPC-10.175
eor-1Protein EOR-10.175
mig-32Protein MIG-320.174
htz-1Protein HTZ-10.172
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx16T-box gene 160.908
bmp2abone morphogenetic protein 2a0.843
tp53tumor protein p530.828
wnt8bwingless-type MMTV integration site family, member 8b0.793
alcamaactivated leukocyte cell adhesion molecule a0.748
bmp2bbone morphogenetic protein 2b0.666
mstnbmyostatin b0.641
notch3notch homolog 30.627
sox9bSRY-box containing gene 9b0.625
rargaretinoic acid receptor gamma a0.598
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.590
cdh1cadherin 1, epithelial0.582
ikzf1IKAROS family zinc finger 1 (Ikaros)0.567
nkx2.2aNK2 transcription factor related 2a0.562
amotl2aangiomotin like 2a0.545
hand2heart and neural crest derivatives expressed transcript 20.540
fabp11afatty acid binding protein 11a0.526
fgf10afibroblast growth factor 10a0.474
fgf3fibroblast growth factor 30.463
foxd5forkhead box D50.456
gdf6agrowth differentiation factor 6a0.453
ascl1aachaete-scute complex-like 1a (Drosophila)0.440
wnt11rwingless-type MMTV integration site family, member 11, related0.439
per3period homolog 3 (Drosophila)0.437
tcf7transcription factor 7 (T-cell specific, HMG-box)0.437
six4bsine oculis homeobox homolog 4b0.435
shhbsonic hedgehog b0.431
kdrlkinase insert domain receptor like0.413
tal1T-cell acute lymphocytic leukemia 10.410
wnt2bbwingless-type MMTV integration site family, member 2Bb0.410
pcdh8protocadherin 80.406
wnt5bwingless-type MMTV integration site family, member 5b0.379
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.378
slit3slit (Drosophila) homolog 30.370
foxa3forkhead box A30.356
pkd2polycystic kidney disease 20.349
wnt1wingless-type MMTV integration site family, member 10.341
ctgfconnective tissue growth factor0.331
wnt4awingless-type MMTV integration site family, member 4a0.328
acvr1lactivin A receptor, type I like0.323
sox19aSRY-box containing gene 19a0.323
jag2jagged 20.318
gli2aGLI-Kruppel family member GLI2a0.308
igf2ainsulin-like growth factor 2a0.307
maflv-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein L0.305
robo2roundabout homolog 20.301
ntn1anetrin 1a0.280
hmx4H6 family homeobox 40.276
her12hairy-related 120.273
arl4abADP-ribosylation factor-like 4ab0.273
ptf1apancreas specific transcription factor, 1a0.271
traf4atnf receptor-associated factor 4a0.270
lmx1b.1LIM homeobox transcription factor 1, beta 10.267
nrg2aneuregulin 2a0.263
hoxb3ahomeo box B3a0.253
irx5airoquois homeobox protein 5a0.253
igf1insulin-like growth factor 10.252
frzbfrizzled-related protein0.245
prox1prospero-related homeobox gene 10.245
hoxa13bhomeo box A13b0.243
pax7apaired box gene 7a0.240
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.240
tbx20T-box 200.230
evx1even-skipped homeobox 10.230
col8a1acollagen, type VIII, alpha 1a0.229
dlx5adistal-less homeobox gene 5a0.229
rarabretinoic acid receptor, alpha b0.228
etv2ets variant gene 20.225
gro1groucho 10.219
notch1anotch homolog 1a0.219
runx2brunt-related transcription factor 2b0.218
gli1GLI-Kruppel family member 10.217
klf4aKruppel-like transcription factor 4a0.217
elk4ELK4, ETS-domain protein0.217
tuba1tubulin, alpha 10.202
wnt3wingless-type MMTV integration site family, member 30.200
otpborthopedia homolog b0.198
hoxd4ahomeo box D4a0.192
fn1fibronectin 10.192
mespamesoderm posterior a0.191
fgfr1afibroblast growth factor receptor 1a0.191
nog1noggin 10.190
rad21RAD21 homolog (S. pombe)0.179
hmx3homeo box (H6 family) 30.178
col1a1acollagen, type I, alpha 1a0.174
fzd5frizzled homolog 50.173
stat3signal transduction and activation of transcription 30.173
dag1dystroglycan 10.173
gro2groucho 20.172
msxemuscle segment homeobox E0.172
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.171
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.170
hhiphedgehog interacting protein0.167
wnt10awingless-type MMTV integration site family, member 10a0.165
wnt2wingless-type MMTV integration site family member 20.165
ephb4beph receptor B4b0.165
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.999
bratbrain tumor0.986
G-oalpha47AG protein oalpha 47A0.986
Akt1CG4006 gene product from transcript CG4006-RA0.986
ovoCG6824 gene product from transcript CG6824-RE0.977
MadMothers against dpp0.974
CdsACDP diglyceride synthetase0.969
HopHsp70/Hsp90 organizing protein homolog0.954
DadDaughters against dpp0.951
sosine oculis0.908
MED4Mediator complex subunit 40.880
Su(H)Suppressor of Hairless0.866
E(spl)Enhancer of split0.836
EcREcdysone receptor0.816
ik2IkappaB kinase-like 20.813
slmbsupernumerary limbs0.805
nkdnaked cuticle0.797
ash2absent, small, or homeotic discs 20.793
CtBPC-terminal Binding Protein0.770
par-6CG5884 gene product from transcript CG5884-RA0.765
chbchromosome bows0.756
Pi3K92ECG4141 gene product from transcript CG4141-RB0.752
Tsc1CG6147 gene product from transcript CG6147-RA0.732
norpAno receptor potential A0.697
EgfrEpidermal growth factor receptor0.688
SceSex combs extra0.688
Pabp2CG2163 gene product from transcript CG2163-RA0.646
SmoxSmad on X0.645
htshu li tai shao0.630
Src64BSrc oncogene at 64B0.617
bambag of marbles0.598
Pp2B-14DProtein phosphatase 2B at 14D0.587
Su(var)2-10Suppressor of variegation 2-100.573
slp1sloppy paired 10.570
C3GCG42328 gene product from transcript CG42328-RC0.558
l(2)gllethal (2) giant larvae0.556
CG8155CG8155 gene product from transcript CG8155-RA0.556
Dap160Dynamin associated protein 1600.538
alpha-Catalpha Catenin0.512
kibrakibra ortholog0.511
ninaEneither inactivation nor afterpotential E0.505
Prp8pre-mRNA processing factor 80.496
myoglianinCG1838 gene product from transcript CG1838-RD0.496
CkIIalphaCasein kinase II alpha subunit0.495
Cdc42CG12530 gene product from transcript CG12530-RA0.494
Rca1Regulator of cyclin A10.490
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CREBBPCREB binding protein1.000
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa1.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
JUNjun proto-oncogene0.999
EGFRepidermal growth factor receptor0.997
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.996
CAV1caveolin 1, caveolae protein, 22kDa0.995
SMAD4SMAD family member 40.994
SMAD2SMAD family member 20.990
ARandrogen receptor0.989
FGFR2fibroblast growth factor receptor 20.987
YAP1Yes-associated protein 10.985
TAL1T-cell acute lymphocytic leukemia 10.982
JAG1jagged 10.970
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.969
PTPN1protein tyrosine phosphatase, non-receptor type 10.969
GSK3Bglycogen synthase kinase 3 beta0.966
FBLN1fibulin 10.957
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.952
NOTCH1notch 10.949
RXRAretinoid X receptor, alpha0.945
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.944
SMAD3SMAD family member 30.943
AXIN1axin 10.940
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.939
SMAD1SMAD family member 10.936
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.933
ZMYND11zinc finger, MYND-type containing 110.927
SMAD7SMAD family member 70.926
LTBP2latent transforming growth factor beta binding protein 20.922
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.917
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.916
MYOD1myogenic differentiation 10.912
SP1Sp1 transcription factor0.910
FN1fibronectin 10.909
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.908
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.905
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.902
HOXB5homeobox B50.896
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.896
ICAM1intercellular adhesion molecule 10.895
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.895
GRB7growth factor receptor-bound protein 70.884
C1QAcomplement component 1, q subcomponent, A chain0.882
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)0.876
CCR5chemokine (C-C motif) receptor 50.870
TEKTEK tyrosine kinase, endothelial0.868
COL1A1collagen, type I, alpha 10.868
NOTCH3notch 30.859
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.856
EP300E1A binding protein p3000.853
CTGFconnective tissue growth factor0.852
SOCS3suppressor of cytokine signaling 30.843
THBS1thrombospondin 10.842
PSEN1presenilin 10.840
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.832
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.831
RAD21RAD21 homolog (S. pombe)0.830
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.822
CCNE1cyclin E10.822
GATA4GATA binding protein 40.822
MED28mediator complex subunit 280.820
TP73tumor protein p730.820
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.817
IL8interleukin 80.815
BTRCbeta-transducin repeat containing0.815
ZNF43zinc finger protein 430.814
FGF1fibroblast growth factor 1 (acidic)0.813
CSNK1Ecasein kinase 1, epsilon0.808
LAMB1laminin, beta 10.808
ESR1estrogen receptor 10.801
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.798
BCAR1breast cancer anti-estrogen resistance 10.795
DICER1dicer 1, ribonuclease type III0.794
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.794
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.789
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.787
HIST1H2BDhistone cluster 1, H2bd0.785
SKILSKI-like oncogene0.784
ATF2activating transcription factor 20.778
PBX1pre-B-cell leukemia homeobox 10.776
APPamyloid beta (A4) precursor protein0.772
TGFB1transforming growth factor, beta 10.772
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.766
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.761
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.746
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.744
FLNAfilamin A, alpha0.743
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.742
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.732
FGFR1fibroblast growth factor receptor 10.724
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.721
SFRP1secreted frizzled-related protein 10.718
GATA2GATA binding protein 20.704
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.702
COL4A2collagen, type IV, alpha 20.702
FYNFYN oncogene related to SRC, FGR, YES0.700
SQSTM1sequestosome 10.695
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
S100a10S100 calcium binding protein A100.762
Nedd4neural precursor cell expressed, developmentally down-regulated 40.725
Fgfr2fibroblast growth factor receptor 20.591
Anxa2annexin A20.511
S100a6S100 calcium binding protein A60.435
Id1inhibitor of DNA binding 10.366
Tcf4transcription factor 40.338
Lgals3lectin, galactoside-binding, soluble, 30.335
Itgamintegrin, alpha M0.322
Gna15guanine nucleotide binding protein, alpha 150.311
Rararetinoic acid receptor, alpha0.310
Galr3galanin receptor 30.307
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.307
Cd4Cd4 molecule0.302
Socs3suppressor of cytokine signaling 30.288
Iappislet amyloid polypeptide0.275
Notch1Notch homolog 1, translocation-associated (Drosophila)0.265
JunJun oncogene0.260
Bmp1bone morphogenetic protein 10.251
Il2rbinterleukin 2 receptor, beta0.239
Ifitm3interferon induced transmembrane protein 30.230
Anxa5annexin A50.230
S100a11S100 calcium binding protein A11 (calizzarin)0.226
Ddr1discoidin domain receptor tyrosine kinase 10.226
Jak1Janus kinase 10.210
S100a9S100 calcium binding protein A90.207
Pls3plastin 3 (T-isoform)0.206
Ccl2chemokine (C-C motif) ligand 20.205
Marcksmyristoylated alanine rich protein kinase C substrate0.204
Tacr2tachykinin receptor 20.204
Ncr1natural cytotoxicity triggering receptor 10.202
Tgfbr2transforming growth factor, beta receptor II0.201
Gabrb1gamma-aminobutyric acid (GABA) A receptor, beta 10.196
Cd44Cd44 molecule0.186
Nrg1neuregulin 10.186
Hckhemopoietic cell kinase0.185
Cishcytokine inducible SH2-containing protein0.184
Stat6signal transducer and activator of transcription 60.180
Igfbp5insulin-like growth factor binding protein 50.178
Nos3nitric oxide synthase 3, endothelial cell0.178
Cxcl2chemokine (C-X-C motif) ligand 20.178
Cxcr5chemokine (C-X-C motif) receptor 50.176
Picalmphosphatidylinositol binding clathrin assembly protein0.175
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.175
Galgalanin prepropeptide0.173
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.169
Ldhclactate dehydrogenase C0.166
Slco2a1solute carrier organic anion transporter family, member 2a10.163
Ccl4chemokine (C-C motif) ligand 40.162
Ccl5chemokine (C-C motif) ligand 50.161
Sirpasignal-regulatory protein alpha0.160
Il1rninterleukin 1 receptor antagonist0.158
Lgals1lectin, galactoside-binding, soluble, 10.156
Akp3alkaline phosphatase 3, intestine, not Mn requiring0.153
Foxd3forkhead box D30.152
Rps6ka1ribosomal protein S6 kinase polypeptide 10.148
Selpselectin P0.148
Nrp1neuropilin 10.147
Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.145
Myadmmyeloid-associated differentiation marker0.144
Smad1SMAD family member 10.142
Anxa1annexin A10.140
Tcof1Treacher Collins-Franceschetti syndrome 1 homolog (human)0.140
Prss22protease, serine, 220.140
Twist2twist homolog 2 (Drosophila)0.139
Gja1gap junction protein, alpha 10.138
Cxcl10chemokine (C-X-C motif) ligand 100.136
Acvr1activin A receptor, type I0.135
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.135
Ubtfupstream binding transcription factor, RNA polymerase I0.134
Sardhsarcosine dehydrogenase0.134
Pld1phospholipase D10.131
Apohapolipoprotein H (beta-2-glycoprotein I)0.131
NrarpNotch-regulated ankyrin repeat protein0.127
Ctrcchymotrypsin C (caldecrin)0.126
Trim29tripartite motif-containing 290.125
S100a8S100 calcium binding protein A80.124
S100a4S100 calcium-binding protein A40.123
Notch3Notch homolog 3 (Drosophila)0.122
Cd5Cd5 molecule0.121
Arpc1bactin related protein 2/3 complex, subunit 1B0.121
Il12binterleukin 12B0.121
Slit3slit homolog 3 (Drosophila)0.121
Cd9CD9 molecule0.120
Pnliprp1pancreatic lipase-related protein 10.120
Nos1nitric oxide synthase 1, neuronal0.119
Icam1intercellular adhesion molecule 10.119
Cntn2contactin 2 (axonal)0.119
Timp3TIMP metallopeptidase inhibitor 30.119
Gata6GATA binding protein 60.118
TriobpTRIO and F-actin binding protein0.118
Cfpcomplement factor properdin0.118
Il1binterleukin 1 beta0.116
Pdgfbplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.116
Bcl2B-cell CLL/lymphoma 20.114
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism