The network for 'programmed necrotic cell death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

programmed necrotic cell death

A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.

NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
BIRC3baculoviral IAP repeat containing 31.000
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 11.000
FADDFas (TNFRSF6)-associated via death domain1.000
FASFas (TNF receptor superfamily, member 6)0.994
TRAF1TNF receptor-associated factor 10.994
CFLARCASP8 and FADD-like apoptosis regulator0.993
CASP10caspase 10, apoptosis-related cysteine peptidase0.993
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.985
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.981
BIRC2baculoviral IAP repeat containing 20.974
TRADDTNFRSF1A-associated via death domain0.968
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.935
TRAF2TNF receptor-associated factor 20.922
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.878
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.703
RIPK2receptor-interacting serine-threonine kinase 20.614
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.599
TBK1TANK-binding kinase 10.539
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.493
TANKTRAF family member-associated NFKB activator0.472
RNF31ring finger protein 310.461
BBS10Bardet-Biedl syndrome 100.385
NLRC4NLR family, CARD domain containing 40.307
TRAF3TNF receptor-associated factor 30.292
FASLGFas ligand (TNF superfamily, member 6)0.285
RIPK3receptor-interacting serine-threonine kinase 30.277
CASP3caspase 3, apoptosis-related cysteine peptidase0.255
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.192
BAK1BCL2-antagonist/killer 10.175
TNFAIP3tumor necrosis factor, alpha-induced protein 30.150
BIDBH3 interacting domain death agonist0.148
TNFtumor necrosis factor0.146
MAP3K14mitogen-activated protein kinase kinase kinase 140.120
CASP7caspase 7, apoptosis-related cysteine peptidase0.117
CLTCclathrin, heavy chain (Hc)0.113
CASP4caspase 4, apoptosis-related cysteine peptidase0.108
SMCR7Smith-Magenis syndrome chromosome region, candidate 70.108
DAXXdeath-domain associated protein0.105
MAP2K4mitogen-activated protein kinase kinase 40.098
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.092
TRAF6TNF receptor-associated factor 60.090
CYLDcylindromatosis (turban tumor syndrome)0.088
HDAC6histone deacetylase 60.079
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.079
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.076
MDM2Mdm2 p53 binding protein homolog (mouse)0.073
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.072
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.068
RNF144Bring finger protein 144B0.060
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.053
XIAPX-linked inhibitor of apoptosis0.050
BCL2B-cell CLL/lymphoma 20.050
MAP3K1mitogen-activated protein kinase kinase kinase 10.050
ZBTB16zinc finger and BTB domain containing 160.045
THOC3THO complex 30.037
MAPK1mitogen-activated protein kinase 10.036
EEF2eukaryotic translation elongation factor 20.034
SHARPINSHANK-associated RH domain interactor0.032
MAP2K7mitogen-activated protein kinase kinase 70.030
FBXO33F-box protein 330.030
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.029
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.028
TRIM21tripartite motif containing 210.028
PPP6Cprotein phosphatase 6, catalytic subunit0.026
C1orf93chromosome 1 open reading frame 930.026
NOD2nucleotide-binding oligomerization domain containing 20.024
GRPEL1GrpE-like 1, mitochondrial (E. coli)0.024
CASP9caspase 9, apoptosis-related cysteine peptidase0.024
MYH10myosin, heavy chain 10, non-muscle0.023
TRIM38tripartite motif containing 380.023
USP15ubiquitin specific peptidase 150.023
DIABLOdiablo, IAP-binding mitochondrial protein0.023
MYH14myosin, heavy chain 14, non-muscle0.023
PYCARDPYD and CARD domain containing0.021
LMO4LIM domain only 40.020
SOCS1suppressor of cytokine signaling 10.020
HSPA1Lheat shock 70kDa protein 1-like0.020
BECN1beclin 1, autophagy related0.019
TRIM25tripartite motif containing 250.018
MAPK8mitogen-activated protein kinase 80.018
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.017
EIF4A1eukaryotic translation initiation factor 4A10.017
YBX1Y box binding protein 10.016
SLC25A5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.016
PABPC4poly(A) binding protein, cytoplasmic 4 (inducible form)0.015
ARRB2arrestin, beta 20.015
NOD1nucleotide-binding oligomerization domain containing 10.015
PRF1perforin 1 (pore forming protein)0.015
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.014
TUBA3Ctubulin, alpha 3c0.014
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.014
PITPNAphosphatidylinositol transfer protein, alpha0.014
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.014
NLKnemo-like kinase0.014
FKBP5FK506 binding protein 50.014
OXA1Loxidase (cytochrome c) assembly 1-like0.013
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor1.000
Tnfaip3tumor necrosis factor, alpha-induced protein 30.994
Ikbkginhibitor of kappaB kinase gamma0.993
Traf2TNF receptor-associated factor 20.991
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.986
Casp8caspase 80.973
Ighimmunoglobulin heavy chain complex0.964
Trp53transformation related protein 530.954
Ptenphosphatase and tensin homolog0.932
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.919
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.914
Ltalymphotoxin A0.826
Ikbkbinhibitor of kappaB kinase beta0.806
Myd88myeloid differentiation primary response gene 880.728
Itchitchy, E3 ubiquitin protein ligase0.726
FasFas (TNF receptor superfamily member 6)0.710
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.691
Cd19CD19 antigen0.687
Map3k14mitogen-activated protein kinase kinase kinase 140.678
BaxBCL2-associated X protein0.642
Tlr4toll-like receptor 40.627
Rnf31ring finger protein 310.613
SharpinSHANK-associated RH domain interacting protein0.610
Map3k7mitogen-activated protein kinase kinase kinase 70.600
Cd40CD40 antigen0.595
Ltblymphotoxin B0.580
Trp63transformation related protein 630.488
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.480
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.468
Ifnginterferon gamma0.465
Birc3baculoviral IAP repeat-containing 30.457
FaddFas (TNFRSF6)-associated via death domain0.357
Bcl3B-cell leukemia/lymphoma 30.351
Bak1BCL2-antagonist/killer 10.334
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.317
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.306
Il7interleukin 70.255
Stat3signal transducer and activator of transcription 30.246
Stat2signal transducer and activator of transcription 20.240
Atf2activating transcription factor 20.234
Nlrp3NLR family, pyrin domain containing 30.227
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.203
Irf1interferon regulatory factor 10.194
Il10interleukin 100.178
Socs1suppressor of cytokine signaling 10.159
Mdm4transformed mouse 3T3 cell double minute 40.159
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.148
Stat6signal transducer and activator of transcription 60.142
Map3k1mitogen-activated protein kinase kinase kinase 10.137
Irf8interferon regulatory factor 80.128
Lystlysosomal trafficking regulator0.124
Foxp3forkhead box P30.123
Cxcl13chemokine (C-X-C motif) ligand 130.122
Mapk8mitogen-activated protein kinase 80.119
Ripk3receptor-interacting serine-threonine kinase 30.117
Hccsholocytochrome c synthetase0.115
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.108
Mavsmitochondrial antiviral signaling protein0.107
Chukconserved helix-loop-helix ubiquitous kinase0.106
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.106
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.100
Map3k8mitogen-activated protein kinase kinase kinase 80.099
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.093
Gbp2guanylate binding protein 20.093
Gbp3guanylate binding protein 30.093
Il1r1interleukin 1 receptor, type I0.079
Ticam1toll-like receptor adaptor molecule 10.078
Tcf3transcription factor 30.076
Ncoa3nuclear receptor coactivator 30.071
Ikzf1IKAROS family zinc finger 10.071
1810019J16RikRIKEN cDNA 1810019J16 gene0.070
Il6stinterleukin 6 signal transducer0.064
Icosinducible T-cell co-stimulator0.061
PycardPYD and CARD domain containing0.061
Cyldcylindromatosis (turban tumor syndrome)0.061
Card11caspase recruitment domain family, member 110.057
Casp7caspase 70.056
Stim2stromal interaction molecule 20.056
Bcl2B-cell leukemia/lymphoma 20.055
Trim21tripartite motif-containing 210.054
Aicdaactivation-induced cytidine deaminase0.054
Irf4interferon regulatory factor 40.053
Cxcr5chemokine (C-X-C motif) receptor 50.050
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.050
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.050
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.050
Pmlpromyelocytic leukemia0.048
Pou2af1POU domain, class 2, associating factor 10.048
Casp3caspase 30.046
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.046
Traf6TNF receptor-associated factor 60.046
Batfbasic leucine zipper transcription factor, ATF-like0.045
Trp73transformation related protein 730.044
Ltbrlymphotoxin B receptor0.043
Eya2eyes absent 2 homolog (Drosophila)0.043
Mlklmixed lineage kinase domain-like0.042
BidBH3 interacting domain death agonist0.041
Tgfb1transforming growth factor, beta 10.041
Bcl6B-cell leukemia/lymphoma 60.040
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Mcpt8mast cell protease 80.586
Ccl5chemokine (C-C motif) ligand 50.490
Cpa3carboxypeptidase A3, mast cell0.336
Cma1chymase 1, mast cell0.256
Prf1perforin 1 (pore forming protein)0.241
Il1binterleukin 1 beta0.202
Slfn2schlafen 20.177
Mdh1malate dehydrogenase 1, NAD (soluble)0.135
Mcpt10mast cell protease 100.117
Igsf6immunoglobulin superfamily, member 60.068
Klrd1killer cell lectin-like receptor, subfamily D, member 10.065
Xcl1chemokine (C motif) ligand 10.061
Mcpt9mast cell protease 90.060
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.056
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.054
Neurl3neuralized homolog 3 (Drosophila)0.049
Rabac1Rab acceptor 1 (prenylated)0.048
Oas1b2-5 oligoadenylate synthetase 1B0.048
Clca4chloride channel accessory 40.047
Smek2SMEK homolog 2, suppressor of mek1 (Dictyostelium)0.045
Gzmcgranzyme C0.045
Klrg1killer cell lectin-like receptor subfamily G, member 10.041
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.040
Cxcl10chemokine (C-X-C motif) ligand 100.038
Pkn2protein kinase N20.035
Tmigd1transmembrane and immunoglobulin domain containing 10.034
Tsxtestis specific X-linked gene0.032
Slc27a1solute carrier family 27 (fatty acid transporter), member 10.032
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.032
Ccr1chemokine (C-C motif) receptor 10.032
Cd2Cd2 molecule0.030
Il1ainterleukin 1 alpha0.029
Il2rbinterleukin 2 receptor, beta0.029
Grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.029
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.028
Hckhemopoietic cell kinase0.027
Ireb2iron responsive element binding protein 20.026
Myd88myeloid differentiation primary response gene 880.026
Ccl2chemokine (C-C motif) ligand 20.025
Il7rinterleukin 7 receptor0.025
Fcn1ficolin (collagen/fibrinogen domain containing) 10.025
Bpgm2,3-bisphosphoglycerate mutase0.024
Ptpn6protein tyrosine phosphatase, non-receptor type 60.024
RGD1564878similar to natural killer cell protease 70.024
Clec9aC-type lectin domain family 9, member a0.023
Sbpspermine binding protein0.023
Fabp4fatty acid binding protein 4, adipocyte0.022
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.022
Tfrctransferrin receptor0.021
Mcpt2mast cell protease 20.021
P2ry14purinergic receptor P2Y, G-protein coupled, 140.021
Cd52CD52 antigen0.021
Gzmbgranzyme B0.021
Il1rl1interleukin 1 receptor-like 10.020
Smc5structural maintenance of chromosomes 50.020
Mca32mast cell antigen 320.020
Spag9sperm associated antigen 90.019
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.019
Ptgfrprostaglandin F receptor0.019
Il1r2interleukin 1 receptor, type II0.019
Slc48a1solute carrier family 48 (heme transporter), member 10.019
Fcnbficolin B0.019
Il18interleukin 180.019
Ctsecathepsin E0.019
LOC287167globin, alpha0.018
Rps6kb1ribosomal protein S6 kinase, polypeptide 10.018
Rnf10ring finger protein 100.018
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.018
Hpgdshematopoietic prostaglandin D synthase0.018
Zfp36l2zinc finger protein 36, C3H type-like 20.018
Map3k8mitogen-activated protein kinase kinase kinase 80.017
Map4k1mitogen activated protein kinase kinase kinase kinase 10.017
Il6interleukin 60.017
Stat4signal transducer and activator of transcription 40.017
Cxcl11chemokine (C-X-C motif) ligand 110.017
Apol3apolipoprotein L, 30.017
Trim23tripartite motif-containing 230.017
Il15interleukin 150.017
Ccl11chemokine (C-C motif) ligand 110.016
Gfi1growth factor independent 1 transcription repressor0.016
Cd3gCD3 molecule, gamma0.016
Ifit3interferon-induced protein with tetratricopeptide repeats 30.016
Nkg7natural killer cell group 7 sequence0.016
Cst3cystatin C0.016
Hist1h2bahistone cluster 1, H2ba0.016
Gys2glycogen synthase 20.016
Lilrb3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.016
Arhgef5Rho guanine nucleotide exchange factor (GEF) 50.016
Hk2hexokinase 20.016
Cyp4f5cytochrome P450, family 4, subfamily f, polypeptide 50.016
Cd40CD40 molecule, TNF receptor superfamily member 50.016
Gcnt1glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)0.016
Mcpt3mast cell peptidase 30.015
Klre1killer cell lectin-like receptor, family E, member 10.015
Pyypeptide YY (mapped)0.015
Tp53tumor protein p530.015
Irak3interleukin-1 receptor-associated kinase 30.015
Qarsglutaminyl-tRNA synthetase0.014
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism