The network for 'stem cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

stem cell proliferation

The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.

NameDescriptionProbabilityFunc Analog Organism
hlh-2Protein HLH-20.327
pha-4Protein PHA-40.223
egl-18Protein EGL-180.205
egl-30Protein EGL-300.178
cnd-1Protein CND-10.171
ten-1Protein TEN-10.165
par-1Protein PAR-10.158
lag-1Protein LAG-10.149
tag-260Protein TAG-2600.140
nhr-67Protein NHR-670.139
tpxl-1Protein TPXL-10.135
sun-1Protein SUN-10.116
K10C3.4Protein K10C3.40.102
hlh-30Protein HLH-300.102
pig-1Protein PIG-10.097
unc-62Protein UNC-620.093
pry-1Protein PRY-10.087
hcp-4Protein HCP-40.074
cam-1Protein CAM-10.073
egl-13Protein EGL-130.070
F36D4.5Protein F36D4.50.062
zim-1Protein ZIM-10.061
let-60Protein LET-600.061
pde-4Protein PDE-40.059
fmi-1Protein FMI-10.058
CELE_F53H1.3Protein F53H1.30.056
sma-6Protein SMA-60.055
lin-25Protein LIN-250.054
nhr-34Protein NHR-340.050
lin-17Protein LIN-170.049
flt-1Protein FLT-10.048
grd-1Protein GRD-10.047
zyg-8Protein ZYG-80.046
daf-12Protein DAF-120.045
dlk-1Protein DLK-10.045
lsy-2Protein LSY-20.045
imb-2Protein IMB-20.041
sur-2Protein SUR-20.038
mes-4Protein MES-40.037
emb-5Protein EMB-50.037
ham-2Protein HAM-20.034
pgp-10Protein PGP-100.033
sas-4Protein SAS-40.033
ast-1Protein AST-10.032
par-5Protein PAR-50.032
hlh-14Protein HLH-140.032
ztf-2Protein ZTF-20.031
lin-59Protein LIN-590.031
mrg-1Protein MRG-10.030
pal-1Protein PAL-10.030
CELE_F20D1.1Protein F20D1.10.029
swsn-7Protein SWSN-70.029
kin-19Protein KIN-190.027
vpr-1Protein VPR-10.027
tax-6Protein TAX-60.027
fkh-2Protein FKH-20.027
unc-76Protein UNC-760.027
mei-1Protein MEI-10.026
sam-10Protein SAM-100.026
elt-6Protein ELT-60.024
B0464.6Protein B0464.60.024
par-6Protein PAR-60.024
unc-11Protein UNC-110.023
Y65A5A.1Protein Y65A5A.10.023
rde-2Protein RDE-20.021
mop-25.2Protein MOP-25.20.021
rab-11.1Protein RAB-11.10.021
goa-1Protein GOA-10.020
T10B10.8Protein T10B10.80.020
bar-1Protein BAR-10.020
sdn-1Protein SDN-10.019
ref-1Protein REF-10.018
hlh-1Protein HLH-10.018
tbb-4Protein TBB-40.018
T20D3.11Protein T20D3.110.017
egl-15Protein EGL-150.017
nphp-4Protein NPHP-40.017
T23G4.3Protein T23G4.30.017
C28C12.12Protein C28C12.120.017
tps-1Protein TPS-10.016
F55A12.5Protein F55A12.50.016
tbx-11Protein TBX-110.016
mlk-1Protein MLK-10.016
Y7A9D.1Protein Y7A9D.10.016
F26E4.7Protein F26E4.70.016
ain-1Protein AIN-10.016
nhr-6Protein NHR-60.015
elt-7Protein ELT-70.015
vha-4Protein VHA-40.015
C34D10.2Protein C34D10.20.015
dhhc-1Protein DHHC-10.015
zip-7Protein ZIP-70.015
hlh-11Protein HLH-110.014
sos-1Protein SOS-10.014
F39B2.1Protein F39B2.10.014
csnk-1Protein CSNK-10.014
air-2Protein AIR-20.014
elc-1Protein ELC-10.014
patr-1Protein PATR-10.014
npp-22Protein NPP-220.014
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.951
pitx3paired-like homeodomain transcription factor 30.905
rargaretinoic acid receptor gamma a0.883
dlx5adistal-less homeobox gene 5a0.878
bmp2abone morphogenetic protein 2a0.843
dkk1bdickkopf 1b0.826
fgf3fibroblast growth factor 30.801
six2asine oculis-related homeobox 2a0.800
notch3notch homolog 30.760
bmp2bbone morphogenetic protein 2b0.742
ndr2nodal-related 20.728
hoxd4ahomeo box D4a0.719
sox32SRY-box containing gene 320.711
hey1hairy/enhancer-of-split related with YRPW motif 10.690
sox2SRY-box containing gene 20.685
sulf1sulfatase 10.681
col2a1acollagen type II, alpha-1a0.671
nkx2.5NK2 transcription factor related 50.638
fgf10afibroblast growth factor 10a0.637
wnt2bbwingless-type MMTV integration site family, member 2Bb0.628
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.622
prickle2prickle-like 2 (Drosophila)0.613
otx2orthodenticle homolog 20.612
sox1aSRY-box containing gene 1a0.607
ilkintegrin linked kinase0.607
rxrbbretinoid x receptor, beta b0.603
atoh1aatonal homolog 1a0.562
nkx2.3NK2 transcription factor related 30.556
mab21l2mab-21-like 20.543
hoxc1ahomeo box C1a0.539
msxcmuscle segment homeobox C0.535
ephb4beph receptor B4b0.534
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.532
fzd7afrizzled homolog 7a0.532
lef1lymphocyte enhancer binding factor 10.529
bocbrother of CDO0.528
eya1eyes absent homolog 10.527
pitx2paired-like homeodomain transcription factor 20.522
spry2sprouty homolog 20.519
irx3airoquois homeobox protein 3a0.510
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.503
gli1GLI-Kruppel family member 10.500
irx5airoquois homeobox protein 5a0.494
gro1groucho 10.493
flot2aflotillin 2a0.487
brpf1bromodomain and PHD finger containing, 10.487
alcambactivated leukocyte cell adhesion molecule b0.478
dusp6dual specificity phosphatase 60.474
pea3ETS-domain transcription factor pea30.468
foxi1forkhead box I10.452
zic1zic family member 1 (odd-paired homolog, Drosophila)0.449
jag1bjagged 1b0.448
wnt3wingless-type MMTV integration site family, member 30.446
her8ahairy-related 8a0.445
igfbp3insulin-like growth factor binding protein 30.439
foxn4forkhead box N40.432
sox19aSRY-box containing gene 19a0.424
notch1anotch homolog 1a0.423
bhlhe22basic helix-loop-helix family, member e220.420
amotl2aangiomotin like 2a0.419
dlx2adistal-less homeobox gene 2a0.414
wnt4awingless-type MMTV integration site family, member 4a0.413
nf1bneurofibromin 1b0.410
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.406
ptch2patched 20.404
leprleptin receptor0.403
fgfr1afibroblast growth factor receptor 1a0.403
her4.2hairy-related 4.20.389
nrarpanotch-regulated ankyrin repeat protein a0.385
fgfr4fibroblast growth factor receptor 40.376
pcdh18bprotocadherin 18b0.373
mapk3mitogen-activated protein kinase 30.370
LOC100003514protein kinase C alpha type-like0.359
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.359
her1hairy-related 10.341
gng3guanine nucleotide binding protein (G protein), gamma 30.340
pdgfaaplatelet-derived growth factor alpha a0.337
gli3GLI-Kruppel family member GLI30.331
barhl2BarH-like 20.329
efnb1ephrin B10.328
ptmabprothymosin, alpha b0.327
onecutlone cut domain, family member, like0.325
nadl1.1neural adhesion molecule L1.10.324
ca7carbonic anhydrase VII0.323
myf5myogenic factor 50.320
melkmaternal embryonic leucine zipper kinase0.319
pknox1.2pbx/knotted 1 homeobox 1.20.317
prrx1apaired related homeobox 1a0.315
ascl1aachaete-scute complex-like 1a (Drosophila)0.315
traf4atnf receptor-associated factor 4a0.314
nkx3.2NK3 homeobox 20.313
mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.312
hmx2H6 family homeobox 20.310
axin2axin 2 (conductin, axil)0.310
fgfr2fibroblast growth factor receptor 20.310
edn1endothelin 10.308
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
emcextra macrochaetae0.992
Ggamma1G protein gamma 10.968
MED6Mediator complex subunit 60.959
cicubitus interruptus0.959
E(spl)Enhancer of split0.951
MED27Mediator complex subunit 270.907
Dhc64CDynein heavy chain 64C0.906
HLHm7E(spl) region transcript m70.904
HLHmgammaE(spl) region transcript mgamma0.889
SAKSak kinase0.858
MED11Mediator complex subunit 110.840
Rac1CG2248 gene product from transcript CG2248-RA0.786
ctpcut up0.748
SmoxSmad on X0.730
Rho1CG8416 gene product from transcript CG8416-RB0.724
l(2)gllethal (2) giant larvae0.694
rapretina aberrant in pattern0.677
InRInsulin-like receptor0.622
chbchromosome bows0.587
MED9Mediator complex subunit 90.586
G-ialpha65AG protein alphai subunit 65A0.582
DadDaughters against dpp0.563
EgfrEpidermal growth factor receptor0.517
MED4Mediator complex subunit 40.500
O-fut1O-fucosyltransferase 10.499
gcmglial cells missing0.483
Ras85DRas oncogene at 85D0.482
Su(H)Suppressor of Hairless0.467
CtBPC-terminal Binding Protein0.448
Stat92ESignal-transducer and activator of transcription protein at 92E0.446
toytwin of eyeless0.443
HLHm3E(spl) region transcript m30.430
MadMothers against dpp0.416
HLHm5E(spl) region transcript m50.414
numbCG3779 gene product from transcript CG3779-RB0.407
G-oalpha47AG protein oalpha 47A0.390
bratbrain tumor0.377
sas-6spindle assembly abnormal 60.362
rheaCG6831 gene product from transcript CG6831-RA0.357
HLHmbetaE(spl) region transcript mbeta0.357
slp1sloppy paired 10.324
slmbsupernumerary limbs0.315
malphaE(spl) region transcript malpha0.312
tefutelomere fusion0.297
katanin-60katanin 600.295
ponpartner of numb0.291
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.285
lkb1CG9374 gene product from transcript CG9374-RJ0.272
myoglianinCG1838 gene product from transcript CG1838-RD0.262
par-1CG8201 gene product from transcript CG8201-RA0.262
Adf1Adh transcription factor 10.252
CG5690CG5690 gene product from transcript CG5690-RA0.241
par-6CG5884 gene product from transcript CG5884-RA0.239
nkdnaked cuticle0.235
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.887
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.723
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.488
FGFR2fibroblast growth factor receptor 20.399
FBXW11F-box and WD repeat domain containing 110.398
EGFRepidermal growth factor receptor0.386
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.383
SMAD7SMAD family member 70.377
PRKCZprotein kinase C, zeta0.372
YAP1Yes-associated protein 10.211
EIF2C2eukaryotic translation initiation factor 2C, 20.201
STK11serine/threonine kinase 110.193
GRB2growth factor receptor-bound protein 20.192
FGFR1fibroblast growth factor receptor 10.180
IGF1Rinsulin-like growth factor 1 receptor0.168
SMAD2SMAD family member 20.161
PLCG1phospholipase C, gamma 10.159
FGF1fibroblast growth factor 1 (acidic)0.159
INSRinsulin receptor0.148
JUPjunction plakoglobin0.128
PAX3paired box 30.117
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.115
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.112
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.108
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.101
SKP1S-phase kinase-associated protein 10.099
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.096
EIF2C1eukaryotic translation initiation factor 2C, 10.094
NRP1neuropilin 10.085
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.084
ARHGAP1Rho GTPase activating protein 10.075
SOS1son of sevenless homolog 1 (Drosophila)0.074
GSK3Bglycogen synthase kinase 3 beta0.073
FKBP1AFK506 binding protein 1A, 12kDa0.070
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.067
EIF2C4eukaryotic translation initiation factor 2C, 40.067
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.066
POU3F2POU class 3 homeobox 20.064
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.061
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.059
EIF2C3eukaryotic translation initiation factor 2C, 30.059
TCF4transcription factor 40.057
IRS1insulin receptor substrate 10.057
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.055
TNIP2TNFAIP3 interacting protein 20.055
CDH5cadherin 5, type 2 (vascular endothelium)0.052
MAPTmicrotubule-associated protein tau0.051
BMPR1Abone morphogenetic protein receptor, type IA0.050
SHC1SHC (Src homology 2 domain containing) transforming protein 10.050
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.050
PSEN1presenilin 10.048
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.048
IL8interleukin 80.047
PTPN11protein tyrosine phosphatase, non-receptor type 110.046
HSPG2heparan sulfate proteoglycan 20.045
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.045
ATN1atrophin 10.042
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.042
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.041
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.040
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.040
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.038
NR4A1nuclear receptor subfamily 4, group A, member 10.038
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.038
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.037
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.036
CDK2cyclin-dependent kinase 20.036
FSTL1follistatin-like 10.035
APCadenomatous polyposis coli0.034
CTBP1C-terminal binding protein 10.034
GNAI3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 30.033
COX6Ccytochrome c oxidase subunit VIc0.033
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.033
CCT8chaperonin containing TCP1, subunit 8 (theta)0.032
CXCL3chemokine (C-X-C motif) ligand 30.032
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.032
LTBP4latent transforming growth factor beta binding protein 40.031
CBX5chromobox homolog 50.030
ZMYND11zinc finger, MYND-type containing 110.030
SNW1SNW domain containing 10.030
GRB10growth factor receptor-bound protein 100.030
FBLN5fibulin 50.030
TBX2T-box 20.030
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.030
SKIv-ski sarcoma viral oncogene homolog (avian)0.030
JUBjub, ajuba homolog (Xenopus laevis)0.030
ZBED1zinc finger, BED-type containing 10.030
DAXXdeath-domain associated protein0.029
SIRT1sirtuin 10.029
SFRP1secreted frizzled-related protein 10.029
TGFB1transforming growth factor, beta 10.028
PKP2plakophilin 20.028
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.028
FBLN1fibulin 10.027
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.027
MDM2Mdm2 p53 binding protein homolog (mouse)0.027
NCOR1nuclear receptor corepressor 10.026
ARID1AAT rich interactive domain 1A (SWI-like)0.026
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.025
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Gli3GLI-Kruppel family member GLI31.000
Fgfr2fibroblast growth factor receptor 21.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Otx2orthodenticle homolog 2 (Drosophila)0.999
Pax2paired box gene 20.999
Gli2GLI-Kruppel family member GLI20.998
Pax6paired box gene 60.998
Pax3paired box gene 30.998
Ptenphosphatase and tensin homolog0.997
Sox2SRY-box containing gene 20.997
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.995
Emx1empty spiracles homolog 1 (Drosophila)0.992
Bmp4bone morphogenetic protein 40.991
Smad6MAD homolog 6 (Drosophila)0.985
Pthlhparathyroid hormone-like peptide0.984
Hes1hairy and enhancer of split 1 (Drosophila)0.979
Ptch1patched homolog 10.979
Fgf10fibroblast growth factor 100.975
Emx2empty spiracles homolog 2 (Drosophila)0.972
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.971
Prrx1paired related homeobox 10.969
Foxc1forkhead box C10.961
Vegfavascular endothelial growth factor A0.960
Bdnfbrain derived neurotrophic factor0.960
Yap1yes-associated protein 10.958
Fgf8fibroblast growth factor 80.958
Ror2receptor tyrosine kinase-like orphan receptor 20.952
Acvr1activin A receptor, type 10.950
Lhx1LIM homeobox protein 10.942
Fzd8frizzled homolog 8 (Drosophila)0.939
Vax1ventral anterior homeobox containing gene 10.939
Smosmoothened homolog (Drosophila)0.937
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.925
Fgfr3fibroblast growth factor receptor 30.924
Nr5a1nuclear receptor subfamily 5, group A, member 10.922
Msx1homeobox, msh-like 10.921
Sox7SRY-box containing gene 70.916
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.915
Pbx1pre B-cell leukemia transcription factor 10.909
Dlx5distal-less homeobox 50.897
Apcadenomatosis polyposis coli0.895
Kitkit oncogene0.895
Tbx3T-box 30.893
Foxc2forkhead box C20.883
Tbx15T-box 150.879
Hoxa10homeobox A100.877
Wnt5awingless-related MMTV integration site 5A0.876
Lef1lymphoid enhancer binding factor 10.875
Dkk1dickkopf homolog 1 (Xenopus laevis)0.871
Gdnfglial cell line derived neurotrophic factor0.870
Wnt3awingless-related MMTV integration site 3A0.867
Lhx3LIM homeobox protein 30.865
Msx2homeobox, msh-like 20.863
Hoxd11homeobox D110.863
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.861
Bmp7bone morphogenetic protein 70.858
Gata4GATA binding protein 40.854
Tbx2T-box 20.849
Zic3zinc finger protein of the cerebellum 30.849
Retret proto-oncogene0.849
Kitlkit ligand0.842
Snai1snail homolog 1 (Drosophila)0.840
Flt4FMS-like tyrosine kinase 40.827
Eya1eyes absent 1 homolog (Drosophila)0.811
Lhx5LIM homeobox protein 50.808
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.796
Meox2mesenchyme homeobox 20.791
Otx1orthodenticle homolog 1 (Drosophila)0.788
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.785
Hoxd13homeobox D130.776
Ntf3neurotrophin 30.768
Ascl1achaete-scute complex homolog 1 (Drosophila)0.758
Sox3SRY-box containing gene 30.751
Tgfb2transforming growth factor, beta 20.748
Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex0.733
Lmx1aLIM homeobox transcription factor 1 alpha0.718
Myod1myogenic differentiation 10.717
Lrp6low density lipoprotein receptor-related protein 60.717
Tgfbr2transforming growth factor, beta receptor II0.716
Kdrkinase insert domain protein receptor0.713
Neurod1neurogenic differentiation 10.711
Fgf3fibroblast growth factor 30.704
Prrx2paired related homeobox 20.698
Hand1heart and neural crest derivatives expressed transcript 10.694
Pafah1b1platelet-activating factor acetylhydrolase, isoform 1b, subunit 10.691
Wt1Wilms tumor 1 homolog0.691
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.690
Wnt1wingless-related MMTV integration site 10.689
Pitx2paired-like homeodomain transcription factor 20.684
Sox11SRY-box containing gene 110.680
Zeb1zinc finger E-box binding homeobox 10.677
Twist2twist homolog 2 (Drosophila)0.676
Tead2TEA domain family member 20.674
Pitx1paired-like homeodomain transcription factor 10.671
Nfianuclear factor I/A0.666
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.661
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hoxb8homeo box B80.016
Ptp4a1protein tyrosine phosphatase type IVA, member 10.013
Myh9myosin, heavy chain 9, non-muscle0.013
Drd3dopamine receptor D30.012
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism