The network for 'cellular response to stress' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

NameDescriptionProbabilityFunc Analog Organism
abu-15Protein ABU-150.848
egl-18Protein EGL-180.826
glp-1Protein GLP-10.601
csn-5Protein CSN-50.549
vab-1Protein VAB-10.549
abu-11Protein ABU-110.499
F58B3.6Protein F58B3.60.451
acs-4Protein ACS-40.440
spd-2Protein SPD-20.417
mes-4Protein MES-40.408
mat-3Protein MAT-30.399
hsp-16.1Protein HSP-16.10.399
hsp-16.2Protein HSP-16.20.394
CELE_T05E11.3Protein T05E11.30.376
hsr-9Protein HSR-90.371
pme-3Protein PME-30.368
retr-1Protein RETR-10.361
let-502Protein LET-5020.353
dpf-3Protein DPF-30.345
abu-8Protein ABU-80.338
gon-4Protein GON-40.337
dao-5Protein DAO-50.327
mel-28Protein MEL-280.325
npl-4.2Protein NPL-4.20.324
pas-6Protein PAS-60.316
pqn-54Protein PQN-540.310
rpt-2Protein RPT-20.310
R11A8.7Protein R11A8.70.306
abu-1Protein ABU-10.304
rpn-11Protein RPN-110.299
CELE_Y69A2AR.16Protein Y69A2AR.160.295
dnj-12Protein DNJ-120.293
rpt-5Protein RPT-50.278
Y110A7A.4Protein Y110A7A.40.275
C34E10.8Protein C34E10.80.274
dnj-13Protein DNJ-130.274
plc-1Protein PLC-10.273
soc-2Protein SOC-20.270
nhr-6Protein NHR-60.254
tbb-2Protein TBB-20.252
crt-1Protein CRT-10.250
hsp-3Protein HSP-30.244
rpt-3Protein RPT-30.243
lin-37Protein LIN-370.242
mek-2Protein MEK-20.241
CELE_T06E4.9Protein T06E4.90.241
mrt-2Protein MRT-20.237
rpa-1Protein RPA-10.236
zyg-8Protein ZYG-80.235
eef-1A.1Protein EEF-1A.10.233
chk-1Protein CHK-10.231
ifg-1Protein IFG-10.219
mbk-1Protein MBK-10.217
Y47D3B.6Protein Y47D3B.60.216
nhr-69Protein NHR-690.213
mcm-7Protein MCM-70.212
C27A12.7Protein C27A12.70.211
Y44E3A.6Protein Y44E3A.60.210
hsp-16.41Protein HSP-16.410.209
csn-4Protein CSN-40.207
vang-1Protein VANG-10.207
air-1Protein AIR-10.207
mix-1Protein MIX-10.206
hus-1Protein HUS-10.204
pbs-5Protein PBS-50.204
unc-51Protein UNC-510.201
CELE_F42F12.3Protein F42F12.30.199
ire-1Protein IRE-10.198
ftt-2Protein FTT-20.198
prp-21Protein PRP-210.198
dpy-30Protein DPY-300.196
polh-1Protein POLH-10.193
mis-12Protein MIS-120.190
elt-6Protein ELT-60.187
his-62Protein HIS-620.186
zyg-9Protein ZYG-90.185
abu-6Protein ABU-60.185
lin-35Protein LIN-350.184
hpo-21Protein HPO-210.183
lag-1Protein LAG-10.181
ucr-2.3Protein UCR-2.30.180
T05E8.3Protein T05E8.30.180
gst-1Protein GST-10.179
cash-1Protein CASH-10.178
CELE_C12D8.1Protein C12D8.10.178
npp-20Protein NPP-200.177
rpt-1Protein RPT-10.177
smp-1Protein SMP-10.176
dct-18Protein DCT-180.176
mig-5Protein MIG-50.175
cyn-4Protein CYN-40.174
ifd-1Protein IFD-10.174
ykt-6Protein YKT-60.173
lin-5Protein LIN-50.173
itx-1Protein ITX-10.173
knl-1Protein KNL-10.173
sec-22Protein SEC-220.171
Y82E9BR.13Protein Y82E9BR.130.169
eri-1Protein ERI-10.169
ect-2Protein ECT-20.168
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
wnt2bbwingless-type MMTV integration site family, member 2Bb0.577
jag2jagged 20.430
notch3notch homolog 30.384
spry4sprouty (Drosophila) homolog 40.333
csnk1dacasein kinase 1, delta a0.333
dkk1bdickkopf 1b0.316
ranras-related nuclear protein0.313
rspo3R-spondin 3 homolog (Xenopus laevis)0.301
ripk2receptor-interacting serine-threonine kinase 20.300
dag1dystroglycan 10.290
her15.1hairy and enhancer of split-related 15.10.270
junbjun B proto-oncogene0.222
tbx16T-box gene 160.211
fen1flap structure-specific endonuclease 10.211
flhfloating head0.205
tgfb3transforming growth factor, beta 30.191
ctsl1acathepsin L, 1 a0.190
tbx6T-box gene 60.187
lmx1b.1LIM homeobox transcription factor 1, beta 10.170
mychmyelocytomatosis oncogene homolog0.170
psmb1proteasome (prosome, macropain) subunit, beta type, 10.164
mapk14amitogen-activated protein kinase 14a0.163
odc1ornithine decarboxylase 10.160
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.159
psma6aproteasome (prosome, macropain) subunit, alpha type, 6a0.157
psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.156
neurodneurogenic differentiation0.156
gata5GATA-binding protein 50.151
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.148
myod1myogenic differentiation 10.147
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.141
ctsl1bcathepsin L, 1 b0.141
tgif1TGFB-induced factor homeobox 10.137
brd2abromodomain-containing 2a0.136
fn1fibronectin 10.136
lamc1laminin, gamma 10.135
hspd1heat shock 60kD protein 1 (chaperonin)0.131
mmp9matrix metalloproteinase 90.125
gro1groucho 10.125
tbx1T-box 10.123
pcdh18bprotocadherin 18b0.122
fgf3fibroblast growth factor 30.118
tram1translocating chain-associating membrane protein 10.117
ube2iubiquitin-conjugating enzyme E2I0.116
osr1odd-skipped related 1 (Drosophila)0.114
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.114
hsp90b1heat shock protein 90, beta (grp94), member 10.114
per3period homolog 3 (Drosophila)0.112
maffv-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian)0.112
eif3jaeukaryotic translation initiation factor 3, subunit Ja0.111
hsp90a.2heat shock protein 90-alpha 20.109
sox32SRY-box containing gene 320.109
rhoabras homolog gene family, member Ab0.107
ndrg4N-myc downstream regulated gene 40.106
manfmesencephalic astrocyte-derived neurotrophic factor0.106
traf4atnf receptor-associated factor 4a0.105
cct8chaperonin containing TCP1, subunit 8 (theta)0.105
akt2v-akt murine thymoma viral oncogene homolog 20.105
grnbgranulin b0.103
mcl1amyeloid cell leukemia sequence 1a0.103
mapk1mitogen-activated protein kinase 10.102
zfyve26zinc finger, FYVE domain containing 260.102
dccdeleted in colorectal carcinoma0.102
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.102
sox9bSRY-box containing gene 9b0.102
gdnfglial cell derived neurotrophic factor0.102
myf5myogenic factor 50.102
chek1CHK1 checkpoint homolog (S. pombe)0.101
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.101
cct5chaperonin containing TCP1, subunit 5 (epsilon)0.100
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.099
alcamaactivated leukocyte cell adhesion molecule a0.099
srsf6bserine/arginine-rich splicing factor 6b0.099
ncor1nuclear receptor co-repressor 10.098
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.098
cdh1cadherin 1, epithelial0.098
rasl11bRAS-like, family 11, member B0.097
atoh1aatonal homolog 1a0.097
her9hairy-related 90.096
wdr76WD repeat domain 760.096
tbx2aT-box gene 2a0.096
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.096
gdf11growth differentiation factor 110.095
ppm1aaprotein phosphatase, Mg2+/Mn2+ dependent, 1Aa0.094
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.093
mpzmyelin protein zero0.092
dvl2dishevelled, dsh homolog 2 (Drosophila)0.091
bonbonnie and clyde0.091
hspa5heat shock protein 50.090
flt4fms-related tyrosine kinase 40.090
wnt5awingless-type MMTV integration site family, member 5a0.088
tuba1ltubulin, alpha 1, like0.088
cav1caveolin 10.087
adh5alcohol dehydrogenase 50.087
snrpasmall nuclear ribonucleoprotein polypeptide A0.086
appaamyloid beta (A4) precursor protein a0.086
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.660
S100a10S100 calcium binding protein A100.635
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.627
Jak1Janus kinase 10.539
JunJun oncogene0.535
Zfp36zinc finger protein 360.527
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.500
Alas2aminolevulinate, delta-, synthase 20.499
Hbbhemoglobin, beta0.492
Oaz1ornithine decarboxylase antizyme 10.481
Mapk1mitogen activated protein kinase 10.480
Anxa2annexin A20.476
Lgals3lectin, galactoside-binding, soluble, 30.469
Psmd13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.455
Il18interleukin 180.443
Psmb3proteasome (prosome, macropain) subunit, beta type 30.438
Gstp1glutathione S-transferase pi 10.427
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.425
Rab7aRAB7A, member RAS oncogene family0.413
Ftlferritin, light polypeptide0.408
Vegfavascular endothelial growth factor A0.408
Klf4Kruppel-like factor 4 (gut)0.403
S100a9S100 calcium binding protein A90.402
Socs3suppressor of cytokine signaling 30.388
Hspb1heat shock protein 10.383
LOC100364500RT1 class I, locus CE11-like0.380
Mapk9mitogen-activated protein kinase 90.377
Cd44Cd44 molecule0.367
Pfkfb16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.365
Prkcgprotein kinase C, gamma0.363
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.357
Tp53tumor protein p530.349
Dusp1dual specificity phosphatase 10.345
Junbjun B proto-oncogene0.345
Myo1bmyosin Ib0.345
Sf1splicing factor 10.344
Psme2proteasome (prosome, macropain) activator subunit 20.344
Il6interleukin 60.343
Ier3immediate early response 30.338
LOC100134871beta globin minor gene0.336
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.333
Metmet proto-oncogene0.326
Foxa2forkhead box A20.325
Btg2BTG family, member 20.320
Nedd4neural precursor cell expressed, developmentally down-regulated 40.308
Tspotranslocator protein0.303
Edn1endothelin 10.303
Prkg2protein kinase, cGMP-dependent, type II0.294
LOC100362824caveolin 2-like0.293
Cfpcomplement factor properdin0.289
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.285
Wdr26WD repeat domain 260.283
Dctn4dynactin 40.275
Fxyd4FXYD domain-containing ion transport regulator 40.272
Olr226olfactory receptor 2260.271
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.270
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.269
Gja6gap junction protein, alpha 60.268
Slc5a5solute carrier family 5 (sodium iodide symporter), member 50.267
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.266
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.261
Hes3hairy and enhancer of split 3 (Drosophila)0.258
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.257
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.254
Add2adducin 2 (beta)0.253
Hba-a2hemoglobin alpha, adult chain 20.252
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.252
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.250
LOC100360501ribonuclease inhibitor-like0.250
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.249
Taok1TAO kinase 10.248
MrgprfMAS-related GPR, member F0.247
Serpinb1aserine (or cysteine) proteinase inhibitor, clade B, member 1a0.247
Creb1cAMP responsive element binding protein 10.245
S100a6S100 calcium binding protein A60.245
Psmb2proteasome (prosome, macropain) subunit, beta type 20.242
Hoxa2homeo box A20.242
Syngr2synaptogyrin 20.239
Errfi1ERBB receptor feedback inhibitor 10.238
March5membrane-associated ring finger (C3HC4) 50.238
Gria1glutamate receptor, ionotropic, AMPA 10.234
Tcf12transcription factor 120.234
Cdkn1acyclin-dependent kinase inhibitor 1A0.234
Npffr2neuropeptide FF receptor 20.232
S1pr2sphingosine-1-phosphate receptor 20.232
Psmb4proteasome (prosome, macropain) subunit, beta type 40.231
Ednrbendothelin receptor type B0.231
Cxcl2chemokine (C-X-C motif) ligand 20.230
Ugt8UDP glycosyltransferase 80.229
Pparaperoxisome proliferator activated receptor alpha0.228
Psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.227
Cryabcrystallin, alpha B0.227
PVRpoliovirus receptor0.226
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.226
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.226
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism