The network for 'positive regulation of intracellular signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of intracellular signal transduction

Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.

NameDescriptionProbabilityFunc Analog Organism
hgrs-1Protein HGRS-10.693
sma-6Protein SMA-60.461
let-60Protein LET-600.440
msp-36Protein MSP-360.417
msp-78Protein MSP-780.343
egl-18Protein EGL-180.342
bar-1Protein BAR-10.325
msp-55Protein MSP-550.319
msp-59Protein MSP-590.265
msp-77Protein MSP-770.252
sem-5Protein SEM-50.220
msp-64Protein MSP-640.192
pry-1Protein PRY-10.135
msp-38Protein MSP-380.132
unc-40Protein UNC-400.131
mpk-1Protein MPK-10.131
msp-76Protein MSP-760.130
npp-7Protein NPP-70.127
nhr-6Protein NHR-60.122
msp-53Protein MSP-530.115
CELE_Y59E9AR.7Protein Y59E9AR.70.111
msp-79Protein MSP-790.102
gap-2Protein GAP-20.096
sel-8Protein SEL-80.094
msp-152Protein MSP-1520.091
unc-32Protein UNC-320.088
C34F6.10Protein C34F6.100.086
msp-19Protein MSP-190.082
ZK1248.17Protein ZK1248.170.081
msp-74Protein MSP-740.080
msp-31Protein MSP-310.075
lin-25Protein LIN-250.072
imb-2Protein IMB-20.070
plc-1Protein PLC-10.067
lmn-1Protein LMN-10.066
msp-40Protein MSP-400.066
let-23Protein LET-230.065
kal-1Protein KAL-10.064
msp-65Protein MSP-650.064
msp-33Protein MSP-330.063
itr-1Protein ITR-10.062
dpy-31Protein DPY-310.060
msp-10Protein MSP-100.060
F22D3.2Protein F22D3.20.057
ccf-1Protein CCF-10.056
daf-19Protein DAF-190.056
msp-45Protein MSP-450.055
msp-142Protein MSP-1420.055
sma-1Protein SMA-10.052
lin-29Protein LIN-290.051
eya-1Protein EYA-10.051
let-756Protein LET-7560.051
rap-1Protein RAP-10.050
pqn-44Protein PQN-440.050
msp-3Protein MSP-30.048
unc-94Protein UNC-940.047
zfp-3Protein ZFP-30.047
csnk-1Protein CSNK-10.046
nphp-4Protein NPHP-40.046
mel-11Protein MEL-110.045
CELE_F22D6.2Protein F22D6.20.045
msp-50Protein MSP-500.044
msp-63Protein MSP-630.044
Y59H11AM.1Protein Y59H11AM.10.043
CELE_C27D8.3Protein C27D8.30.043
ZK546.3Protein ZK546.30.042
ham-1Protein HAM-10.042
mab-31Protein MAB-310.041
guk-1Protein GUK-10.040
egl-30Protein EGL-300.039
cdf-1Protein CDF-10.039
mek-2Protein MEK-20.039
cst-1Protein CST-10.039
daf-2Protein DAF-20.037
exoc-7Protein EXOC-70.037
CELE_C17H12.13Protein C17H12.130.037
hmg-1.1Protein HMG-1.10.036
ykt-6Protein YKT-60.036
dpy-22Protein DPY-220.036
trim-9Protein TRIM-90.036
rpm-1Protein RPM-10.035
glr-4Protein GLR-40.035
eor-2Protein EOR-20.035
cdt-1Protein CDT-10.035
sys-1Protein SYS-10.035
CELE_Y41D4B.4Protein Y41D4B.40.035
K10D6.4Protein K10D6.40.035
thoc-1Protein THOC-10.034
CELE_T03F6.3Protein T03F6.30.034
sur-2Protein SUR-20.034
nspd-2Protein NSPD-20.034
zoo-1Protein ZOO-10.033
tlk-1Protein TLK-10.033
mom-4Protein MOM-40.033
ubc-20Protein UBC-200.033
sym-4Protein SYM-40.032
lin-53Protein LIN-530.032
CELE_F52C6.12Protein F52C6.120.032
mat-3Protein MAT-30.031
K08E3.5Protein K08E3.50.031
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2abone morphogenetic protein 2a0.170
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.055
shhasonic hedgehog a0.046
cd63Cd63 antigen0.040
angptl2angiopoietin-like 20.037
prox1prospero-related homeobox gene 10.035
tal1T-cell acute lymphocytic leukemia 10.035
neo1neogenin 10.033
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.030
plcg1phospholipase C, gamma 10.029
tnfrsfatumor necrosis factor receptor superfamily, member a0.028
cdoncell adhesion molecule-related/down-regulated by oncogenes0.028
hey1hairy/enhancer-of-split related with YRPW motif 10.027
pkd2polycystic kidney disease 20.027
lmx1b.1LIM homeobox transcription factor 1, beta 10.026
ip6k2inositol hexaphosphate kinase 20.026
igf1insulin-like growth factor 10.026
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.026
ywhabatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a0.025
dll4delta-like 4 (Drosophila)0.025
jag1bjagged 1b0.025
bdnfbrain-derived neurotrophic factor0.024
foxp2forkhead box P20.023
fzd7afrizzled homolog 7a0.022
esr1estrogen receptor 10.022
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.022
phox2bpaired-like homeobox 2b0.022
igfbp1binsulin-like growth factor binding protein 1b0.021
notch1bnotch homolog 1b0.021
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.021
jag2jagged 20.021
evx1even-skipped homeobox 10.021
nod1nucleotide-binding oligomerization domain containing 10.021
zgc:73359zgc:733590.020
mifmacrophage migration inhibitory factor0.020
tbx2aT-box gene 2a0.020
bmp2bbone morphogenetic protein 2b0.019
gbx2gastrulation brain homeo box 20.019
si:dkeyp-22b2.3si:dkeyp-22b2.30.019
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.018
cxcr4bchemokine (C-X-C motif), receptor 4b0.018
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.018
il6stinterleukin 6 signal transducer0.018
atoh1aatonal homolog 1a0.018
efnb2aephrin B2a0.018
traf4atnf receptor-associated factor 4a0.017
nkx2.3NK2 transcription factor related 30.016
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.016
pdgfaaplatelet-derived growth factor alpha a0.016
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.016
fgfr4fibroblast growth factor receptor 40.016
tgfb3transforming growth factor, beta 30.016
adipor1badiponectin receptor 1b0.016
il6rinterleukin 6 receptor0.016
pcsk5bproprotein convertase subtilisin/kexin type 5b0.016
runx3runt-related transcription factor 30.016
tnfatumor necrosis factor a (TNF superfamily, member 2)0.015
gata1aGATA binding protein 1a0.015
plekhh1pleckstrin homology domain containing, family H (with MyTH4 domain) member 10.015
adrb2aadrenergic receptor, beta 2a0.015
stmn4stathmin-like 40.015
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.015
cyp1acytochrome P450, family 1, subfamily A0.015
thtyrosine hydroxylase0.015
celf1cugbp, Elav-like family member 10.014
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.014
cpceruloplasmin0.014
foxn4forkhead box N40.014
bocbrother of CDO0.014
angpt2angiopoietin 20.014
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.014
otpaorthopedia homolog a0.014
pcp4aPurkinje cell protein 4a0.014
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.014
leprleptin receptor0.014
twist1atwist1a0.014
bbc3BCL2 binding component 30.014
eporerythropoietin receptor0.014
si:dkey-8l13.4si:dkey-8l13.40.013
pycardPYD and CARD domain containing0.013
crfa31.2IL-4RA-like protein 20.013
igf1rainsulin-like growth factor 1a receptor0.013
fzd5frizzled homolog 50.013
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.013
cdc42cell division cycle 420.013
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.013
epas1bendothelial PAS domain protein 1b0.013
LOC100003330melanocortin-2 receptor accessory protein 2-like0.013
gpr126G protein-coupled receptor 1260.013
nrp2bneuropilin 2b0.013
pcdh18bprotocadherin 18b0.013
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.013
arf2ADP-ribosylation factor 20.013
csnk1dacasein kinase 1, delta a0.013
ldb1aLIM-domain binding factor 1a0.013
si:ch73-60e21.1si:ch73-60e21.10.012
efna2ephrin A20.012
nrp2aneuropilin 2a0.012
per3period homolog 3 (Drosophila)0.012
dag1dystroglycan 10.012
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.810
stcksteamer duck0.591
TlToll0.549
shishibire0.547
MadMothers against dpp0.411
hephemipterous0.377
miltmilton0.376
Lis-1Lissencephaly-10.366
mbcmyoblast city0.354
Stat92ESignal-transducer and activator of transcription protein at 92E0.337
JraJun-related antigen0.281
babobaboon0.280
mnbminibrain0.275
drkdownstream of receptor kinase0.271
aopanterior open0.263
Ras85DRas oncogene at 85D0.259
NetBNetrin-B0.256
SmoxSmad on X0.251
bskbasket0.234
spasspastin0.231
Trx-2thioredoxin-20.210
Gap1GTPase-activating protein 10.206
phlpole hole0.201
fzfrizzled0.196
rlrolled0.190
Sema-1bCG6446 gene product from transcript CG6446-RA0.186
ShcSHC-adaptor protein0.171
Fmr1CG6203 gene product from transcript CG6203-RC0.166
bratbrain tumor0.163
spn-Aspindle A0.162
ash2absent, small, or homeotic discs 20.160
Socs36ESuppressor of cytokine signaling at 36E0.159
Tak1TGF-beta activated kinase 10.158
exexpanded0.155
jebjelly belly0.153
srpserpent0.153
atoatonal0.150
Nrx-IVNeurexin IV0.148
lealeak0.148
trioCG18214 gene product from transcript CG18214-RA0.147
S6kRPS6-p70-protein kinase0.147
EndoGIEndonuclease G inhibitor0.144
Cp190Centrosomal protein 190kD0.143
HLHmgammaE(spl) region transcript mgamma0.142
Ptp69DProtein tyrosine phosphatase 69D0.142
mttmangetout0.142
cv-ccrossveinless c0.141
l(1)G0232lethal (1) G02320.136
ykiyorkie0.135
tbcetubulin-specific chaperone E0.134
hrghiiragi0.133
CG5794CG5794 gene product from transcript CG5794-RB0.131
CblCG7037 gene product from transcript CG7037-RB0.130
shrbshrub0.128
Atg1Autophagy-specific gene 10.127
HLHm3E(spl) region transcript m30.127
edechinoid0.126
kaykayak0.125
MEP-1CG1244 gene product from transcript CG1244-RG0.123
mre11meiotic recombination 110.121
commcommissureless0.121
dcodiscs overgrown0.121
E(spl)Enhancer of split0.120
rutrutabaga0.120
CadNCadherin-N0.117
cazcabeza0.117
MAN1CG3167 gene product from transcript CG3167-RA0.116
Pp2B-14DProtein phosphatase 2B at 14D0.114
tutlturtle0.113
Cbp80cap binding protein 800.111
piepineapple eye0.110
Pp1alpha-96AProtein phosphatase 1alpha at 96A0.110
CG18764CG18764 gene product from transcript CG18764-RA0.109
Mpk2CG5475 gene product from transcript CG5475-RB0.106
krzkurtz0.106
Akt1CG4006 gene product from transcript CG4006-RA0.105
panpangolin0.105
dpndeadpan0.104
HLHm7E(spl) region transcript m70.103
eIF-4EEukaryotic initiation factor 4E0.102
HLHmbetaE(spl) region transcript mbeta0.101
katanin-60katanin 600.100
spensplit ends0.099
Dsor1Downstream of raf10.099
domedomeless0.098
emcextra macrochaetae0.098
Fcp1CG12252 gene product from transcript CG12252-RA0.097
PcafCG4107 gene product from transcript CG4107-RA0.096
RicRas which interacts with Calmodulin0.096
spispitz0.096
l(2)k16918lethal (2) k169180.096
pnutpeanut0.095
Vps35Vacuolar protein sorting 350.094
Cip4CG15015 gene product from transcript CG15015-RA0.094
keykenny0.092
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.092
wtswarts0.091
Rcd1Reduction in Cnn dots 10.091
CSN5COP9 complex homolog subunit 50.091
hthhomothorax0.090
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Itgamintegrin, alpha M0.635
Ccl4chemokine (C-C motif) ligand 40.615
Slco2b1solute carrier organic anion transporter family, member 2b10.583
Grm7glutamate receptor, metabotropic 70.574
Il6interleukin 60.445
Adora2aadenosine A2a receptor0.433
Tnftumor necrosis factor (TNF superfamily, member 2)0.420
S100a8S100 calcium binding protein A80.417
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.409
Ccl3chemokine (C-C motif) ligand 30.405
Il1ainterleukin 1 alpha0.401
Pspparotid secretory protein0.380
Cx3cr1chemokine (C-X3-C motif) receptor 10.376
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.375
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.356
Cd4Cd4 molecule0.352
Arpc1bactin related protein 2/3 complex, subunit 1B0.345
Mpeg1macrophage expressed 10.343
Mapk1mitogen activated protein kinase 10.336
Prdm2PR domain containing 2, with ZNF domain0.332
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.319
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.315
Nedd4neural precursor cell expressed, developmentally down-regulated 40.315
Lgals5lectin, galactose binding, soluble 50.314
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.314
Fgfr2fibroblast growth factor receptor 20.311
Cxcl2chemokine (C-X-C motif) ligand 20.307
Nfibnuclear factor I/B0.299
Tgfbr2transforming growth factor, beta receptor II0.293
Jak2Janus kinase 20.291
Acrv1acrosomal vesicle protein 10.291
Bcanbrevican0.287
Epas1endothelial PAS domain protein 10.287
Tgm1transglutaminase 1, K polypeptide0.284
Jtbjumping translocation breakpoint0.277
LOC100363783rCG53773-like0.268
Agtr1aangiotensin II receptor, type 1a0.263
Il1binterleukin 1 beta0.262
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.260
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.260
Cybbcytochrome b-245, beta polypeptide0.259
Cd14CD14 molecule0.258
Ctsjcathepsin J0.257
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.257
Egfrepidermal growth factor receptor0.257
Mapk9mitogen-activated protein kinase 90.255
Calcrlcalcitonin receptor-like0.253
Tmem101transmembrane protein 1010.250
Ednrbendothelin receptor type B0.249
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.249
Timp3TIMP metallopeptidase inhibitor 30.247
Oprd1opioid receptor, delta 10.243
Cxcl13chemokine (C-X-C motif) ligand 130.242
Adarb2adenosine deaminase, RNA-specific, B20.241
S100a9S100 calcium binding protein A90.241
Rgs12regulator of G-protein signaling 120.240
Ccl2chemokine (C-C motif) ligand 20.239
Oprm1opioid receptor, mu 10.236
Notch3Notch homolog 3 (Drosophila)0.232
Inpp5dinositol polyphosphate-5-phosphatase D0.225
Hbe1hemoglobin, epsilon 10.224
Shox2short stature homeobox 20.223
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.223
Cdk4cyclin-dependent kinase 40.221
Fgf5fibroblast growth factor 50.221
Ncr1natural cytotoxicity triggering receptor 10.220
Fgbfibrinogen beta chain0.220
Trhrthyrotropin releasing hormone receptor0.219
Jak1Janus kinase 10.219
Bcl2B-cell CLL/lymphoma 20.217
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.217
Acracrosin0.217
Unc5bunc-5 homolog B (C. elegans)0.217
Tcf4transcription factor 40.210
Ddr1discoidin domain receptor tyrosine kinase 10.207
Slc6a7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.206
Cntn2contactin 2 (axonal)0.204
Sirpasignal-regulatory protein alpha0.204
Mmp10matrix metallopeptidase 100.201
Ptk2bPTK2B protein tyrosine kinase 2 beta0.201
Csf1colony stimulating factor 1 (macrophage)0.201
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.198
Sdc3syndecan 30.198
Cd8aCD8a molecule0.198
Htr75-hydroxytryptamine (serotonin) receptor 70.197
Lpllipoprotein lipase0.196
Ifnginterferon gamma0.193
Olr416olfactory receptor 4160.191
Capgcapping protein (actin filament), gelsolin-like0.190
Fgf16fibroblast growth factor 160.189
Gga1golgi associated, gamma adaptin ear containing, ARF binding protein 10.189
Gng7guanine nucleotide binding protein (G protein), gamma 70.186
Mc4rmelanocortin 4 receptor0.184
Ptgfrprostaglandin F receptor0.183
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.181
Ccr5chemokine (C-C motif) receptor 50.180
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.180
Iappislet amyloid polypeptide0.179
Reg1aregenerating islet-derived 1 alpha0.177
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.177
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SSK2Ssk2p0.864
ERP4Erp4p0.786
NBP2Nbp2p0.451
FUS3Fus3p0.417
RHO1Rho1p0.310
IZH4Izh4p0.304
SSK1Ssk1p0.264
TOR1Tor1p0.225
ERP3Erp3p0.224
PBS2Pbs2p0.220
ENA5Ena5p0.167
IRA1Ira1p0.161
PTC1Ptc1p0.150
HOS4Hos4p0.146
FAR1Far1p0.132
TCO89Tco89p0.129
STE5Ste5p0.115
SSK22Ssk22p0.111
STE4Ste4p0.103
BMH1Bmh1p0.097
MEH1Meh1p0.094
MKS1Mks1p0.090
MSG5Msg5p0.088
SIF2Sif2p0.086
ENA2Ena2p0.084
SRP54Srp54p0.074
BEM2Bem2p0.074
AHP1Ahp1p0.073
KEL3Kel3p0.070
STE7Ste7p0.063
GPB2Gpb2p0.061
RAS2Ras2p0.061
YOR1Yor1p0.054
TOM1Tom1p0.054
OLE1Ole1p0.053
HOS2Hos2p0.047
CHS6Chs6p0.047
RAS1Ras1p0.046
KIN3Kin3p0.046
OSH7Osh7p0.044
PPH3Pph3p0.043
STE11Ste11p0.043
OSH6Osh6p0.043
AVO1Avo1p0.042
HST1Hst1p0.042
NSR1Nsr1p0.041
MKK1Mkk1p0.038
ARF2Arf2p0.037
ROM2Rom2p0.036
HOG1Hog1p0.035
SLG1Slg1p0.035
ITT1Itt1p0.034
VPS64Vps64p0.033
RDI1Rdi1p0.030
RGD2Rgd2p0.029
SLA2Sla2p0.029
YNL024Chypothetical protein0.028
SNT1Snt1p0.027
PIB2Pib2p0.026
PZF1Pzf1p0.026
SIC1Sic1p0.025
KSS1Kss1p0.025
ARR3Arr3p0.024
CPR1Cpr1p0.024
BCK1Bck1p0.023
SKI3Ski3p0.022
VPS27Vps27p0.021
MON1Mon1p0.021
PCP1Pcp1p0.020
TOR2Tor2p0.020
STT4Stt4p0.020
SVF1Svf1p0.020
GAT2Gat2p0.019
PHO23Pho23p0.019
FAR11Far11p0.019
TSA2Tsa2p0.019
MGA2Mga2p0.018
PBP4Pbp4p0.018
KDX1Kdx1p0.018
IME2Ime2p0.018
RBD2Rbd2p0.017
RHO4Rho4p0.017
SYP1Syp1p0.017
GPR1Gpr1p0.017
UTP7Utp7p0.017
LCB4Lcb4p0.017
CTR2Ctr2p0.017
ETR1Etr1p0.017
HIR3Hir3p0.016
SUT1Sut1p0.016
ATG2Atg2p0.016
RTC1Rtc1p0.016
SGE1Sge1p0.016
AQR1Aqr1p0.016
TSR3Tsr3p0.015
UFO1Ufo1p0.015
SLM4Slm4p0.015
RMT2Rmt2p0.015
PKC1Pkc1p0.015
SLM1Slm1p0.015