The network for 'response to external stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to external stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.934
vab-3Protein VAB-30.917
unc-9Protein UNC-90.861
cam-1Protein CAM-10.767
efn-2Protein EFN-20.756
sma-6Protein SMA-60.724
ima-3Protein IMA-30.714
daf-11Protein DAF-110.699
pkg-1Protein PKG-10.667
hlh-2Protein HLH-20.640
sli-1Protein SLI-10.626
syg-1Protein SYG-10.613
sem-5Protein SEM-50.581
par-5Protein PAR-50.573
ldb-1Protein LDB-10.563
pdfr-1Protein PDFR-10.561
pry-1Protein PRY-10.556
lin-25Protein LIN-250.556
ceh-20Protein CEH-200.547
odr-3Protein ODR-30.528
CELE_C17H12.8Protein C17H12.80.527
gpb-1Protein GPB-10.526
ncam-1Protein NCAM-10.507
rol-6Protein ROL-60.503
sax-3Protein SAX-30.500
lrp-2Protein LRP-20.491
sqt-1Protein SQT-10.488
atat-2Protein ATAT-20.481
clh-5Protein CLH-50.473
unc-6Protein UNC-60.454
unc-115Protein UNC-1150.444
plc-1Protein PLC-10.440
dpy-13Protein DPY-130.435
egl-27Protein EGL-270.422
col-104Protein COL-1040.410
tbb-4Protein TBB-40.407
che-1Protein CHE-10.406
cnd-1Protein CND-10.393
nhr-25Protein NHR-250.393
tax-4Protein TAX-40.391
hlh-1Protein HLH-10.390
ilys-3Protein ILYS-30.390
apl-1Protein APL-10.387
unc-103Protein UNC-1030.384
scl-2Protein SCL-20.381
che-2Protein CHE-20.376
gfi-3Protein GFI-30.370
atp-2Protein ATP-20.369
che-3Protein CHE-30.367
tax-6Protein TAX-60.367
hmg-1.2Protein HMG-1.20.366
flt-1Protein FLT-10.365
CELE_F55G11.8Protein F55G11.80.360
ahcy-1Protein AHCY-10.352
rig-6Protein RIG-60.351
hda-3Protein HDA-30.349
atg-18Protein ATG-180.346
glr-5Protein GLR-50.343
ttyh-1Protein TTYH-10.341
kle-2Protein KLE-20.339
unc-104Protein UNC-1040.336
nhr-67Protein NHR-670.334
T05G5.1Protein T05G5.10.334
mep-1Protein MEP-10.331
fkh-2Protein FKH-20.320
dod-17Protein DOD-170.317
glp-1Protein GLP-10.315
eor-1Protein EOR-10.314
osm-5Protein OSM-50.313
daf-2Protein DAF-20.309
ten-1Protein TEN-10.305
ist-1Protein IST-10.304
abl-1Protein ABL-10.304
F28E10.1Protein F28E10.10.304
mig-38Protein MIG-380.303
D1007.5Protein D1007.50.301
unc-32Protein UNC-320.300
ida-1Protein IDA-10.299
rpn-12Protein RPN-120.297
col-146Protein COL-1460.297
ifg-1Protein IFG-10.293
vav-1Protein VAV-10.292
let-60Protein LET-600.291
F47D12.6Protein F47D12.60.291
gpa-14Protein GPA-140.288
sqt-3Protein SQT-30.284
olrn-1Protein OLRN-10.283
C05D11.7Protein C05D11.70.283
pxf-1Protein PXF-10.282
K11G12.5Protein K11G12.50.281
unc-7Protein UNC-70.281
col-173Protein COL-1730.281
cst-1Protein CST-10.281
cul-2Protein CUL-20.279
pha-4Protein PHA-40.278
ina-1Protein INA-10.277
daf-25Protein DAF-250.277
enu-3Protein ENU-30.277
cki-1Protein CKI-10.275
col-181Protein COL-1810.272
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dlx5adistal-less homeobox gene 5a0.988
gli2aGLI-Kruppel family member GLI2a0.986
chdchordin0.985
fgfr1afibroblast growth factor receptor 1a0.981
fgf3fibroblast growth factor 30.981
her15.1hairy and enhancer of split-related 15.10.977
shhasonic hedgehog a0.977
otpaorthopedia homolog a0.976
robo3roundabout homolog 30.975
efnb2aephrin B2a0.969
gata5GATA-binding protein 50.956
dlx2adistal-less homeobox gene 2a0.945
ntlano tail a0.945
tbx1T-box 10.944
wnt10awingless-type MMTV integration site family, member 10a0.944
lmx1b.1LIM homeobox transcription factor 1, beta 10.943
ndr2nodal-related 20.937
egr1early growth response 10.935
bdnfbrain-derived neurotrophic factor0.921
pitx3paired-like homeodomain transcription factor 30.919
notch2notch homolog 20.908
gli1GLI-Kruppel family member 10.902
tp53tumor protein p530.895
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.894
sox2SRY-box containing gene 20.892
gro1groucho 10.889
slit3slit (Drosophila) homolog 30.888
cdh23cadherin-like 230.886
pax2apaired box gene 2a0.885
arnt2aryl hydrocarbon receptor nuclear translocator 20.875
fgfr2fibroblast growth factor receptor 20.874
wnt8bwingless-type MMTV integration site family, member 8b0.872
igf1rainsulin-like growth factor 1a receptor0.859
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.855
nos2anitric oxide synthase 2a, inducible0.848
glud1aglutamate dehydrogenase 1a0.843
lamc1laminin, gamma 10.823
angptl2angiopoietin-like 20.820
col1a1acollagen, type I, alpha 1a0.820
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.817
alcamaactivated leukocyte cell adhesion molecule a0.814
fn1fibronectin 10.807
ext2exostoses (multiple) 20.787
runx2brunt-related transcription factor 2b0.786
rad21RAD21 homolog (S. pombe)0.785
nos1nitric oxide synthase 1 (neuronal)0.785
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.785
gad2glutamate decarboxylase 20.771
itgb1bintegrin, beta 1b0.767
prnprs3prion protein, related sequence 30.765
vasavasa homolog0.763
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.754
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.752
notch1anotch homolog 1a0.751
smosmoothened homolog (Drosophila)0.747
cd63Cd63 antigen0.744
dmddystrophin0.738
kal1bKallmann syndrome 1b sequence0.736
per3period homolog 3 (Drosophila)0.734
wnt1wingless-type MMTV integration site family, member 10.730
nxph1neurexophilin 10.723
sox9aSRY-box containing gene 9a0.715
frem3Fras1 related extracellular matrix 30.712
mnx1motor neuron and pancreas homeobox 10.710
mycbp2MYC binding protein 20.709
dag1dystroglycan 10.708
plxnb2aplexin b2a0.708
wnt2bbwingless-type MMTV integration site family, member 2Bb0.701
dharmadharma0.696
gata2aGATA-binding protein 2a0.690
plcg1phospholipase C, gamma 10.690
rargaretinoic acid receptor gamma a0.684
ihhaIndian hedgehog homolog a0.680
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.678
apoebapolipoprotein Eb0.678
atp1a3aATPase, Na+/K+ transporting, alpha 3a polypeptide0.675
dladeltaA0.667
dusp6dual specificity phosphatase 60.665
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.660
fabp7afatty acid binding protein 7, brain, a0.656
nrp2bneuropilin 2b0.654
snai1asnail homolog 1a (Drosophila)0.652
per2period homolog 2 (Drosophila)0.649
robo2roundabout homolog 20.646
gbx2gastrulation brain homeo box 20.644
tlr3toll-like receptor 30.639
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.635
LOC567678avidin-like0.634
olig2oligodendrocyte lineage transcription factor 20.634
acheacetylcholinesterase0.628
col14a1collagen, type XIV, alpha 10.627
dbhdopamine beta hydroxylase0.627
pax8paired box gene 80.626
traf4atnf receptor-associated factor 4a0.625
eng2aengrailed 2a0.625
col1a2collagen, type I, alpha 20.623
spry2sprouty homolog 20.621
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.619
il6rinterleukin 6 receptor0.615
eno1enolase 1, (alpha)0.614
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ATG1Atg1p0.990
TOR1Tor1p0.969
MSN2Msn2p0.886
HSP82Hsp82p0.869
GAL11Gal11p0.837
GLN3Gln3p0.796
ATG21Atg21p0.787
KSP1Ksp1p0.728
RIM101Rim101p0.640
RTG3Rtg3p0.614
RPN4Rpn4p0.604
BMH2Bmh2p0.556
SNF4Snf4p0.532
YPT1Ypt1p0.524
ATG13Atg13p0.497
COG3Cog3p0.495
SIP1Sip1p0.489
HRK1Hrk1p0.472
GPR1Gpr1p0.471
ATG4Atg4p0.459
RVS167Rvs167p0.453
RIM15Rim15p0.451
VID24Vid24p0.450
OM45Om45p0.439
HSP33Hsp33p0.433
SLT2Slt2p0.427
MYO5Myo5p0.413
NUP170Nup170p0.410
VPS30Vps30p0.399
MKS1Mks1p0.396
PEP5Pep5p0.392
HSP32Hsp32p0.386
ISW1Isw1p0.386
ATG12Atg12p0.385
KGD1Kgd1p0.384
CLB3Clb3p0.380
CKA2Cka2p0.376
HSV2Hsv2p0.376
SOD1Sod1p0.372
CAT8Cat8p0.369
CCZ1Ccz1p0.368
STE2Ste2p0.362
ASP3-1Asp3-1p0.360
ATG3Atg3p0.347
NGR1Ngr1p0.347
VHS1Vhs1p0.338
GAL80Gal80p0.336
SMF2Smf2p0.335
NET1Net1p0.328
SNF5Snf5p0.327
KDX1Kdx1p0.316
DBF2Dbf2p0.314
DNF3Dnf3p0.309
GAL3Gal3p0.308
GLK1Glk1p0.304
GAT2Gat2p0.301
IZH4Izh4p0.301
AQY2Aqy2p0.299
ASP3-2Asp3-2p0.286
ATG14Atg14p0.283
ASP3-3Asp3-3p0.281
GAL4Gal4p0.278
SEC2Sec2p0.275
ENA5Ena5p0.274
ATG23Atg23p0.274
VPS36Vps36p0.273
SNX4Snx4p0.268
YOL087Chypothetical protein0.268
FMP40Fmp40p0.267
STP2Stp2p0.262
ASP3-4Asp3-4p0.261
IML1Iml1p0.260
FIG4Fig4p0.256
SNF2Snf2p0.255
RLM1Rlm1p0.253
VAM6Vam6p0.252
PHO11Pho11p0.251
GSH1Gsh1p0.248
RRD1Rrd1p0.245
BDH2Bdh2p0.245
ARP7Arp7p0.240
CLB4Clb4p0.240
ITC1Itc1p0.233
ATG20Atg20p0.231
SWI1Swi1p0.228
MCK1Mck1p0.226
MET4Met4p0.226
YPK2Ypk2p0.226
SUM1Sum1p0.225
MON1Mon1p0.224
KAR2Kar2p0.223
GAL7Gal7p0.218
DGR2Dgr2p0.216
CIS1Cis1p0.216
RUD3Rud3p0.214
SSN3Ssn3p0.214
CHD1Chd1p0.213
VAC8Vac8p0.211
HOG1Hog1p0.211
GPA2Gpa2p0.208