The network for 'antigen processing and presentation of peptide antigen' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

antigen processing and presentation of peptide antigen

The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.

NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HLA-Amajor histocompatibility complex, class I, A1.000
HLA-DRAmajor histocompatibility complex, class II, DR alpha1.000
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 11.000
TAPBPTAP binding protein (tapasin)0.999
HLA-Fmajor histocompatibility complex, class I, F0.999
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.998
HLA-Bmajor histocompatibility complex, class I, B0.994
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.994
HLA-Cmajor histocompatibility complex, class I, C0.963
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.959
HLA-DMBmajor histocompatibility complex, class II, DM beta0.958
B2Mbeta-2-microglobulin0.932
HLA-Gmajor histocompatibility complex, class I, G0.925
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.915
HLA-DRB5major histocompatibility complex, class II, DR beta 50.801
HLA-DPB1major histocompatibility complex, class II, DP beta 10.674
HLA-Emajor histocompatibility complex, class I, E0.489
SYKspleen tyrosine kinase0.414
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.307
PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)0.287
GRNgranulin0.254
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.222
PDIA3protein disulfide isomerase family A, member 30.159
NPC2Niemann-Pick disease, type C20.154
HLA-DRB4major histocompatibility complex, class II, DR beta 40.137
PSAPprosaposin0.103
PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)0.095
CTSAcathepsin A0.072
PSMB10proteasome (prosome, macropain) subunit, beta type, 100.044
NLRC4NLR family, CARD domain containing 40.040
CST3cystatin C0.036
TPP1tripeptidyl peptidase I0.034
TAPBPLTAP binding protein-like0.034
P4HBprolyl 4-hydroxylase, beta polypeptide0.028
BLNKB-cell linker0.027
MEFVMediterranean fever0.026
MAN2B1mannosidase, alpha, class 2B, member 10.023
GM2AGM2 ganglioside activator0.022
CTSScathepsin S0.022
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.020
UBASH3Bubiquitin associated and SH3 domain containing B0.019
BAG3BCL2-associated athanogene 30.018
TAP2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.018
HLA-DQA2major histocompatibility complex, class II, DQ alpha 20.017
PSME1proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)0.017
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.016
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.016
C1orf38chromosome 1 open reading frame 380.016
OS9osteosarcoma amplified 9, endoplasmic reticulum lectin0.015
LY86lymphocyte antigen 860.015
RARRES3retinoic acid receptor responder (tazarotene induced) 30.015
CTSHcathepsin H0.015
TYROBPTYRO protein tyrosine kinase binding protein0.014
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.014
HCP5HLA complex P50.014
CAPGcapping protein (actin filament), gelsolin-like0.013
PELI3pellino homolog 3 (Drosophila)0.013
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.012
IFI30interferon, gamma-inducible protein 300.011
CTSBcathepsin B0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.999
H2-Ab1histocompatibility 2, class II antigen A, beta 10.998
H2-Aahistocompatibility 2, class II antigen A, alpha0.996
H2-Eb1histocompatibility 2, class II antigen E beta0.986
H2-DMahistocompatibility 2, class II, locus DMa0.947
H2-DMb2histocompatibility 2, class II, locus Mb20.936
B2mbeta-2 microglobulin0.933
TapbpTAP binding protein0.924
H2-K1histocompatibility 2, K1, K region0.867
Cd40CD40 antigen0.861
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.834
H2-Q7histocompatibility 2, Q region locus 70.826
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.689
Lyz2lysozyme 20.666
Ciitaclass II transactivator0.644
H2-D1histocompatibility 2, D region locus 10.628
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.616
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.573
Ptprcprotein tyrosine phosphatase, receptor type, C0.454
H2-Q6histocompatibility 2, Q region locus 60.417
C1qacomplement component 1, q subcomponent, alpha polypeptide0.308
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.266
Ctsbcathepsin B0.250
Gbp5guanylate binding protein 50.223
Aif1allograft inflammatory factor 10.219
TcraT-cell receptor alpha chain0.212
C1qccomplement component 1, q subcomponent, C chain0.210
Casp1caspase 10.193
Latlinker for activation of T cells0.178
Ccl5chemokine (C-C motif) ligand 50.152
H2-Obhistocompatibility 2, O region beta locus0.132
Irf8interferon regulatory factor 80.126
H2-Q8histocompatibility 2, Q region locus 80.110
TyrobpTYRO protein tyrosine kinase binding protein0.106
C1qbcomplement component 1, q subcomponent, beta polypeptide0.087
Irf5interferon regulatory factor 50.085
Trim21tripartite motif-containing 210.077
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.075
Lcklymphocyte protein tyrosine kinase0.075
Gm2aGM2 ganglioside activator protein0.073
Casp4caspase 4, apoptosis-related cysteine peptidase0.073
Psapprosaposin0.069
Birc3baculoviral IAP repeat-containing 30.066
Unc93b1unc-93 homolog B1 (C. elegans)0.061
Cd79bCD79B antigen0.057
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.055
Apobec1apolipoprotein B mRNA editing enzyme, catalytic polypeptide 10.053
Ncf1neutrophil cytosolic factor 10.052
Cxcl9chemokine (C-X-C motif) ligand 90.050
H2-M3histocompatibility 2, M region locus 30.050
Cybbcytochrome b-245, beta polypeptide0.049
Ly86lymphocyte antigen 860.045
Il2rginterleukin 2 receptor, gamma chain0.043
H2-Blhistocompatibility 2, blastocyst0.043
Agtr1aangiotensin II receptor, type 1a0.043
Ccr9chemokine (C-C motif) receptor 90.043
Ctszcathepsin Z0.041
Itgalintegrin alpha L0.040
Lamp1lysosomal-associated membrane protein 10.040
Myd88myeloid differentiation primary response gene 880.040
Sh2d2aSH2 domain protein 2A0.038
Apoeapolipoprotein E0.038
Pld4phospholipase D family, member 40.036
Psmb10proteasome (prosome, macropain) subunit, beta type 100.036
BlkB lymphoid kinase0.035
Tnfaip3tumor necrosis factor, alpha-induced protein 30.034
H2-DMb1histocompatibility 2, class II, locus Mb10.034
Lyz1lysozyme 10.033
Il7rinterleukin 7 receptor0.032
Cd22CD22 antigen0.032
Aim2absent in melanoma 20.031
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.029
Cd19CD19 antigen0.029
Plbd1phospholipase B domain containing 10.028
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.028
Slc12a1solute carrier family 12, member 10.028
AW112010expressed sequence AW1120100.028
Ctshcathepsin H0.027
Gabarapgamma-aminobutyric acid receptor associated protein0.027
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.027
Epb4.1erythrocyte protein band 4.10.027
Inpp5dinositol polyphosphate-5-phosphatase D0.026
Uba7ubiquitin-like modifier activating enzyme 70.025
Cd86CD86 antigen0.025
Zfp36zinc finger protein 360.025
C3complement component 30.025
Klrd1killer cell lectin-like receptor, subfamily D, member 10.024
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.024
Mavsmitochondrial antiviral signaling protein0.024
Elaneelastase, neutrophil expressed0.024
Dnase1l3deoxyribonuclease 1-like 30.022
C920025E04RikRIKEN cDNA C920025E04 gene0.021
ItkIL2-inducible T-cell kinase0.021
Nlrp6NLR family, pyrin domain containing 60.021
Tgfb1transforming growth factor, beta 10.021
Il2rbinterleukin 2 receptor, beta chain0.020
Ifngr1interferon gamma receptor 10.020
Tbxas1thromboxane A synthase 1, platelet0.020
Folr2folate receptor 2 (fetal)0.020
Celsr2cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.019
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.984
RT1-DaRT1 class II, locus Da0.983
RT1-Db1RT1 class II, locus Db10.971
RT1-BaRT1 class II, locus Ba0.866
RT1-DMbRT1 class II, locus DMb0.811
RT1-EC2RT1 class Ib, locus EC20.584
RT1-BbRT1 class II, locus Bb0.459
RT1-DMaRT1 class II, locus DMa0.160
C1qbcomplement component 1, q subcomponent, B chain0.147
Cd37CD37 molecule0.140
Ctsscathepsin S0.090
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.084
Aif1allograft inflammatory factor 10.081
Lyz2lysozyme 20.065
Lgals3lectin, galactoside-binding, soluble, 30.055
Serpinb1aserine (or cysteine) proteinase inhibitor, clade B, member 1a0.050
C1qccomplement component 1, q subcomponent, C chain0.044
Pdia4protein disulfide isomerase family A, member 40.031
Ms4a6bmembrane-spanning 4-domains, subfamily A, member 6B0.030
P4hbprolyl 4-hydroxylase, beta polypeptide0.030
Napsanapsin A aspartic peptidase0.029
Ctsbcathepsin B0.027
Ftlferritin, light polypeptide0.027
Lamp2lysosomal-associated membrane protein 20.027
Ctshcathepsin H0.026
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.023
Plac8placenta-specific 80.023
Laptm5lysosomal protein transmembrane 50.022
Ccl5chemokine (C-C motif) ligand 50.020
C4-2complement component 4, gene 20.020
Ctsacathepsin A0.020
Clec10aC-type lectin domain family 10, member A0.020
C1qacomplement component 1, q subcomponent, A chain0.019
Xdhxanthine dehydrogenase0.019
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.019
Cd53Cd53 molecule0.016
Surf4surfeit 40.016
Alox5aparachidonate 5-lipoxygenase activating protein0.014
Ifitm3interferon induced transmembrane protein 30.014
Irf1interferon regulatory factor 10.014
GabarapGABA(A) receptor-associated protein0.014
Lilrb3lleukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like0.013
C3complement component 30.013
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.013
Hdlbphigh density lipoprotein binding protein0.012
Nucb1nucleobindin 10.012
Cd81Cd81 molecule0.012
Irf7interferon regulatory factor 70.011
Myo1amyosin IA0.011
Tmbim6transmembrane BAX inhibitor motif containing 60.011
Ddostdolichyl-diphosphooligosaccharide-protein glycosyltransferase0.011
RGD1566001similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed0.011
Lrg1leucine-rich alpha-2-glycoprotein 10.011
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.011
Cfbcomplement factor B0.010
Ptgirprostaglandin I2 (prostacyclin) receptor (IP)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism