The network for 'negative regulation of multicellular organismal process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of multicellular organismal process

Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.943
mig-5Protein MIG-50.824
vab-3Protein VAB-30.755
unc-73Protein UNC-730.647
egl-46Protein EGL-460.645
gex-3Protein GEX-30.614
mes-3Protein MES-30.607
hlh-1Protein HLH-10.590
lin-45Protein LIN-450.567
pkg-1Protein PKG-10.559
npp-4Protein NPP-40.546
glp-1Protein GLP-10.464
mes-4Protein MES-40.459
lag-1Protein LAG-10.438
lin-11Protein LIN-110.432
dpy-22Protein DPY-220.423
snr-4Protein SNR-40.417
hlh-2Protein HLH-20.415
mep-1Protein MEP-10.407
sma-6Protein SMA-60.406
lin-53Protein LIN-530.399
lin-12Protein LIN-120.392
sas-4Protein SAS-40.383
snr-6Protein SNR-60.381
sel-12Protein SEL-120.377
pry-1Protein PRY-10.372
npp-7Protein NPP-70.357
sax-3Protein SAX-30.353
crm-1Protein CRM-10.336
sur-2Protein SUR-20.331
lin-36Protein LIN-360.330
rsp-5Protein RSP-50.327
mat-3Protein MAT-30.327
wrm-1Protein WRM-10.320
mab-31Protein MAB-310.315
tbh-1Protein TBH-10.309
eor-2Protein EOR-20.306
F08B4.7Protein F08B4.70.305
flt-1Protein FLT-10.302
lin-17Protein LIN-170.298
nrde-3Protein NRDE-30.294
mix-1Protein MIX-10.289
odr-3Protein ODR-30.288
CELE_C23G10.8Protein C23G10.80.283
F49C12.9Protein F49C12.90.279
hcf-1Protein HCF-10.279
lin-25Protein LIN-250.277
sdz-28Protein SDZ-280.274
mab-5Protein MAB-50.273
eor-1Protein EOR-10.271
mml-1Protein MML-10.268
R10E12.2Protein R10E12.20.267
ima-3Protein IMA-30.266
swan-2Protein SWAN-20.264
hmg-1.2Protein HMG-1.20.261
cki-1Protein CKI-10.261
tam-1Protein TAM-10.257
egl-27Protein EGL-270.249
spr-5Protein SPR-50.249
bar-1Protein BAR-10.247
cam-1Protein CAM-10.242
akt-1Protein AKT-10.241
egl-8Protein EGL-80.240
ida-1Protein IDA-10.238
sma-1Protein SMA-10.238
zyg-8Protein ZYG-80.236
htz-1Protein HTZ-10.235
daf-4Protein DAF-40.233
CELE_C56A3.8Protein C56A3.80.231
rsp-3Protein RSP-30.230
R11A8.7Protein R11A8.70.230
ceh-20Protein CEH-200.228
F42C5.9Protein F42C5.90.228
nhr-25Protein NHR-250.228
F33H2.3Protein F33H2.30.227
daf-12Protein DAF-120.225
snr-5Protein SNR-50.224
ain-1Protein AIN-10.223
nhr-6Protein NHR-60.221
Y87G2A.1Protein Y87G2A.10.221
hmp-1Protein HMP-10.220
hda-1Protein HDA-10.219
egl-13Protein EGL-130.219
hmg-4Protein HMG-40.217
unc-70Protein UNC-700.217
psa-3Protein PSA-30.216
emb-5Protein EMB-50.215
CELE_Y105E8B.7Protein Y105E8B.70.214
ifa-1Protein IFA-10.214
abi-1Protein ABI-10.213
kle-2Protein KLE-20.211
hcp-3Protein HCP-30.211
ing-3Protein ING-30.210
epi-1Protein EPI-10.210
psf-1Protein PSF-10.209
fkh-2Protein FKH-20.209
unc-7Protein UNC-70.209
W03F8.4Protein W03F8.40.205
inx-3Protein INX-30.204
Y54G9A.5Protein Y54G9A.50.203
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.967
tbx1T-box 10.943
tbx16T-box gene 160.939
gdf6agrowth differentiation factor 6a0.917
wnt11rwingless-type MMTV integration site family, member 11, related0.898
dlx5adistal-less homeobox gene 5a0.814
pax7apaired box gene 7a0.802
sox9bSRY-box containing gene 9b0.800
gli1GLI-Kruppel family member 10.771
lef1lymphocyte enhancer binding factor 10.736
fn1fibronectin 10.735
wnt10awingless-type MMTV integration site family, member 10a0.683
spry4sprouty (Drosophila) homolog 40.653
notch3notch homolog 30.647
pax2apaired box gene 2a0.642
cdh1cadherin 1, epithelial0.625
nrp1aneuropilin 1a0.616
ndr2nodal-related 20.604
ptf1apancreas specific transcription factor, 1a0.602
bmp2abone morphogenetic protein 2a0.599
tcf7transcription factor 7 (T-cell specific, HMG-box)0.596
foxa3forkhead box A30.561
fzd7afrizzled homolog 7a0.550
col1a1acollagen, type I, alpha 1a0.550
fgfr3fibroblast growth factor receptor 30.542
vsx2visual system homeobox 20.539
fgfr1afibroblast growth factor receptor 1a0.536
fgf17fibroblast growth factor 170.527
foxa1forkhead box A10.526
amotl2aangiomotin like 2a0.522
phox2apaired-like homeobox 2a0.513
otpborthopedia homolog b0.511
egr2bearly growth response 2b0.506
thtyrosine hydroxylase0.503
irx2airoquois homeobox protein 2, a0.502
tp63tumor protein p630.487
slit3slit (Drosophila) homolog 30.477
wnt2bbwingless-type MMTV integration site family, member 2Bb0.459
dab1adisabled homolog 1a (Drosophila)0.455
pcdh8protocadherin 80.448
aldh1a3aldehyde dehydrogenase 1 family, member A30.447
wnt1wingless-type MMTV integration site family, member 10.441
nrg2aneuregulin 2a0.415
ikzf1IKAROS family zinc finger 1 (Ikaros)0.413
her1hairy-related 10.411
slc17a6bsolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b0.409
wlswntless homolog (Drosophila)0.391
ascl1aachaete-scute complex-like 1a (Drosophila)0.389
her12hairy-related 120.378
traf4atnf receptor-associated factor 4a0.376
neurog1neurogenin 10.363
olfm1aolfactomedin 1a0.340
fgfrl1bfibroblast growth factor receptor-like 1b0.333
lhx2bLIM homeobox 2b0.332
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.332
lmx1b.1LIM homeobox transcription factor 1, beta 10.330
tbx20T-box 200.328
atoh8atonal homolog 80.326
tbx6T-box gene 60.325
scn8aasodium channel, voltage-gated, type VIII, alpha a0.324
tbx5aT-box 5a0.319
fgf4fibroblast growth factor 40.316
evx1even-skipped homeobox 10.313
capns1acalpain, small subunit 1 a0.308
sema3dsemaphorin 3d0.303
dlx1adistal-less homeobox gene 1a0.300
her11hairy-related 110.299
hoxb3ahomeo box B3a0.296
rarabretinoic acid receptor, alpha b0.294
fgfr2fibroblast growth factor receptor 20.279
bocbrother of CDO0.276
foxd3forkhead box D30.274
hmx3homeo box (H6 family) 30.269
pdgfaaplatelet-derived growth factor alpha a0.259
ncoa2nuclear receptor coactivator 20.259
plxnb2aplexin b2a0.244
foxd5forkhead box D50.243
gfra1agdnf family receptor alpha 1a0.242
mapk1mitogen-activated protein kinase 10.241
onecutlone cut domain, family member, like0.241
fgf3fibroblast growth factor 30.239
nog1noggin 10.235
wnt5bwingless-type MMTV integration site family, member 5b0.234
shhbsonic hedgehog b0.234
sox3SRY-box containing gene 30.231
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.229
LOC100151531zinc finger protein Gfi-1b-like0.229
nkx2.2aNK2 transcription factor related 2a0.227
six3bsine oculis homeobox homolog 3b0.226
spsb4asplA/ryanodine receptor domain and SOCS box containing 4a0.224
vcanaversican a0.222
hmx4H6 family homeobox 40.216
hoxa2bhomeo box A2b0.213
pou3f3aPOU class 3 homeobox 3a0.212
mef2dmyocyte enhancer factor 2d0.211
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor0.994
MadMothers against dpp0.994
E(spl)Enhancer of split0.950
Akt1CG4006 gene product from transcript CG4006-RA0.901
Pi3K92ECG4141 gene product from transcript CG4141-RB0.884
G-oalpha47AG protein oalpha 47A0.882
DadDaughters against dpp0.867
norpAno receptor potential A0.834
ovoCG6824 gene product from transcript CG6824-RE0.807
CaMKIICalcium/calmodulin-dependent protein kinase II0.771
bratbrain tumor0.737
argosCG4531 gene product from transcript CG4531-RA0.715
cicubitus interruptus0.704
MED6Mediator complex subunit 60.680
spensplit ends0.671
foxoforkhead box, sub-group O0.616
Pp2B-14DProtein phosphatase 2B at 14D0.577
Sema-1aCG18405 gene product from transcript CG18405-RD0.575
Tsc1CG6147 gene product from transcript CG6147-RA0.574
CkIIalphaCasein kinase II alpha subunit0.529
phlpole hole0.525
slmbsupernumerary limbs0.492
LanB2Laminin B20.472
laceCG4162 gene product from transcript CG4162-RA0.468
fz2frizzled 20.467
TbhTyramine beta hydroxylase0.457
TolloCG6890 gene product from transcript CG6890-RA0.455
Gp150CG5820 gene product from transcript CG5820-RA0.448
Drl-2Derailed 20.424
Tao-1CG14217 gene product from transcript CG14217-RF0.421
pashapartner of drosha0.415
Su(H)Suppressor of Hairless0.408
Eps-15Epidermal growth factor receptor pathway substrate clone 150.405
snssticks and stones0.401
RASSF8CG5053 gene product from transcript CG5053-RA0.393
jebjelly belly0.385
S6kIIRPS6-protein kinase-II0.378
eyaeyes absent0.374
CG5794CG5794 gene product from transcript CG5794-RB0.374
skpACG16983 gene product from transcript CG16983-RD0.372
nkdnaked cuticle0.354
CdsACDP diglyceride synthetase0.341
bowlbrother of odd with entrails limited0.329
InRInsulin-like receptor0.326
Mekk1CG7717 gene product from transcript CG7717-RB0.316
Dap160Dynamin associated protein 1600.316
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CREBBPCREB binding protein1.000
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.999
EGFRepidermal growth factor receptor0.997
PTPN1protein tyrosine phosphatase, non-receptor type 10.997
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.996
IRAK2interleukin-1 receptor-associated kinase 20.993
TP53tumor protein p530.992
NOTCH1notch 10.986
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.983
SMAD2SMAD family member 20.981
JAG1jagged 10.981
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.976
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.974
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.972
YAP1Yes-associated protein 10.970
FGFR2fibroblast growth factor receptor 20.965
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.957
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.955
IRAK1interleukin-1 receptor-associated kinase 10.953
TAL1T-cell acute lymphocytic leukemia 10.946
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.940
IL6interleukin 6 (interferon, beta 2)0.935
APPamyloid beta (A4) precursor protein0.934
TIMP3TIMP metallopeptidase inhibitor 30.933
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.929
MYD88myeloid differentiation primary response gene (88)0.928
IL1R1interleukin 1 receptor, type I0.923
SNX9sorting nexin 90.923
TRAF6TNF receptor-associated factor 60.918
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.916
IL1Binterleukin 1, beta0.906
SQSTM1sequestosome 10.903
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.902
BBS10Bardet-Biedl syndrome 100.898
CCT8chaperonin containing TCP1, subunit 8 (theta)0.896
APOA1apolipoprotein A-I0.896
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.895
TGFB1transforming growth factor, beta 10.894
C1QAcomplement component 1, q subcomponent, A chain0.889
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.888
IQGAP1IQ motif containing GTPase activating protein 10.886
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.879
EEF1Geukaryotic translation elongation factor 1 gamma0.877
VEGFAvascular endothelial growth factor A0.876
TCF4transcription factor 40.871
COL4A1collagen, type IV, alpha 10.858
HDAC4histone deacetylase 40.855
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.852
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.850
NCOR2nuclear receptor corepressor 20.850
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.849
MMP14matrix metallopeptidase 14 (membrane-inserted)0.845
COL1A1collagen, type I, alpha 10.843
AXIN1axin 10.842
HDAC6histone deacetylase 60.842
TEKTEK tyrosine kinase, endothelial0.824
CCT7chaperonin containing TCP1, subunit 7 (eta)0.820
PTPN6protein tyrosine phosphatase, non-receptor type 60.817
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.813
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.810
WNT1wingless-type MMTV integration site family, member 10.809
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.807
ARandrogen receptor0.804
HLA-Amajor histocompatibility complex, class I, A0.799
CCL4chemokine (C-C motif) ligand 40.799
LAMC1laminin, gamma 1 (formerly LAMB2)0.798
GATA4GATA binding protein 40.794
HLA-Bmajor histocompatibility complex, class I, B0.794
RUNX1runt-related transcription factor 10.784
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.782
NCK2NCK adaptor protein 20.781
ZNF43zinc finger protein 430.777
COL3A1collagen, type III, alpha 10.775
IL8interleukin 80.769
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.768
CSNK1Ecasein kinase 1, epsilon0.766
SFRP1secreted frizzled-related protein 10.765
JUNjun proto-oncogene0.765
HLA-Cmajor histocompatibility complex, class I, C0.764
FOXD3forkhead box D30.762
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.760
PBX1pre-B-cell leukemia homeobox 10.759
PMLpromyelocytic leukemia0.754
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.752
HDAC3histone deacetylase 30.746
CUL1cullin 10.741
FGF1fibroblast growth factor 1 (acidic)0.740
THBS1thrombospondin 10.732
COL5A1collagen, type V, alpha 10.727
NRP1neuropilin 10.727
IGFBP5insulin-like growth factor binding protein 50.726
FBXW11F-box and WD repeat domain containing 110.715
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.715
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.713
COL1A2collagen, type I, alpha 20.709
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.708
CCT4chaperonin containing TCP1, subunit 4 (delta)0.704
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.702
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Itgamintegrin, alpha M0.848
S100a6S100 calcium binding protein A60.825
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.752
Ifitm3interferon induced transmembrane protein 30.725
Junbjun B proto-oncogene0.699
Cd4Cd4 molecule0.682
Nrg1neuregulin 10.661
Fgfr2fibroblast growth factor receptor 20.600
Galr3galanin receptor 30.582
Sirpasignal-regulatory protein alpha0.568
Socs3suppressor of cytokine signaling 30.550
Twist2twist homolog 2 (Drosophila)0.542
Itpr2inositol 1,4,5-triphosphate receptor, type 20.524
Gna15guanine nucleotide binding protein, alpha 150.497
Neurod2neurogenic differentiation 20.465
Lgals3lectin, galactoside-binding, soluble, 30.459
F2rl1coagulation factor II (thrombin) receptor-like 10.452
Htr65-hydroxytryptamine (serotonin) receptor 60.438
Aspgasparaginase homolog (S. cerevisiae)0.434
S100a10S100 calcium binding protein A100.424
Nos3nitric oxide synthase 3, endothelial cell0.421
Acvr1activin A receptor, type I0.407
Gja6gap junction protein, alpha 60.389
Sdcbpsyndecan binding protein0.384
Pzppregnancy-zone protein0.374
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.371
Prkcgprotein kinase C, gamma0.369
Anxa1annexin A10.362
Dnase1l3deoxyribonuclease 1-like 30.351
Cfpcomplement factor properdin0.337
Onecut1one cut homeobox 10.335
Atp12aATPase, H+/K+ transporting, nongastric, alpha polypeptide0.333
Ms4a8amembrane-spanning 4-domains, subfamily A, member 8A0.331
Jak2Janus kinase 20.330
Fgf18fibroblast growth factor 180.330
Agtr1aangiotensin II receptor, type 1a0.328
Notch3Notch homolog 3 (Drosophila)0.327
Mgat5mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase0.324
Tgfbr2transforming growth factor, beta receptor II0.324
Adora2aadenosine A2a receptor0.318
Cav1caveolin 1, caveolae protein0.317
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.316
Foxe3forkhead box E30.308
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.308
Nedd4neural precursor cell expressed, developmentally down-regulated 40.308
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.306
Gja1gap junction protein, alpha 10.305
Sstr1somatostatin receptor 10.300
Gja5gap junction protein, alpha 50.292
Itm2bintegral membrane protein 2B0.292
Fgfr1Fibroblast growth factor receptor 10.288
Foxd3forkhead box D30.288
Grm5glutamate receptor, metabotropic 50.287
Trhthyrotropin releasing hormone0.286
Slc22a7solute carrier family 22 (organic anion transporter), member 70.286
S1pr2sphingosine-1-phosphate receptor 20.280
RorbRAR-related orphan receptor B0.277
Lgals1lectin, galactoside-binding, soluble, 10.276
Plauplasminogen activator, urokinase0.272
Pde5aphosphodiesterase 5A, cGMP-specific0.268
Slco2b1solute carrier organic anion transporter family, member 2b10.266
Stat6signal transducer and activator of transcription 60.263
Icam1intercellular adhesion molecule 10.262
Anxa5annexin A50.260
Mylk2myosin light chain kinase 20.259
Fxyd1FXYD domain-containing ion transport regulator 10.256
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.256
Nos1nitric oxide synthase 1, neuronal0.254
Galgalanin prepropeptide0.253
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.252
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.251
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.249
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.248
S100a9S100 calcium binding protein A90.244
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.244
Cd9CD9 molecule0.243
Il1rninterleukin 1 receptor antagonist0.243
Fam70bfamily with sequence similarity 70, member B0.238
Klf2Kruppel-like factor 2 (lung)0.235
Bmp1bone morphogenetic protein 10.226
Ctrcchymotrypsin C (caldecrin)0.225
Flt1FMS-related tyrosine kinase 10.225
Wisp1WNT1 inducible signaling pathway protein 10.223
Sdc3syndecan 30.223
Prlhrprolactin releasing hormone receptor0.222
Bcl2B-cell CLL/lymphoma 20.221
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.221
LOC100360587hypothetical protein LOC1003605870.220
Lgals5lectin, galactose binding, soluble 50.219
Ephb3Eph receptor B30.219
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.218
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.218
Ghsrgrowth hormone secretagogue receptor0.218
Runx1runt-related transcription factor 10.218
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism