The network for 'apoptotic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

apoptotic process

A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

NameDescriptionProbabilityFunc Analog Organism
rad-26Protein RAD-260.943
lmn-1Protein LMN-10.894
hsp-1Protein HSP-10.878
par-5Protein PAR-50.850
sma-6Protein SMA-60.842
pas-4Protein PAS-40.822
eps-8Protein EPS-80.805
vab-3Protein VAB-30.801
pha-4Protein PHA-40.776
kle-2Protein KLE-20.766
F25B5.2Protein F25B5.20.761
egl-18Protein EGL-180.737
F36D4.5Protein F36D4.50.730
his-47Protein HIS-470.723
nhr-2Protein NHR-20.714
vha-8Protein VHA-80.713
cra-1Protein CRA-10.691
ced-4Protein CED-40.668
glp-1Protein GLP-10.635
egl-46Protein EGL-460.631
klp-15Protein KLP-150.624
rpl-16Protein RPL-160.608
cct-4Protein CCT-40.608
F28B3.1Protein F28B3.10.602
mei-1Protein MEI-10.600
T21B10.3Protein T21B10.30.599
nud-2Protein NUD-20.595
nud-1Protein NUD-10.591
emb-5Protein EMB-50.588
unc-73Protein UNC-730.580
rpl-18Protein RPL-180.569
crt-1Protein CRT-10.567
mix-1Protein MIX-10.566
sem-5Protein SEM-50.564
egl-44Protein EGL-440.559
acs-4Protein ACS-40.556
pbs-3Protein PBS-30.556
cyk-3Protein CYK-30.548
rars-1Protein RARS-10.547
mig-5Protein MIG-50.545
him-1Protein HIM-10.544
rps-15Protein RPS-150.533
T04B8.5Protein T04B8.50.531
rps-12Protein RPS-120.530
unc-40Protein UNC-400.527
scc-1Protein SCC-10.527
atg-13Protein ATG-130.526
rnr-2Protein RNR-20.524
eftu-2Protein EFTU-20.520
rpt-2Protein RPT-20.514
gld-1Protein GLD-10.512
bub-1Protein BUB-10.510
let-99Protein LET-990.505
icd-1Protein ICD-10.505
rpl-24.1Protein RPL-24.10.504
sel-10Protein SEL-100.502
ifg-1Protein IFG-10.497
C14C10.4Protein C14C10.40.497
mec-2Protein MEC-20.496
rps-4Protein RPS-40.494
lag-1Protein LAG-10.489
F53B1.2Protein F53B1.20.488
pdr-1Protein PDR-10.486
inx-15Protein INX-150.483
nhr-67Protein NHR-670.482
atx-3Protein ATX-30.481
tol-1Protein TOL-10.481
unc-108Protein UNC-1080.480
T05E8.3Protein T05E8.30.478
egl-15Protein EGL-150.474
rpl-12Protein RPL-120.472
aspm-1Protein ASPM-10.466
rpn-6.1Protein RPN-6.10.465
nmt-1Protein NMT-10.465
R10E4.1Protein R10E4.10.464
elo-6Protein ELO-60.462
gex-3Protein GEX-30.458
rpl-6Protein RPL-60.456
F35F11.1Protein F35F11.10.450
cif-1Protein CIF-10.448
rpb-2Protein RPB-20.447
rps-0Protein RPS-00.444
rpl-19Protein RPL-190.444
tbb-2Protein TBB-20.444
eif-3.CProtein EIF-3.C0.442
pde-2Protein PDE-20.442
npp-22Protein NPP-220.442
uba-1Protein UBA-10.441
F26H11.4Protein F26H11.40.440
cct-7Protein CCT-70.438
npp-7Protein NPP-70.437
sta-1Protein STA-10.436
mes-3Protein MES-30.435
pas-6Protein PAS-60.434
rps-5Protein RPS-50.430
rps-10Protein RPS-100.429
madd-4Protein MADD-40.427
C14B1.2Protein C14B1.20.427
ddx-23Protein DDX-230.425
hpo-22Protein HPO-220.423
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hand2heart and neural crest derivatives expressed transcript 20.955
tbx1T-box 10.863
gli1GLI-Kruppel family member 10.786
fgf8afibroblast growth factor 8 a0.777
evx1even-skipped homeobox 10.771
shhasonic hedgehog a0.769
sox2SRY-box containing gene 20.763
flt4fms-related tyrosine kinase 40.751
tbx20T-box 200.719
gata3GATA-binding protein 30.703
fgfr1afibroblast growth factor receptor 1a0.702
ptch2patched 20.698
thtyrosine hydroxylase0.695
rpl19ribosomal protein L190.680
tp53tumor protein p530.654
csnk1dacasein kinase 1, delta a0.647
baxabcl2-associated X protein, a0.644
plcg1phospholipase C, gamma 10.626
runx2brunt-related transcription factor 2b0.623
efnb2aephrin B2a0.616
hspa5heat shock protein 50.616
tnfrsfatumor necrosis factor receptor superfamily, member a0.612
nrg2aneuregulin 2a0.611
bmp2bbone morphogenetic protein 2b0.608
kitakit receptor a0.608
rpsaribosomal protein SA0.595
sox3SRY-box containing gene 30.591
col2a1acollagen type II, alpha-1a0.569
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.564
bmp4bone morphogenetic protein 40.562
dlx5adistal-less homeobox gene 5a0.558
fgf10afibroblast growth factor 10a0.555
ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.552
spry4sprouty (Drosophila) homolog 40.546
cav1caveolin 10.521
tshbthyroid stimulating hormone, beta subunit0.509
sema3aasemaphorin 3aa0.505
pitx3paired-like homeodomain transcription factor 30.489
egr1early growth response 10.485
bbc3BCL2 binding component 30.479
vcanaversican a0.466
sox32SRY-box containing gene 320.463
bcl2l1bcl2-like 10.461
klf4aKruppel-like transcription factor 4a0.460
bdnfbrain-derived neurotrophic factor0.457
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.445
ptf1apancreas specific transcription factor, 1a0.435
gli2aGLI-Kruppel family member GLI2a0.419
wnt11rwingless-type MMTV integration site family, member 11, related0.418
traf4atnf receptor-associated factor 4a0.410
ctsl1bcathepsin L, 1 b0.410
rpl13ribosomal protein L130.405
notch1anotch homolog 1a0.404
hey1hairy/enhancer-of-split related with YRPW motif 10.393
trpm7transient receptor potential cation channel, subfamily M, member 70.384
notch2notch homolog 20.382
myod1myogenic differentiation 10.376
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.364
ascl1aachaete-scute complex-like 1a (Drosophila)0.363
piwil1piwi-like 1 (Drosophila)0.360
rpl35ribosomal protein L350.360
gbx2gastrulation brain homeo box 20.351
cnr1cannabinoid receptor 10.350
rpl18aribosomal protein L18a0.349
otpaorthopedia homolog a0.348
lhx1aLIM homeobox 1a0.347
pax2apaired box gene 2a0.347
col14a1collagen, type XIV, alpha 10.339
tcf12transcription factor 120.338
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.337
rpl36aribosomal protein L36A0.337
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.337
tal1T-cell acute lymphocytic leukemia 10.327
mcl1amyeloid cell leukemia sequence 1a0.326
fgfr3fibroblast growth factor receptor 30.323
plxnb2aplexin b2a0.317
lmx1b.1LIM homeobox transcription factor 1, beta 10.312
zgc:65861zgc:658610.311
pcnaproliferating cell nuclear antigen0.309
foxp2forkhead box P20.306
aplnrbapelin receptor b0.303
notch3notch homolog 30.298
rps2ribosomal protein S20.296
per2period homolog 2 (Drosophila)0.295
sox11aSRY-box containing gene 11a0.289
pea3ETS-domain transcription factor pea30.288
kdrlkinase insert domain receptor like0.284
nav3neuron navigator 30.284
tyrtyrosinase0.283
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.281
zfand5azinc finger, AN1-type domain 5a0.280
vegfaavascular endothelial growth factor Aa0.276
eif4eeukaryotic translation initiation factor 4e0.275
nrg1neuregulin 10.270
rps15aribosomal protein S15a0.267
nr0b1nuclear receptor subfamily 0, group B, member 10.266
vdravitamin D receptor a0.266
cyp1b1cytochrome P450, family 1, subfamily B, polypeptide 10.264
adrb2aadrenergic receptor, beta 2a0.263
fauaFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed a0.262
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
nejnejire0.995
Atg1Autophagy-specific gene 10.974
wgwingless0.965
cicubitus interruptus0.931
slmbsupernumerary limbs0.931
Pi3K92ECG4141 gene product from transcript CG4141-RB0.929
Akt1CG4006 gene product from transcript CG4006-RA0.910
putpunt0.898
S6kRPS6-p70-protein kinase0.895
skpACG16983 gene product from transcript CG16983-RD0.886
nkdnaked cuticle0.874
eIF-4aEukaryotic initiation factor 4a0.847
kaykayak0.843
phlpole hole0.792
Dsp1Dorsal switch protein 10.774
Ras85DRas oncogene at 85D0.765
giggigas0.764
Sin3ACG8815 gene product from transcript CG8815-RC0.761
HHairless0.745
lealeak0.729
PtenCG5671 gene product from transcript CG5671-RB0.726
Tak1TGF-beta activated kinase 10.716
tsrtwinstar0.710
jarjaguar0.695
sdscalloped0.674
ftz-f1ftz transcription factor 10.662
eyaeyes absent0.647
dacdachshund0.645
MoeMoesin0.635
EgfrEpidermal growth factor receptor0.621
CspCysteine string protein0.618
crolcrooked legs0.610
rlrolled0.604
lwrlesswright0.596
smt3CG4494 gene product from transcript CG4494-RA0.577
pydpolychaetoid0.575
shotshort stop0.566
jingCG9397 gene product from transcript CG9397-RI0.562
TorTarget of rapamycin0.562
mus209mutagen-sensitive 2090.558
uspultraspiracle0.555
gekgenghis khan0.550
CtBPC-terminal Binding Protein0.549
TER94CG2331 gene product from transcript CG2331-RA0.542
smidsmallminded0.540
DadDaughters against dpp0.535
CycECyclin E0.515
CG11347CG11347 gene product from transcript CG11347-RE0.513
Rac1CG2248 gene product from transcript CG2248-RA0.511
RASSF8CG5053 gene product from transcript CG5053-RA0.507
Hrb98DEHeterogeneous nuclear ribonucleoprotein at 98DE0.498
rprreaper0.497
egreiger0.494
l(2)gllethal (2) giant larvae0.481
Prp8pre-mRNA processing factor 80.477
p53CG33336 gene product from transcript CG33336-RB0.473
sopstring of pearls0.473
alpha-Catalpha Catenin0.467
RbfRetinoblastoma-family protein0.453
atoatonal0.449
G-salpha60AG protein salpha 60A0.442
CycGCyclin G0.438
SaraSmad anchor for receptor activation0.436
Dcp-1Death caspase-10.432
Rpd3CG7471 gene product from transcript CG7471-RA0.431
rdxroadkill0.426
Top2Topoisomerase 20.423
Gp150CG5820 gene product from transcript CG5820-RA0.420
eggeggless0.416
foxoforkhead box, sub-group O0.408
LamCLamin C0.408
PvrPDGF- and VEGF-receptor related0.405
CG5741CG5741 gene product from transcript CG5741-RC0.403
JraJun-related antigen0.401
imdimmune deficiency0.398
tintinman0.397
kelkelch0.396
tlltailless0.393
brkbrinker0.392
Int6Int6 homologue0.389
PakPAK-kinase0.386
Lis-1Lissencephaly-10.385
gcmglial cells missing0.374
RpL10AbRibosomal protein L10Ab0.371
Rpt1CG1341 gene product from transcript CG1341-RA0.371
shishibire0.368
Vap-33-1CG5014 gene product from transcript CG5014-RB0.365
gloglorund0.364
tefutelomere fusion0.360
eIF-4EEukaryotic initiation factor 4E0.359
dupdouble parked0.355
rapretina aberrant in pattern0.354
slp1sloppy paired 10.352
twitwist0.351
grogroucho0.350
MhcMyosin heavy chain0.349
Nop60BNucleolar protein at 60B0.348
acachaete0.345
stcksteamer duck0.341
eveeven skipped0.341
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Prkcgprotein kinase C, gamma0.801
Anxa2annexin A20.786
Ahsgalpha-2-HS-glycoprotein0.772
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.765
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.762
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.738
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.733
Hspd1heat shock protein 1 (chaperonin)0.724
S100a10S100 calcium binding protein A100.718
Cd14CD14 molecule0.693
Mapk3mitogen activated protein kinase 30.681
Gzmkgranzyme K0.677
Nr4a3nuclear receptor subfamily 4, group A, member 30.674
Dusp1dual specificity phosphatase 10.664
Anxa4annexin A40.650
Btg2BTG family, member 20.646
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.639
Agtr1aangiotensin II receptor, type 1a0.625
Tmem88transmembrane protein 880.623
Cdc42cell division cycle 42 (GTP binding protein)0.623
Tgfb1transforming growth factor, beta 10.615
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.612
Hand2heart and neural crest derivatives expressed 20.607
Cd4Cd4 molecule0.606
Rap1bRAP1B, member of RAS oncogene family0.602
S100a6S100 calcium binding protein A60.594
Ptch1patched homolog 1 (Drosophila)0.592
Fgf10fibroblast growth factor 100.589
Hspb1heat shock protein 10.589
Vat1vesicle amine transport protein 1 homolog (T californica)0.584
Cd44Cd44 molecule0.583
Tspotranslocator protein0.580
Gria2glutamate receptor, ionotropic, AMPA 20.569
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.562
Hoxa2homeo box A20.560
Cpxm2carboxypeptidase X (M14 family), member 20.560
Txnrd1thioredoxin reductase 10.560
Jak2Janus kinase 20.554
Dctn4dynactin 40.552
Slco2b1solute carrier organic anion transporter family, member 2b10.552
Cd9CD9 molecule0.548
Adora2aadenosine A2a receptor0.548
Cdh5cadherin 50.542
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.537
Dlgap1discs, large (Drosophila) homolog-associated protein 10.531
Arpc1bactin related protein 2/3 complex, subunit 1B0.526
Tbxa2rthromboxane A2 receptor0.524
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.521
Grk1G protein-coupled receptor kinase 10.511
Smad1SMAD family member 10.499
Klf4Kruppel-like factor 4 (gut)0.497
Grm5glutamate receptor, metabotropic 50.488
Junbjun B proto-oncogene0.487
Vipvasoactive intestinal peptide0.477
Csf3colony stimulating factor 3 (granulocyte)0.475
Itgamintegrin, alpha M0.472
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.468
Notch3Notch homolog 3 (Drosophila)0.467
JunJun oncogene0.459
Socs3suppressor of cytokine signaling 30.459
Litaflipopolysaccharide-induced TNF factor0.456
Slit3slit homolog 3 (Drosophila)0.456
Pipprolactin induced protein0.449
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.447
Muskmuscle, skeletal, receptor tyrosine kinase0.446
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.444
Myo1bmyosin Ib0.441
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.440
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.439
Rararetinoic acid receptor, alpha0.433
Akt1v-akt murine thymoma viral oncogene homolog 10.427
Tagln2transgelin 20.426
Cdc37cell division cycle 37 homolog (S. cerevisiae)0.424
Neurod2neurogenic differentiation 20.423
Fgfr2fibroblast growth factor receptor 20.421
F2rl1coagulation factor II (thrombin) receptor-like 10.419
Errfi1ERBB receptor feedback inhibitor 10.416
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.414
Cct4chaperonin containing Tcp1, subunit 4 (delta)0.414
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.412
Nr4a1nuclear receptor subfamily 4, group A, member 10.412
Unc5aunc-5 homolog A (C. elegans)0.410
Vamp1vesicle-associated membrane protein 10.405
Slc28a3solute carrier family 28 (sodium-coupled nucleoside transporter), member 30.399
Pfkfb36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 30.398
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.398
Mapk1mitogen activated protein kinase 10.397
Foxd3forkhead box D30.392
FosFBJ osteosarcoma oncogene0.390
Hspa5heat shock protein 50.387
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.386
Casp2caspase 20.386
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.385
Stip1stress-induced phosphoprotein 10.385
Gnai3guanine nucleotide binding protein (G protein), alpha inhibiting 30.384
Ccnd3cyclin D30.384
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.382
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.382
Syt4synaptotagmin IV0.379
Mmp3matrix metallopeptidase 30.376
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
HSP82Hsp82p0.382
SLT2Slt2p0.220
KAR2Kar2p0.191
STI1Sti1p0.135
SSA1Ssa1p0.109
RPT6Rpt6p0.102
RAD23Rad23p0.100
RPS1ARps1ap0.098
RPL10Rpl10p0.091
PET9Pet9p0.087
CDC55Cdc55p0.085
HYP2Hyp2p0.084
PEP4Pep4p0.067
MUS81Mus81p0.062
STE11Ste11p0.062
HTB1Htb1p0.060
RPS6BRps6bp0.059
PBS2Pbs2p0.058
BFR1Bfr1p0.057
NOG2Nog2p0.056
SLA1Sla1p0.053
RPL5Rpl5p0.052
MSH2Msh2p0.050
CCT2Cct2p0.050
MCK1Mck1p0.048
IDH2Idh2p0.047
TIF5Tif5p0.045
ARB1Arb1p0.045
NOP56Nop56p0.044
CCT6Cct6p0.043
OYE2Oye2p0.041
BMH1Bmh1p0.041
MKT1Mkt1p0.039
RAD54Rad54p0.038
RPN12Rpn12p0.038
TIF35Tif35p0.038
RPL25Rpl25p0.037
NDE1Nde1p0.037
GUT2Gut2p0.036
ESS1Ess1p0.036
TSA1Tsa1p0.036
RPN13Rpn13p0.036
SUB2Sub2p0.036
HHF1Hhf1p0.035
CMD1Cmd1p0.035
SCH9Sch9p0.033
YHR033Whypothetical protein0.033
SUP45Sup45p0.033
RPS5Rps5p0.032
RPS3Rps3p0.032
SWI5Swi5p0.031
TRA1Tra1p0.031
RPT3Rpt3p0.030
PIL1Pil1p0.030
RPS7ARps7ap0.029
RPL32Rpl32p0.029
RAD16Rad16p0.029
MSH3Msh3p0.028
ULA1Ula1p0.028
HER2Her2p0.027
RSC9Rsc9p0.027
RPL18ARpl18ap0.027
RPL13ARpl13ap0.026
PPH3Pph3p0.026
URA7Ura7p0.026
TIF6Tif6p0.026
DSK2Dsk2p0.026
ATG3Atg3p0.026
PPH22Pph22p0.026
STM1Stm1p0.026
CCP1Ccp1p0.025
RPS1BRps1bp0.025
ENO1Eno1p0.025
RPL21ARpl21ap0.025
TSC11Tsc11p0.024
KSP1Ksp1p0.024
SOD2Sod2p0.024
KSS1Kss1p0.024
LAP4Lap4p0.024
TEF4Tef4p0.024
RPL19BRpl19bp0.024
MYO5Myo5p0.023
RPL20ARpl20ap0.023
UMP1Ump1p0.023
SEC1Sec1p0.023
RPN3Rpn3p0.023
HHT1Hht1p0.023
PSP2Psp2p0.023
RPL11ARpl11ap0.023
RPL1ARpl1ap0.023
RLF2Rlf2p0.023
MDM20Mdm20p0.022
ESP1Esp1p0.022
ALD6Ald6p0.022
RPL3Rpl3p0.022
UBP9Ubp9p0.022
RPL16BRpl16bp0.022
MAD1Mad1p0.022
ATP1Atp1p0.022
MDV1Mdv1p0.022