The network for 'negative regulation of ion transmembrane transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of ion transmembrane transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

NameDescriptionProbabilityFunc Analog Organism
inx-12Protein INX-120.483
unc-9Protein UNC-90.444
unc-36Protein UNC-360.442
vab-3Protein VAB-30.401
unc-7Protein UNC-70.256
mec-2Protein MEC-20.231
efn-2Protein EFN-20.185
eat-4Protein EAT-40.149
inx-17Protein INX-170.146
glr-5Protein GLR-50.134
inx-4Protein INX-40.132
inx-8Protein INX-80.124
dep-1Protein DEP-10.107
dyb-1Protein DYB-10.086
syg-1Protein SYG-10.082
ZC247.2Protein ZC247.20.077
egl-19Protein EGL-190.070
rad-51Protein RAD-510.060
ifd-1Protein IFD-10.059
sdz-28Protein SDZ-280.056
che-3Protein CHE-30.055
T23G4.3Protein T23G4.30.054
inx-9Protein INX-90.051
glr-1Protein GLR-10.050
bath-41Protein BATH-410.050
cka-2Protein CKA-20.048
R148.4Protein R148.40.046
inx-5Protein INX-50.043
CELE_Y75B12B.1Protein Y75B12B.10.042
R03H10.2Protein R03H10.20.039
ser-2Protein SER-20.039
cam-1Protein CAM-10.038
che-2Protein CHE-20.037
acl-14Protein ACL-140.036
pdfr-1Protein PDFR-10.034
tbh-1Protein TBH-10.033
C49A9.6Protein C49A9.60.032
R13A5.9Protein R13A5.90.032
tag-256Protein TAG-2560.032
unc-1Protein UNC-10.031
ape-1Protein APE-10.031
rilp-1Protein RILP-10.031
npr-1Protein NPR-10.030
lin-11Protein LIN-110.030
nlg-1Protein NLG-10.030
madd-4Protein MADD-40.030
hrg-4Protein HRG-40.029
wrk-1Protein WRK-10.029
K10D6.2Protein K10D6.20.029
C29F5.1Protein C29F5.10.028
prmt-3Protein PRMT-30.028
F48E3.4Protein F48E3.40.027
che-1Protein CHE-10.027
T19D12.6Protein T19D12.60.027
C18A3.4Protein C18A3.40.027
mdt-28Protein MDT-280.027
T05F1.11Protein T05F1.110.026
fard-1Protein FARD-10.025
aat-1Protein AAT-10.025
kgb-1Protein KGB-10.025
insc-1Protein INSC-10.025
hrg-3Protein HRG-30.024
CELE_W04E12.7Protein W04E12.70.024
CELE_Y14H12B.2Protein Y14H12B.20.024
ZK813.3Protein ZK813.30.023
W01D2.5Protein W01D2.50.023
clc-5Protein CLC-50.023
sgca-1Protein SGCA-10.023
F39G3.5Protein F39G3.50.023
CELE_Y44A6D.3Protein Y44A6D.30.023
col-76Protein COL-760.022
T27A3.1Protein T27A3.10.022
rig-1Protein RIG-10.022
inx-13Protein INX-130.022
C47D12.5Protein C47D12.50.021
aqp-10Protein AQP-100.021
clc-3Protein CLC-30.021
C48B4.8Protein C48B4.80.021
clhm-1Protein CLHM-10.020
K10D3.4Protein K10D3.40.020
F14B8.6Protein F14B8.60.020
vha-15Protein VHA-150.020
hum-4Protein HUM-40.020
twk-18Protein TWK-180.020
nhr-31Protein NHR-310.020
unc-86Protein UNC-860.019
upp-1Protein UPP-10.019
ceh-48Protein CEH-480.019
CELE_F14H3.6Protein F14H3.60.019
C08G9.2Protein C08G9.20.019
iglr-1Protein IGLR-10.019
CELE_C25A1.5Protein C25A1.50.019
C14A4.6Protein C14A4.60.019
F42C5.9Protein F42C5.90.019
tsp-7Protein TSP-70.019
lec-5Protein LEC-50.019
CELE_C27A7.6Protein C27A7.60.019
tnt-3Protein TNT-30.019
klp-3Protein KLP-30.019
gcy-28Protein GCY-280.018
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GSTM2glutathione S-transferase mu 2 (muscle)0.997
GSTM1glutathione S-transferase mu 10.989
SMURF2SMAD specific E3 ubiquitin protein ligase 20.955
INSRinsulin receptor0.928
TGFB1transforming growth factor, beta 10.895
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.852
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.685
MED15mediator complex subunit 150.639
CAB39calcium binding protein 390.618
IGF1Rinsulin-like growth factor 1 receptor0.599
AKT1v-akt murine thymoma viral oncogene homolog 10.580
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.562
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.547
SMAD4SMAD family member 40.519
TGFBR1transforming growth factor, beta receptor 10.510
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.507
CALM1calmodulin 1 (phosphorylase kinase, delta)0.505
NEDD4neural precursor cell expressed, developmentally down-regulated 40.497
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.479
FLNAfilamin A, alpha0.469
WWP1WW domain containing E3 ubiquitin protein ligase 10.415
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.371
GSTM4glutathione S-transferase mu 40.294
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.236
SH3RF1SH3 domain containing ring finger 10.226
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.215
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.204
NCF1neutrophil cytosolic factor 10.203
GNB2guanine nucleotide binding protein (G protein), beta polypeptide 20.186
SMAD7SMAD family member 70.185
GRB10growth factor receptor-bound protein 100.182
TBC1D10ATBC1 domain family, member 10A0.181
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.175
CRHcorticotropin releasing hormone0.174
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.170
ILKintegrin-linked kinase0.166
TRIM5tripartite motif containing 50.163
PDLIM1PDZ and LIM domain 10.160
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.154
SMURF1SMAD specific E3 ubiquitin protein ligase 10.149
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.148
PRKCZprotein kinase C, zeta0.146
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.146
ACVR1Bactivin A receptor, type IB0.143
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.128
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.127
MYH9myosin, heavy chain 9, non-muscle0.125
CDCP1CUB domain containing protein 10.121
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.119
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.115
PKD1polycystic kidney disease 1 (autosomal dominant)0.114
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.113
MYOZ1myozenin 10.113
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.113
TRPC1transient receptor potential cation channel, subfamily C, member 10.103
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.102
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.095
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.095
ZNF263zinc finger protein 2630.092
ADORA2Aadenosine A2a receptor0.091
EPORerythropoietin receptor0.088
WWP2WW domain containing E3 ubiquitin protein ligase 20.086
SPTBspectrin, beta, erythrocytic0.079
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.079
ANKRD13Aankyrin repeat domain 13A0.078
CAPZBcapping protein (actin filament) muscle Z-line, beta0.077
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.076
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.075
MMP12matrix metallopeptidase 12 (macrophage elastase)0.073
GLRXglutaredoxin (thioltransferase)0.073
CALD1caldesmon 10.069
ACTR1AARP1 actin-related protein 1 homolog A, centractin alpha (yeast)0.067
CAPNS1calpain, small subunit 10.067
ZFYVE9zinc finger, FYVE domain containing 90.066
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.065
MTORmechanistic target of rapamycin (serine/threonine kinase)0.065
FYNFYN oncogene related to SRC, FGR, YES0.064
ACTN4actinin, alpha 40.064
SH3BGRL3SH3 domain binding glutamic acid-rich protein like 30.060
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.060
SMAD1SMAD family member 10.058
TSC22D1TSC22 domain family, member 10.056
SH2B1SH2B adaptor protein 10.056
PSEN2presenilin 2 (Alzheimer disease 4)0.055
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.053
CXXC5CXXC finger protein 50.053
SMAD2SMAD family member 20.052
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.045
WNK4WNK lysine deficient protein kinase 40.045
PRKCGprotein kinase C, gamma0.045
IRS1insulin receptor substrate 10.044
TIMP2TIMP metallopeptidase inhibitor 20.044
MYL4myosin, light chain 4, alkali; atrial, embryonic0.043
THBS2thrombospondin 20.043
MAP3K3mitogen-activated protein kinase kinase kinase 30.042
PTPN1protein tyrosine phosphatase, non-receptor type 10.041
FBXL15F-box and leucine-rich repeat protein 150.041
CCDC115coiled-coil domain containing 1150.040
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Slc34a1solute carrier family 34 (sodium phosphate), member 10.481
Ptgs2prostaglandin-endoperoxide synthase 20.083
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.066
Ryr2ryanodine receptor 2, cardiac0.054
Dtnadystrobrevin alpha0.051
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.048
Gjd3gap junction protein, delta 30.027
Nr3c1nuclear receptor subfamily 3, group C, member 10.027
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.025
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.024
Dmddystrophin, muscular dystrophy0.024
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.024
Adora2aadenosine A2a receptor0.023
Mtap2microtubule-associated protein 20.020
Ren1renin 1 structural0.019
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.019
Pygmmuscle glycogen phosphorylase0.018
Bcl6B-cell leukemia/lymphoma 60.018
Itsn1intersectin 1 (SH3 domain protein 1A)0.018
Slc17a1solute carrier family 17 (sodium phosphate), member 10.018
Kcnk3potassium channel, subfamily K, member 30.018
Nos3nitric oxide synthase 3, endothelial cell0.017
Tlr4toll-like receptor 40.016
Vdrvitamin D receptor0.016
Nos1nitric oxide synthase 1, neuronal0.016
Akt1thymoma viral proto-oncogene 10.014
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.014
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.014
Smad3MAD homolog 3 (Drosophila)0.014
Wnk4WNK lysine deficient protein kinase 40.013
Pdzk1PDZ domain containing 10.013
Tnfsf15tumor necrosis factor (ligand) superfamily, member 150.013
Slc12a2solute carrier family 12, member 20.013
Apbb1amyloid beta (A4) precursor protein-binding, family B, member 10.012
Mks1Meckel syndrome, type 10.012
Platplasminogen activator, tissue0.012
XkKell blood group precursor (McLeod phenotype) homolog0.011
Vamp2vesicle-associated membrane protein 20.011
Il6stinterleukin 6 signal transducer0.011
Zfp592zinc finger protein 5920.011
Prlrprolactin receptor0.011
Hrchistidine rich calcium binding protein0.011
Mybpc3myosin binding protein C, cardiac0.011
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.011
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.011
Itga7integrin alpha 70.010
Col4a3collagen, type IV, alpha 30.010
Adrbk1adrenergic receptor kinase, beta 10.010
Ccr1chemokine (C-C motif) receptor 10.010
Drd2dopamine receptor D20.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.304
Eef2eukaryotic translation elongation factor 20.113
LOC100362824caveolin 2-like0.098
Cav2caveolin 20.054
Hk1hexokinase 10.046
Gfra2GDNF family receptor alpha 20.038
Pygmphosphorylase, glycogen, muscle0.037
Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.033
Pde3aphosphodiesterase 3A, cGMP inhibited0.030
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.029
Csrp3cysteine and glycine-rich protein 30.029
Celcarboxyl ester lipase0.029
Gna12guanine nucleotide binding protein (G protein) alpha 120.026
MosMoloney sarcoma oncogene0.025
Gnb3guanine nucleotide binding protein (G protein), beta polypeptide 30.025
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.024
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.023
Smpxsmall muscle protein, X-linked0.022
Nrapnebulin-related anchoring protein0.022
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.021
Ncr1natural cytotoxicity triggering receptor 10.020
Serpini2serine (or cysteine) peptidase inhibitor, clade I, member 20.020
Dsppdentin sialophosphoprotein0.019
Eef1a2eukaryotic translation elongation factor 1 alpha 20.019
Rcor2REST corepressor 20.019
Spink3serine peptidase inhibitor, Kazal type 30.019
Nckap1NCK-associated protein 10.018
Strnstriatin, calmodulin binding protein0.018
Mchr1melanin-concentrating hormone receptor 10.017
Tomm20translocase of outer mitochondrial membrane 20 homolog (yeast)0.017
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.016
Ghrlghrelin/obestatin prepropeptide0.016
Smcpsperm mitochondria-associated cysteine-rich protein0.016
KitlgKIT ligand0.016
Gabregamma-aminobutyric acid (GABA) A receptor, epsilon0.015
Scarb1scavenger receptor class B, member 10.014
Impg2interphotoreceptor matrix proteoglycan 20.014
Unc45bunc-45 homolog B (C. elegans)0.014
Kif6kinesin family member 60.014
Cyth1cytohesin 10.013
Efhd2EF-hand domain family, member D20.013
Clic4chloride intracellular channel 40.013
Myl1myosin, light chain 10.013
Esr2estrogen receptor 2 (ER beta)0.013
Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 10.013
Adcy5adenylate cyclase 50.013
Ifnginterferon gamma0.013
Fgfr1Fibroblast growth factor receptor 10.013
Rab1bRAB1B, member RAS oncogene family0.013
Myh9myosin, heavy chain 9, non-muscle0.013
Nf1neurofibromin 10.013
Actn4actinin alpha 40.012
Kcna5potassium voltage-gated channel, shaker-related subfamily, member 50.012
Emp1epithelial membrane protein 10.012
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.012
Ckmcreatine kinase, muscle0.012
Zg16zymogen granule protein 160.012
Psgb1pregnancy-specific beta 1-glycoprotein0.012
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.011
Acrv1acrosomal vesicle protein 10.011
Syt7synaptotagmin VII0.011
Grk1G protein-coupled receptor kinase 10.011
P2rx6purinergic receptor P2X, ligand-gated ion channel, 60.011
Prss1protease, serine, 1 (trypsin 1)0.011
Fitm1fat storage-inducing transmembrane protein 10.011
Slc4a3solute carrier family 4 (anion exchanger), member 30.011
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.011
Cml3camello-like 30.011
Cnga1cyclic nucleotide gated channel alpha 10.011
Syt2synaptotagmin II0.011
Il9rinterleukin 9 receptor0.011
Xcl1chemokine (C motif) ligand 10.011
Makmale germ cell-associated kinase0.010
Crtc3CREB regulated transcription coactivator 30.010
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.010
Vps52vacuolar protein sorting 52 homolog (S. cerevisiae)0.010
Epha8Eph receptor A80.010
Oxtroxytocin receptor0.010
Sgtasmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha0.010
Neu2sialidase 2 (cytosolic sialidase)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism