The network for 'negative regulation of transmembrane transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of transmembrane transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.

NameDescriptionProbabilityFunc Analog Organism
vab-3Protein VAB-30.141
unc-7Protein UNC-70.136
efn-2Protein EFN-20.123
unc-36Protein UNC-360.115
inx-4Protein INX-40.097
inx-5Protein INX-50.089
mec-2Protein MEC-20.081
cam-1Protein CAM-10.056
sdz-28Protein SDZ-280.054
eat-4Protein EAT-40.054
nhr-91Protein NHR-910.054
ZC247.2Protein ZC247.20.053
T23G4.3Protein T23G4.30.051
upp-1Protein UPP-10.046
K10D3.4Protein K10D3.40.043
syg-1Protein SYG-10.038
ifd-1Protein IFD-10.036
dep-1Protein DEP-10.036
hst-6Protein HST-60.035
ser-2Protein SER-20.034
ape-1Protein APE-10.034
unc-86Protein UNC-860.034
rig-5Protein RIG-50.034
hrg-4Protein HRG-40.033
R08D7.7Protein R08D7.70.033
M01H9.3Protein M01H9.30.032
nmgp-1Protein NMGP-10.032
F26E4.3Protein F26E4.30.032
daf-6Protein DAF-60.032
F48E3.4Protein F48E3.40.031
che-3Protein CHE-30.030
lec-5Protein LEC-50.030
acl-14Protein ACL-140.029
lev-8Protein LEV-80.029
R03H10.2Protein R03H10.20.028
glr-5Protein GLR-50.028
igcm-1Protein IGCM-10.028
lin-11Protein LIN-110.027
clc-5Protein CLC-50.027
rad-51Protein RAD-510.026
him-14Protein HIM-140.026
glr-1Protein GLR-10.026
vha-16Protein VHA-160.025
CELE_Y57A10A.2Protein Y57A10A.20.025
F42C5.9Protein F42C5.90.025
aat-2Protein AAT-20.025
cup-4Protein CUP-40.024
unc-9Protein UNC-90.024
nhr-31Protein NHR-310.024
slo-1Protein SLO-10.024
C18A3.4Protein C18A3.40.023
col-76Protein COL-760.023
lin-25Protein LIN-250.023
cng-4Protein CNG-40.023
rme-4Protein RME-40.023
unc-1Protein UNC-10.023
C48B4.7Protein C48B4.70.022
che-2Protein CHE-20.022
T05G5.1Protein T05G5.10.022
lgc-22Protein LGC-220.022
mec-1Protein MEC-10.022
madd-4Protein MADD-40.022
chw-1Protein CHW-10.021
klo-1Protein KLO-10.021
inx-17Protein INX-170.021
klp-3Protein KLP-30.021
K07C11.4Protein K07C11.40.021
T19D12.6Protein T19D12.60.021
inx-12Protein INX-120.021
inx-22Protein INX-220.020
vha-7Protein VHA-70.020
CELE_M03D4.4Protein M03D4.40.020
tsp-7Protein TSP-70.020
clhm-1Protein CLHM-10.020
egl-19Protein EGL-190.020
F13D2.1Protein F13D2.10.020
CELE_Y14H12B.2Protein Y14H12B.20.020
R07E4.3Protein R07E4.30.020
atat-2Protein ATAT-20.019
cwp-2Protein CWP-20.019
vha-15Protein VHA-150.019
CELE_M176.5Protein M176.50.019
K10D6.2Protein K10D6.20.019
CELE_ZK682.2Protein ZK682.20.019
jbts-14Protein JBTS-140.018
ger-1Protein GER-10.018
CELE_C27A7.6Protein C27A7.60.018
C30F12.1Protein C30F12.10.018
che-1Protein CHE-10.018
CELE_F40F9.5Protein F40F9.50.018
egl-18Protein EGL-180.018
inx-8Protein INX-80.018
unc-129Protein UNC-1290.018
Y87G2A.11Protein Y87G2A.110.018
gly-6Protein GLY-60.018
tbb-4Protein TBB-40.018
fard-1Protein FARD-10.018
ceh-32Protein CEH-320.017
T27A3.6Protein T27A3.60.017
Y54G2A.36Protein Y54G2A.360.017
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG34400CG34400 gene product from transcript CG34400-RD0.012
CG42629CG42629 gene product from transcript CG42629-RB0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GSTM1glutathione S-transferase mu 10.933
SMURF2SMAD specific E3 ubiquitin protein ligase 20.914
GSTM2glutathione S-transferase mu 2 (muscle)0.797
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.614
INSRinsulin receptor0.594
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.577
MED15mediator complex subunit 150.561
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.493
TGFB1transforming growth factor, beta 10.474
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.450
WWP1WW domain containing E3 ubiquitin protein ligase 10.347
NOXA1NADPH oxidase activator 10.344
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.342
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.284
AKT1v-akt murine thymoma viral oncogene homolog 10.274
CRHcorticotropin releasing hormone0.251
TGFBR1transforming growth factor, beta receptor 10.216
SETD8SET domain containing (lysine methyltransferase) 80.188
STRNstriatin, calmodulin binding protein0.185
GSTM4glutathione S-transferase mu 40.184
TRIM39tripartite motif containing 390.160
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.154
APOA1apolipoprotein A-I0.145
PKD1polycystic kidney disease 1 (autosomal dominant)0.134
IGF1Rinsulin-like growth factor 1 receptor0.128
ACVR1Bactivin A receptor, type IB0.127
ZNF263zinc finger protein 2630.122
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.121
STRN3striatin, calmodulin binding protein 30.119
STK24serine/threonine kinase 240.117
STRN4striatin, calmodulin binding protein 40.111
MMP12matrix metallopeptidase 12 (macrophage elastase)0.110
GRB10growth factor receptor-bound protein 100.109
RNF11ring finger protein 110.109
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.104
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.101
ACTN4actinin, alpha 40.100
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.097
FYNFYN oncogene related to SRC, FGR, YES0.097
SMAD7SMAD family member 70.094
RNF126ring finger protein 1260.093
ANKRD13Aankyrin repeat domain 13A0.087
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.085
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.084
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.080
TRIM5tripartite motif containing 50.080
CAB39calcium binding protein 390.079
SMAD3SMAD family member 30.078
NEDD4neural precursor cell expressed, developmentally down-regulated 40.077
CTTNBP2NLCTTNBP2 N-terminal like0.072
SMAD4SMAD family member 40.070
MYOZ1myozenin 10.069
ALBalbumin0.069
ZYXzyxin0.068
DMDdystrophin0.068
WWP2WW domain containing E3 ubiquitin protein ligase 20.068
TBC1D10ATBC1 domain family, member 10A0.067
ZFYVE9zinc finger, FYVE domain containing 90.066
SMAD2SMAD family member 20.065
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.065
GFAPglial fibrillary acidic protein0.064
FBXL15F-box and leucine-rich repeat protein 150.062
PDLIM1PDZ and LIM domain 10.062
PRKCZprotein kinase C, zeta0.061
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.060
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.059
ADORA2Aadenosine A2a receptor0.059
SMAD1SMAD family member 10.059
CAPNS1calpain, small subunit 10.058
TSC22D1TSC22 domain family, member 10.058
FAPfibroblast activation protein, alpha0.057
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.057
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.057
ROCK1Rho-associated, coiled-coil containing protein kinase 10.056
ILKintegrin-linked kinase0.055
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.054
MAP3K3mitogen-activated protein kinase kinase kinase 30.054
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.053
GRPEL1GrpE-like 1, mitochondrial (E. coli)0.053
SMURF1SMAD specific E3 ubiquitin protein ligase 10.050
CALCOCO2calcium binding and coiled-coil domain 20.049
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.048
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.048
SFRP4secreted frizzled-related protein 40.046
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.044
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.044
TRPC1transient receptor potential cation channel, subfamily C, member 10.044
ACTR1AARP1 actin-related protein 1 homolog A, centractin alpha (yeast)0.044
GLRXglutaredoxin (thioltransferase)0.043
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.041
FAM40Afamily with sequence similarity 40, member A0.041
EPORerythropoietin receptor0.041
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.040
CTTNBP2cortactin binding protein 20.040
MOBKL3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.040
FLNAfilamin A, alpha0.040
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.040
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.039
CAPN2calpain 2, (m/II) large subunit0.038
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.038
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Slc34a1solute carrier family 34 (sodium phosphate), member 10.650
Ascl1achaete-scute complex homolog 1 (Drosophila)0.594
Neurod1neurogenic differentiation 10.555
Ldb3LIM domain binding 30.399
Pax6paired box gene 60.237
Otx2orthodenticle homolog 2 (Drosophila)0.216
Neurod4neurogenic differentiation 40.208
Kiss1KiSS-1 metastasis-suppressor0.135
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.127
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.106
Shhsonic hedgehog0.101
Neurog3neurogenin 30.091
Lepleptin0.091
Neurog2neurogenin 20.088
Lhx3LIM homeobox protein 30.085
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.083
Nos1nitric oxide synthase 1, neuronal0.080
Hand2heart and neural crest derivatives expressed transcript 20.077
Gnrh1gonadotropin releasing hormone 10.077
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.076
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.063
Onecut1one cut domain, family member 10.061
Isl1ISL1 transcription factor, LIM/homeodomain0.061
Gata1GATA binding protein 10.060
Gpr50G-protein-coupled receptor 500.055
Kcnk3potassium channel, subfamily K, member 30.054
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.052
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.047
Emx1empty spiracles homolog 1 (Drosophila)0.045
Ptf1apancreas specific transcription factor, 1a0.045
MecomMDS1 and EVI1 complex locus0.044
Ptgs2prostaglandin-endoperoxide synthase 20.043
Gata4GATA binding protein 40.042
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.041
Mybpc3myosin binding protein C, cardiac0.040
Ank1ankyrin 1, erythroid0.040
Ryr2ryanodine receptor 2, cardiac0.038
Nos3nitric oxide synthase 3, endothelial cell0.038
Hrchistidine rich calcium binding protein0.038
Dtnadystrobrevin alpha0.038
Pitx2paired-like homeodomain transcription factor 20.037
En1engrailed 10.034
Nr3c1nuclear receptor subfamily 3, group C, member 10.034
Gjd3gap junction protein, delta 30.033
Vegfavascular endothelial growth factor A0.033
Actn2actinin alpha 20.032
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.031
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.030
BtkBruton agammaglobulinemia tyrosine kinase0.030
Hspb7heat shock protein family, member 7 (cardiovascular)0.030
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.029
Pnliprp2pancreatic lipase-related protein 20.029
Crb1crumbs homolog 1 (Drosophila)0.029
Tgfbr1transforming growth factor, beta receptor I0.028
Ptenphosphatase and tensin homolog0.028
Hes1hairy and enhancer of split 1 (Drosophila)0.028
Ighimmunoglobulin heavy chain complex0.028
Nhlh2nescient helix loop helix 20.028
Ccm2cerebral cavernous malformation 2 homolog (human)0.027
Il6stinterleukin 6 signal transducer0.026
Pax9paired box gene 90.025
Cd40CD40 antigen0.025
Efna2ephrin A20.025
Dmpkdystrophia myotonica-protein kinase0.025
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.025
Tal1T-cell acute lymphocytic leukemia 10.025
Prkceprotein kinase C, epsilon0.024
Tgfb1transforming growth factor, beta 10.024
XkKell blood group precursor (McLeod phenotype) homolog0.024
Prox1prospero-related homeobox 10.023
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.022
Mplmyeloproliferative leukemia virus oncogene0.022
Pdpk13-phosphoinositide dependent protein kinase 10.022
Slc12a2solute carrier family 12, member 20.022
Lhx5LIM homeobox protein 50.022
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.022
Desdesmin0.022
Hand1heart and neural crest derivatives expressed transcript 10.022
Ebf2early B-cell factor 20.021
Myl3myosin, light polypeptide 30.021
Irs2insulin receptor substrate 20.021
Plin4perilipin 40.020
Lhcgrluteinizing hormone/choriogonadotropin receptor0.020
Sycnsyncollin0.020
Zeb1zinc finger E-box binding homeobox 10.020
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.020
Amhr2anti-Mullerian hormone type 2 receptor0.020
Loxlysyl oxidase0.019
Pkd1polycystic kidney disease 1 homolog0.019
Add1adducin 1 (alpha)0.019
Nppanatriuretic peptide type A0.019
Myh7myosin, heavy polypeptide 7, cardiac muscle, beta0.019
Zfp592zinc finger protein 5920.019
Tcaptitin-cap0.019
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.019
Nr5a1nuclear receptor subfamily 5, group A, member 10.019
Atoh7atonal homolog 7 (Drosophila)0.019
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.019
Tcf15transcription factor 150.019
Grb2growth factor receptor bound protein 20.018
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.037
Gna12guanine nucleotide binding protein (G protein) alpha 120.012
Actc1actin, alpha, cardiac muscle 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism