The network for 'negative regulation of signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.

NameDescriptionProbabilityFunc Analog Organism
vab-3Protein VAB-30.603
egl-18Protein EGL-180.522
unc-9Protein UNC-90.362
pkg-1Protein PKG-10.202
akt-1Protein AKT-10.161
pry-1Protein PRY-10.115
egg-6Protein EGG-60.114
bar-1Protein BAR-10.109
egl-8Protein EGL-80.105
atg-2Protein ATG-20.099
unc-40Protein UNC-400.098
pha-4Protein PHA-40.088
mes-3Protein MES-30.087
goa-1Protein GOA-10.083
sur-2Protein SUR-20.079
pdfr-1Protein PDFR-10.076
inx-3Protein INX-30.074
magi-1Protein MAGI-10.074
lin-11Protein LIN-110.073
K10D6.4Protein K10D6.40.072
ida-1Protein IDA-10.072
inx-13Protein INX-130.070
ten-1Protein TEN-10.069
chd-7Protein CHD-70.068
nhr-67Protein NHR-670.067
ncam-1Protein NCAM-10.067
unc-42Protein UNC-420.067
skn-1Protein SKN-10.065
gld-1Protein GLD-10.064
alx-1Protein ALX-10.064
mec-2Protein MEC-20.064
mat-3Protein MAT-30.063
pat-12Protein PAT-120.063
zyg-8Protein ZYG-80.062
lin-3Protein LIN-30.061
npp-7Protein NPP-70.059
R90.1Protein R90.10.059
unc-7Protein UNC-70.059
atg-18Protein ATG-180.058
smp-1Protein SMP-10.057
exc-5Protein EXC-50.056
peb-1Protein PEB-10.056
mig-5Protein MIG-50.056
let-23Protein LET-230.056
elt-6Protein ELT-60.056
che-2Protein CHE-20.055
ajm-1Protein AJM-10.054
hda-3Protein HDA-30.054
emb-5Protein EMB-50.054
T28F4.1Protein T28F4.10.053
hcp-3Protein HCP-30.053
che-3Protein CHE-30.053
lin-37Protein LIN-370.053
unc-70Protein UNC-700.052
lmn-1Protein LMN-10.051
itr-1Protein ITR-10.051
ant-1.1Protein ANT-1.10.051
ceh-44Protein CEH-440.051
eat-4Protein EAT-40.051
alg-1Protein ALG-10.050
ttyh-1Protein TTYH-10.049
lin-25Protein LIN-250.048
teg-4Protein TEG-40.047
glp-1Protein GLP-10.047
dlg-1Protein DLG-10.047
eat-6Protein EAT-60.046
gsk-3Protein GSK-30.046
egl-5Protein EGL-50.046
C48B6.3Protein C48B6.30.046
cam-1Protein CAM-10.046
F52A8.1Protein F52A8.10.045
pde-2Protein PDE-20.045
plc-1Protein PLC-10.045
let-60Protein LET-600.045
eef-1A.1Protein EEF-1A.10.045
kal-1Protein KAL-10.044
acs-4Protein ACS-40.043
pmp-3Protein PMP-30.043
pal-1Protein PAL-10.042
ptp-3Protein PTP-30.042
bath-42Protein BATH-420.042
daf-12Protein DAF-120.042
lec-1Protein LEC-10.042
eps-8Protein EPS-80.041
hst-1Protein HST-10.041
atn-1Protein ATN-10.041
ztf-7Protein ZTF-70.040
sea-2Protein SEA-20.040
sup-12Protein SUP-120.040
C10E2.6Protein C10E2.60.040
C14B9.2Protein C14B9.20.039
sax-7Protein SAX-70.039
tam-1Protein TAM-10.039
lin-53Protein LIN-530.039
pkn-1Protein PKN-10.038
epg-2Protein EPG-20.038
F36D4.5Protein F36D4.50.038
egl-27Protein EGL-270.038
mpk-1Protein MPK-10.038
akt-2Protein AKT-20.038
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.907
tbx1T-box 10.863
pea3ETS-domain transcription factor pea30.777
gli1GLI-Kruppel family member 10.713
chdchordin0.674
per3period homolog 3 (Drosophila)0.637
sox10SRY-box containing gene 100.598
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.590
fn1fibronectin 10.556
egr1early growth response 10.540
bmp4bone morphogenetic protein 40.523
wnt4awingless-type MMTV integration site family, member 4a0.507
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.493
sox9aSRY-box containing gene 9a0.483
runx2brunt-related transcription factor 2b0.473
sema3aasemaphorin 3aa0.465
ndr2nodal-related 20.463
shhasonic hedgehog a0.458
wnt3wingless-type MMTV integration site family, member 30.432
wnt11rwingless-type MMTV integration site family, member 11, related0.416
lef1lymphocyte enhancer binding factor 10.416
fzd7afrizzled homolog 7a0.414
snai1asnail homolog 1a (Drosophila)0.406
pcdh18bprotocadherin 18b0.405
gdf6agrowth differentiation factor 6a0.404
hcrthypocretin (orexin) neuropeptide precursor0.379
wnt10awingless-type MMTV integration site family, member 10a0.371
mt2metallothionein 20.363
pomcaproopiomelanocortin a0.348
tbx6T-box gene 60.329
mapk3mitogen-activated protein kinase 30.324
hey1hairy/enhancer-of-split related with YRPW motif 10.315
edn1endothelin 10.301
trpm7transient receptor potential cation channel, subfamily M, member 70.299
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.295
csnk1dacasein kinase 1, delta a0.294
pcnaproliferating cell nuclear antigen0.293
bcl2l1bcl2-like 10.291
fgf3fibroblast growth factor 30.288
znf703zinc finger protein 7030.288
otpaorthopedia homolog a0.277
robo3roundabout homolog 30.272
zeb2azinc finger E-box binding homeobox 2a0.271
etv5bets variant 5b0.269
col2a1acollagen type II, alpha-1a0.266
cxcr4bchemokine (C-X-C motif), receptor 4b0.255
twist3twist30.255
runx1runt-related transcription factor 10.254
zgc:158603zgc:1586030.245
nrg1neuregulin 10.245
adipor2adiponectin receptor 20.244
nf1aneurofibromin 1a0.239
trpv6transient receptor potential cation channel, subfamily V, member 60.232
yap1Yes-associated protein 10.230
spry4sprouty (Drosophila) homolog 40.227
dlx6adistal-less homeobox gene 6a0.223
igf1rbinsulin-like growth factor 1b receptor0.220
spry2sprouty homolog 20.220
mcl1amyeloid cell leukemia sequence 1a0.219
twist1atwist1a0.217
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.216
sulf1sulfatase 10.216
fgfr3fibroblast growth factor receptor 30.212
wnt5bwingless-type MMTV integration site family, member 5b0.211
adra2badrenergic, alpha-2B-, receptor0.208
lhx2bLIM homeobox 2b0.205
zbtb4zinc finger and BTB domain containing 40.199
flhfloating head0.199
mef2dmyocyte enhancer factor 2d0.198
lama5laminin, alpha 50.197
epb41l5erythrocyte membrane protein band 4.1 like 50.197
fgf20afibroblast growth factor 20a0.194
cmybtranscription factor cmyb0.191
frem3Fras1 related extracellular matrix 30.191
aldh1a2aldehyde dehydrogenase 1 family, member A20.187
bocbrother of CDO0.183
bmp2abone morphogenetic protein 2a0.183
rereaarginine-glutamic acid dipeptide (RE) repeats a0.181
baxabcl2-associated X protein, a0.180
tnfrsfatumor necrosis factor receptor superfamily, member a0.180
acvr1bactivin A receptor, type IB0.178
hmgb2bhigh-mobility group box 2b0.177
bmp1abone morphogenetic protein 1a0.171
tp53bp2tumor protein p53 binding protein, 20.169
frzbfrizzled-related protein0.169
bmperBMP binding endothelial regulator0.168
dlx1adistal-less homeobox gene 1a0.168
zmynd11zinc finger, MYND domain containing 110.168
sox11bSRY-box containing gene 11b0.168
brd4bromodomain containing 40.167
rbb4retinoblastoma binding protein 40.166
nkx2.2aNK2 transcription factor related 2a0.166
notch2notch homolog 20.164
whsc1Wolf-Hirschhorn syndrome candidate 10.164
gli2aGLI-Kruppel family member GLI2a0.163
zdhhc8bzinc finger, DHHC-type containing 8b0.163
lmo4aLIM domain only 4a0.163
shhbsonic hedgehog b0.161
socs3asuppressor of cytokine signaling 3a0.161
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.159
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.998
Akt1CG4006 gene product from transcript CG4006-RA0.998
saxsaxophone0.997
rlrolled0.995
dncdunce0.970
chicoCG5686 gene product from transcript CG5686-RB0.969
NetBNetrin-B0.962
SosSon of sevenless0.960
hephemipterous0.960
UbxUltrabithorax0.958
drkdownstream of receptor kinase0.955
MadMothers against dpp0.947
EcREcdysone receptor0.942
Ras85DRas oncogene at 85D0.930
InRInsulin-like receptor0.924
tshteashirt0.917
tkvthickveins0.912
krzkurtz0.907
S6kRPS6-p70-protein kinase0.906
agoarchipelago0.898
pucpuckered0.893
rutrutabaga0.889
giggigas0.878
MoeMoesin0.873
cicubitus interruptus0.860
fufused0.852
Pka-C1cAMP-dependent protein kinase 10.850
shnschnurri0.849
Dcr-2Dicer-20.844
E2f2E2F transcription factor 20.829
shishibire0.826
Dsor1Downstream of raf10.820
p38bCG7393 gene product from transcript CG7393-RA0.808
slmbsupernumerary limbs0.806
Src64BSrc oncogene at 64B0.798
mib1mind bomb 10.790
Sir2CG5216 gene product from transcript CG5216-RA0.785
LnkCG17367 gene product from transcript CG17367-RC0.778
kiskismet0.775
Rho1CG8416 gene product from transcript CG8416-RB0.773
Atg1Autophagy-specific gene 10.755
rprreaper0.754
ChroChromator0.754
bibifid0.744
rhorhomboid0.740
C3GCG42328 gene product from transcript CG42328-RC0.734
sbbscribbler0.733
TlToll0.719
NFATNFAT homolog0.708
cazcabeza0.703
Trim9CG31721 gene product from transcript CG31721-RB0.703
brkbrinker0.701
witwishful thinking0.685
DscamDown syndrome cell adhesion molecule0.682
CG8155CG8155 gene product from transcript CG8155-RA0.681
ykiyorkie0.678
Cdc42CG12530 gene product from transcript CG12530-RA0.670
Rac2CG8556 gene product from transcript CG8556-RA0.663
ecdecdysoneless0.650
MerMerlin0.649
Pk61CProtein kinase 61C0.647
hpohippo0.642
chercheerio0.639
HcfHost cell factor0.614
apapterous0.604
Zyx102EFCG32018 gene product from transcript CG32018-RA0.595
SfmbtScm-related gene containing four mbt domains0.595
hbshibris0.582
argosCG4531 gene product from transcript CG4531-RA0.579
Dcr-1Dicer-10.578
Ptp69DProtein tyrosine phosphatase 69D0.573
fngfringe0.573
MESK2Misexpression suppressor of KSR 20.572
lwrlesswright0.568
cv-ccrossveinless c0.560
PoxnPox neuro0.559
PtenCG5671 gene product from transcript CG5671-RB0.554
Su(H)Suppressor of Hairless0.551
Rab5Rab-protein 50.546
lealeak0.545
UbqnUbiquilin0.544
Chmp1CG4108 gene product from transcript CG4108-RA0.539
lidlittle imaginal discs0.533
mspsmini spindles0.533
PcafCG4107 gene product from transcript CG4107-RA0.530
AlkCG8250 gene product from transcript CG8250-RA0.528
kaykayak0.515
CG9425CG9425 gene product from transcript CG9425-RB0.515
NNotch0.512
grogroucho0.509
Btk29ABtk family kinase at 29A0.508
Ets97DEts at 97D0.505
rictorrapamycin-insensitive companion of Tor0.503
nejnejire0.496
dshdishevelled0.493
keykenny0.490
CycDCyclin D0.488
jarjaguar0.488
chbchromosome bows0.488
MedMedea0.486
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.567
Pctk1PCTAIRE protein kinase 10.449
Ddr1discoidin domain receptor tyrosine kinase 10.393
Rps6ka1ribosomal protein S6 kinase polypeptide 10.388
Adora2aadenosine A2a receptor0.366
Pfn1profilin 10.365
Sdc3syndecan 30.349
DbpD site of albumin promoter (albumin D-box) binding protein0.341
Gria1glutamate receptor, ionotropic, AMPA 10.338
Cmklr1chemokine-like receptor 10.324
Nos3nitric oxide synthase 3, endothelial cell0.323
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.311
Ncanneurocan0.310
Phox2apaired-like homeobox 2a0.302
Sirpasignal-regulatory protein alpha0.296
Homer1homer homolog 1 (Drosophila)0.294
Pnlippancreatic lipase0.281
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.276
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.269
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.269
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.260
Grm7glutamate receptor, metabotropic 70.257
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.257
Fgfr2fibroblast growth factor receptor 20.251
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.250
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.247
Slfn2schlafen 20.246
Klf2Kruppel-like factor 2 (lung)0.241
Cishcytokine inducible SH2-containing protein0.241
Usf2upstream transcription factor 2, c-fos interacting0.238
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.232
Itgamintegrin, alpha M0.230
Ins2insulin 20.229
Crhr1corticotropin releasing hormone receptor 10.228
Tcfe2atranscription factor E2a0.225
Sgk1serum/glucocorticoid regulated kinase 10.224
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.222
Gria2glutamate receptor, ionotropic, AMPA 20.221
Baiap2BAI1-associated protein 20.219
Jak2Janus kinase 20.218
Il3interleukin 30.216
Gipgastric inhibitory polypeptide0.213
Dlgap1discs, large (Drosophila) homolog-associated protein 10.212
Ptgs2prostaglandin-endoperoxide synthase 20.211
Gdnfglial cell derived neurotrophic factor0.211
Masp1mannan-binding lectin serine peptidase 10.210
Calcrlcalcitonin receptor-like0.208
Adam1aa disintegrin and metallopeptidase domain 1a0.204
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.202
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.202
Sox17SRY (sex determining region Y)-box 170.202
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.201
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.200
Gastgastrin0.199
Foxe3forkhead box E30.198
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.197
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.196
Dock8dedicator of cytokinesis 80.194
Notch3Notch homolog 3 (Drosophila)0.192
Teddm1transmembrane epididymal protein 10.191
Nfascneurofascin0.189
Phka1phosphorylase kinase, alpha 10.188
Scarb1scavenger receptor class B, member 10.188
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.185
Nos2nitric oxide synthase 2, inducible0.179
SeboxSEBOX homeobox0.179
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.179
Grm6glutamate receptor, metabotropic 60.176
Ppp3cbprotein phosphatase 3, catalytic subunit, beta isoform0.176
Dccdeleted in colorectal carcinoma0.175
Slc22a6solute carrier family 22 (organic anion transporter), member 60.175
Kcna6potassium voltage gated channel, shaker related subfamily, member 60.174
Gabbr1gamma-aminobutyric acid (GABA) B receptor 10.173
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.173
Slc6a9solute carrier family 6 (neurotransmitter transporter, glycine), member 90.171
Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha0.168
Syt8synaptotagmin VIII0.161
Phkg1phosphorylase kinase, gamma 10.160
Jdp2Jun dimerization protein 20.160
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.159
Foxa3forkhead box A30.158
Mgat5mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase0.158
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.157
Lphn1latrophilin 10.156
Tmod2tropomodulin 20.155
Grip1glutamate receptor interacting protein 10.155
Nxph4neurexophilin 40.154
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.153
Csf1colony stimulating factor 1 (macrophage)0.153
Alcamactivated leukocyte cell adhesion molecule0.150
Ptk2bPTK2B protein tyrosine kinase 2 beta0.149
UncxUNC homeobox0.149
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.147
Grpgastrin releasing peptide0.147
Nrp1neuropilin 10.147
F13a1coagulation factor XIII, A1 polypeptide0.145
Irf2interferon regulatory factor 20.142
Epn1Epsin 10.141
Pde4bphosphodiesterase 4B, cAMP specific0.141
Ptmsparathymosin0.140
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PPH21Pph21p0.838
KSS1Kss1p0.640
FUS3Fus3p0.475
BCK1Bck1p0.436
CDC25Cdc25p0.426
SSN8Ssn8p0.379
BBC1Bbc1p0.376
DID4Did4p0.334
RTS1Rts1p0.321
BEM1Bem1p0.321
STI1Sti1p0.282
SHO1Sho1p0.238
CHC1Chc1p0.206
IRA1Ira1p0.195
MKK1Mkk1p0.183
BOI1Boi1p0.178
REG1Reg1p0.176
PPE1Ppe1p0.170
VPS20Vps20p0.167
VPS45Vps45p0.156
SIT4Sit4p0.152
YOL087Chypothetical protein0.149
MDS3Mds3p0.145
ROM2Rom2p0.136
SSA3Ssa3p0.122
FAR1Far1p0.119
END3End3p0.119
STE7Ste7p0.118
GSC2Gsc2p0.113
TPS1Tps1p0.111
TPK2Tpk2p0.103
VMA13Vma13p0.103
RLM1Rlm1p0.103
TPK1Tpk1p0.101
PEP1Pep1p0.100
VPS36Vps36p0.095
HKR1Hkr1p0.092
HSP60Hsp60p0.091
TEC1Tec1p0.090
CRG1Crg1p0.086
STE23Ste23p0.084
VPS4Vps4p0.082
ULP2Ulp2p0.082
GLC7Glc7p0.080
PBS2Pbs2p0.079
CDC34Cdc34p0.079
CMK1Cmk1p0.077
CRZ1Crz1p0.077
RTT101Rtt101p0.075
SLA2Sla2p0.075
FAR11Far11p0.074
SCP1Scp1p0.072
FTH1Fth1p0.070
MSN2Msn2p0.069
STE20Ste20p0.066
EBS1Ebs1p0.064
SWI5Swi5p0.064
DID2Did2p0.063
ICE2Ice2p0.062
FPK1Fpk1p0.062
SKT5Skt5p0.061
YCL042Whypothetical protein0.059
BMH1Bmh1p0.058
YKR017Chypothetical protein0.058
HRP1Hrp1p0.057
SLX5Slx5p0.056
MEH1Meh1p0.056
CDC55Cdc55p0.056
RAD16Rad16p0.055
MSS18Mss18p0.054
STE12Ste12p0.053
SOK1Sok1p0.053
KIC1Kic1p0.053
TAF8Taf8p0.053
SAC7Sac7p0.053
MSG5Msg5p0.052
BEM2Bem2p0.051
STE4Ste4p0.051
SLX8Slx8p0.051
NHA1Nha1p0.049
PEP5Pep5p0.048
PHO85Pho85p0.048
SIZ1Siz1p0.046
YIL001Whypothetical protein0.046
SUR1Sur1p0.045
PMR1Pmr1p0.044
RHO1Rho1p0.043
GIS1Gis1p0.043
CCL1Ccl1p0.042
HSV2Hsv2p0.042
LHS1Lhs1p0.041
NOG2Nog2p0.041
VTA1Vta1p0.041
CCR4Ccr4p0.040
DIG1Dig1p0.040
BRE5Bre5p0.040
MKK2Mkk2p0.040
STD1Std1p0.040
RSC8Rsc8p0.039
LSB1Lsb1p0.039