The network for 'epithelial tube morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epithelial tube morphogenesis

The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.

NameDescriptionProbabilityFunc Analog Organism
pha-4Protein PHA-40.963
T21B6.3Protein T21B6.30.641
osm-5Protein OSM-50.563
atn-1Protein ATN-10.477
egl-18Protein EGL-180.442
rig-6Protein RIG-60.413
cst-1Protein CST-10.391
lin-29Protein LIN-290.368
elt-6Protein ELT-60.359
unc-53Protein UNC-530.350
mnp-1Protein MNP-10.337
syd-2Protein SYD-20.311
egl-23Protein EGL-230.260
soc-2Protein SOC-20.256
spc-1Protein SPC-10.227
ldb-1Protein LDB-10.223
che-13Protein CHE-130.211
trim-9Protein TRIM-90.207
agr-1Protein AGR-10.206
hlb-1Protein HLB-10.206
egl-15Protein EGL-150.203
lin-17Protein LIN-170.200
unc-62Protein UNC-620.200
ceh-6Protein CEH-60.199
F43D9.1Protein F43D9.10.198
ain-1Protein AIN-10.192
che-11Protein CHE-110.191
cst-2Protein CST-20.182
epi-1Protein EPI-10.177
egl-46Protein EGL-460.163
unc-112Protein UNC-1120.162
sem-5Protein SEM-50.160
hlh-1Protein HLH-10.160
glp-1Protein GLP-10.157
unc-73Protein UNC-730.154
exc-5Protein EXC-50.152
sel-8Protein SEL-80.146
let-2Protein LET-20.145
vab-3Protein VAB-30.145
F54E12.2Protein F54E12.20.142
K04B12.2Protein K04B12.20.141
crm-1Protein CRM-10.141
osm-3Protein OSM-30.141
pry-1Protein PRY-10.135
odd-2Protein ODD-20.135
daf-12Protein DAF-120.134
ajm-1Protein AJM-10.134
myo-3Protein MYO-30.132
ctg-1Protein CTG-10.131
apb-1Protein APB-10.128
cdh-3Protein CDH-30.128
ten-1Protein TEN-10.126
ptp-1Protein PTP-10.126
bar-1Protein BAR-10.126
snf-11Protein SNF-110.123
let-60Protein LET-600.122
cec-5Protein CEC-50.120
ceh-27Protein CEH-270.117
cdf-1Protein CDF-10.116
pax-3Protein PAX-30.116
sos-1Protein SOS-10.115
magu-2Protein MAGU-20.115
bre-1Protein BRE-10.115
sup-12Protein SUP-120.115
sma-6Protein SMA-60.115
dsh-1Protein DSH-10.114
scd-1Protein SCD-10.112
lin-12Protein LIN-120.112
kal-1Protein KAL-10.111
Y65A5A.1Protein Y65A5A.10.111
dim-1Protein DIM-10.108
somi-1Protein SOMI-10.107
CELE_C06B8.7Protein C06B8.70.106
tag-241Protein TAG-2410.104
let-23Protein LET-230.103
R07H5.8Protein R07H5.80.102
emb-9Protein EMB-90.101
pop-1Protein POP-10.099
ztf-2Protein ZTF-20.098
rsd-3Protein RSD-30.097
sfrp-1Protein SFRP-10.097
let-756Protein LET-7560.097
unc-87Protein UNC-870.096
unc-5Protein UNC-50.096
dnj-29Protein DNJ-290.096
osm-6Protein OSM-60.096
zip-7Protein ZIP-70.094
W02C12.1Protein W02C12.10.094
egl-13Protein EGL-130.091
syg-2Protein SYG-20.091
T27A3.1Protein T27A3.10.090
tmc-2Protein TMC-20.090
egl-30Protein EGL-300.090
col-97Protein COL-970.089
hsp-3Protein HSP-30.089
egl-36Protein EGL-360.088
mig-13Protein MIG-130.088
ncam-1Protein NCAM-10.088
che-2Protein CHE-20.087
hlh-2Protein HLH-20.086
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cdh2cadherin 2, neuronal0.998
shhasonic hedgehog a0.996
ttnatitin a0.986
wnt11wingless-type MMTV integration site family, member 110.971
bmp2bbone morphogenetic protein 2b0.966
kdrlkinase insert domain receptor like0.966
tbx1T-box 10.965
pax8paired box gene 80.964
hnf1baHNF1 homeobox Ba0.963
myod1myogenic differentiation 10.963
aldh1a2aldehyde dehydrogenase 1 family, member A20.957
mecomMDS1 and EVI1 complex locus0.956
cdx4caudal type homeo box transcription factor 40.929
foxa2forkhead box A20.924
fbn2bfibrillin 2b0.920
dccdeleted in colorectal carcinoma0.912
etv5bets variant 5b0.896
tal1T-cell acute lymphocytic leukemia 10.886
hoxb5bhomeo box B5b0.882
ntlano tail a0.878
egr2bearly growth response 2b0.869
edn1endothelin 10.864
gata3GATA-binding protein 30.863
cdh1cadherin 1, epithelial0.859
sulf1sulfatase 10.824
jag1bjagged 1b0.809
ndr2nodal-related 20.801
fn1fibronectin 10.782
dusp6dual specificity phosphatase 60.777
traf4atnf receptor-associated factor 4a0.774
flhfloating head0.764
fgf8afibroblast growth factor 8 a0.756
foxd3forkhead box D30.754
lmx1b.1LIM homeobox transcription factor 1, beta 10.753
notch3notch homolog 30.747
wnt5bwingless-type MMTV integration site family, member 5b0.735
osr2odd-skipped related 2 (Drosophila)0.731
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.728
gdf6agrowth differentiation factor 6a0.728
fli1afriend leukemia integration 1a0.700
crabp2acellular retinoic acid binding protein 2, a0.693
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.686
fzd10frizzled homolog 100.682
wt1bwilms tumor 1b0.678
shhbsonic hedgehog b0.672
gro1groucho 10.671
mibmind bomb0.670
tp53tumor protein p530.659
rfx2regulatory factor X, 2 (influences HLA class II expression)0.656
tbx16T-box gene 160.650
foxi1forkhead box I10.640
jag2jagged 20.635
smad5MAD homolog 5 (Drosophila)0.620
lrrc6leucine rich repeat containing 60.615
fgf3fibroblast growth factor 30.614
pcdh8protocadherin 80.605
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.590
metmet proto-oncogene (hepatocyte growth factor receptor)0.586
emx3empty spiracles homeobox 30.583
pkd2polycystic kidney disease 20.583
myhz2myosin, heavy polypeptide 2, fast muscle specific0.570
vdravitamin D receptor a0.557
gata2aGATA-binding protein 2a0.553
sema3aasemaphorin 3aa0.542
irx1airoquois homeobox protein 1, a0.533
wnt11rwingless-type MMTV integration site family, member 11, related0.532
etv2ets variant gene 20.531
wlswntless homolog (Drosophila)0.524
wt1awilms tumor 1a0.520
col2a1acollagen type II, alpha-1a0.511
pitx3paired-like homeodomain transcription factor 30.509
coblcordon-bleu homolog (mouse)0.504
smosmoothened homolog (Drosophila)0.483
dag1dystroglycan 10.478
tbx6T-box gene 60.475
lfnglunatic fringe homolog0.474
bmp2abone morphogenetic protein 2a0.469
ift88intraflagellar transport 88 homolog0.454
tnnt2atroponin T2a, cardiac0.450
pax7apaired box gene 7a0.446
bonbonnie and clyde0.443
lamc1laminin, gamma 10.442
nrarpanotch-regulated ankyrin repeat protein a0.442
ccm2cerebral cavernous malformation 20.437
foxj1aforkhead box J1a0.437
lamb1alaminin, beta 1a0.433
smad9MAD homolog 9 (Drosophila)0.429
efnb2aephrin B2a0.427
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.425
fabp11afatty acid binding protein 11a0.422
wnt10awingless-type MMTV integration site family, member 10a0.417
foxg1aforkhead box G1a0.414
hs6st1aheparan sulfate 6-O-sulfotransferase 1a0.414
atoh1batonal homolog 1b0.410
ptch2patched 20.398
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.985
mewmultiple edematous wings0.978
cicubitus interruptus0.978
argosCG4531 gene product from transcript CG4531-RA0.943
stumpsCG31317 gene product from transcript CG31317-RC0.929
emcextra macrochaetae0.927
EgfrEpidermal growth factor receptor0.919
HLHm7E(spl) region transcript m70.910
E(spl)Enhancer of split0.901
salmspalt major0.828
aopanterior open0.776
LanB2Laminin B20.713
ShawShaker cognate w0.704
slp1sloppy paired 10.702
abd-Aabdominal A0.686
Src42ASrc oncogene at 42A0.676
EcREcdysone receptor0.670
foxoforkhead box, sub-group O0.669
elBelbow B0.662
Nsf2NEM-sensitive fusion protein 20.637
Rac1CG2248 gene product from transcript CG2248-RA0.577
vvlventral veins lacking0.567
jingCG9397 gene product from transcript CG9397-RI0.542
cdicenter divider0.522
Wnt4Wnt oncogene analog 40.500
CycACyclin A0.489
eyaeyes absent0.477
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.445
snssticks and stones0.443
Nrx-IVNeurexin IV0.424
slmbsupernumerary limbs0.424
HphHIF prolyl hydroxylase0.393
HLHmbetaE(spl) region transcript mbeta0.379
kirrekin of irre0.369
Akt1CG4006 gene product from transcript CG4006-RA0.363
fkhfork head0.359
MrtfMyocardin-related transcription factor0.359
HLHmdeltaE(spl) region transcript mdelta0.354
Rho1CG8416 gene product from transcript CG8416-RB0.342
opaodd paired0.341
fz2frizzled 20.337
grhgrainy head0.329
stanstarry night0.307
CtBPC-terminal Binding Protein0.303
LanB1CG7123 gene product from transcript CG7123-RA0.299
RalaRas-related protein0.294
lblladybird late0.291
NotumCG13076 gene product from transcript CG13076-RB0.283
cv-ccrossveinless c0.282
amosabsent MD neurons and olfactory sensilla0.278
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.997
FGFR2fibroblast growth factor receptor 20.993
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.957
ESR1estrogen receptor 10.956
SMN1survival of motor neuron 1, telomeric0.944
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.932
NOTCH1notch 10.923
VEGFAvascular endothelial growth factor A0.893
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.870
MDM2Mdm2 p53 binding protein homolog (mouse)0.857
CREBBPCREB binding protein0.843
DVL3dishevelled, dsh homolog 3 (Drosophila)0.825
SMAD3SMAD family member 30.819
JAG1jagged 10.805
BMPR1Abone morphogenetic protein receptor, type IA0.783
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.739
APCadenomatous polyposis coli0.734
SQSTM1sequestosome 10.725
NRP1neuropilin 10.713
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.674
XIAPX-linked inhibitor of apoptosis0.672
WNK4WNK lysine deficient protein kinase 40.662
NCOR2nuclear receptor corepressor 20.618
TSC2tuberous sclerosis 20.613
IQGAP1IQ motif containing GTPase activating protein 10.589
TRIP6thyroid hormone receptor interactor 60.577
TP53tumor protein p530.559
BMP7bone morphogenetic protein 70.542
RXRAretinoid X receptor, alpha0.539
BMP2bone morphogenetic protein 20.525
COL4A1collagen, type IV, alpha 10.518
FGF1fibroblast growth factor 1 (acidic)0.512
NOTCH3notch 30.504
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.503
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.497
GATA4GATA binding protein 40.485
FBXW11F-box and WD repeat domain containing 110.482
CUL3cullin 30.481
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.429
EPAS1endothelial PAS domain protein 10.422
MEIS1Meis homeobox 10.412
FKBP1AFK506 binding protein 1A, 12kDa0.400
HOXB5homeobox B50.393
CASP9caspase 9, apoptosis-related cysteine peptidase0.382
TIMP3TIMP metallopeptidase inhibitor 30.380
STK4serine/threonine kinase 40.373
PTK2PTK2 protein tyrosine kinase 20.370
HIC1hypermethylated in cancer 10.368
TBX5T-box 50.343
GSK3Bglycogen synthase kinase 3 beta0.342
HOXA10homeobox A100.340
EP300E1A binding protein p3000.340
CTNND1catenin (cadherin-associated protein), delta 10.329
COL4A2collagen, type IV, alpha 20.328
FGF8fibroblast growth factor 8 (androgen-induced)0.327
EGFRepidermal growth factor receptor0.318
CAB39calcium binding protein 390.312
ERBB2IPerbb2 interacting protein0.311
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.287
COL2A1collagen, type II, alpha 10.284
MEOX2mesenchyme homeobox 20.284
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.281
SEC23ASec23 homolog A (S. cerevisiae)0.270
ACTBactin, beta0.270
YAP1Yes-associated protein 10.264
FGF10fibroblast growth factor 100.262
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.262
PBX1pre-B-cell leukemia homeobox 10.252
LRRK2leucine-rich repeat kinase 20.247
PKD2polycystic kidney disease 2 (autosomal dominant)0.233
FZD1frizzled homolog 1 (Drosophila)0.224
FOXF1forkhead box F10.216
SEMA4Asema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A0.216
SFRP1secreted frizzled-related protein 10.209
WNT3Awingless-type MMTV integration site family, member 3A0.203
CASP3caspase 3, apoptosis-related cysteine peptidase0.198
SMAD2SMAD family member 20.198
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.193
FOXF2forkhead box F20.184
RARAretinoic acid receptor, alpha0.184
DVL1dishevelled, dsh homolog 1 (Drosophila)0.180
CDC37cell division cycle 37 homolog (S. cerevisiae)0.177
SORBS3sorbin and SH3 domain containing 30.176
PRKCZprotein kinase C, zeta0.176
WT1Wilms tumor 10.173
FSTL1follistatin-like 10.164
FGFR1fibroblast growth factor receptor 10.163
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.162
HOXA9homeobox A90.162
FGF3fibroblast growth factor 30.160
TGFBR1transforming growth factor, beta receptor 10.155
TGFB3transforming growth factor, beta 30.154
POU3F2POU class 3 homeobox 20.153
TM4SF1transmembrane 4 L six family member 10.152
HOXA11homeobox A110.150
BCL6B-cell CLL/lymphoma 60.150
JAG2jagged 20.142
MSX1msh homeobox 10.142
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.141
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Foxc1forkhead box C11.000
Pitx2paired-like homeodomain transcription factor 21.000
Fgfr2fibroblast growth factor receptor 21.000
Pax2paired box gene 21.000
Gli3GLI-Kruppel family member GLI31.000
Pax3paired box gene 31.000
Shhsonic hedgehog1.000
Gli2GLI-Kruppel family member GLI21.000
Fgfr1fibroblast growth factor receptor 11.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Tgfb2transforming growth factor, beta 21.000
Jag1jagged 11.000
Vegfavascular endothelial growth factor A1.000
Pbx1pre B-cell leukemia transcription factor 11.000
Hand1heart and neural crest derivatives expressed transcript 11.000
Gata4GATA binding protein 41.000
Ptenphosphatase and tensin homolog1.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Foxc2forkhead box C21.000
Notch1Notch gene homolog 1 (Drosophila)1.000
Sox9SRY-box containing gene 90.999
Wt1Wilms tumor 1 homolog0.999
Bmp4bone morphogenetic protein 40.999
Meox2mesenchyme homeobox 20.999
Msx1homeobox, msh-like 10.999
Eya1eyes absent 1 homolog (Drosophila)0.999
Sox2SRY-box containing gene 20.998
Efnb2ephrin B20.998
Tcfap2atranscription factor AP-2, alpha0.998
Tcf21transcription factor 210.998
Fgf8fibroblast growth factor 80.998
Tbx2T-box 20.997
Prrx1paired related homeobox 10.997
Msx2homeobox, msh-like 20.997
Smad3MAD homolog 3 (Drosophila)0.997
Rarbretinoic acid receptor, beta0.997
Ror2receptor tyrosine kinase-like orphan receptor 20.997
Egfrepidermal growth factor receptor0.995
Psen1presenilin 10.994
Prrx2paired related homeobox 20.994
Ednraendothelin receptor type A0.993
Notch2Notch gene homolog 2 (Drosophila)0.993
Zeb1zinc finger E-box binding homeobox 10.993
Gata6GATA binding protein 60.993
Apcadenomatosis polyposis coli0.993
Gscgoosecoid homeobox0.992
Hoxa11homeobox A110.992
Hes1hairy and enhancer of split 1 (Drosophila)0.992
Otx2orthodenticle homolog 2 (Drosophila)0.991
Nr5a1nuclear receptor subfamily 5, group A, member 10.990
Hoxa5homeobox A50.990
Rararetinoic acid receptor, alpha0.989
Hoxa1homeobox A10.989
Nos3nitric oxide synthase 3, endothelial cell0.989
Pax6paired box gene 60.988
Bmp7bone morphogenetic protein 70.988
Pkd1polycystic kidney disease 1 homolog0.987
Bcl2B-cell leukemia/lymphoma 20.987
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.987
Trp53transformation related protein 530.986
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.986
Arandrogen receptor0.985
Mks1Meckel syndrome, type 10.984
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.983
Notch3Notch gene homolog 3 (Drosophila)0.980
Hspg2perlecan (heparan sulfate proteoglycan 2)0.980
Pax1paired box gene 10.979
Cxcr4chemokine (C-X-C motif) receptor 40.977
Hoxa2homeobox A20.977
Fgf10fibroblast growth factor 100.976
Retret proto-oncogene0.976
Vdrvitamin D receptor0.975
Twist2twist homolog 2 (Drosophila)0.974
Hoxd11homeobox D110.974
Ptpn11protein tyrosine phosphatase, non-receptor type 110.973
Tbx3T-box 30.973
Dlx5distal-less homeobox 50.972
Rxraretinoid X receptor alpha0.972
Smosmoothened homolog (Drosophila)0.972
Nf1neurofibromatosis 10.971
Snai1snail homolog 1 (Drosophila)0.970
Zic3zinc finger protein of the cerebellum 30.970
Esr1estrogen receptor 1 (alpha)0.969
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.968
Pax8paired box gene 80.967
Nkx2-1NK2 homeobox 10.966
Hoxb6homeobox B60.965
Ptch1patched homolog 10.962
Dll1delta-like 1 (Drosophila)0.962
Pou5f1POU domain, class 5, transcription factor 10.961
Epha4Eph receptor A40.960
Foxa2forkhead box A20.959
Ephb2Eph receptor B20.958
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.954
Emx2empty spiracles homolog 2 (Drosophila)0.950
Efnb1ephrin B10.949
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Igfbp5insulin-like growth factor binding protein 50.030
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.024
Fgfr2fibroblast growth factor receptor 20.023
Smad7SMAD family member 70.022
Prrx1paired related homeobox 10.018
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.017
Sox17SRY (sex determining region Y)-box 170.017
Lims1LIM and senescent cell antigen-like domains 10.015
Nos3nitric oxide synthase 3, endothelial cell0.015
Ascl1achaete-scute complex homolog 1 (Drosophila)0.015
RGD1564327similar to integrin alpha 80.013
Gna12guanine nucleotide binding protein (G protein) alpha 120.012
Tgfbr3transforming growth factor, beta receptor III0.012
Trhr2thyrotropin releasing hormone receptor 20.011
Reg3aregenerating islet-derived 3 alpha0.011
Jak2Janus kinase 20.011
Bmp6bone morphogenetic protein 60.011
Ptgfrprostaglandin F receptor0.011
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.011
Unc5bunc-5 homolog B (C. elegans)0.011
Dchs1dachsous 1 (Drosophila)0.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism