The network for 'production of molecular mediator of immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

production of molecular mediator of immune response

The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.

NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gata6GATA-binding protein 60.670
LOC557072caspase recruitment domain-containing protein 11-like0.249
gata4GATA-binding protein 40.245
pycardPYD and CARD domain containing0.241
gata5GATA-binding protein 50.149
bmp2bbone morphogenetic protein 2b0.148
hspa5heat shock protein 50.139
cmybtranscription factor cmyb0.132
nod1nucleotide-binding oligomerization domain containing 10.121
crip2cysteine-rich protein 20.120
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.115
grnagranulin a0.109
ripk2receptor-interacting serine-threonine kinase 20.103
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.101
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.099
gfi1.1growth factor independent 1.10.095
ecrg4aesophageal cancer related gene 4a0.093
LOC100000934hypothetical protein LOC1000009340.090
mycamyelocytomatosis oncogene a0.089
myh11amyosin, heavy polypeptide 11, smooth muscle a0.088
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.086
relv-rel reticuloendotheliosis viral oncogene homolog0.085
dlg2discs, large (Drosophila) homolog 20.084
eya2eyes absent homolog 2 (Drosophila)0.081
caspacaspase a0.079
vcanbversican b0.079
zfp36l1azinc finger protein 36, C3H type-like 1a0.079
tlr9toll-like receptor 90.076
dlg4discs, large (Drosophila) homolog 4 and discs, large homolog 4 (Drosophila)0.075
tlr3toll-like receptor 30.074
ezh2enhancer of zeste homolog 2 (Drosophila)0.074
LOC100534776toll-like receptor 7-like0.073
rorcaRAR-related orphan receptor C a0.073
nos2anitric oxide synthase 2a, inducible0.072
mef2amyocyte enhancer factor 2a0.068
gclcglutamate-cysteine ligase, catalytic subunit0.068
irak4interleukin-1 receptor-associated kinase 40.068
emx1empty spiracles homeobox 10.068
abcb3l1ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 10.067
ifnphi1interferon phi 10.066
tbx5bT-box 5b0.066
mybl2myeloblastosis oncogene-like 20.066
il7rinterleukin 7 receptor0.066
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.064
terttelomerase reverse transcriptase0.064
cd40lgCD40 ligand0.064
foxi2forkhead box I20.064
bmp7bbone morphogenetic protein 7b0.063
serpinb1serpin peptidase inhibitor, clade B (ovalbumin), member 10.063
smc4structural maintenance of chromosomes 40.063
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.063
alkanaplastic lymphoma kinase (Ki-1)0.062
pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.062
ppargperoxisome proliferator activated receptor gamma0.060
greb1growth regulation by estrogen in breast cancer 10.059
ifng1-2interferon, gamma 1-20.058
lrrc33leucine rich repeat containing 330.058
tgfb2transforming growth factor, beta 20.058
ikzf1IKAROS family zinc finger 1 (Ikaros)0.057
plcg1phospholipase C, gamma 10.056
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.056
foxp3aforkhead box P3a0.055
mbpmyelin basic protein0.054
nitr5novel immune-type receptor 5 and immune-type receptor 5-like0.054
klf2bKruppel-like factor 2b0.054
skianuclear oncoprotein skia0.053
nap1l1nucleosome assembly protein 1, like 10.052
stxbp2syntaxin binding protein 20.052
grnbgranulin b0.052
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.052
jak1Janus kinase 10.051
tlr18toll-like receptor 180.051
card9caspase recruitment domain family, member 90.050
sema3dsemaphorin 3d0.050
il6stinterleukin 6 signal transducer0.050
il8interleukin 80.049
tgfb3transforming growth factor, beta 30.049
tcf21transcription factor 210.049
crb2acrumbs homolog 2a0.048
tlr20atoll-like receptor 20a0.048
mitfamicrophthalmia-associated transcription factor a0.048
myl7myosin, light polypeptide 7, regulatory0.047
tiraptoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.047
mcm6MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae)0.047
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.046
sec24cSEC24 family, member C (S. cerevisiae)0.046
sp2sp2 transcription factor0.046
nfycnuclear transcription factor Y, gamma0.046
timm13translocase of inner mitochondrial membrane 13 homolog (yeast)0.046
tbx21T-box 210.045
hapln1ahyaluronan and proteoglycan link protein 1a0.045
nt5e5'-nucleotidase, ecto (CD73)0.045
ticam1toll-like receptor adaptor molecule 10.045
tlr2toll-like receptor 20.045
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PGRP-LCPeptidoglycan recognition protein LC0.896
Spn27ASerpin 27A0.866
Spn28DSerpin 28D0.808
PGRP-SAPeptidoglycan recognition protein SA0.799
IrcImmune-regulated catalase0.793
grassGram-positive Specific Serine protease0.714
PGRP-SDCG7496 gene product from transcript CG7496-RA0.666
SPESpatzle-Processing Enzyme0.663
Myd88CG2078 gene product from transcript CG2078-RA0.637
ird5immune response deficient 50.526
Spn1Serine protease inhibitor 10.455
ird1immune response deficient 10.379
imdimmune deficiency0.372
Sp7Serine protease 70.318
CG15917CG15917 gene product from transcript CG15917-RA0.231
pirkpoor Imd response upon knock-in0.214
DreddDeath related ced-3/Nedd2-like protein0.203
eaterCG6124 gene product from transcript CG6124-RB0.174
CG7910CG7910 gene product from transcript CG7910-RA0.167
GNBP3Gram-negative bacteria binding protein 30.162
CG32185CG32185 gene product from transcript CG32185-RA0.157
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.115
CG9184CG9184 gene product from transcript CG9184-RB0.111
modSPmodular serine protease0.106
amosabsent MD neurons and olfactory sensilla0.100
emcextra macrochaetae0.098
CG12766CG12766 gene product from transcript CG12766-RA0.097
IM18Immune induced molecule 180.096
l(3)mbnlethal (3) malignant blood neoplasm0.094
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.091
Atg13Autophagy-specific gene 130.090
CG18594CG18594 gene product from transcript CG18594-RA0.087
ftz-f1ftz transcription factor 10.085
CG13641CG13641 gene product from transcript CG13641-RA0.082
MED15Mediator complex subunit 150.079
gekgenghis khan0.075
CG16718CG16718 gene product from transcript CG16718-RA0.073
AGO2Argonaute 20.071
PGRP-LFPeptidoglycan recognition protein LF0.065
Mpk2CG5475 gene product from transcript CG5475-RB0.064
p53CG33336 gene product from transcript CG33336-RB0.061
CG8586CG8586 gene product from transcript CG8586-RA0.058
BG4CG12297 gene product from transcript CG12297-RA0.058
MED14Mediator complex subunit 140.053
GNBP1Gram-negative bacteria binding protein 10.053
upd3unpaired 30.053
rev7CG2948 gene product from transcript CG2948-RA0.050
Tsp42EfTetraspanin 42Ef0.045
spiritSerine Protease Immune Response Integrator0.044
CG1103CG1103 gene product from transcript CG1103-RA0.044
bin3bicoid-interacting protein 30.044
PGRP-LBPeptidoglycan recognition protein LB0.044
Spn77BaSerpin 77Ba0.044
DptBDiptericin B0.042
CG5794CG5794 gene product from transcript CG5794-RB0.042
RfxCG6312 gene product from transcript CG6312-RA0.041
Lip3CG8823 gene product from transcript CG8823-RA0.041
tamoCG4057 gene product from transcript CG4057-RA0.041
CG11286CG11286 gene product from transcript CG11286-RA0.040
foxoforkhead box, sub-group O0.039
TepIIThiolester containing protein II0.039
Rpn2CG11888 gene product from transcript CG11888-RA0.037
CG13373CG13373 gene product from transcript CG13373-RB0.037
NijANinjurin A0.035
TM9SF4CG7364 gene product from transcript CG7364-RA0.035
PvrPDGF- and VEGF-receptor related0.034
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.963
IL4Rinterleukin 4 receptor0.873
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.861
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.772
TRAF6TNF receptor-associated factor 60.765
PTPN6protein tyrosine phosphatase, non-receptor type 60.747
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.745
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.735
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.585
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.509
RIPK2receptor-interacting serine-threonine kinase 20.494
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.473
SYKspleen tyrosine kinase0.454
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.412
IRAK2interleukin-1 receptor-associated kinase 20.352
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.342
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.337
IL2RGinterleukin 2 receptor, gamma0.326
TRAF3TNF receptor-associated factor 30.308
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.300
IL8interleukin 80.297
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.289
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.273
TNIP2TNFAIP3 interacting protein 20.270
BRCA1breast cancer 1, early onset0.268
IL10RAinterleukin 10 receptor, alpha0.239
CHUKconserved helix-loop-helix ubiquitous kinase0.226
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.220
PILRApaired immunoglobin-like type 2 receptor alpha0.216
NRP1neuropilin 10.212
IL1Binterleukin 1, beta0.208
HLA-Fmajor histocompatibility complex, class I, F0.207
CCR5chemokine (C-C motif) receptor 50.195
MX2myxovirus (influenza virus) resistance 2 (mouse)0.179
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.172
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.170
RXRAretinoid X receptor, alpha0.168
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.155
LTAlymphotoxin alpha (TNF superfamily, member 1)0.150
AXLAXL receptor tyrosine kinase0.145
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.144
MDC1mediator of DNA-damage checkpoint 10.141
LATlinker for activation of T cells0.126
MSH6mutS homolog 6 (E. coli)0.124
APLFaprataxin and PNKP like factor0.124
CD40CD40 molecule, TNF receptor superfamily member 50.123
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.106
CD33CD33 molecule0.105
H2AFXH2A histone family, member X0.103
BCL3B-cell CLL/lymphoma 30.098
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.098
TGIF1TGFB-induced factor homeobox 10.097
FASLGFas ligand (TNF superfamily, member 6)0.094
SQSTM1sequestosome 10.091
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.091
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.089
TAL1T-cell acute lymphocytic leukemia 10.086
PTK2BPTK2B protein tyrosine kinase 2 beta0.084
TRAF5TNF receptor-associated factor 50.082
BIRC3baculoviral IAP repeat containing 30.082
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.082
CCR1chemokine (C-C motif) receptor 10.082
FANCD2Fanconi anemia, complementation group D20.081
ZNF830zinc finger protein 8300.080
PAX3paired box 30.079
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.078
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.078
RPA2replication protein A2, 32kDa0.077
HLA-DRB5major histocompatibility complex, class II, DR beta 50.075
GRAP2GRB2-related adaptor protein 20.073
CXCL9chemokine (C-X-C motif) ligand 90.070
VEGFAvascular endothelial growth factor A0.070
PMS2PMS2 postmeiotic segregation increased 2 (S. cerevisiae)0.068
CCL7chemokine (C-C motif) ligand 70.067
SOX10SRY (sex determining region Y)-box 100.066
IFI44Linterferon-induced protein 44-like0.065
BRIP1BRCA1 interacting protein C-terminal helicase 10.065
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.063
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.062
RAD50RAD50 homolog (S. cerevisiae)0.061
TLR2toll-like receptor 20.061
TNFRSF9tumor necrosis factor receptor superfamily, member 90.057
CCL8chemokine (C-C motif) ligand 80.055
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.055
SIGLEC7sialic acid binding Ig-like lectin 70.054
TP53BP1tumor protein p53 binding protein 10.053
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.052
TNFAIP3tumor necrosis factor, alpha-induced protein 30.052
TYMPthymidine phosphorylase0.052
ATMataxia telangiectasia mutated0.051
IL4interleukin 40.050
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.049
THOC5THO complex 50.048
CCL2chemokine (C-C motif) ligand 20.048
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.046
MAP3K7mitogen-activated protein kinase kinase kinase 70.045
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.045
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor1.000
Cd40CD40 antigen1.000
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.999
Stat3signal transducer and activator of transcription 30.999
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.997
Tlr4toll-like receptor 40.992
Lyz2lysozyme 20.987
Il10interleukin 100.986
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.973
Myd88myeloid differentiation primary response gene 880.966
Casp4caspase 4, apoptosis-related cysteine peptidase0.949
Ccl4chemokine (C-C motif) ligand 40.946
Atmataxia telangiectasia mutated homolog (human)0.936
Foxp3forkhead box P30.931
Il2rginterleukin 2 receptor, gamma chain0.927
Ifnginterferon gamma0.913
Socs1suppressor of cytokine signaling 10.909
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.877
Rag1recombination activating gene 10.876
Il2interleukin 20.861
Il4interleukin 40.860
Ccl2chemokine (C-C motif) ligand 20.854
FasFas (TNF receptor superfamily member 6)0.847
Il6interleukin 60.836
Trp53transformation related protein 530.835
Clec4dC-type lectin domain family 4, member d0.821
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.818
Il1binterleukin 1 beta0.809
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.793
Cd28CD28 antigen0.790
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.765
Il1r1interleukin 1 receptor, type I0.744
Cd180CD180 antigen0.738
S1pr2sphingosine-1-phosphate receptor 20.729
Rag2recombination activating gene 20.718
Ltalymphotoxin A0.714
Map3k14mitogen-activated protein kinase kinase kinase 140.712
Zeb1zinc finger E-box binding homeobox 10.694
H2-Aahistocompatibility 2, class II antigen A, alpha0.690
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.688
Cd19CD19 antigen0.680
Ptprcprotein tyrosine phosphatase, receptor type, C0.673
Stat5asignal transducer and activator of transcription 5A0.666
Sh2d2aSH2 domain protein 2A0.644
Birc3baculoviral IAP repeat-containing 30.635
Ptenphosphatase and tensin homolog0.625
Kdrkinase insert domain protein receptor0.619
Ikzf1IKAROS family zinc finger 10.616
Ikbkginhibitor of kappaB kinase gamma0.605
Tbx3T-box 30.601
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.594
Nos2nitric oxide synthase 2, inducible0.575
Inpp5dinositol polyphosphate-5-phosphatase D0.571
Ccr2chemokine (C-C motif) receptor 20.558
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.554
Tnip1TNFAIP3 interacting protein 10.552
Cxcl9chemokine (C-X-C motif) ligand 90.549
TcraT-cell receptor alpha chain0.543
Lag3lymphocyte-activation gene 30.542
Traf6TNF receptor-associated factor 60.541
Cd14CD14 antigen0.538
Irg1immunoresponsive gene 10.526
Ccl22chemokine (C-C motif) ligand 220.524
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.518
C3ar1complement component 3a receptor 10.514
Tnfaip3tumor necrosis factor, alpha-induced protein 30.508
Nlrp3NLR family, pyrin domain containing 30.505
Prf1perforin 1 (pore forming protein)0.505
Irf1interferon regulatory factor 10.483
Sfpi1SFFV proviral integration 10.480
Gdf3growth differentiation factor 30.474
Rxraretinoid X receptor alpha0.466
Ccr7chemokine (C-C motif) receptor 70.464
Bcl6B-cell leukemia/lymphoma 60.458
Stat5bsignal transducer and activator of transcription 5B0.455
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.454
Apoeapolipoprotein E0.443
Ptgs2prostaglandin-endoperoxide synthase 20.431
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.429
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.417
Csf1colony stimulating factor 1 (macrophage)0.412
Vegfavascular endothelial growth factor A0.409
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.399
Ctsscathepsin S0.372
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.371
Ccl8chemokine (C-C motif) ligand 80.367
FynFyn proto-oncogene0.365
Cxcl10chemokine (C-X-C motif) ligand 100.360
Aireautoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)0.359
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.356
Stat6signal transducer and activator of transcription 60.346
Gbp2guanylate binding protein 20.345
Foxc2forkhead box C20.342
Ikbkbinhibitor of kappaB kinase beta0.339
BtkBruton agammaglobulinemia tyrosine kinase0.339
Grap2GRB2-related adaptor protein 20.331
H2-K1histocompatibility 2, K1, K region0.328
Ch25hcholesterol 25-hydroxylase0.328
Lyz1lysozyme 10.327
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-DaRT1 class II, locus Da0.089
RT1-BaRT1 class II, locus Ba0.034
RT1-DMbRT1 class II, locus DMb0.015
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.011
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.011
Cd53Cd53 molecule0.011
Cd37CD37 molecule0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism