The network for 'endodermal cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.

NameDescriptionProbabilityFunc Analog Organism
pop-1Protein POP-10.437
egl-18Protein EGL-180.187
pry-1Protein PRY-10.180
lag-2Protein LAG-20.123
lam-2Protein LAM-20.116
hlh-1Protein HLH-10.101
let-60Protein LET-600.096
flt-1Protein FLT-10.090
hbl-1Protein HBL-10.083
trim-9Protein TRIM-90.079
bar-1Protein BAR-10.071
sma-6Protein SMA-60.067
B0393.3Protein B0393.30.063
pha-4Protein PHA-40.063
sos-1Protein SOS-10.062
ten-1Protein TEN-10.061
nhr-25Protein NHR-250.054
cnd-1Protein CND-10.054
lin-29Protein LIN-290.054
cam-1Protein CAM-10.052
CELE_C27D8.3Protein C27D8.30.048
gei-4Protein GEI-40.048
hlh-2Protein HLH-20.046
eor-1Protein EOR-10.045
unc-98Protein UNC-980.045
unc-40Protein UNC-400.042
elt-2Protein ELT-20.038
wrm-1Protein WRM-10.037
tag-260Protein TAG-2600.037
lag-1Protein LAG-10.035
sel-12Protein SEL-120.034
ketn-1Protein KETN-10.034
R02D5.1Protein R02D5.10.032
unc-62Protein UNC-620.032
med-1Protein MED-10.031
mps-2Protein MPS-20.030
cwn-2Protein CWN-20.030
CELE_Y57G11C.22Protein Y57G11C.220.029
dve-1Protein DVE-10.029
nhr-67Protein NHR-670.028
CELE_C27A7.1Protein C27A7.10.028
odd-2Protein ODD-20.028
unc-120Protein UNC-1200.028
med-2Protein MED-20.027
elt-6Protein ELT-60.026
C14H10.2Protein C14H10.20.026
F42C5.9Protein F42C5.90.024
mig-6Protein MIG-60.024
F38E9.5Protein F38E9.50.023
let-268Protein LET-2680.023
mab-31Protein MAB-310.023
mom-2Protein MOM-20.023
B0454.9Protein B0454.90.022
F11D5.1Protein F11D5.10.022
cpna-2Protein CPNA-20.022
CELE_T05B11.1Protein T05B11.10.022
W02B8.1Protein W02B8.10.022
CELE_F56D5.6Protein F56D5.60.021
sys-1Protein SYS-10.021
Y42G9A.1Protein Y42G9A.10.021
flh-2Protein FLH-20.021
ZK1058.9Protein ZK1058.90.021
sem-5Protein SEM-50.020
CELE_F32A7.5Protein F32A7.50.020
ztf-22Protein ZTF-220.020
egl-36Protein EGL-360.020
C27C12.1Protein C27C12.10.019
C14A4.12Protein C14A4.120.019
prx-13Protein PRX-130.019
CELE_T04H1.2Protein T04H1.20.019
C37C3.2Protein C37C3.20.019
islo-1Protein ISLO-10.019
T21B6.3Protein T21B6.30.018
K04F10.1Protein K04F10.10.018
T24B8.3Protein T24B8.30.018
ech-8Protein ECH-80.018
gsp-2Protein GSP-20.017
Y65A5A.1Protein Y65A5A.10.017
vang-1Protein VANG-10.017
fkh-2Protein FKH-20.017
F43C9.2Protein F43C9.20.017
F22D3.6Protein F22D3.60.016
psa-3Protein PSA-30.016
npp-19Protein NPP-190.016
srj-14Protein SRJ-140.016
sma-10Protein SMA-100.016
agr-1Protein AGR-10.016
cwn-1Protein CWN-10.016
ceh-16Protein CEH-160.016
sma-9Protein SMA-90.016
F21C10.7Protein F21C10.70.016
sorb-1Protein SORB-10.016
ceh-20Protein CEH-200.015
zoo-1Protein ZOO-10.015
ubc-3Protein UBC-30.015
mep-1Protein MEP-10.015
gad-1Protein GAD-10.015
hnd-1Protein HND-10.015
lin-18Protein LIN-180.015
CELE_Y71A12B.2Protein Y71A12B.20.015
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chdchordin0.997
flhfloating head0.987
bmp2bbone morphogenetic protein 2b0.937
ventventral expressed homeobox0.865
mmp2matrix metalloproteinase 20.748
fgf3fibroblast growth factor 30.734
fgfr2fibroblast growth factor receptor 20.734
dlcdeltaC0.724
bmp4bone morphogenetic protein 40.717
tbx16T-box gene 160.699
pax2apaired box gene 2a0.681
wnt5bwingless-type MMTV integration site family, member 5b0.638
fn1fibronectin 10.540
fgf8afibroblast growth factor 8 a0.535
tbx2bT-box 2b0.477
pcdh8protocadherin 80.465
dusp6dual specificity phosphatase 60.430
mespamesoderm posterior a0.422
her7hairy and enhancer of split related-70.419
emx3empty spiracles homeobox 30.373
prickle1aprickle-like 1 (Drosophila) a0.367
snai1asnail homolog 1a (Drosophila)0.344
jag2jagged 20.344
tbx20T-box 200.335
fgf17fibroblast growth factor 170.332
spry4sprouty (Drosophila) homolog 40.326
eomesaeomesodermin homolog a0.291
sox1aSRY-box containing gene 1a0.278
dharmadharma0.264
foxg1aforkhead box G1a0.260
gbx2gastrulation brain homeo box 20.259
rarabretinoic acid receptor, alpha b0.250
hoxa2bhomeo box A2b0.244
dlddeltaD0.229
bmpr2bbone morphogenetic protein receptor, type II b (serine/threonine kinase)0.223
gli2aGLI-Kruppel family member GLI2a0.217
vedventrally expressed dharma/bozozok antagonist0.210
fzd8bfrizzled homolog 8b0.206
lhx1aLIM homeobox 1a0.200
fli1afriend leukemia integration 1a0.199
foxd5forkhead box D50.194
pitx2paired-like homeodomain transcription factor 20.181
si:ch211-235f6.2si:ch211-235f6.20.178
dkk1bdickkopf 1b0.174
lef1lymphocyte enhancer binding factor 10.173
ndr1nodal-related 10.165
otx1borthodenticle homolog 1b0.163
lfnglunatic fringe homolog0.162
spns2spinster homolog 2 (Drosophila)0.161
eya1eyes absent homolog 10.161
gata3GATA-binding protein 30.160
fgfr1afibroblast growth factor receptor 1a0.156
ascl1aachaete-scute complex-like 1a (Drosophila)0.154
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.153
si:ch211-212m21.5si:ch211-212m21.50.148
bocbrother of CDO0.142
hmx4H6 family homeobox 40.140
runx2brunt-related transcription factor 2b0.138
col11a1bcollagen type XI alpha-1b and collagen, type XI, alpha 1b0.137
dlx2adistal-less homeobox gene 2a0.133
lhx1bLIM homeobox 1b0.133
hnf1baHNF1 homeobox Ba0.132
sox32SRY-box containing gene 320.128
gro1groucho 10.128
acvr2aactivin receptor IIa0.126
msxbmuscle segment homeobox B0.125
cdh1cadherin 1, epithelial0.124
tbx2aT-box gene 2a0.119
foxh1forkhead box H10.119
her1hairy-related 10.116
dlbdeltaB0.114
has2hyaluronan synthase 20.110
pou3f3bPOU class 3 homeobox 3b0.106
ctgfconnective tissue growth factor0.106
dusp5dual specificity phosphatase 50.106
oepone-eyed pinhead0.105
cdx4caudal type homeo box transcription factor 40.104
hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.102
acvr2bactivin receptor IIb0.102
ntlano tail a0.100
cdh2cadherin 2, neuronal0.100
tp63tumor protein p630.099
ndr2nodal-related 20.097
dbx1adeveloping brain homeobox 1a0.097
cxcr4achemokine (C-X-C motif) receptor 4a0.095
ccm2cerebral cavernous malformation 20.093
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.091
lft1lefty10.090
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.090
nanos3nanos homolog 30.088
klf4Kruppel-like factor 40.087
six4bsine oculis homeobox homolog 4b0.086
mespbmesoderm posterior b0.086
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.084
admpanti-dorsalizing morphogenic protein0.083
tmem2transmembrane protein 20.083
sox19bSRY-box containing gene 19b0.082
notch2notch homolog 20.082
egr1early growth response 10.082
fibinfin bud initiation factor0.081
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp1.000
DadDaughters against dpp0.981
shnschnurri0.898
grogroucho0.835
tkvthickveins0.703
LanALaminin A0.666
EgfrEpidermal growth factor receptor0.626
MedMedea0.549
dshdishevelled0.516
cicubitus interruptus0.505
TlToll0.464
srpserpent0.459
Rac1CG2248 gene product from transcript CG2248-RA0.449
stumpsCG31317 gene product from transcript CG31317-RC0.432
sglsugarless0.423
tldtolloid0.401
ushu-shaped0.383
armarmadillo0.373
ecdecdysoneless0.301
bnlbranchless0.301
eyaeyes absent0.296
mysmyospheroid0.272
enengrailed0.271
htlheartless0.245
wgwingless0.224
saxsaxophone0.221
zfh2Zn finger homeodomain 20.215
gbbglass bottom boat0.211
wbwing blister0.175
knknot0.165
AblAbl tyrosine kinase0.163
mewmultiple edematous wings0.161
sogshort gastrulation0.160
dppdecapentaplegic0.154
CG4168CG4168 gene product from transcript CG4168-RA0.153
LanB2Laminin B20.147
phlpole hole0.143
sdscalloped0.138
ovoCG6824 gene product from transcript CG6824-RE0.133
Btk29ABtk family kinase at 29A0.124
scbscab0.113
srstripe0.102
Ras85DRas oncogene at 85D0.100
Mef2Myocyte enhancer factor 20.096
sbbscribbler0.094
emcextra macrochaetae0.091
Doc2Dorsocross20.089
CG5591CG5591 gene product from transcript CG5591-RA0.085
mblmuscleblind0.084
Su(H)Suppressor of Hairless0.083
smosmoothened0.082
zfh1Zn finger homeodomain 10.080
ospoutspread0.074
ttvtout-velu0.073
Fak56DFocal Adhesion Kinase0.067
fngfringe0.064
snostrawberry notch0.064
Nrx-IVNeurexin IV0.063
bazbazooka0.061
rhorhomboid0.061
mbcmyoblast city0.061
Bre1CG10542 gene product from transcript CG10542-RA0.059
EcREcdysone receptor0.059
NijANinjurin A0.058
myoglianinCG1838 gene product from transcript CG1838-RD0.057
SmoxSmad on X0.057
Src64BSrc oncogene at 64B0.057
tsgtwisted gastrulation0.057
cactcactus0.056
Gef26CG9491 gene product from transcript CG9491-RB0.056
cnocanoe0.055
beta-Specbeta Spectrin0.055
ftz-f1ftz transcription factor 10.052
LanB1CG7123 gene product from transcript CG7123-RA0.052
WASpCG1520 gene product from transcript CG1520-RA0.051
Mes2CG11100 gene product from transcript CG11100-RB0.047
numbCG3779 gene product from transcript CG3779-RB0.047
Sin3ACG8815 gene product from transcript CG8815-RC0.047
Spt5CG7626 gene product from transcript CG7626-RA0.046
Pi3K92ECG4141 gene product from transcript CG4141-RB0.045
atmsantimeros0.045
zipzipper0.044
Rac2CG8556 gene product from transcript CG8556-RA0.044
lablabial0.042
Wnt2Wnt oncogene analog 20.040
spzspatzle0.040
eaeaster0.040
rawCG12437 gene product from transcript CG12437-RB0.039
ash2absent, small, or homeotic discs 20.038
hbshibris0.038
O-fut1O-fucosyltransferase 10.038
binbiniou0.037
PvrPDGF- and VEGF-receptor related0.036
cswcorkscrew0.036
eastenhanced adult sensory threshold0.035
inscinscuteable0.035
frcfringe connection0.035
srwshrew0.035
rolsrolling pebbles0.034
elBelbow B0.033
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
COL1A1collagen, type I, alpha 11.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
COL1A2collagen, type I, alpha 20.997
FHL2four and a half LIM domains 20.996
COL3A1collagen, type III, alpha 10.988
COL4A2collagen, type IV, alpha 20.978
BMP2bone morphogenetic protein 20.972
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.970
PAX3paired box 30.964
ITGB4integrin, beta 40.951
COL6A1collagen, type VI, alpha 10.949
FGF1fibroblast growth factor 1 (acidic)0.947
FLNAfilamin A, alpha0.947
SMAD7SMAD family member 70.940
COL5A1collagen, type V, alpha 10.917
PDIA3protein disulfide isomerase family A, member 30.914
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.907
BMPR1Abone morphogenetic protein receptor, type IA0.855
DVL3dishevelled, dsh homolog 3 (Drosophila)0.810
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.798
FN1fibronectin 10.796
COL7A1collagen, type VII, alpha 10.764
COL4A1collagen, type IV, alpha 10.762
COL5A2collagen, type V, alpha 20.746
LTBP2latent transforming growth factor beta binding protein 20.739
BMP1bone morphogenetic protein 10.710
SMAD5SMAD family member 50.699
LCKlymphocyte-specific protein tyrosine kinase0.625
CSNK1Ecasein kinase 1, epsilon0.611
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.595
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.588
FOXD3forkhead box D30.583
DVL1dishevelled, dsh homolog 1 (Drosophila)0.583
MMP14matrix metallopeptidase 14 (membrane-inserted)0.578
WISP1WNT1 inducible signaling pathway protein 10.558
JAG1jagged 10.556
RANBP2RAN binding protein 20.539
SMAD2SMAD family member 20.539
DDR2discoidin domain receptor tyrosine kinase 20.511
PXNpaxillin0.504
BMPR1Bbone morphogenetic protein receptor, type IB0.480
FBN1fibrillin 10.463
COL6A3collagen, type VI, alpha 30.433
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.432
COL11A1collagen, type XI, alpha 10.412
COL18A1collagen, type XVIII, alpha 10.409
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.403
SMAD3SMAD family member 30.401
POSTNperiostin, osteoblast specific factor0.396
BGNbiglycan0.373
LAMC1laminin, gamma 1 (formerly LAMB2)0.371
ENGendoglin0.357
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.345
BMP7bone morphogenetic protein 70.321
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.320
THBS2thrombospondin 20.315
ADAM12ADAM metallopeptidase domain 120.313
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.306
SYKspleen tyrosine kinase0.306
FAPfibroblast activation protein, alpha0.292
POU3F2POU class 3 homeobox 20.286
NOTCH3notch 30.285
TGFB2transforming growth factor, beta 20.280
THBS1thrombospondin 10.278
SOX2SRY (sex determining region Y)-box 20.275
LAMB1laminin, beta 10.270
SMAD1SMAD family member 10.267
FYNFYN oncogene related to SRC, FGR, YES0.267
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.258
SMAD4SMAD family member 40.255
HSPG2heparan sulfate proteoglycan 20.254
PXDNperoxidasin homolog (Drosophila)0.230
SP1Sp1 transcription factor0.228
LAMC2laminin, gamma 20.225
MMP11matrix metallopeptidase 11 (stromelysin 3)0.221
COL4A6collagen, type IV, alpha 60.221
SOX11SRY (sex determining region Y)-box 110.218
PLECplectin0.210
GDF5growth differentiation factor 50.196
TNCtenascin C0.180
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif, 20.177
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.176
MXRA5matrix-remodelling associated 50.166
COL4A4collagen, type IV, alpha 40.164
CTGFconnective tissue growth factor0.162
FLNBfilamin B, beta0.161
BMP4bone morphogenetic protein 40.161
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.156
COL10A1collagen, type X, alpha 10.154
MAPK8mitogen-activated protein kinase 80.145
FKBP1AFK506 binding protein 1A, 12kDa0.144
ITGA6integrin, alpha 60.141
COL16A1collagen, type XVI, alpha 10.136
SMN1survival of motor neuron 1, telomeric0.135
MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)0.134
COL6A2collagen, type VI, alpha 20.125
BBS10Bardet-Biedl syndrome 100.120
THY1Thy-1 cell surface antigen0.107
LRRC15leucine rich repeat containing 150.106
DCNdecorin0.104
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.999
Ctnnb1catenin (cadherin associated protein), beta 10.987
Sox2SRY-box containing gene 20.961
Gli3GLI-Kruppel family member GLI30.952
Bmp4bone morphogenetic protein 40.945
Otx2orthodenticle homolog 2 (Drosophila)0.944
Pitx2paired-like homeodomain transcription factor 20.940
Vangl2vang-like 2 (van gogh, Drosophila)0.937
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.924
Fgfr1fibroblast growth factor receptor 10.875
Shhsonic hedgehog0.865
Chd7chromodomain helicase DNA binding protein 70.855
Prrx1paired related homeobox 10.830
Hand1heart and neural crest derivatives expressed transcript 10.822
Pax3paired box gene 30.774
Fgfr3fibroblast growth factor receptor 30.736
Nodalnodal0.728
Ptpn11protein tyrosine phosphatase, non-receptor type 110.556
Pax2paired box gene 20.518
Alx4aristaless-like homeobox 40.500
Foxg1forkhead box G10.476
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.454
Tbx3T-box 30.453
Jag1jagged 10.424
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.409
Foxc1forkhead box C10.397
Hspg2perlecan (heparan sulfate proteoglycan 2)0.392
Hes1hairy and enhancer of split 1 (Drosophila)0.387
Nognoggin0.366
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.348
Isl1ISL1 transcription factor, LIM/homeodomain0.307
Dvl2dishevelled 2, dsh homolog (Drosophila)0.306
Tcfap2atranscription factor AP-2, alpha0.305
Snai1snail homolog 1 (Drosophila)0.300
Fgf8fibroblast growth factor 80.300
Thbs1thrombospondin 10.299
Apcadenomatosis polyposis coli0.280
Pitx1paired-like homeodomain transcription factor 10.279
Lrp6low density lipoprotein receptor-related protein 60.274
Hand2heart and neural crest derivatives expressed transcript 20.250
Eya1eyes absent 1 homolog (Drosophila)0.249
Sox11SRY-box containing gene 110.235
Smad1MAD homolog 1 (Drosophila)0.218
Gata4GATA binding protein 40.211
Hoxa1homeobox A10.211
Col4a1collagen, type IV, alpha 10.208
Gbx2gastrulation brain homeobox 20.191
Dlx5distal-less homeobox 50.184
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.172
Foxc2forkhead box C20.171
Efnb2ephrin B20.153
Sall4sal-like 4 (Drosophila)0.149
Tgfb2transforming growth factor, beta 20.137
Wnt3awingless-related MMTV integration site 3A0.122
Hoxa13homeobox A130.122
Engendoglin0.121
Col2a1collagen, type II, alpha 10.115
Meox2mesenchyme homeobox 20.115
En1engrailed 10.114
Pou5f1POU domain, class 5, transcription factor 10.103
Lef1lymphoid enhancer binding factor 10.102
Vangl1vang-like 1 (van gogh, Drosophila)0.101
Col11a1collagen, type XI, alpha 10.100
Pou3f3POU domain, class 3, transcription factor 30.099
Smad4MAD homolog 4 (Drosophila)0.097
Smad6MAD homolog 6 (Drosophila)0.094
Col6a2collagen, type VI, alpha 20.093
Smosmoothened homolog (Drosophila)0.092
Gata6GATA binding protein 60.090
Retret proto-oncogene0.088
Bdnfbrain derived neurotrophic factor0.087
Dll1delta-like 1 (Drosophila)0.086
Tbx1T-box 10.085
Acvr1activin A receptor, type 10.085
Col5a1collagen, type V, alpha 10.084
Chrdchordin0.082
Hoxd13homeobox D130.082
Runx2runt related transcription factor 20.079
Lhx3LIM homeobox protein 30.079
Dvl3dishevelled 3, dsh homolog (Drosophila)0.079
Col4a2collagen, type IV, alpha 20.078
Zic3zinc finger protein of the cerebellum 30.077
Foxf1aforkhead box F1a0.075
Msx1homeobox, msh-like 10.073
Foxn1forkhead box N10.071
Fgf10fibroblast growth factor 100.071
Tbx2T-box 20.069
Col1a1collagen, type I, alpha 10.069
Msx2homeobox, msh-like 20.067
Rnf2ring finger protein 20.065
Foxh1forkhead box H10.063
Ror2receptor tyrosine kinase-like orphan receptor 20.063
UncxUNC homeobox0.063
Hmx3H6 homeobox 30.062
Zeb1zinc finger E-box binding homeobox 10.061
Col3a1collagen, type III, alpha 10.061
Fgf3fibroblast growth factor 30.061
Gli2GLI-Kruppel family member GLI20.060
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.059
Alx3aristaless-like homeobox 30.057
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism