The network for 'positive regulation of synaptic transmission' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of synaptic transmission

Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

NameDescriptionProbabilityFunc Analog Organism
unc-9Protein UNC-90.708
goa-1Protein GOA-10.481
unc-10Protein UNC-100.468
pdfr-1Protein PDFR-10.379
unc-36Protein UNC-360.183
ist-1Protein IST-10.182
F32B5.7Protein F32B5.70.163
gar-3Protein GAR-30.156
gar-2Protein GAR-20.152
eat-4Protein EAT-40.148
F45E4.3Protein F45E4.30.129
glr-5Protein GLR-50.088
itr-1Protein ITR-10.082
trp-1Protein TRP-10.081
mod-1Protein MOD-10.078
myo-6Protein MYO-60.077
aat-5Protein AAT-50.075
jnk-1Protein JNK-10.071
nrx-1Protein NRX-10.068
CELE_R13H7.2Protein R13H7.20.065
F54G2.1Protein F54G2.10.061
ver-3Protein VER-30.059
pdl-1Protein PDL-10.058
exc-7Protein EXC-70.058
apb-1Protein APB-10.055
csnk-1Protein CSNK-10.053
grk-2Protein GRK-20.052
unc-2Protein UNC-20.051
plc-3Protein PLC-30.049
sol-1Protein SOL-10.048
pkg-1Protein PKG-10.047
frm-3Protein FRM-30.047
T14B1.1Protein T14B1.10.046
C43H6.4Protein C43H6.40.046
magu-4Protein MAGU-40.045
syg-1Protein SYG-10.044
nlg-1Protein NLG-10.043
ser-2Protein SER-20.041
flt-1Protein FLT-10.040
dyb-1Protein DYB-10.040
slo-1Protein SLO-10.038
let-23Protein LET-230.036
inx-6Protein INX-60.036
unc-116Protein UNC-1160.035
ZC190.4Protein ZC190.40.035
unc-7Protein UNC-70.033
haf-3Protein HAF-30.032
fhod-1Protein FHOD-10.032
pkc-1Protein PKC-10.032
dop-5Protein DOP-50.031
cal-4Protein CAL-40.031
ins-1Protein INS-10.030
klp-20Protein KLP-200.030
mab-23Protein MAB-230.029
twk-29Protein TWK-290.029
pqn-39Protein PQN-390.029
F59E12.6Protein F59E12.60.029
plc-1Protein PLC-10.028
mec-6Protein MEC-60.028
R90.1Protein R90.10.027
F55A4.2Protein F55A4.20.027
ajm-1Protein AJM-10.027
apg-1Protein APG-10.027
psd-1Protein PSD-10.026
egl-8Protein EGL-80.024
sma-1Protein SMA-10.024
mig-15Protein MIG-150.024
pqn-89Protein PQN-890.024
K09E4.4Protein K09E4.40.024
ceh-57Protein CEH-570.023
tbx-2Protein TBX-20.023
camt-1Protein CAMT-10.023
gpb-1Protein GPB-10.023
let-60Protein LET-600.022
CELE_C06B8.7Protein C06B8.70.022
tax-6Protein TAX-60.022
mig-17Protein MIG-170.022
stn-1Protein STN-10.022
prkl-1Protein PRKL-10.022
ncs-5Protein NCS-50.021
zoo-1Protein ZOO-10.021
ced-10Protein CED-100.021
unc-47Protein UNC-470.021
syd-2Protein SYD-20.021
R03G8.3Protein R03G8.30.021
F49H12.3Protein F49H12.30.021
grk-1Protein GRK-10.020
rhgf-2Protein RHGF-20.020
C03B1.7Protein C03B1.70.020
cdc-42Protein CDC-420.019
npr-2Protein NPR-20.019
vav-1Protein VAV-10.019
T14B4.8Protein T14B4.80.019
inx-1Protein INX-10.019
F28E10.1Protein F28E10.10.019
nlp-31Protein NLP-310.019
egl-5Protein EGL-50.018
odr-2Protein ODR-20.018
C31E10.5Protein C31E10.50.018
cnd-1Protein CND-10.018
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
GluRIIAGlutamate receptor IIA0.976
brpbruchpilot0.771
Nrx-1Neurexin 10.613
Ank2Ankyrin 20.508
neuroliginCG13772 gene product from transcript CG13772-RA0.389
unc-104CG8566 gene product from transcript CG8566-RB0.361
nwknervous wreck0.350
hiwhighwire0.291
eagether a go-go0.195
Nmdar1NMDA receptor 10.195
dncdunce0.191
fd85Eforkhead domain 85E0.180
CG42629CG42629 gene product from transcript CG42629-RB0.167
KaiRIACG18039 gene product from transcript CG18039-RA0.162
jebjelly belly0.158
stnAstoned A0.156
Syx1ASyntaxin 1A0.153
dlg1discs large 10.123
stnBstoned B0.118
CG32635CG32635 gene product from transcript CG32635-RA0.113
caccacophony0.098
CaMKIICalcium/calmodulin-dependent protein kinase II0.098
Syt1Synaptotagmin 10.096
stjstraightjacket0.094
VGlutVesicular glutamate transporter0.087
CG13253CG13253 gene product from transcript CG13253-RB0.083
rtGEFrho-type guanine exchange factor0.081
dysdysfusion0.074
Frq1Frequenin 10.069
AdoRAdenosine receptor0.066
Frq2Frequenin 20.060
kdnknockdown0.057
SnapSoluble NSF attachment protein0.056
Octbeta2RCG33976 gene product from transcript CG33976-RA0.053
fuslfuseless0.052
Dap160Dynamin associated protein 1600.051
GluRIIEGlutamate receptor IIE0.051
GluRIIBGlutamate receptor IIB0.050
CG11317CG11317 gene product from transcript CG11317-RA0.050
paraparalytic0.049
Gad1Glutamic acid decarboxylase 10.048
Snap25Synapse protein 250.044
PP2A-B'CG7913 gene product from transcript CG7913-RK0.044
witwishful thinking0.043
unc-13CG2999 gene product from transcript CG2999-RA0.043
Pka-R1cAMP-dependent protein kinase R10.043
sosine oculis0.042
mtgmind the gap0.040
n-sybn-synaptobrevin0.039
CG43073CG43073 gene product from transcript CG43073-RF0.037
Smg1CG32743 gene product from transcript CG32743-RA0.036
DabDisabled0.036
GripGlutamate receptor binding protein0.036
CdsACDP diglyceride synthetase0.034
cpocouch potato0.034
CCKLR-17D1CCK-like receptor at 17D10.033
myoglianinCG1838 gene product from transcript CG1838-RD0.032
rutrutabaga0.031
hdcheadcase0.030
BsgBasigin0.030
SoxNSoxNeuro0.029
cpxcomplexin0.028
mttmangetout0.028
sevsevenless0.028
TyrRTyramine receptor0.028
PIP5K59BCG3682 gene product from transcript CG3682-RE0.027
CG10260CG10260 gene product from transcript CG10260-RB0.026
GluRIICGlutamate receptor IIC0.026
onecutCG1922 gene product from transcript CG1922-RA0.025
ActbetaActivin-beta0.025
Rab3Rab-protein 30.024
CG34139CG34139 gene product from transcript CG34139-RD0.024
glglass0.023
RimCG33547 gene product from transcript CG33547-RB0.023
NrtNeurotactin0.023
CanA1Calcineurin A10.022
Khc-73Kinesin-730.022
Mpk2CG5475 gene product from transcript CG5475-RB0.021
elavembryonic lethal abnormal vision0.021
CG31146CG31146 gene product from transcript CG31146-RD0.021
CG9339CG9339 gene product from transcript CG9339-RG0.021
RicRas which interacts with Calmodulin0.021
simjsimjang0.021
VAChTCG32848 gene product from transcript CG32848-RA0.020
CakiCalcium/calmodulin-dependent protein kinase0.019
AmphAmphiphysin0.017
stmAstambha A0.017
HDAC6CG6170 gene product from transcript CG6170-RA0.017
recrecombination-defective0.017
Nf1Neurofibromin 10.017
l(2)k16918lethal (2) k169180.017
shishibire0.017
VmatVesicular monoamine transporter0.017
ewgerect wing0.017
DskDrosulfakinin0.017
JraJun-related antigen0.016
dimmdimmed0.015
CG15765CG15765 gene product from transcript CG15765-RA0.015
CDaseCeramidase0.015
giggigas0.015
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.998
MAPTmicrotubule-associated protein tau0.998
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.995
DLG4discs, large homolog 4 (Drosophila)0.994
SNAP23synaptosomal-associated protein, 23kDa0.952
ARRB1arrestin, beta 10.933
DRD2dopamine receptor D20.930
SNAP25synaptosomal-associated protein, 25kDa0.925
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.886
GSK3Bglycogen synthase kinase 3 beta0.870
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.865
CRHR1corticotropin releasing hormone receptor 10.854
DLGAP1discs, large (Drosophila) homolog-associated protein 10.834
CRHcorticotropin releasing hormone0.814
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.808
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.792
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.743
APPamyloid beta (A4) precursor protein0.690
DLG2discs, large homolog 2 (Drosophila)0.672
ARHGAP1Rho GTPase activating protein 10.662
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.638
STX1Asyntaxin 1A (brain)0.616
ADORA2Aadenosine A2a receptor0.591
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.588
VAC14Vac14 homolog (S. cerevisiae)0.519
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.506
VAMP3vesicle-associated membrane protein 3 (cellubrevin)0.494
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.477
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.397
NTRK3neurotrophic tyrosine kinase, receptor, type 30.394
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.393
NTF4neurotrophin 40.387
APCadenomatous polyposis coli0.372
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.359
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.357
RPH3Arabphilin 3A homolog (mouse)0.355
FBXO7F-box protein 70.352
SNAI1snail homolog 1 (Drosophila)0.327
NRXN1neurexin 10.325
TK1thymidine kinase 1, soluble0.316
F11RF11 receptor0.305
TOR1AIP2torsin A interacting protein 20.301
EGR3early growth response 30.295
MAP3K5mitogen-activated protein kinase kinase kinase 50.283
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.281
GRIA1glutamate receptor, ionotropic, AMPA 10.275
KIAA0408KIAA04080.273
RIMS1regulating synaptic membrane exocytosis 10.270
IL8interleukin 80.265
HIPK2homeodomain interacting protein kinase 20.264
MAST1microtubule associated serine/threonine kinase 10.264
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.263
CCKcholecystokinin0.250
MAP3K1mitogen-activated protein kinase kinase kinase 10.248
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.239
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.239
PRKCEprotein kinase C, epsilon0.238
DLGAP2discs, large (Drosophila) homolog-associated protein 20.237
EGR2early growth response 20.235
MYO16myosin XVI0.232
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.226
GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 10.221
ACTL6Bactin-like 6B0.216
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.209
VAMP2vesicle-associated membrane protein 2 (synaptobrevin 2)0.207
MATKmegakaryocyte-associated tyrosine kinase0.205
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.201
BRAFv-raf murine sarcoma viral oncogene homolog B10.199
STX5syntaxin 50.199
PRKCGprotein kinase C, gamma0.198
DLG3discs, large homolog 3 (Drosophila)0.197
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.197
TROtrophinin0.187
STMN2stathmin-like 20.187
NGFnerve growth factor (beta polypeptide)0.174
IER2immediate early response 20.173
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.167
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.163
CACNB4calcium channel, voltage-dependent, beta 4 subunit0.154
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.151
KCNMA1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.149
GRIK1glutamate receptor, ionotropic, kainate 10.145
TPPPtubulin polymerization promoting protein0.145
GRIA2glutamate receptor, ionotropic, AMPA 20.144
GRIP1glutamate receptor interacting protein 10.139
APBA1amyloid beta (A4) precursor protein-binding, family A, member 10.139
DDNdendrin0.138
ADRB2adrenergic, beta-2-, receptor, surface0.138
TAC1tachykinin, precursor 10.137
NECAB2N-terminal EF-hand calcium binding protein 20.137
SNCAIPsynuclein, alpha interacting protein0.137
SDC2syndecan 20.136
SYN2synapsin II0.135
NINninein (GSK3B interacting protein)0.135
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.134
COPS4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)0.133
ADORA1adenosine A1 receptor0.132
GRIA4glutamate receptor, ionotrophic, AMPA 40.131
RIMS2regulating synaptic membrane exocytosis 20.125
NLGN3neuroligin 30.123
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gng7guanine nucleotide binding protein (G protein), gamma 70.806
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.767
S100a6S100 calcium binding protein A60.681
Stx1asyntaxin 1A (brain)0.669
S100a8S100 calcium binding protein A80.635
Syn1synapsin I0.589
Anxa2annexin A20.563
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.550
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.448
Gad2glutamate decarboxylase 20.439
Ppyr1pancreatic polypeptide receptor 10.421
Csf1colony stimulating factor 1 (macrophage)0.410
Fgf7fibroblast growth factor 70.409
Adora2aadenosine A2a receptor0.378
Nrxn1neurexin 10.372
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.367
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.347
Nr4a3nuclear receptor subfamily 4, group A, member 30.346
Vamp2vesicle-associated membrane protein 20.345
Vegp2von Ebners gland protein 20.326
Grm5glutamate receptor, metabotropic 50.317
Tacr2tachykinin receptor 20.316
Adra2cadrenergic, alpha-2C-, receptor0.314
Nfascneurofascin0.314
Hrh3histamine receptor H30.306
Snap25synaptosomal-associated protein 250.304
Npy5rneuropeptide Y receptor Y50.298
UncxUNC homeobox0.291
Kcnq2potassium voltage-gated channel, KQT-like subfamily, member 20.289
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.289
S100a9S100 calcium binding protein A90.284
Nmbrneuromedin B receptor0.278
Dlgap1discs, large (Drosophila) homolog-associated protein 10.270
Gnao1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.267
Gria1glutamate receptor, ionotropic, AMPA 10.267
Nlgn3neuroligin 30.266
Rims1regulating synaptic membrane exocytosis 10.266
Grid1glutamate receptor, ionotropic, delta 10.266
Grm7glutamate receptor, metabotropic 70.265
Cd28Cd28 molecule0.264
Olr287olfactory receptor 2870.263
Prkcgprotein kinase C, gamma0.260
Shank2SH3 and multiple ankyrin repeat domains 20.254
Anxa1annexin A10.249
Egr2early growth response 20.239
Kalrnkalirin, RhoGEF kinase0.235
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.234
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.231
Adora1adenosine A1 receptor0.229
FaslgFas ligand (TNF superfamily, member 6)0.226
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.225
FevFEV (ETS oncogene family)0.222
Gabrdgamma-aminobutyric acid (GABA) A receptor, delta0.219
Dlg4discs, large homolog 4 (Drosophila)0.207
Glp1rglucagon-like peptide 1 receptor0.203
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.200
Camk4calcium/calmodulin-dependent protein kinase IV0.200
S100a10S100 calcium binding protein A100.199
Cgaglycoprotein hormones, alpha polypeptide0.196
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.195
Slc1a1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 10.195
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.194
Cacna1gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.193
Arandrogen receptor0.192
Cntn1contactin 10.189
Acrv1acrosomal vesicle protein 10.187
Chrna7cholinergic receptor, nicotinic, alpha 70.184
Ncr1natural cytotoxicity triggering receptor 10.182
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.182
Nrxn3neurexin 30.181
CamkvCaM kinase-like vesicle-associated0.180
Crhbpcorticotropin releasing hormone binding protein0.176
Scn8asodium channel, voltage gated, type VIII, alpha subunit0.175
Slc7a3solute carrier family 7 (cationic amino acid transporter, y+ system), member 30.175
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.172
Citcitron0.169
Drd1adopamine receptor D1A0.168
Htr75-hydroxytryptamine (serotonin) receptor 70.167
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.166
Tac2tachykinin 20.164
Egr1early growth response 10.161
FosFBJ osteosarcoma oncogene0.160
Foxd3forkhead box D30.159
Gabbr1gamma-aminobutyric acid (GABA) B receptor 10.153
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.153
CartptCART prepropeptide0.152
Ctsjcathepsin J0.151
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.149
Dlgap2discs, large (Drosophila) homolog-associated protein 20.148
Lalbalactalbumin, alpha0.147
Prlprolactin0.147
Mas1MAS1 oncogene0.145
S100a4S100 calcium-binding protein A40.144
Vipvasoactive intestinal peptide0.144
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.144
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.143
Gjb4gap junction protein, beta 40.142
Grid2glutamate receptor, ionotropic, delta 20.141
KlKlotho0.141
Avparginine vasopressin0.140
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism