The network for 'positive regulation of small gtpase mediated signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of small gtpase mediated signal transduction

Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.

NameDescriptionProbabilityFunc Analog Organism
lin-45Protein LIN-450.837
mek-2Protein MEK-20.574
let-60Protein LET-600.522
mpk-1Protein MPK-10.462
egl-18Protein EGL-180.368
sem-5Protein SEM-50.211
cdf-1Protein CDF-10.159
rig-6Protein RIG-60.123
gpr-1Protein GPR-10.067
lin-25Protein LIN-250.066
plc-1Protein PLC-10.063
eor-2Protein EOR-20.062
sur-7Protein SUR-70.055
snr-7Protein SNR-70.055
abts-1Protein ABTS-10.055
mat-3Protein MAT-30.044
ash-2Protein ASH-20.044
lmn-1Protein LMN-10.041
sel-8Protein SEL-80.041
hda-1Protein HDA-10.037
bar-1Protein BAR-10.035
sur-2Protein SUR-20.035
CELE_F11A3.2Protein F11A3.20.032
cpsf-2Protein CPSF-20.031
rpm-1Protein RPM-10.031
sma-6Protein SMA-60.031
CELE_F08D12.1Protein F08D12.10.029
let-756Protein LET-7560.028
CELE_T26A8.4Protein T26A8.40.027
CELE_F22D6.2Protein F22D6.20.026
gld-1Protein GLD-10.026
aat-9Protein AAT-90.024
lin-12Protein LIN-120.024
rsp-1Protein RSP-10.024
ntl-4Protein NTL-40.023
pkn-1Protein PKN-10.023
Y10G11A.1Protein Y10G11A.10.022
nhr-34Protein NHR-340.022
daf-3Protein DAF-30.020
ced-10Protein CED-100.019
pat-3Protein PAT-30.019
lag-1Protein LAG-10.019
plc-3Protein PLC-30.018
vnut-1Protein VNUT-10.018
cul-3Protein CUL-30.018
cyn-7Protein CYN-70.017
nkcc-1Protein NKCC-10.017
pme-1Protein PME-10.017
Y55F3BR.8Protein Y55F3BR.80.016
daf-12Protein DAF-120.016
CELE_T04H1.2Protein T04H1.20.016
R01H10.7Protein R01H10.70.016
C11H1.3Protein C11H1.30.016
uaf-1Protein UAF-10.015
goa-1Protein GOA-10.015
dnj-25Protein DNJ-250.014
svh-2Protein SVH-20.014
T23D8.3Protein T23D8.30.013
sca-1Protein SCA-10.013
lsy-2Protein LSY-20.013
ama-1Protein AMA-10.012
ccf-1Protein CCF-10.012
pop-1Protein POP-10.012
unc-43Protein UNC-430.012
R90.1Protein R90.10.011
tax-6Protein TAX-60.011
F59F4.3Protein F59F4.30.011
itr-1Protein ITR-10.011
egl-27Protein EGL-270.011
nhr-45Protein NHR-450.011
ran-1Protein RAN-10.011
zfp-3Protein ZFP-30.011
obr-3Protein OBR-30.011
crm-1Protein CRM-10.010
unc-53Protein UNC-530.010
nra-3Protein NRA-30.010
par-4Protein PAR-40.010
B0464.9Protein B0464.90.010
rsp-7Protein RSP-70.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.995
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.972
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.912
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.463
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.448
acsbg2acyl-CoA synthetase bubblegum family member 20.292
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.287
ywhabatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a0.286
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.265
ywhaqatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a0.246
mapk3mitogen-activated protein kinase 30.241
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.204
sulf1sulfatase 10.179
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.153
phf21aPHD finger protein 21A0.141
celf1cugbp, Elav-like family member 10.135
piguphosphatidylinositol glycan anchor biosynthesis, class U0.120
apcadenomatosis polyposis coli0.118
tbx2bT-box 2b0.106
tspan7btetraspanin 7b0.105
mllt11myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 110.104
dpysl2bdihydropyrimidinase-like 2b0.102
znf711zinc finger protein 7110.100
safbscaffold attachment factor B0.095
neo1neogenin 10.093
lama1laminin, alpha 10.092
tead3aTEA domain family member 3 a0.089
smad9MAD homolog 9 (Drosophila)0.088
tmem2transmembrane protein 20.086
rbm39bRNA binding motif protein 39b0.084
gsnagelsolin a0.081
fzd3afrizzled homolog 3a0.079
lef1lymphocyte enhancer binding factor 10.079
trnau1apltRNA selenocysteine 1 associated protein 1, like0.078
sf3b1splicing factor 3b, subunit 10.078
nat10N-acetyltransferase 100.076
kbpkif1-binding protein0.073
dpysl5adihydropyrimidinase-like 5a0.071
rbmxRNA binding motif protein, X-linked0.070
bnc2basonuclin 20.070
ywhaityrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide0.069
rykreceptor-like tyrosine kinase0.068
hk1hexokinase 10.068
pcf11cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)0.067
appbamyloid beta (A4) precursor protein b0.066
fgfr1bfibroblast growth factor receptor 1b0.065
wnt5awingless-type MMTV integration site family, member 5a0.065
ube2v2ubiquitin-conjugating enzyme E2 variant 20.065
leo1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.064
fbn2bfibrillin 2b0.062
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.061
appaamyloid beta (A4) precursor protein a0.060
LOC569128hypothetical protein LOC5691280.059
rxraaretinoid X receptor, alpha a0.059
hs2st1aheparan sulfate 2-O-sulfotransferase 1a0.058
mmp2matrix metalloproteinase 20.057
sumo1SMT3 suppressor of mif two 3 homolog 1 (yeast)0.056
sept7aseptin 7a0.056
spna2spectrin alpha 20.055
hdac4histone deacetylase 40.055
rnd3aRho family GTPase 3a0.054
egfl7EGF-like-domain, multiple 70.053
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.053
ppp2cbprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform0.052
mfn2mitofusin 20.052
mapk7mitogen-activated protein kinase 70.051
gna13aguanine nucleotide binding protein (G protein), alpha 13a0.051
smu1smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)0.050
cntfrciliary neurotrophic factor receptor0.050
tial1TIA1 cytotoxic granule-associated RNA binding protein-like 10.050
fmnl2bformin-like 2b0.050
ube2i2ubiquitin-conjugating enzyme E2I20.049
hnrnpmheterogeneous nuclear ribonucleoprotein M0.049
matr3lmatrin 3-like0.049
fkbp4FK506 binding protein 40.048
mapk1mitogen-activated protein kinase 10.048
ndufa4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 40.048
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.048
ctnnb1catenin (cadherin-associated protein), beta 10.047
hnrnpdheterogeneous nuclear ribonucleoprotein D0.046
nrg1neuregulin 10.046
ck2bcasein kinase 2 beta0.046
pobpartial optokinetic response b0.046
clk4aCDC-like kinase 4a0.045
sf3a2splicing factor 3a, subunit 20.045
btbd6bBTB (POZ) domain containing 6b0.044
ppp3r1bprotein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b0.043
cdc16cell division cycle 16 homolog (S. cerevisiae)0.042
ltkleukocyte tyrosine kinase0.041
ruvbl2RuvB-like 2 (E. coli)0.041
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
phlpole hole0.021
Sry-deltaSerendipity delta0.019
drkdownstream of receptor kinase0.017
CG9797CG9797 gene product from transcript CG9797-RA0.017
robo3CG5423 gene product from transcript CG5423-RA0.016
CG14641CG14641 gene product from transcript CG14641-RA0.016
CG1792CG1792 gene product from transcript CG1792-RA0.015
saspermatocyte arrest0.014
az2CG1605 gene product from transcript CG1605-RA0.013
CG7386CG7386 gene product from transcript CG7386-RA0.013
Saf-BScaffold attachment factor B0.013
Ras85DRas oncogene at 85D0.013
Stat92ESignal-transducer and activator of transcription protein at 92E0.012
Tap42Two A-associated protein of 42kDa0.012
CG6654CG6654 gene product from transcript CG6654-RA0.012
unc-5CG8166 gene product from transcript CG8166-RA0.012
aPKCatypical protein kinase C0.011
pUf68poly U binding factor 68kD0.011
Ssl1CG11115 gene product from transcript CG11115-RA0.011
Rcd1Reduction in Cnn dots 10.011
EgfrEpidermal growth factor receptor0.011
CG5859CG5859 gene product from transcript CG5859-RA0.011
BRWD3CG31132 gene product from transcript CG31132-RA0.011
CG10274CG10274 gene product from transcript CG10274-RA0.011
Srp54CG4602 gene product from transcript CG4602-RA0.011
CG13472CG13472 gene product from transcript CG13472-RA0.010
CG11188CG11188 gene product from transcript CG11188-RA0.010
lqfRliquid facets-Related0.010
RhoGAP93BCG3421 gene product from transcript CG3421-RA0.010
Dsor1Downstream of raf10.010
ShcSHC-adaptor protein0.010
Spt5CG7626 gene product from transcript CG7626-RA0.010
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide1.000
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide1.000
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.999
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.999
FGFR2fibroblast growth factor receptor 20.980
EGFRepidermal growth factor receptor0.956
FGFR1fibroblast growth factor receptor 10.927
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.907
PLCG1phospholipase C, gamma 10.864
BRAFv-raf murine sarcoma viral oncogene homolog B10.838
JAG1jagged 10.798
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.612
IGF1Rinsulin-like growth factor 1 receptor0.587
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.562
MAP2K1mitogen-activated protein kinase kinase 10.459
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.424
NOTCH1notch 10.398
FGF10fibroblast growth factor 100.396
ZNF496zinc finger protein 4960.309
SNIP1Smad nuclear interacting protein 10.243
MAPK1mitogen-activated protein kinase 10.177
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.166
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.162
NOTCH3notch 30.160
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.129
LATlinker for activation of T cells0.123
NGFnerve growth factor (beta polypeptide)0.113
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.098
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.093
PTPN1protein tyrosine phosphatase, non-receptor type 10.086
MOBKL3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.083
SLMAPsarcolemma associated protein0.083
SRPK2SRSF protein kinase 20.083
ITGB1BP3integrin beta 1 binding protein 30.081
RHOAras homolog gene family, member A0.079
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.076
MAPK3mitogen-activated protein kinase 30.075
MAPK14mitogen-activated protein kinase 140.074
PTCHD2patched domain containing 20.073
STRNstriatin, calmodulin binding protein0.059
TNK2tyrosine kinase, non-receptor, 20.057
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.057
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.052
ABI1abl-interactor 10.046
MAP2K4mitogen-activated protein kinase kinase 40.044
MAP3K1mitogen-activated protein kinase kinase kinase 10.042
NCK1NCK adaptor protein 10.042
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.040
BAG1BCL2-associated athanogene0.040
ARRB2arrestin, beta 20.038
RHEBRas homolog enriched in brain0.037
PEBP4phosphatidylethanolamine-binding protein 40.036
CAV1caveolin 1, caveolae protein, 22kDa0.036
ARRB1arrestin, beta 10.032
METmet proto-oncogene (hepatocyte growth factor receptor)0.032
APCadenomatous polyposis coli0.031
NAV1neuron navigator 10.031
FGF7fibroblast growth factor 70.030
MPRIPmyosin phosphatase Rho interacting protein0.028
MAP2K2mitogen-activated protein kinase kinase 20.028
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.026
SHC1SHC (Src homology 2 domain containing) transforming protein 10.024
PEBP1phosphatidylethanolamine binding protein 10.024
GRB10growth factor receptor-bound protein 100.022
RPTORregulatory associated protein of MTOR, complex 10.022
CTTNBP2NLCTTNBP2 N-terminal like0.022
LCATlecithin-cholesterol acyltransferase0.021
STK4serine/threonine kinase 40.021
FGFR1OP2FGFR1 oncogene partner 20.021
DLL1delta-like 1 (Drosophila)0.021
APOC1apolipoprotein C-I0.021
MAP3K5mitogen-activated protein kinase kinase kinase 50.020
STMN2stathmin-like 20.020
GRB2growth factor receptor-bound protein 20.020
JAG2jagged 20.019
INSRinsulin receptor0.019
FGF1fibroblast growth factor 1 (acidic)0.018
SIKE1suppressor of IKBKE 10.018
DIAPH1diaphanous homolog 1 (Drosophila)0.018
MAPK10mitogen-activated protein kinase 100.018
ROCK1Rho-associated, coiled-coil containing protein kinase 10.018
NTF4neurotrophin 40.018
PDE4DIPphosphodiesterase 4D interacting protein0.018
PRPF38APRP38 pre-mRNA processing factor 38 (yeast) domain containing A0.017
STK3serine/threonine kinase 30.017
GAB2GRB2-associated binding protein 20.017
FGF8fibroblast growth factor 8 (androgen-induced)0.017
EPORerythropoietin receptor0.017
COL1A2collagen, type I, alpha 20.016
USPL1ubiquitin specific peptidase like 10.016
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.015
AXLAXL receptor tyrosine kinase0.015
STK24serine/threonine kinase 240.015
SOS1son of sevenless homolog 1 (Drosophila)0.015
PBKPDZ binding kinase0.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.086
Rnf4ring finger protein 40.062
Ccnt2cyclin T20.045
Sf3b1splicing factor 3b, subunit 10.041
Ptp4a2protein tyrosine phosphatase 4a20.035
Cdc34cell division cycle 34 homolog (S. cerevisiae)0.029
Metmet proto-oncogene0.028
Sfrs18splicing factor, arginine/serine-rich 180.026
Clk1CDC-like kinase 10.025
Sfrs11splicing factor, arginine/serine-rich 110.021
Clcn3chloride channel 30.020
LOC100360174lysM and putative peptidoglycan-binding domain-containing protein 3-like0.018
Col5a2collagen, type V, alpha 20.016
Nefhneurofilament, heavy polypeptide0.016
Strnstriatin, calmodulin binding protein0.015
Ube2hubiquitin-conjugating enzyme E2H0.014
Rac1ras-related C3 botulinum toxin substrate 10.014
RGD1359529similar to chromosome 1 open reading frame 630.014
Clk4CDC like kinase 40.014
Pgrprogesterone receptor0.013
Guk1guanylate kinase 10.013
Kcnab1potassium voltage-gated channel, shaker-related subfamily, beta member 10.012
Jtbjumping translocation breakpoint0.012
BokBCL2-related ovarian killer0.012
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.012
Prpf39PRP39 pre-mRNA processing factor 39 homolog (S. cerevisiae)0.011
Plekha1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.010
Chatcholine acetyltransferase0.010
Prkcaprotein kinase C, alpha0.010
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism