The network for 'regulation of lamellipodium assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of lamellipodium assembly

Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.

NameDescriptionProbabilityFunc Analog Organism
cdc-42Protein CDC-420.747
vps-32.1Protein VPS-32.10.414
fce-1Protein FCE-10.213
goa-1Protein GOA-10.173
gsp-1Protein GSP-10.172
rab-1Protein RAB-10.111
F38A5.2Protein F38A5.20.090
sem-5Protein SEM-50.087
F22D3.2Protein F22D3.20.087
arx-1Protein ARX-10.086
unc-60Protein UNC-600.077
T19A6.1Protein T19A6.10.073
set-16Protein SET-160.068
mig-2Protein MIG-20.058
cap-1Protein CAP-10.044
scpl-2Protein SCPL-20.044
hmg-1.2Protein HMG-1.20.039
rab-5Protein RAB-50.039
pph-4.1Protein PPH-4.10.037
CELE_Y47G6A.18Protein Y47G6A.180.036
pmp-3Protein PMP-30.034
plc-4Protein PLC-40.029
yif-1Protein YIF-10.028
D2013.6Protein D2013.60.027
lir-1Protein LIR-10.027
D2085.5Protein D2085.50.026
CELE_B0238.10Protein B0238.100.025
kin-3Protein KIN-30.025
gmeb-1Protein GMEB-10.025
atf-7Protein ATF-70.023
clic-1Protein CLIC-10.023
rnf-121Protein RNF-1210.022
unc-50Protein UNC-500.021
C18E9.2Protein C18E9.20.021
unc-108Protein UNC-1080.021
hmgr-1Protein HMGR-10.021
mlc-5Protein MLC-50.020
Y18H1A.2Protein Y18H1A.20.020
abts-1Protein ABTS-10.020
paqr-2Protein PAQR-20.019
eat-3Protein EAT-30.019
sel-12Protein SEL-120.019
tag-335Protein TAG-3350.019
Y22D7AL.7Protein Y22D7AL.70.019
CELE_W05H12.1Protein W05H12.10.019
helq-1Protein HELQ-10.018
vps-36Protein VPS-360.018
cam-1Protein CAM-10.018
cnt-2Protein CNT-20.018
C33H5.18Protein C33H5.180.018
lin-28Protein LIN-280.017
riok-3Protein RIOK-30.017
rig-4Protein RIG-40.017
smp-1Protein SMP-10.017
dcn-1Protein DCN-10.016
let-60Protein LET-600.016
mig-38Protein MIG-380.016
ced-10Protein CED-100.016
unc-32Protein UNC-320.016
T23F11.1Protein T23F11.10.015
CELE_C30H7.2Protein C30H7.20.015
Y48E1B.3Protein Y48E1B.30.015
CELE_Y116A8C.26Protein Y116A8C.260.014
rsy-1Protein RSY-10.014
ttx-7Protein TTX-70.014
C41H7.5Protein C41H7.50.014
riok-1Protein RIOK-10.014
unc-94Protein UNC-940.014
unc-73Protein UNC-730.013
ubc-3Protein UBC-30.013
hipr-1Protein HIPR-10.013
sars-1Protein SARS-10.013
Y32H12A.8Protein Y32H12A.80.013
nmy-1Protein NMY-10.013
nkb-1Protein NKB-10.013
rap-2Protein RAP-20.013
wrk-1Protein WRK-10.012
Y50C1A.1Protein Y50C1A.10.012
F41H10.4Protein F41H10.40.012
hut-1Protein HUT-10.012
snf-1Protein SNF-10.012
B0416.5Protein B0416.50.012
afd-1Protein AFD-10.012
K02B12.7Protein K02B12.70.012
F45G2.4Protein F45G2.40.012
CELE_F52C6.12Protein F52C6.120.011
Y54G2A.2Protein Y54G2A.20.011
pac-1Protein PAC-10.011
snx-27Protein SNX-270.011
nhr-49Protein NHR-490.011
F54B11.5Protein F54B11.50.011
lin-40Protein LIN-400.011
CELE_F59B2.2Protein F59B2.20.011
rilp-1Protein RILP-10.011
clr-1Protein CLR-10.011
unc-45Protein UNC-450.011
tag-333Protein TAG-3330.011
iglr-2Protein IGLR-20.011
C13F10.4Protein C13F10.40.011
tbc-15Protein TBC-150.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Sop2Suppressor of profilin 20.664
Rac1CG2248 gene product from transcript CG2248-RA0.652
Rho1CG8416 gene product from transcript CG8416-RB0.651
Cdc42CG12530 gene product from transcript CG12530-RA0.642
cpbcapping protein beta0.620
mbcmyoblast city0.507
EphrinCG1862 gene product from transcript CG1862-RA0.473
Vrp1Verprolin 10.445
DlicDynein light intermediate chain0.210
Rab11Rab-protein 110.128
Syx1ASyntaxin 1A0.125
AblAbl tyrosine kinase0.118
par-1CG8201 gene product from transcript CG8201-RA0.105
RalaRas-related protein0.090
Dhc64CDynein heavy chain 64C0.079
Arp66BActin-related protein 66B0.077
Akt1CG4006 gene product from transcript CG4006-RA0.075
sec6CG5341 gene product from transcript CG5341-RA0.072
cpacapping protein alpha0.066
sds22CG5851 gene product from transcript CG5851-RA0.063
Rac2CG8556 gene product from transcript CG8556-RA0.051
CragCalmodulin-binding protein related to a Rab3 GDP/GTP exchange protein0.048
KhcKinesin heavy chain0.042
Arp14DActin-related protein 14D0.036
gcmglial cells missing0.033
ric8aCG15797 gene product from transcript CG15797-RA0.031
pod1CG4532 gene product from transcript CG4532-RF0.030
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.030
Act5CActin 5C0.027
RanBPMRan-binding protein M0.026
Src64BSrc oncogene at 64B0.026
rheaCG6831 gene product from transcript CG6831-RA0.025
Rab5Rab-protein 50.023
Arc-p34CG10954 gene product from transcript CG10954-RA0.020
S6kRPS6-p70-protein kinase0.020
jingCG9397 gene product from transcript CG9397-RI0.019
sqhspaghetti squash0.019
pholpleiohomeotic like0.018
CrebB-17ACyclic-AMP response element binding protein B at 17A0.017
HSPC300CG30173 gene product from transcript CG30173-RA0.017
ShcSHC-adaptor protein0.017
p120ctnAdherens junction protein p1200.016
laceCG4162 gene product from transcript CG4162-RA0.016
alpha-Specalpha Spectrin0.015
G-oalpha47AG protein oalpha 47A0.015
CG17082CG17082 gene product from transcript CG17082-RD0.014
Lim3CG10699 gene product from transcript CG10699-RB0.014
MrtfMyocardin-related transcription factor0.013
katanin-60katanin 600.012
kermitCG11546 gene product from transcript CG11546-RB0.012
CG4511CG4511 gene product from transcript CG4511-RA0.011
tomosynCG17762 gene product from transcript CG17762-RB0.011
zfh1Zn finger homeodomain 10.011
DscamDown syndrome cell adhesion molecule0.010
PtenCG5671 gene product from transcript CG5671-RB0.010
Ctr1ACopper transporter 1A0.010
Upf1CG1559 gene product from transcript CG1559-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.957
ZNF746zinc finger protein 7460.755
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.735
PRKCZprotein kinase C, zeta0.436
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.410
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.377
ARPC1Bactin related protein 2/3 complex, subunit 1B, 41kDa0.288
BAIAP2BAI1-associated protein 20.274
GAS7growth arrest-specific 70.161
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.155
PFDN1prefoldin subunit 10.132
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.129
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.116
NCKAP1NCK-associated protein 10.093
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.079
GRB7growth factor receptor-bound protein 70.079
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.073
MEF2Amyocyte enhancer factor 2A0.065
NUMBnumb homolog (Drosophila)0.062
ARPC3actin related protein 2/3 complex, subunit 3, 21kDa0.061
LDOC1leucine zipper, down-regulated in cancer 10.056
ABI1abl-interactor 10.054
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.053
PTOV1prostate tumor overexpressed 10.053
MYL12Bmyosin, light chain 12B, regulatory0.048
ILKintegrin-linked kinase0.043
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.043
LLGL2lethal giant larvae homolog 2 (Drosophila)0.040
RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.035
LLGL1lethal giant larvae homolog 1 (Drosophila)0.034
SORBS3sorbin and SH3 domain containing 30.031
CAPZBcapping protein (actin filament) muscle Z-line, beta0.029
FASLGFas ligand (TNF superfamily, member 6)0.026
ABI2abl-interactor 20.026
SPRR2Asmall proline-rich protein 2A0.026
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.023
SPTBN1spectrin, beta, non-erythrocytic 10.023
SH3BGRL3SH3 domain binding glutamic acid-rich protein like 30.022
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.020
NCF2neutrophil cytosolic factor 20.019
LRRK2leucine-rich repeat kinase 20.019
EPHA8EPH receptor A80.019
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.018
MAP3K11mitogen-activated protein kinase kinase kinase 110.018
CAPZA1capping protein (actin filament) muscle Z-line, alpha 10.018
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.018
PFN1profilin 10.018
EPS8epidermal growth factor receptor pathway substrate 80.018
COTL1coactosin-like 1 (Dictyostelium)0.017
EFHD2EF-hand domain family, member D20.017
CDC42EP3CDC42 effector protein (Rho GTPase binding) 30.015
PACSIN1protein kinase C and casein kinase substrate in neurons 10.014
PRKCIprotein kinase C, iota0.014
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.014
PREX1phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 10.014
HOOK2hook homolog 2 (Drosophila)0.013
LRP6low density lipoprotein receptor-related protein 60.013
VHLvon Hippel-Lindau tumor suppressor0.012
GOLGA2golgin A20.012
ZNF71zinc finger protein 710.012
NCK1NCK adaptor protein 10.012
ZNF775zinc finger protein 7750.012
HCKhemopoietic cell kinase0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Vaspvasodilator-stimulated phosphoprotein0.922
Rac1RAS-related C3 botulinum substrate 10.920
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.904
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.885
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.779
Wdr1WD repeat domain 10.774
Rhoaras homolog gene family, member A0.678
Actr3ARP3 actin-related protein 3 homolog (yeast)0.624
Arpc4actin related protein 2/3 complex, subunit 40.596
EvlEna-vasodilator stimulated phosphoprotein0.546
Lrrk2leucine-rich repeat kinase 20.532
Mef2dmyocyte enhancer factor 2D0.457
Capzbcapping protein (actin filament) muscle Z-line, beta0.435
Arhgap1Rho GTPase activating protein 10.380
Calm1calmodulin 10.333
Tpm4tropomyosin 40.323
Smurf2SMAD specific E3 ubiquitin protein ligase 20.319
Mapkap1mitogen-activated protein kinase associated protein 10.262
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.244
Slit3slit homolog 3 (Drosophila)0.244
Robo1roundabout homolog 1 (Drosophila)0.213
Actg1actin, gamma, cytoplasmic 10.182
9430031J16RikRIKEN cDNA 9430031J16 gene0.174
Necap2NECAP endocytosis associated 20.166
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.147
Csrp1cysteine and glycine-rich protein 10.146
Cskc-src tyrosine kinase0.143
Sh3bgrl3SH3 domain binding glutamic acid-rich protein-like 30.133
Bzw1basic leucine zipper and W2 domains 10.128
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.120
Rptorregulatory associated protein of MTOR, complex 10.119
Rap1bRAS related protein 1b0.118
Robo2roundabout homolog 2 (Drosophila)0.118
Abi1abl-interactor 10.115
Bcl10B-cell leukemia/lymphoma 100.115
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.115
Enahenabled homolog (Drosophila)0.114
Rnd3Rho family GTPase 30.114
Shisa5shisa homolog 5 (Xenopus laevis)0.114
Apbb1ipamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.104
Gnb1guanine nucleotide binding protein (G protein), beta 10.100
Actbactin, beta0.100
Actn1actinin, alpha 10.098
Pfn2profilin 20.096
Kctd10potassium channel tetramerisation domain containing 100.093
Slit1slit homolog 1 (Drosophila)0.088
Plekho1pleckstrin homology domain containing, family O member 10.088
Cotl1coactosin-like 1 (Dictyostelium)0.083
Cfl1cofilin 1, non-muscle0.082
Capza2capping protein (actin filament) muscle Z-line, alpha 20.081
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.079
Sdcbpsyndecan binding protein0.079
Morf4l2mortality factor 4 like 20.078
Prr13proline rich 130.078
Dazap2DAZ associated protein 20.078
Ctnnb1catenin (cadherin associated protein), beta 10.077
Cltcclathrin, heavy polypeptide (Hc)0.073
Hn1hematological and neurological expressed sequence 10.072
Arf1ADP-ribosylation factor 10.070
Pfn1profilin 10.068
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.066
Capza1capping protein (actin filament) muscle Z-line, alpha 10.065
Cdc42se1CDC42 small effector 10.065
Arpc3actin related protein 2/3 complex, subunit 30.064
Arf4ADP-ribosylation factor 40.063
Crlf3cytokine receptor-like factor 30.061
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.060
2310014H01RikRIKEN cDNA 2310014H01 gene0.059
Lasp1LIM and SH3 protein 10.057
Acot9acyl-CoA thioesterase 90.056
Cnn2calponin 20.053
Arpc2actin related protein 2/3 complex, subunit 20.053
Pdlim5PDZ and LIM domain 50.053
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.051
Mapkapk2MAP kinase-activated protein kinase 20.051
Frmd8FERM domain containing 80.050
Cald1caldesmon 10.048
Tmod3tropomodulin 30.047
Akt1thymoma viral proto-oncogene 10.047
Glipr2GLI pathogenesis-related 20.046
Rap1gds1RAP1, GTP-GDP dissociation stimulator 10.045
Gdi2guanosine diphosphate (GDP) dissociation inhibitor 20.045
Efhd2EF hand domain containing 20.045
Actr2ARP2 actin-related protein 2 homolog (yeast)0.045
Hspa8heat shock protein 80.041
Gja1gap junction protein, alpha 10.041
Marcksl1MARCKS-like 10.041
Bmpr1abone morphogenetic protein receptor, type 1A0.040
Coro1acoronin, actin binding protein 1A0.040
Abractive BCR-related gene0.037
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.036
Mlst8MTOR associated protein, LST8 homolog (S. cerevisiae)0.035
Eedembryonic ectoderm development0.035
Coro1ccoronin, actin binding protein 1C0.034
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hspa8heat shock protein 80.057
Arpc2actin related protein 2/3 complex, subunit 20.022
Hspd1heat shock protein 1 (chaperonin)0.018
Mapre1microtubule-associated protein, RP/EB family, member 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism