The network for 'spindle checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

spindle checkpoint

A cell cycle checkpoint that originates from the mitotic or meiotic spindle.

NameDescriptionProbabilityFunc Analog Organism
air-1Protein AIR-10.480
gpr-2Protein GPR-20.125
ZK507.6Protein ZK507.60.102
rnr-1Protein RNR-10.090
C49H3.9Protein C49H3.90.075
cdl-1Protein CDL-10.070
his-42Protein HIS-420.063
R02F11.4Protein R02F11.40.062
pcn-1Protein PCN-10.061
CELE_C24H12.5Protein C24H12.50.059
fzy-1Protein FZY-10.052
cyb-1Protein CYB-10.050
his-45Protein HIS-450.048
air-2Protein AIR-20.046
cyb-2.2Protein CYB-2.20.046
cyb-3Protein CYB-30.042
asd-1Protein ASD-10.041
rga-1Protein RGA-10.041
npp-11Protein NPP-110.040
gly-20Protein GLY-200.039
mex-3Protein MEX-30.039
T08A11.2Protein T08A11.20.037
pri-2Protein PRI-20.037
capg-2Protein CAPG-20.037
mex-5Protein MEX-50.037
lmn-1Protein LMN-10.036
his-6Protein HIS-60.035
imb-2Protein IMB-20.035
dsh-2Protein DSH-20.034
T19H12.2Protein T19H12.20.033
cec-5Protein CEC-50.030
bmk-1Protein BMK-10.029
B0205.9Protein B0205.90.029
sac-1Protein SAC-10.028
T28D9.4Protein T28D9.40.028
B0393.6Protein B0393.60.027
hpo-10Protein HPO-100.027
lin-3Protein LIN-30.027
F25B3.6Protein F25B3.60.027
hcp-1Protein HCP-10.027
rsd-6Protein RSD-60.026
CELE_T03F6.3Protein T03F6.30.026
lst-1Protein LST-10.025
CELE_F14H3.5Protein F14H3.50.025
oma-1Protein OMA-10.025
his-9Protein HIS-90.025
ttll-4Protein TTLL-40.024
CELE_F13E9.1Protein F13E9.10.024
panl-2Protein PANL-20.023
pqn-51Protein PQN-510.022
htz-1Protein HTZ-10.022
T08B2.11Protein T08B2.110.022
kin-19Protein KIN-190.021
spdl-1Protein SPDL-10.021
T12B3.4Protein T12B3.40.020
vps-53Protein VPS-530.020
F12F6.1Protein F12F6.10.020
brc-1Protein BRC-10.019
fli-1Protein FLI-10.019
dpy-26Protein DPY-260.019
mrg-1Protein MRG-10.019
spn-4Protein SPN-40.019
set-1Protein SET-10.018
kin-10Protein KIN-100.018
puf-6Protein PUF-60.018
his-16Protein HIS-160.018
T22C1.1Protein T22C1.10.018
math-33Protein MATH-330.018
F36A2.2Protein F36A2.20.017
scc-1Protein SCC-10.017
zif-1Protein ZIF-10.017
rab-1Protein RAB-10.017
mcm-2Protein MCM-20.017
tba-2Protein TBA-20.016
F15D4.2Protein F15D4.20.016
sas-5Protein SAS-50.016
rnp-7Protein RNP-70.016
clec-88Protein CLEC-880.015
egg-1Protein EGG-10.015
mcm-7Protein MCM-70.015
swsn-6Protein SWSN-60.015
uaf-1Protein UAF-10.015
mcm-3Protein MCM-30.015
klp-19Protein KLP-190.015
ccdc-47Protein CCDC-470.014
ZK1053.4Protein ZK1053.40.014
C41D11.4Protein C41D11.40.014
ppfr-2Protein PPFR-20.014
cks-1Protein CKS-10.014
cul-1Protein CUL-10.014
yif-1Protein YIF-10.014
mat-3Protein MAT-30.014
gck-1Protein GCK-10.014
R144.5Protein R144.50.014
Y59E9AL.4Protein Y59E9AL.40.014
mcm-5Protein MCM-50.014
R11A8.1Protein R11A8.10.014
bath-41Protein BATH-410.014
CELE_C39E9.12Protein C39E9.120.014
cki-2Protein CKI-20.013
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CycBCyclin B0.318
aslasterless0.142
Cks30ACyclin-dependent kinase subunit 30A0.119
CycB3Cyclin B30.069
ncdnon-claret disjunctional0.069
BubR1Bub1-related kinase0.063
Mcm10Sensitized chromosome inheritance modifier 190.061
flflfalafel0.056
mad2CG17498 gene product from transcript CG17498-RA0.050
thrthree rows0.039
Sep2Septin-20.035
Cap-GCG34438 gene product from transcript CG34438-RF0.031
nodno distributive disjunction0.028
gishgilgamesh0.028
ruxroughex0.027
bambag of marbles0.027
cnncentrosomin0.027
KP78bCG17216 gene product from transcript CG17216-RB0.024
mus301mutagen-sensitive 3010.024
cdc16CG6759 gene product from transcript CG6759-RA0.024
r2d2CG7138 gene product from transcript CG7138-RB0.020
Mcm2Minichromosome maintenance 20.020
piepineapple eye0.020
tacctransforming acidic coiled-coil protein0.019
Sgt1CG9617 gene product from transcript CG9617-RA0.018
ldslodestar0.017
ogreoptic ganglion reduced0.017
msb1lCG10364 gene product from transcript CG10364-RA0.017
MEP-1CG1244 gene product from transcript CG1244-RG0.016
I-2Inhibitor-20.016
alphaTub67Calpha-Tubulin at 67C0.016
CG4887CG4887 gene product from transcript CG4887-RA0.015
CG8223CG8223 gene product from transcript CG8223-RA0.014
atmsantimeros0.014
mei-9meiotic 90.014
Klp3AKinesin-like protein at 3A0.014
SMC2CG10212 gene product from transcript CG10212-RA0.014
Hsp83Heat shock protein 830.014
hayhaywire0.014
DNApol-alpha60DNA polymerase alpha 60kD0.014
betaTub60Dbeta-Tubulin at 60D0.014
CG10722CG10722 gene product from transcript CG10722-RA0.013
CycACyclin A0.013
weeCG4488 gene product from transcript CG4488-RA0.013
waplwings apart-like0.012
fzyfizzy0.012
Sld5CG14549 gene product from transcript CG14549-RA0.012
CatCatalase0.012
mlemaleless0.012
enokenoki mushroom0.012
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.012
CG3225CG3225 gene product from transcript CG3225-RA0.012
Grip75CG6176 gene product from transcript CG6176-RA0.011
CG6439CG6439 gene product from transcript CG6439-RA0.011
AGO2Argonaute 20.011
betaTub85Dbeta-Tubulin at 85D0.011
Vha100-1CG1709 gene product from transcript CG1709-RF0.011
cavcaravaggio0.010
taitaiman0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDC20cell division cycle 20 homolog (S. cerevisiae)0.983
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.957
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.918
AURKBaurora kinase B0.903
H2AFXH2A histone family, member X0.799
CDC27cell division cycle 27 homolog (S. cerevisiae)0.695
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.605
CCT8chaperonin containing TCP1, subunit 8 (theta)0.486
BRCA2breast cancer 2, early onset0.363
ANAPC4anaphase promoting complex subunit 40.357
INCENPinner centromere protein antigens 135/155kDa0.317
CDCA8cell division cycle associated 80.272
CENPJcentromere protein J0.266
PLK1polo-like kinase 10.233
CBX5chromobox homolog 50.213
SASS6spindle assembly 6 homolog (C. elegans)0.169
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.142
STARD9StAR-related lipid transfer (START) domain containing 90.138
CDT1chromatin licensing and DNA replication factor 10.128
ANAPC7anaphase promoting complex subunit 70.120
C19orf39chromosome 19 open reading frame 390.088
CCT4chaperonin containing TCP1, subunit 4 (delta)0.087
FXR2fragile X mental retardation, autosomal homolog 20.081
KIF2Ckinesin family member 2C0.076
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.070
HDAC1histone deacetylase 10.070
TP53BP1tumor protein p53 binding protein 10.065
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.059
CDK1cyclin-dependent kinase 10.058
CDK2cyclin-dependent kinase 20.057
NEK2NIMA (never in mitosis gene a)-related kinase 20.054
CDC23cell division cycle 23 homolog (S. cerevisiae)0.053
TROAPtrophinin associated protein (tastin)0.052
MDC1mediator of DNA-damage checkpoint 10.048
ANAPC1anaphase promoting complex subunit 10.048
ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)0.046
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.044
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.043
ANAPC5anaphase promoting complex subunit 50.043
RANBP9RAN binding protein 90.043
PBKPDZ binding kinase0.040
PTTG1pituitary tumor-transforming 10.040
SGOL1shugoshin-like 1 (S. pombe)0.039
TOP2Atopoisomerase (DNA) II alpha 170kDa0.037
CDC16cell division cycle 16 homolog (S. cerevisiae)0.037
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.036
ZW10ZW10, kinetochore associated, homolog (Drosophila)0.036
PARP3poly (ADP-ribose) polymerase family, member 30.035
CDC25Ccell division cycle 25 homolog C (S. pombe)0.035
ANAPC11anaphase promoting complex subunit 110.033
UBE2Cubiquitin-conjugating enzyme E2C0.032
LMNAlamin A/C0.032
CCNA2cyclin A20.031
TP53tumor protein p530.031
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.030
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.030
GAS2L3growth arrest-specific 2 like 30.029
CEP135centrosomal protein 135kDa0.029
MYST1MYST histone acetyltransferase 10.029
HERC2hect domain and RLD 20.028
PRNPprion protein0.028
TCP1t-complex 10.027
TERF2IPtelomeric repeat binding factor 2, interacting protein0.027
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.027
PLK4polo-like kinase 40.027
TINF2TERF1 (TRF1)-interacting nuclear factor 20.026
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.025
KIF11kinesin family member 110.025
RAD51L1RAD51-like 1 (S. cerevisiae)0.025
TRIP13thyroid hormone receptor interactor 130.024
GTSE1G-2 and S-phase expressed 10.023
NASPnuclear autoantigenic sperm protein (histone-binding)0.023
CENPFcentromere protein F, 350/400kDa (mitosin)0.023
PPME1protein phosphatase methylesterase 10.022
PPP4Cprotein phosphatase 4, catalytic subunit0.022
MED1mediator complex subunit 10.022
NKAPNFKB activating protein0.022
C13orf34chromosome 13 open reading frame 340.022
ATMINATM interactor0.022
HNRNPMheterogeneous nuclear ribonucleoprotein M0.022
BAG3BCL2-associated athanogene 30.021
CSNK2Bcasein kinase 2, beta polypeptide0.021
KPNA3karyopherin alpha 3 (importin alpha 4)0.021
KAT5K(lysine) acetyltransferase 50.020
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.020
HUWE1HECT, UBA and WWE domain containing 10.020
HSPB1heat shock 27kDa protein 10.020
GSK3Bglycogen synthase kinase 3 beta0.020
CCNFcyclin F0.020
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.020
PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 10.020
HIST1H2ALhistone cluster 1, H2al0.019
HIST1H1Ehistone cluster 1, H1e0.019
SGOL2shugoshin-like 2 (S. pombe)0.019
AXIN2axin 20.019
PKMYT1protein kinase, membrane associated tyrosine/threonine 10.018
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.018
TAF15TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa0.018
HIST1H4Fhistone cluster 1, H4f0.018
AKT1v-akt murine thymoma viral oncogene homolog 10.018
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ccnb1cyclin B10.753
Cdk1cyclin-dependent kinase 10.671
Ccnb2cyclin B20.627
Prc1protein regulator of cytokinesis 10.598
Kif20akinesin family member 20A0.499
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.464
Kif22kinesin family member 220.462
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.200
Dlgap5discs, large (Drosophila) homolog-associated protein 50.185
Kif2ckinesin family member 2C0.171
Aurkaaurora kinase A0.169
Spag5sperm associated antigen 50.152
Brca2breast cancer 20.140
Trp53transformation related protein 530.137
Ccna2cyclin A20.126
Mki67antigen identified by monoclonal antibody Ki 670.121
Rnf2ring finger protein 20.118
Trim59tripartite motif-containing 590.116
Brca1breast cancer 10.115
Cdca8cell division cycle associated 80.114
Kdm2blysine (K)-specific demethylase 2B0.099
Ckap2cytoskeleton associated protein 20.098
C330027C09RikRIKEN cDNA C330027C09 gene0.094
Cdkn3cyclin-dependent kinase inhibitor 30.089
Cenpecentromere protein E0.089
Sgol2shugoshin-like 2 (S. pombe)0.087
Ube2cubiquitin-conjugating enzyme E2C0.079
Birc5baculoviral IAP repeat-containing 50.072
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.071
Hmmrhyaluronan mediated motility receptor (RHAMM)0.071
Ccnfcyclin F0.065
TtkTtk protein kinase0.065
Top2atopoisomerase (DNA) II alpha0.061
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.060
Cks2CDC28 protein kinase regulatory subunit 20.059
Dtldenticleless homolog (Drosophila)0.059
Kif4kinesin family member 40.058
Kif23kinesin family member 230.057
Kif11kinesin family member 110.056
Cdc25ccell division cycle 25 homolog C (S. pombe)0.056
Ncapgnon-SMC condensin I complex, subunit G0.049
Cenpkcentromere protein K0.047
Ect2ect2 oncogene0.047
Rpgrip1lRpgrip1-like0.045
Ooepoocyte expressed protein homolog (dog)0.041
Lrrk2leucine-rich repeat kinase 20.039
Mis18bp1MIS18 binding protein 10.034
Racgap1Rac GTPase-activating protein 10.033
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.032
Aurkbaurora kinase B0.030
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.028
Cep55centrosomal protein 550.028
Ube2tubiquitin-conjugating enzyme E2T (putative)0.027
Dna2DNA replication helicase 2 homolog (yeast)0.027
Ccdc99coiled-coil domain containing 990.027
Skp1aS-phase kinase-associated protein 1A0.025
Melkmaternal embryonic leucine zipper kinase0.025
Anlnanillin, actin binding protein0.025
2810417H13RikRIKEN cDNA 2810417H13 gene0.025
Ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.024
Axin1axin 10.024
Smc4structural maintenance of chromosomes 40.024
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.023
BlmBloom syndrome, RecQ helicase-like0.023
Plk4polo-like kinase 4 (Drosophila)0.022
Cenpacentromere protein A0.021
Trp63transformation related protein 630.019
Lin28alin-28 homolog A (C. elegans)0.018
Hist1h2bmhistone cluster 1, H2bm0.018
Naspnuclear autoantigenic sperm protein (histone-binding)0.018
Sgol1shugoshin-like 1 (S. pombe)0.018
Cdk4cyclin-dependent kinase 40.018
Rad51ap1RAD51 associated protein 10.018
Ccne2cyclin E20.016
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.016
Tacc3transforming, acidic coiled-coil containing protein 30.016
Gtse1G two S phase expressed protein 10.015
Sass6spindle assembly 6 homolog (C. elegans)0.015
Hmgb2high mobility group box 20.014
E2f8E2F transcription factor 80.014
Gsg2germ cell-specific gene 20.014
Cops7bCOP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis thaliana)0.014
StilScl/Tal1 interrupting locus0.014
Depdc1aDEP domain containing 1a0.013
Rbl1retinoblastoma-like 1 (p107)0.013
Trip13thyroid hormone receptor interactor 130.013
4632434I11RikRIKEN cDNA 4632434I11 gene0.012
H2afzH2A histone family, member Z0.012
Mdm2transformed mouse 3T3 cell double minute 20.011
Lin9lin-9 homolog (C. elegans)0.011
Scaf4SR-related CTD-associated factor 40.010
Mns1meiosis-specific nuclear structural protein 10.010
Pot1aprotection of telomeres 1A0.010
Zfp598zinc finger protein 5980.010
Carm1coactivator-associated arginine methyltransferase 10.010
Pgrprogesterone receptor0.010
Csnk2a1casein kinase 2, alpha 1 polypeptide0.010
Cenpncentromere protein N0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
MAD2Mad2p0.813
PPH22Pph22p0.807
GLC7Glc7p0.789
BUB3Bub3p0.782
PPH21Pph21p0.701
CDC28Cdc28p0.594
TIP41Tip41p0.572
BUB2Bub2p0.546
CDC20Cdc20p0.526
BUB1Bub1p0.525
CSE4Cse4p0.443
BMH2Bmh2p0.402
SIC1Sic1p0.399
CTF13Ctf13p0.394
BMH1Bmh1p0.385
MAD3Mad3p0.383
MCM21Mcm21p0.354
GIC1Gic1p0.346
HTA1Hta1p0.313
IML3Iml3p0.308
ASE1Ase1p0.302
SLI15Sli15p0.294
BFA1Bfa1p0.269
REG1Reg1p0.268
SDS22Sds22p0.268
CTF3Ctf3p0.227
DAM1Dam1p0.225
CKS1Cks1p0.207
PCL10Pcl10p0.199
DMA2Dma2p0.188
NUD1Nud1p0.183
SLK19Slk19p0.176
KIP1Kip1p0.164
CHL4Chl4p0.161
RTS1Rts1p0.160
FIN1Fin1p0.154
NDD1Ndd1p0.148
CDC14Cdc14p0.146
GIP2Gip2p0.143
CBF2Cbf2p0.128
CLB4Clb4p0.125
KIC1Kic1p0.116
CDC6Cdc6p0.103
CDC55Cdc55p0.103
ORC3Orc3p0.099
CLB6Clb6p0.095
MCM22Mcm22p0.092
MTW1Mtw1p0.088
CIN1Cin1p0.088
CDC123Cdc123p0.087
CLB1Clb1p0.083
SKM1Skm1p0.081
NBL1Nbl1p0.080
PPZ1Ppz1p0.079
HTB1Htb1p0.079
MSA2Msa2p0.078
DMA1Dma1p0.075
STE23Ste23p0.074
CDC15Cdc15p0.070
BIM1Bim1p0.070
CLB3Clb3p0.066
SGV1Sgv1p0.065
CKA1Cka1p0.063
DSN1Dsn1p0.062
ZDS1Zds1p0.062
PSK1Psk1p0.061
SPC24Spc24p0.061
FRK1Frk1p0.058
STE4Ste4p0.057
PSY4Psy4p0.057
CDH1Cdh1p0.056
GLG1Glg1p0.055
PIG2Pig2p0.055
STU1Stu1p0.054
NTO1Nto1p0.054
MDM20Mdm20p0.052
SWC4Swc4p0.052
GAC1Gac1p0.051
YIL151Chypothetical protein0.046
SFI1Sfi1p0.045
PTR3Ptr3p0.045
KIN1Kin1p0.044
MIF2Mif2p0.044
CHL1Chl1p0.044
YKL075Chypothetical protein0.043
BUD8Bud8p0.041
SOL1Sol1p0.041
NSP1Nsp1p0.038
CKB2Ckb2p0.037
SPC110Spc110p0.037
VHS2Vhs2p0.037
VIK1Vik1p0.036
HST3Hst3p0.036
CIN8Cin8p0.035
SRD1Srd1p0.034
CDC5Cdc5p0.034
SKP2Skp2p0.034
CAB3Cab3p0.033
FMP48Fmp48p0.033
SPL2Spl2p0.031