The network for 'activation of jun kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation of jun kinase activity

The initiation of the activity of the inactive enzyme JUN kinase (JNK).

NameDescriptionProbabilityFunc Analog Organism
meg-2Protein MEG-20.127
daf-19Protein DAF-190.054
sax-3Protein SAX-30.051
pqn-82Protein PQN-820.050
F21A10.2Protein F21A10.20.046
oga-1Protein OGA-10.042
nhr-34Protein NHR-340.036
sym-4Protein SYM-40.035
K10D6.4Protein K10D6.40.033
gap-2Protein GAP-20.033
T14G11.1Protein T14G11.10.031
lin-36Protein LIN-360.030
pup-2Protein PUP-20.030
glit-1Protein GLIT-10.029
let-19Protein LET-190.028
alg-1Protein ALG-10.027
C36B7.6Protein C36B7.60.027
vav-1Protein VAV-10.025
sor-1Protein SOR-10.025
unc-18Protein UNC-180.023
dpy-22Protein DPY-220.023
T04F8.6Protein T04F8.60.022
obr-3Protein OBR-30.021
cec-1Protein CEC-10.021
syd-2Protein SYD-20.020
K05B2.2Protein K05B2.20.020
dpy-23Protein DPY-230.019
sax-7Protein SAX-70.019
mig-10Protein MIG-100.018
cdf-1Protein CDF-10.018
dsh-1Protein DSH-10.017
hpo-22Protein HPO-220.017
sec-15Protein SEC-150.017
zoo-1Protein ZOO-10.017
cgef-1Protein CGEF-10.017
agr-1Protein AGR-10.016
F59F4.3Protein F59F4.30.016
ksr-1Protein KSR-10.014
csnk-1Protein CSNK-10.014
scd-1Protein SCD-10.014
unc-129Protein UNC-1290.014
F48F7.6Protein F48F7.60.014
ZC53.1Protein ZC53.10.014
F28B3.1Protein F28B3.10.014
pop-1Protein POP-10.014
F47A4.5Protein F47A4.50.013
F17E5.2Protein F17E5.20.013
T09B9.4Protein T09B9.40.013
rme-6Protein RME-60.013
B0416.5Protein B0416.50.013
bar-1Protein BAR-10.013
saeg-2Protein SAEG-20.012
eor-2Protein EOR-20.012
axl-1Protein AXL-10.011
K09F5.6Protein K09F5.60.011
unc-10Protein UNC-100.011
plx-1Protein PLX-10.011
chd-7Protein CHD-70.011
tps-1Protein TPS-10.010
lip-1Protein LIP-10.010
cst-1Protein CST-10.010
sto-4Protein STO-40.010
CELE_H28G03.2Protein H28G03.20.010
F38B6.6Protein F38B6.60.010
tir-1Protein TIR-10.010
C24H10.2Protein C24H10.20.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dzip1DAZ interacting protein 10.247
lef1lymphocyte enhancer binding factor 10.153
gata1aGATA binding protein 1a0.106
gro2groucho 20.100
cdh17cadherin 17, LI cadherin (liver-intestine)0.095
etv2ets variant gene 20.082
wnt7bbwingless-type MMTV integration site family, member 7Bb0.077
zbtb4zinc finger and BTB domain containing 40.074
dusp6dual specificity phosphatase 60.066
gro1groucho 10.064
csnk1g2acasein kinase 1, gamma 2a0.063
gli3GLI-Kruppel family member GLI30.062
wnt3wingless-type MMTV integration site family, member 30.061
mrc1amannose receptor, C type 1a0.059
map2k4bmitogen-activated protein kinase kinase 4b0.058
itih2inter-alpha (globulin) inhibitor H20.057
pbx4pre-B-cell leukemia transcription factor 40.053
nortnotch-regulated transcript0.052
zgc:193613zgc:1936130.051
apoc2apolipoprotein C-II0.051
mtmr8myotubularin related protein 80.046
robo1roundabout homolog 10.046
LOC100151531zinc finger protein Gfi-1b-like0.044
axin1axin 10.042
LOC566708FL cytokine receptor-like0.037
wnt5awingless-type MMTV integration site family, member 5a0.037
wnt7aawingless-type MMTV integration site family, member 7Aa0.036
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.036
wnt11wingless-type MMTV integration site family, member 110.036
tie1endothelium-specific receptor tyrosine kinase 10.035
twist1atwist1a0.035
mkksMcKusick-Kaufman syndrome0.034
ercc2excision repair cross-complementing rodent repair deficiency, complementation group 20.034
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.032
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.031
spsb4asplA/ryanodine receptor domain and SOCS box containing 4a0.031
tie2endothelium-specific receptor tyrosine kinase 20.030
bhmtbetaine-homocysteine methyltransferase0.030
oepone-eyed pinhead0.029
wnt16wingless-type MMTV integration site family, member 160.029
nrarpanotch-regulated ankyrin repeat protein a0.029
sult3st1sulfotransferase family 3, cytosolic sulfotransferase 10.028
celf1cugbp, Elav-like family member 10.026
ctnnb1catenin (cadherin-associated protein), beta 10.026
wwp1WW domain containing E3 ubiquitin protein ligase 10.026
gipgastric inhibitory polypeptide0.026
rbl1retinoblastoma-like 1 (p107)0.025
dkk3dickkopf homolog 3 (Xenopus laevis)0.025
fbn2bfibrillin 2b0.025
glcebglucuronyl C5-epimerase b0.024
map2k7mitogen-activated protein kinase kinase 70.024
si:dkey-273o13.1si:dkey-273o13.10.024
ptprbprotein tyrosine phosphatase, receptor type, b0.024
hspa12bheat shock protein 12B0.023
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.023
si:dkey-261h17.1si:dkey-261h17.10.023
sulf1sulfatase 10.022
ahctf1AT hook containing transcription factor 10.021
stac3SH3 and cysteine rich domain 30.021
dhrs3adehydrogenase/reductase (SDR family) member 3a0.021
zgc:161979zgc:1619790.021
notch3notch homolog 30.021
bmpr1aabone morphogenetic protein receptor, type 1aa0.021
atoh8atonal homolog 80.020
zgc:101761zgc:1017610.020
cbx2chromobox homolog 2 (Drosophila Pc class)0.020
tmpoathymopoietin a0.019
kopaskopos0.019
hdrhematopoietic death receptor0.019
zgc:111944zgc:1119440.019
ddr2bdiscoidin domain receptor family, member 2b0.018
dkk1bdickkopf 1b0.018
lamb1alaminin, beta 1a0.018
greb1growth regulation by estrogen in breast cancer 10.018
ogt.1O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 10.017
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.017
stk36serine/threonine kinase 36 (fused homolog, Drosophila)0.017
wnt7bawingless-type MMTV integration site family, member 7Ba0.016
stat1bsignal transducer and activator of transcription 1b0.016
flt4fms-related tyrosine kinase 40.016
skianuclear oncoprotein skia0.016
scube2signal peptide, CUB domain, EGF-like 20.016
dvl2dishevelled, dsh homolog 2 (Drosophila)0.016
fggfibrinogen, gamma polypeptide0.016
kdm4blysine (K)-specific demethylase 4B0.015
fcho2FCH domain only 20.015
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.014
igf2bp1insulin-like growth factor 2 mRNA binding protein 10.014
pacsin3protein kinase C and casein kinase substrate in neurons 30.014
twist3twist30.014
mbnl2muscleblind-like 2 (Drosophila)0.014
iba57IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)0.014
anxa4annexin A40.014
zgc:66100zgc:661000.014
ckap5cytoskeleton associated protein 50.014
zgc:194131zgc:1941310.014
apaf1apoptotic protease activating factor 10.014
lamc1laminin, gamma 10.014
mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.014
ptk2.1protein tyrosine kinase 2a0.013
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
ykiyorkie0.232
hephemipterous0.213
pucpuckered0.180
Pi3K92ECG4141 gene product from transcript CG4141-RB0.164
Sema-1aCG18405 gene product from transcript CG18405-RD0.117
PknProtein kinase related to protein kinase N0.103
bskbasket0.088
GugGrunge0.080
CG5794CG5794 gene product from transcript CG5794-RB0.079
kaykayak0.062
msnmisshapen0.051
Atg1Autophagy-specific gene 10.047
diadiaphanous0.039
cnkconnector enhancer of ksr0.037
rapretina aberrant in pattern0.037
Tak1TGF-beta activated kinase 10.033
rokRho-kinase0.032
Sra-1specifically Rac1-associated protein 10.032
grogroucho0.029
JraJun-related antigen0.029
AblAbl tyrosine kinase0.028
maskmultiple ankyrin repeats single KH domain0.028
spasspastin0.026
slikSterile20-like kinase0.026
arrarrow0.026
phlpole hole0.024
skdskuld0.024
chicoCG5686 gene product from transcript CG5686-RB0.024
LnkCG17367 gene product from transcript CG17367-RC0.024
krzkurtz0.023
pydpolychaetoid0.021
kibrakibra ortholog0.021
CG14614CG14614 gene product from transcript CG14614-RA0.020
PP2A-B'CG7913 gene product from transcript CG7913-RK0.020
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.020
fufused0.019
S6kRPS6-p70-protein kinase0.019
miltmilton0.018
Smg1CG32743 gene product from transcript CG32743-RA0.018
cicubitus interruptus0.018
Ten-mTenascin major0.017
SosSon of sevenless0.017
RYBPRing and YY1 Binding Protein0.017
RalaRas-related protein0.016
dltdiscs lost0.016
Src42ASrc oncogene at 42A0.016
synjsynaptojanin0.015
gekgenghis khan0.015
yrtyurt0.014
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.014
POSHPlenty of SH3s0.014
RRoughened0.014
ari-2ariadne 20.013
SaraSmad anchor for receptor activation0.013
pntpointed0.013
Apc2Adenomatous polyposis coli tumor suppressor homolog 20.013
liglingerer0.012
CG1347CG1347 gene product from transcript CG1347-RB0.012
Dcr-1Dicer-10.012
Rab5Rab-protein 50.012
sglsugarless0.012
Rab30CG9100 gene product from transcript CG9100-RB0.012
pUf68poly U binding factor 68kD0.012
rlrolled0.012
p53CG33336 gene product from transcript CG33336-RB0.012
rictorrapamycin-insensitive companion of Tor0.011
CG6194CG6194 gene product from transcript CG6194-RA0.011
PatjCG12021 gene product from transcript CG12021-RC0.011
porporcupine0.011
Zyx102EFCG32018 gene product from transcript CG32018-RA0.011
laplike-AP1800.011
unkunkempt0.010
lokloki0.010
flflfalafel0.010
InRInsulin-like receptor0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MAPK8mitogen-activated protein kinase 80.942
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.638
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.593
EGFRepidermal growth factor receptor0.547
MAP3K1mitogen-activated protein kinase kinase kinase 10.425
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.404
DCAF7DDB1 and CUL4 associated factor 70.241
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.213
MAP3K7mitogen-activated protein kinase kinase kinase 70.141
LATlinker for activation of T cells0.138
MAPK9mitogen-activated protein kinase 90.128
MAP2K7mitogen-activated protein kinase kinase 70.112
MAP3K5mitogen-activated protein kinase kinase kinase 50.098
GRB2growth factor receptor-bound protein 20.096
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.093
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.081
BBS10Bardet-Biedl syndrome 100.072
MAP3K11mitogen-activated protein kinase kinase kinase 110.051
BLNKB-cell linker0.045
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.042
MAP2K4mitogen-activated protein kinase kinase 40.034
SOS1son of sevenless homolog 1 (Drosophila)0.032
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.030
PTPN11protein tyrosine phosphatase, non-receptor type 110.026
UBASH3Bubiquitin associated and SH3 domain containing B0.026
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.025
SMURF2SMAD specific E3 ubiquitin protein ligase 20.024
LRP6low density lipoprotein receptor-related protein 60.023
ARHGAP5Rho GTPase activating protein 50.022
PIK3CAphosphoinositide-3-kinase, catalytic, alpha polypeptide0.022
ARRB1arrestin, beta 10.021
VAV3vav 3 guanine nucleotide exchange factor0.021
SMAD7SMAD family member 70.020
IRS1insulin receptor substrate 10.019
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.018
CSNK1Ecasein kinase 1, epsilon0.018
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.018
SH3KBP1SH3-domain kinase binding protein 10.016
GAB2GRB2-associated binding protein 20.013
ARL4DADP-ribosylation factor-like 4D0.013
GSK3Aglycogen synthase kinase 3 alpha0.012
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.012
FZD1frizzled homolog 1 (Drosophila)0.012
IGF1Rinsulin-like growth factor 1 receptor0.011
EXOC5exocyst complex component 50.011
PXNpaxillin0.011
C1orf93chromosome 1 open reading frame 930.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.908
Tnftumor necrosis factor0.883
Ifnginterferon gamma0.771
Cd40CD40 antigen0.755
C3ar1complement component 3a receptor 10.721
Cxcl13chemokine (C-X-C motif) ligand 130.692
Ccr1chemokine (C-C motif) receptor 10.625
Klc1kinesin light chain 10.590
Msr1macrophage scavenger receptor 10.580
Ltalymphotoxin A0.555
Ccl12chemokine (C-C motif) ligand 120.537
Grb2growth factor receptor bound protein 20.535
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.430
Ccl8chemokine (C-C motif) ligand 80.351
Ccl2chemokine (C-C motif) ligand 20.322
Il1binterleukin 1 beta0.284
Ltblymphotoxin B0.253
Fcgr1Fc receptor, IgG, high affinity I0.239
Map3k14mitogen-activated protein kinase kinase kinase 140.234
Pdcd1programmed cell death 10.212
Mapk8mitogen-activated protein kinase 80.195
Cxcr5chemokine (C-X-C motif) receptor 50.186
Clec4dC-type lectin domain family 4, member d0.180
Gzmagranzyme A0.168
Folr2folate receptor 2 (fetal)0.167
Shc1src homology 2 domain-containing transforming protein C10.155
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.151
Ccl4chemokine (C-C motif) ligand 40.149
Ccl3chemokine (C-C motif) ligand 30.142
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.125
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.119
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.115
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.114
Il4interleukin 40.112
C1qbcomplement component 1, q subcomponent, beta polypeptide0.104
Cxcl2chemokine (C-X-C motif) ligand 20.103
Prkceprotein kinase C, epsilon0.103
TyrobpTYRO protein tyrosine kinase binding protein0.099
Cd19CD19 antigen0.097
Icosinducible T-cell co-stimulator0.097
Il7interleukin 70.096
Crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.093
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.092
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.090
Mmp12matrix metallopeptidase 120.087
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.085
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.084
Aoahacyloxyacyl hydrolase0.084
Irg1immunoresponsive gene 10.083
Cd28CD28 antigen0.078
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.077
BtkBruton agammaglobulinemia tyrosine kinase0.076
Csf1rcolony stimulating factor 1 receptor0.074
Ch25hcholesterol 25-hydroxylase0.074
Ighimmunoglobulin heavy chain complex0.073
Mrc1mannose receptor, C type 10.073
CblCasitas B-lineage lymphoma0.073
Cd5lCD5 antigen-like0.071
Cd14CD14 antigen0.071
Tbxas1thromboxane A synthase 1, platelet0.070
Il6interleukin 60.068
Inpp5dinositol polyphosphate-5-phosphatase D0.064
Metmet proto-oncogene0.062
Ccl22chemokine (C-C motif) ligand 220.061
Toxthymocyte selection-associated high mobility group box0.060
Csf1colony stimulating factor 1 (macrophage)0.059
Cd22CD22 antigen0.057
C5ar1complement component 5a receptor 10.056
Aif1allograft inflammatory factor 10.056
Cd86CD86 antigen0.056
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.051
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.049
Clec4nC-type lectin domain family 4, member n0.046
Slpisecretory leukocyte peptidase inhibitor0.045
Ikzf1IKAROS family zinc finger 10.045
Ccl17chemokine (C-C motif) ligand 170.044
Batfbasic leucine zipper transcription factor, ATF-like0.041
Ccr5chemokine (C-C motif) receptor 50.039
Ccl7chemokine (C-C motif) ligand 70.039
Itgaxintegrin alpha X0.039
Mmp8matrix metallopeptidase 80.038
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.038
Lyz2lysozyme 20.038
AF251705cDNA sequence AF2517050.038
Socs1suppressor of cytokine signaling 10.038
Clec4a2C-type lectin domain family 4, member a20.037
Clec4eC-type lectin domain family 4, member e0.037
Traf6TNF receptor-associated factor 60.037
C1qccomplement component 1, q subcomponent, C chain0.036
Il10rainterleukin 10 receptor, alpha0.035
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.035
Map2k4mitogen-activated protein kinase kinase 40.035
Il1rninterleukin 1 receptor antagonist0.034
Batf2basic leucine zipper transcription factor, ATF-like 20.034
Pf4platelet factor 40.033
Slfn4schlafen 40.032
Gripap1GRIP1 associated protein 10.032
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.032
Fpr2formyl peptide receptor 20.031
Alox15arachidonate 15-lipoxygenase0.031
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism