The network for 'hematopoietic or lymphoid organ development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hematopoietic or lymphoid organ development

The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.

NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cmybtranscription factor cmyb1.000
osr1odd-skipped related 1 (Drosophila)1.000
runx1runt-related transcription factor 11.000
hhexhematopoietically expressed homeobox0.997
ikzf1IKAROS family zinc finger 1 (Ikaros)0.995
plcg1phospholipase C, gamma 10.994
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.993
gata1aGATA binding protein 1a0.985
hbbe1.1hemoglobin beta embryonic-1.10.984
spns2spinster homolog 2 (Drosophila)0.982
tfr1atransferrin receptor 1a0.978
LOC566708FL cytokine receptor-like0.975
metmet proto-oncogene (hepatocyte growth factor receptor)0.963
smad5MAD homolog 5 (Drosophila)0.963
pcnaproliferating cell nuclear antigen0.960
rag1recombination activating gene 10.959
wnt2bbwingless-type MMTV integration site family, member 2Bb0.954
gata6GATA-binding protein 60.951
tp53tumor protein p530.951
trim33tripartite motif-containing 330.949
alas2aminolevulinate, delta-, synthetase 20.948
kitakit receptor a0.930
lcp1lymphocyte cytosolic plastin 10.929
hoxd4ahomeo box D4a0.929
lmo2LIM domain only 2 (rhombotin-like 1)0.926
fgf8afibroblast growth factor 8 a0.919
ephb4beph receptor B4b0.911
traf4atnf receptor-associated factor 4a0.911
hey2hairy/enhancer-of-split related with YRPW motif 20.902
notch3notch homolog 30.888
tbx5aT-box 5a0.882
dnmt4DNA (cytosine-5-)-methyltransferase 40.870
myf5myogenic factor 50.864
wnt4awingless-type MMTV integration site family, member 4a0.861
uroduroporphyrinogen decarboxylase0.855
mmp2matrix metalloproteinase 20.848
hbaa1hemoglobin alpha adult-10.846
tal1T-cell acute lymphocytic leukemia 10.845
mibmind bomb0.844
cdh5cadherin 50.807
npm1nucleophosmin 10.806
tbx16T-box gene 160.799
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.799
klf4Kruppel-like factor 40.796
sox7SRY-box containing gene 70.796
efnb2aephrin B2a0.789
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.789
eporerythropoietin receptor0.783
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.781
hbbe3hemoglobin beta embryonic-30.780
etv2ets variant gene 20.761
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.756
egr1early growth response 10.750
fgf10afibroblast growth factor 10a0.748
snrnp70small nuclear ribonucleoprotein 70 (U1)0.739
znfl2azinc finger-like gene 2a0.739
jag2jagged 20.730
trpv6transient receptor potential cation channel, subfamily V, member 60.730
hand2heart and neural crest derivatives expressed transcript 20.729
bmp2bbone morphogenetic protein 2b0.728
ndr2nodal-related 20.726
kdrlkinase insert domain receptor like0.723
dusp6dual specificity phosphatase 60.722
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.721
bmperBMP binding endothelial regulator0.710
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.702
hhiphedgehog interacting protein0.698
ppoxprotoporphyrinogen oxidase0.696
hnf1baHNF1 homeobox Ba0.693
nola1nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)0.681
tpm4tropomyosin 40.680
tbx1T-box 10.679
cdx4caudal type homeo box transcription factor 40.672
csnk1a1casein kinase 1, alpha 10.670
otpaorthopedia homolog a0.666
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.664
gli2aGLI-Kruppel family member GLI2a0.662
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.655
bmp4bone morphogenetic protein 40.649
ddx18DEAD (Asp-Glu-Ala-Asp) box polypeptide 180.644
fn1fibronectin 10.642
tie1endothelium-specific receptor tyrosine kinase 10.632
cpoxcoproporphyrinogen oxidase0.632
cpsf1cleavage and polyadenylation specific factor 10.626
fzd5frizzled homolog 50.621
rpl11ribosomal protein L110.619
eomesaeomesodermin homolog a0.614
rarabretinoic acid receptor, alpha b0.614
wnt9bwingless-type MMTV integration site family, member 9B0.607
hbae1hemoglobin alpha embryonic-10.599
dll4delta-like 4 (Drosophila)0.593
haus3HAUS augmin-like complex, subunit 30.592
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.578
fgfr4fibroblast growth factor receptor 40.577
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rac1CG2248 gene product from transcript CG2248-RA0.959
rapretina aberrant in pattern0.792
PtenCG5671 gene product from transcript CG5671-RB0.729
PvrPDGF- and VEGF-receptor related0.665
drkdownstream of receptor kinase0.621
EgfrEpidermal growth factor receptor0.527
DadDaughters against dpp0.521
numbCG3779 gene product from transcript CG3779-RB0.477
gbbglass bottom boat0.473
RalaRas-related protein0.465
E(spl)Enhancer of split0.463
mbcmyoblast city0.373
Atg1Autophagy-specific gene 10.362
snssticks and stones0.342
hipkhomeodomain interacting protein kinase0.316
zfh1Zn finger homeodomain 10.302
cicubitus interruptus0.281
Pi3K92ECG4141 gene product from transcript CG4141-RB0.273
oho23Bovergrown hematopoietic organs at 23B0.273
Pp2B-14DProtein phosphatase 2B at 14D0.273
MhcMyosin heavy chain0.254
Rab7Rab-protein 70.246
MadMothers against dpp0.236
Akt1CG4006 gene product from transcript CG4006-RA0.230
Adf1Adh transcription factor 10.223
E(bx)Enhancer of bithorax0.203
ik2IkappaB kinase-like 20.191
MrtfMyocardin-related transcription factor0.188
G-oalpha47AG protein oalpha 47A0.183
CycACyclin A0.168
ThorCG8846 gene product from transcript CG8846-RA0.161
TomTwin of m40.161
RpS6Ribosomal protein S60.159
Socs36ESuppressor of cytokine signaling at 36E0.159
HLHm7E(spl) region transcript m70.158
ash2absent, small, or homeotic discs 20.156
l(2)gllethal (2) giant larvae0.147
BRWD3CG31132 gene product from transcript CG31132-RA0.142
Cdk4Cyclin-dependent kinase 40.132
Adgf-AAdenosine deaminase-related growth factor A0.131
MED19Mediator complex subunit 190.129
DdcDopa decarboxylase0.129
Kap-alpha3karyopherin alpha30.129
AlkCG8250 gene product from transcript CG8250-RA0.127
Kr-h1Kruppel homolog 10.127
aopanterior open0.126
reporeversed polarity0.125
Cip4CG15015 gene product from transcript CG15015-RA0.124
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence1.000
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.999
CREBBPCREB binding protein0.999
TAL1T-cell acute lymphocytic leukemia 10.999
SMAD2SMAD family member 20.999
RUNX1runt-related transcription factor 10.998
LCKlymphocyte-specific protein tyrosine kinase0.997
NCOR2nuclear receptor corepressor 20.996
MDM2Mdm2 p53 binding protein homolog (mouse)0.995
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.995
SMAD3SMAD family member 30.992
STAT1signal transducer and activator of transcription 1, 91kDa0.990
EP300E1A binding protein p3000.987
RB1retinoblastoma 10.985
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.980
FGFR1fibroblast growth factor receptor 10.975
NOTCH1notch 10.975
ICAM1intercellular adhesion molecule 10.971
ARandrogen receptor0.960
PMLpromyelocytic leukemia0.959
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.955
PTPN6protein tyrosine phosphatase, non-receptor type 60.953
DAXXdeath-domain associated protein0.953
CD40CD40 molecule, TNF receptor superfamily member 50.943
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.940
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.936
FGFR2fibroblast growth factor receptor 20.933
TP53tumor protein p530.930
ATN1atrophin 10.929
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.928
HLA-Bmajor histocompatibility complex, class I, B0.927
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.926
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.924
ESR1estrogen receptor 10.922
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.914
TRAF1TNF receptor-associated factor 10.910
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.908
HIPK2homeodomain interacting protein kinase 20.903
SIN3ASIN3 homolog A, transcription regulator (yeast)0.899
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.898
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.889
RXRAretinoid X receptor, alpha0.888
FASFas (TNF receptor superfamily, member 6)0.888
TGFB1transforming growth factor, beta 10.887
JUNjun proto-oncogene0.885
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.879
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.874
CCR7chemokine (C-C motif) receptor 70.870
IL4Rinterleukin 4 receptor0.860
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.853
SP1Sp1 transcription factor0.852
PSEN1presenilin 10.844
LATlinker for activation of T cells0.844
UBCubiquitin C0.842
IL2RBinterleukin 2 receptor, beta0.831
SHC1SHC (Src homology 2 domain containing) transforming protein 10.824
CAV1caveolin 1, caveolae protein, 22kDa0.817
BHLHE40basic helix-loop-helix family, member e400.815
KAT2BK(lysine) acetyltransferase 2B0.814
IRF1interferon regulatory factor 10.812
NR4A1nuclear receptor subfamily 4, group A, member 10.808
TCF12transcription factor 120.806
C1QAcomplement component 1, q subcomponent, A chain0.806
SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)0.805
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.800
CCR5chemokine (C-C motif) receptor 50.794
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.791
BIRC3baculoviral IAP repeat containing 30.790
CXCL9chemokine (C-X-C motif) ligand 90.788
SLAMF1signaling lymphocytic activation molecule family member 10.781
IL6interleukin 6 (interferon, beta 2)0.781
VEGFAvascular endothelial growth factor A0.776
ZNF43zinc finger protein 430.769
JAK2Janus kinase 20.768
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.764
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.763
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.761
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.758
CSNK2A1casein kinase 2, alpha 1 polypeptide0.757
NCOA2nuclear receptor coactivator 20.754
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.750
CASP3caspase 3, apoptosis-related cysteine peptidase0.749
GATA1GATA binding protein 1 (globin transcription factor 1)0.744
IRF4interferon regulatory factor 40.732
SYKspleen tyrosine kinase0.730
IL2RGinterleukin 2 receptor, gamma0.726
JAG1jagged 10.725
STAT5Asignal transducer and activator of transcription 5A0.719
IL8interleukin 80.718
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.709
KLF4Kruppel-like factor 4 (gut)0.707
IL10RAinterleukin 10 receptor, alpha0.705
SH3BP2SH3-domain binding protein 20.696
ZFYVE9zinc finger, FYVE domain containing 90.689
HDAC3histone deacetylase 30.687
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.686
JUNBjun B proto-oncogene0.680
PTPN1protein tyrosine phosphatase, non-receptor type 10.679
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Dusp1dual specificity phosphatase 10.540
Zfp36zinc finger protein 360.298
Hbbhemoglobin, beta0.297
Alas2aminolevulinate, delta-, synthase 20.269
Mylk2myosin light chain kinase 20.206
LOC287167globin, alpha0.202
LOC100134871beta globin minor gene0.193
Nek9NIMA (never in mitosis gene a)- related kinase 90.189
Sirpasignal-regulatory protein alpha0.171
Bcl2B-cell CLL/lymphoma 20.140
Jak1Janus kinase 10.136
Hba-a2hemoglobin alpha, adult chain 20.131
Errfi1ERBB receptor feedback inhibitor 10.125
Ccl5chemokine (C-C motif) ligand 50.124
Itgamintegrin, alpha M0.115
Prkchprotein kinase C, eta0.107
Eporerythropoietin receptor0.104
Cd247Cd247 molecule0.102
Ptger4prostaglandin E receptor 4 (subtype EP4)0.100
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.098
Atf3activating transcription factor 30.098
Cfpcomplement factor properdin0.095
Cd37CD37 molecule0.095
Rgs1regulator of G-protein signaling 10.091
Laptm5lysosomal protein transmembrane 50.091
Lifrleukemia inhibitory factor receptor alpha0.088
FosFBJ osteosarcoma oncogene0.087
Prf1perforin 1 (pore forming protein)0.087
Tgfbr2transforming growth factor, beta receptor II0.086
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.083
Hist1h2bahistone cluster 1, H2ba0.081
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.081
Stat4signal transducer and activator of transcription 40.079
Smad1SMAD family member 10.075
Lyz2lysozyme 20.073
Dusp6dual specificity phosphatase 60.072
Tgfb1transforming growth factor, beta 10.071
Junbjun B proto-oncogene0.071
Slco2b1solute carrier organic anion transporter family, member 2b10.069
Klf4Kruppel-like factor 4 (gut)0.069
RT1-Db1RT1 class II, locus Db10.065
Ptprcprotein tyrosine phosphatase, receptor type, C0.065
Cd5Cd5 molecule0.065
Il2rbinterleukin 2 receptor, beta0.061
Hbb-b1hemoglobin, beta adult major chain0.058
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.055
Shc3SHC (Src homology 2 domain containing) transforming protein 30.054
Oxtroxytocin receptor0.054
Bmp6bone morphogenetic protein 60.052
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.050
Btg2BTG family, member 20.049
Bin2bridging integrator 20.048
Ccl4chemokine (C-C motif) ligand 40.047
TcrbT-cell receptor beta chain0.046
Lyl1lymphoblastic leukemia derived sequence 10.046
Map4k1mitogen activated protein kinase kinase kinase kinase 10.044
Tmem176btransmembrane protein 176B0.044
Mycmyelocytomatosis oncogene0.044
Cd2Cd2 molecule0.044
Arhgap4Rho GTPase activating protein 40.043
Calcrcalcitonin receptor0.042
Lypd3Ly6/Plaur domain containing 30.041
RT1-DaRT1 class II, locus Da0.041
Fgfr1Fibroblast growth factor receptor 10.041
Fosl2fos-like antigen 20.040
Il1binterleukin 1 beta0.039
Ciitaclass II, major histocompatibility complex, transactivator0.039
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.038
Trpv1transient receptor potential cation channel, subfamily V, member 10.038
Cd68Cd68 molecule0.038
Rassf5Ras association (RalGDS/AF-6) domain family member 50.037
Nfyanuclear transcription factor-Y alpha0.037
Rararetinoic acid receptor, alpha0.036
Ccl3chemokine (C-C motif) ligand 30.036
LOC687711similar to small nuclear ribonucleoprotein D30.034
Spta1spectrin, alpha, erythrocytic 1 (elliptocytosis 2)0.034
Sp1Sp1 transcription factor0.034
Cd86CD86 molecule0.034
Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 10.034
Slfn2schlafen 20.034
Ccr5chemokine (C-C motif) receptor 50.034
Hbe1hemoglobin, epsilon 10.033
Gpr176G protein-coupled receptor 1760.033
Actn4actinin alpha 40.033
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.033
Olr837olfactory receptor 8370.033
Flt4fms-related tyrosine kinase 40.033
Gzmkgranzyme K0.033
LOC100363671hypothetical protein LOC1003636710.033
Ntn1netrin 10.033
Marcksmyristoylated alanine rich protein kinase C substrate0.032
Cyfip1cytoplasmic FMR1 interacting protein 10.032
Ece1endothelin converting enzyme 10.032
Man2b1mannosidase, alpha, class 2B, member 10.031
Il8rbinterleukin 8 receptor, beta0.031
Galr3galanin receptor 30.031
FaslgFas ligand (TNF superfamily, member 6)0.031
Dnase1l3deoxyribonuclease 1-like 30.031
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism