The network for 'protein modification process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

NameDescriptionProbabilityFunc Analog Organism
dsh-2Protein DSH-20.630
dep-1Protein DEP-10.590
egl-18Protein EGL-180.577
sun-1Protein SUN-10.549
atg-18Protein ATG-180.491
mel-26Protein MEL-260.491
lit-1Protein LIT-10.453
CELE_Y52B11A.9Protein Y52B11A.90.441
mat-3Protein MAT-30.428
glp-1Protein GLP-10.409
unc-9Protein UNC-90.402
cam-1Protein CAM-10.392
nud-2Protein NUD-20.392
unc-83Protein UNC-830.392
pdfr-1Protein PDFR-10.391
ZK507.6Protein ZK507.60.384
let-60Protein LET-600.380
pup-2Protein PUP-20.377
M01A8.2Protein M01A8.20.372
D1081.8Protein D1081.80.368
egl-8Protein EGL-80.366
par-5Protein PAR-50.365
pqn-59Protein PQN-590.363
pkg-1Protein PKG-10.362
klc-2Protein KLC-20.362
vab-3Protein VAB-30.361
sli-1Protein SLI-10.359
kle-2Protein KLE-20.353
spc-1Protein SPC-10.351
sas-5Protein SAS-50.340
sma-6Protein SMA-60.335
ina-1Protein INA-10.318
ceh-39Protein CEH-390.315
klp-7Protein KLP-70.315
lin-25Protein LIN-250.314
nlg-1Protein NLG-10.311
gyg-2Protein GYG-20.304
R11A8.7Protein R11A8.70.299
ida-1Protein IDA-10.291
ifet-1Protein IFET-10.286
pkc-3Protein PKC-30.275
C05D10.4Protein C05D10.40.273
zag-1Protein ZAG-10.273
imb-2Protein IMB-20.272
homt-1Protein HOMT-10.272
skn-1Protein SKN-10.267
unc-53Protein UNC-530.266
tps-1Protein TPS-10.266
clh-5Protein CLH-50.264
sta-1Protein STA-10.260
Y54E5A.7Protein Y54E5A.70.258
sma-1Protein SMA-10.258
pmk-1Protein PMK-10.257
atn-1Protein ATN-10.252
swsn-4Protein SWSN-40.251
pcaf-1Protein PCAF-10.249
hum-5Protein HUM-50.249
B0336.3Protein B0336.30.247
ceh-18Protein CEH-180.246
cbd-1Protein CBD-10.244
vps-53Protein VPS-530.239
pde-2Protein PDE-20.235
his-64Protein HIS-640.234
mrck-1Protein MRCK-10.234
csn-5Protein CSN-50.233
cdk-9Protein CDK-90.232
cids-2Protein CIDS-20.232
mig-15Protein MIG-150.232
mbk-2Protein MBK-20.226
M03F8.3Protein M03F8.30.225
klp-18Protein KLP-180.224
let-70Protein LET-700.223
his-1Protein HIS-10.219
K03E6.7Protein K03E6.70.218
dpy-10Protein DPY-100.217
nhr-67Protein NHR-670.217
C30C11.4Protein C30C11.40.216
C16C8.4Protein C16C8.40.216
tbb-1Protein TBB-10.215
math-33Protein MATH-330.213
T22C1.1Protein T22C1.10.212
rsa-1Protein RSA-10.209
rfc-4Protein RFC-40.206
npp-23Protein NPP-230.206
frm-7Protein FRM-70.205
frm-2Protein FRM-20.202
app-1Protein APP-10.201
scc-1Protein SCC-10.200
asd-1Protein ASD-10.200
swsn-2.1Protein SWSN-2.10.199
cfim-2Protein CFIM-20.199
cki-2Protein CKI-20.197
gei-11Protein GEI-110.197
ptr-2Protein PTR-20.196
hcp-3Protein HCP-30.194
vrk-1Protein VRK-10.193
CELE_C25A1.4Protein C25A1.40.192
C05D2.10Protein C05D2.100.191
gdi-1Protein GDI-10.191
ubr-1Protein UBR-10.189
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tp53tumor protein p530.856
efnb2aephrin B2a0.827
bmp2bbone morphogenetic protein 2b0.767
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.744
bmp4bone morphogenetic protein 40.720
dusp6dual specificity phosphatase 60.712
myod1myogenic differentiation 10.668
shhasonic hedgehog a0.634
her6hairy-related 60.625
wnt10awingless-type MMTV integration site family, member 10a0.572
fgf3fibroblast growth factor 30.508
per3period homolog 3 (Drosophila)0.422
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.410
sall1asal-like 1a (Drosophila)0.380
wnt2bbwingless-type MMTV integration site family, member 2Bb0.380
ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.347
foxi1forkhead box I10.336
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.333
supt5hsuppressor of Ty 5 homolog (S. cerevisiae)0.330
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.327
ccnb1cyclin B10.321
nrg2aneuregulin 2a0.319
rbb4retinoblastoma binding protein 40.314
smad1MAD homolog 1 (Drosophila)0.313
rarabretinoic acid receptor, alpha b0.297
cops3COP9 constitutive photomorphogenic homolog subunit 30.296
enc1ectodermal-neural cortex (with BTB-like domain)0.292
tgfb1atransforming growth factor, beta 1a0.287
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.287
runx2arunt-related transcription factor 2a0.287
kdrlkinase insert domain receptor like0.286
notch1anotch homolog 1a0.282
gro2groucho 20.272
ywhaityrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide0.268
spry4sprouty (Drosophila) homolog 40.266
gpr126G protein-coupled receptor 1260.256
prdm2bPR domain containing 2, with ZNF domain b0.255
klf4Kruppel-like factor 40.254
mapk6mitogen-activated protein kinase 60.250
smarcb1aSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a0.250
mstnbmyostatin b0.249
ptk2.1protein tyrosine kinase 2a0.246
cdh1cadherin 1, epithelial0.244
zbtb16azinc finger and BTB domain containing 16a0.242
mapk3mitogen-activated protein kinase 30.226
fgfr3fibroblast growth factor receptor 30.218
sox32SRY-box containing gene 320.217
sass6spindle assembly 6 homolog (C. elegans)0.206
ezh2enhancer of zeste homolog 2 (Drosophila)0.202
cdc25cell division cycle 25 homolog0.202
setdb1bSET domain, bifurcated 1b0.202
fgf17fibroblast growth factor 170.198
celf1cugbp, Elav-like family member 10.197
nrp2bneuropilin 2b0.196
chek1CHK1 checkpoint homolog (S. pombe)0.191
foxo3bforkhead box O3b0.191
irf6interferon regulatory factor 60.190
park7parkinson disease (autosomal recessive, early onset) 70.190
mmp9matrix metalloproteinase 90.189
wnt3awingless-type MMTV integration site family, member 3A0.188
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.179
bhmtbetaine-homocysteine methyltransferase0.179
psen1presenilin 10.179
appaamyloid beta (A4) precursor protein a0.176
ccnd1cyclin D10.176
btg2B-cell translocation gene 20.175
aplp2amyloid beta (A4) precursor-like protein 20.173
crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.171
zbtb4zinc finger and BTB domain containing 40.166
tlr3toll-like receptor 30.166
flhfloating head0.165
jag2jagged 20.164
junbjun B proto-oncogene0.163
ext1aexostoses (multiple) 1a0.160
runx2brunt-related transcription factor 2b0.158
col2a1acollagen type II, alpha-1a0.158
kif23kinesin family member 230.158
pcdh8protocadherin 80.157
naspnuclear autoantigenic sperm protein (histone-binding)0.157
jupjunction plakoglobin0.156
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.155
nusap1nucleolar and spindle associated protein 10.155
prkciprotein kinase C, iota0.154
llgl2lethal giant larvae homolog 2 (Drosophila)0.154
gli1GLI-Kruppel family member 10.154
tal1T-cell acute lymphocytic leukemia 10.152
rtn1areticulon 1a0.152
arpp19acAMP-regulated phosphoprotein 19a0.152
osr1odd-skipped related 1 (Drosophila)0.151
wt1bwilms tumor 1b0.150
socs3asuppressor of cytokine signaling 3a0.149
eomesaeomesodermin homolog a0.148
chrna4cholinergic receptor, nicotinic, alpha 40.148
ptenaphosphatase and tensin homolog A0.148
gpibglucose phosphate isomerase b0.147
wacaWW domain containing adaptor with coiled-coil a0.146
hmgn3high mobility group nucleosomal binding domain 30.143
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.991
Atg1Autophagy-specific gene 10.984
ebiCG4063 gene product from transcript CG4063-RA0.968
Akt1CG4006 gene product from transcript CG4006-RA0.966
Su(H)Suppressor of Hairless0.959
CycACyclin A0.950
Pp1-87BProtein phosphatase 1 at 87B0.943
slmbsupernumerary limbs0.921
Pi3K92ECG4141 gene product from transcript CG4141-RB0.921
rapretina aberrant in pattern0.917
CkIIalphaCasein kinase II alpha subunit0.915
Rho1CG8416 gene product from transcript CG8416-RB0.903
RbfRetinoblastoma-family protein0.859
SmoxSmad on X0.858
eIF-4EEukaryotic initiation factor 4E0.849
Ube3aUbiquitin protein ligase E3A0.836
par-1CG8201 gene product from transcript CG8201-RA0.828
Pp2B-14DProtein phosphatase 2B at 14D0.816
CSN5COP9 complex homolog subunit 50.812
numbCG3779 gene product from transcript CG3779-RB0.796
unc-13CG2999 gene product from transcript CG2999-RA0.795
BEAF-32Boundary element-associated factor of 32kD0.781
Dsp1Dorsal switch protein 10.781
Cdc37CG12019 gene product from transcript CG12019-RA0.778
p53CG33336 gene product from transcript CG33336-RB0.771
ph-ppolyhomeotic proximal0.764
Rac1CG2248 gene product from transcript CG2248-RA0.753
aopanterior open0.751
CG13298CG13298 gene product from transcript CG13298-RA0.746
cindrCIN85 and CD2AP orthologue0.743
Sema-1aCG18405 gene product from transcript CG18405-RD0.739
PtenCG5671 gene product from transcript CG5671-RB0.735
poloCG12306 gene product from transcript CG12306-RA0.731
Ras85DRas oncogene at 85D0.717
Cdc42CG12530 gene product from transcript CG12530-RA0.715
fs(1)hfemale sterile (1) homeotic0.713
dcodiscs overgrown0.709
bratbrain tumor0.697
MybMyb oncogene-like0.696
Tao-1CG14217 gene product from transcript CG14217-RF0.683
sbrsmall bristles0.666
SaraSmad anchor for receptor activation0.662
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.662
Rab5Rab-protein 50.659
wdswill die slowly0.658
E(spl)Enhancer of split0.650
Tsc1CG6147 gene product from transcript CG6147-RA0.649
ImpIGF-II mRNA-binding protein0.640
RYBPRing and YY1 Binding Protein0.639
Klp10ACG1453 gene product from transcript CG1453-RA0.636
Dhc64CDynein heavy chain 64C0.634
wocwithout children0.628
shotshort stop0.624
WnkCG7177 gene product from transcript CG7177-RA0.624
CG4400CG4400 gene product from transcript CG4400-RA0.617
CakiCalcium/calmodulin-dependent protein kinase0.613
E(z)Enhancer of zeste0.612
crolcrooked legs0.600
Mgat1UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I0.588
Hsp83Heat shock protein 830.588
pr-set7CG3307 gene product from transcript CG3307-RC0.587
Uch-L3Ubiquitin C-terminal hydrolase0.585
Nrx-IVNeurexin IV0.584
CG5794CG5794 gene product from transcript CG5794-RB0.583
Mekk1CG7717 gene product from transcript CG7717-RB0.578
Top1Topoisomerase 10.578
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism