The network for 'muscle fiber development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

muscle fiber development

The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.

NameDescriptionProbabilityFunc Analog Organism
unc-73Protein UNC-730.251
cst-1Protein CST-10.116
rig-6Protein RIG-60.079
cpna-1Protein CPNA-10.075
egl-30Protein EGL-300.073
egl-18Protein EGL-180.061
inx-3Protein INX-30.059
pde-4Protein PDE-40.057
unc-6Protein UNC-60.054
pat-12Protein PAT-120.053
kal-1Protein KAL-10.047
unc-43Protein UNC-430.047
bli-1Protein BLI-10.045
unc-45Protein UNC-450.044
ncx-1Protein NCX-10.044
lin-59Protein LIN-590.044
lev-11Protein LEV-110.044
unc-15Protein UNC-150.044
nhr-67Protein NHR-670.041
C02F4.4Protein C02F4.40.041
csq-1Protein CSQ-10.040
unc-89Protein UNC-890.040
syg-1Protein SYG-10.039
unc-53Protein UNC-530.038
cst-2Protein CST-20.037
hlh-2Protein HLH-20.037
lin-12Protein LIN-120.037
cwn-1Protein CWN-10.036
elt-6Protein ELT-60.035
nekl-3Protein NEKL-30.034
eat-6Protein EAT-60.034
snf-11Protein SNF-110.034
hum-7Protein HUM-70.032
myo-5Protein MYO-50.032
olrn-1Protein OLRN-10.031
vab-10Protein VAB-100.030
sel-8Protein SEL-80.030
egl-1Protein EGL-10.030
emb-9Protein EMB-90.030
daf-11Protein DAF-110.030
pha-4Protein PHA-40.029
magu-2Protein MAGU-20.029
chd-3Protein CHD-30.029
pyc-1Protein PYC-10.028
F46G11.2Protein F46G11.20.028
acr-16Protein ACR-160.028
daf-4Protein DAF-40.028
F13B6.1Protein F13B6.10.027
cwn-2Protein CWN-20.027
lin-7Protein LIN-70.026
tag-241Protein TAG-2410.026
tag-278Protein TAG-2780.026
unc-38Protein UNC-380.026
rps-6Protein RPS-60.026
jmjc-1Protein JMJC-10.025
clhm-1Protein CLHM-10.025
unc-87Protein UNC-870.025
mlt-10Protein MLT-100.025
slt-1Protein SLT-10.025
CELE_K08D8.3Protein K08D8.30.025
ain-1Protein AIN-10.025
egl-2Protein EGL-20.024
tbc-4Protein TBC-40.024
myo-3Protein MYO-30.024
hil-3Protein HIL-30.024
col-38Protein COL-380.024
lgc-31Protein LGC-310.024
unc-47Protein UNC-470.024
sqt-1Protein SQT-10.024
let-60Protein LET-600.024
pmk-1Protein PMK-10.024
mig-2Protein MIG-20.023
vab-8Protein VAB-80.023
C06E4.2Protein C06E4.20.023
F57A8.1Protein F57A8.10.023
ketn-1Protein KETN-10.023
F16C3.2Protein F16C3.20.023
C05C9.1Protein C05C9.10.023
R90.1Protein R90.10.023
cpna-2Protein CPNA-20.023
C18E3.3Protein C18E3.30.023
pkg-1Protein PKG-10.023
clc-3Protein CLC-30.023
F55C10.4Protein F55C10.40.023
C53C9.2Protein C53C9.20.023
dos-2Protein DOS-20.022
F01G4.6Protein F01G4.60.022
ceh-18Protein CEH-180.022
atf-2Protein ATF-20.022
lev-8Protein LEV-80.022
mpz-1Protein MPZ-10.022
kel-8Protein KEL-80.022
lit-1Protein LIT-10.022
unc-96Protein UNC-960.022
T21B6.3Protein T21B6.30.022
egl-20Protein EGL-200.022
F57A8.6Protein F57A8.60.021
nhr-25Protein NHR-250.021
T16G1.2Protein T16G1.20.021
egl-23Protein EGL-230.021
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
actn3aactinin alpha 3a0.917
actn2actinin, alpha 20.801
gli1GLI-Kruppel family member 10.777
myf5myogenic factor 50.742
myod1myogenic differentiation 10.727
unc45bunc-45 homolog B (C. elegans)0.716
cdh2cadherin 2, neuronal0.699
sox9aSRY-box containing gene 9a0.693
gyltl1bglycosyltransferase-like 1b0.678
myhz2myosin, heavy polypeptide 2, fast muscle specific0.676
rx3retinal homeobox gene 30.614
neo1neogenin 10.597
hsp90a.1heat shock protein 90-alpha 10.566
foxd3forkhead box D30.491
tnni2a.4troponin I, skeletal, fast 2a.40.477
smyd1bSET and MYND domain containing 1b0.475
ttnatitin a0.454
notch3notch homolog 30.429
six4asine oculis homeobox homolog 4a0.372
gli2aGLI-Kruppel family member GLI2a0.365
actn3bactinin alpha 3b0.348
col8a1acollagen, type VIII, alpha 1a0.348
mbnl2muscleblind-like 2 (Drosophila)0.339
ambra1autophagy/beclin-1 regulator 10.295
stac3SH3 and cysteine rich domain 30.287
chsy1chondroitin sulfate synthase 10.281
ntlano tail a0.257
lama2laminin, alpha 20.241
ptch2patched 20.237
actn1actinin, alpha 10.236
vax2ventral anterior homeobox 20.219
smyhc2slow myosin heavy chain 20.216
emp2epithelial membrane protein 20.212
tnni1altroponin I, skeletal, slow like0.208
skianuclear oncoprotein skia0.208
pdlim7PDZ and LIM domain 70.206
il1binterleukin 1, beta and interleukin 1, beta0.190
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.189
nova2neuro-oncological ventral antigen 20.185
mef2camyocyte enhancer factor 2ca0.185
pcdh8protocadherin 80.181
lats1LATS, large tumor suppressor, homolog 1 (Drosophila)0.180
runx2brunt-related transcription factor 2b0.179
tcf12transcription factor 120.177
acta1aactin, alpha 1a, skeletal muscle0.176
six1bsine oculis homeobox homolog 1b0.170
brd4bromodomain containing 40.168
notch2notch homolog 20.165
bmp2bbone morphogenetic protein 2b0.161
fstl1bfollistatin-like 1b0.157
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.156
mef2dmyocyte enhancer factor 2d0.152
srfserum response factor0.152
prrx1apaired related homeobox 1a0.151
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.149
ldb3aLIM-domain binding factor 3a0.147
axin2axin 2 (conductin, axil)0.146
pdgfaaplatelet-derived growth factor alpha a0.146
igf3insulin-like growth factor 30.145
stau2staufen, RNA binding protein, homolog 2 (Drosophila)0.144
xirp1xin actin-binding repeat containing 10.144
tbx24T-box 240.142
hgfahepatocyte growth factor a0.141
eya4eyes absent homolog 4 (Drosophila)0.138
rad21RAD21 homolog (S. pombe)0.138
dmrta2doublesex and mab-3 related transcription factor like family A20.136
scube2signal peptide, CUB domain, EGF-like 20.134
plce1phospholipase C, epsilon 10.133
msxemuscle segment homeobox E0.130
otx1aorthodenticle homolog 1a0.128
mstnbmyostatin b0.128
pth2parathyroid hormone 20.127
hoxa9ahomeo box A9a0.127
robo3roundabout homolog 30.126
cbfbcore-binding factor, beta subunit0.126
wt1bwilms tumor 1b0.121
hhiphedgehog interacting protein0.118
smosmoothened homolog (Drosophila)0.115
lmnalamin A0.113
slc39a4solute carrier family 39 (zinc transporter), member 40.110
myhc4myosin heavy chain 40.108
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.105
kbtbd10bkelch repeat and BTB (POZ) domain containing 10b0.105
slc30a7solute carrier family 30 (zinc transporter), member 70.104
chrndcholinergic receptor, nicotinic, delta polypeptide0.103
mbnl1muscleblind-like (Drosophila)0.103
acta1bactin, alpha 1b, skeletal muscle0.103
ehd2EH-domain containing 20.101
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.097
tll1tolloid-like 10.097
ventventral expressed homeobox0.096
efnb2aephrin B2a0.096
plagl2pleiomorphic adenoma gene-like 20.094
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Btk29ABtk family kinase at 29A0.504
stumpsCG31317 gene product from transcript CG31317-RC0.388
Rac1CG2248 gene product from transcript CG2248-RA0.384
Pp2B-14DProtein phosphatase 2B at 14D0.265
S6kIIRPS6-protein kinase-II0.236
MhcMyosin heavy chain0.222
Act87EActin 87E0.203
aopanterior open0.192
mbcmyoblast city0.188
Rho1CG8416 gene product from transcript CG8416-RB0.184
Mef2Myocyte enhancer factor 20.171
Atg1Autophagy-specific gene 10.162
myoglianinCG1838 gene product from transcript CG1838-RD0.162
G-oalpha47AG protein oalpha 47A0.148
Eip75BEcdysone-induced protein 75B0.122
Arp66BActin-related protein 66B0.112
Fas2Fasciclin 20.108
BicDBicaudal D0.093
LanB2Laminin B20.090
cicubitus interruptus0.090
ImpIGF-II mRNA-binding protein0.085
CG34139CG34139 gene product from transcript CG34139-RD0.081
kirrekin of irre0.075
CG3563CG3563 gene product from transcript CG3563-RA0.069
betaggt-Ibeta subunit of type I geranylgeranyl transferase0.069
HsfHeat shock factor0.068
Mpk2CG5475 gene product from transcript CG5475-RB0.063
Rac2CG8556 gene product from transcript CG8556-RA0.062
MrtfMyocardin-related transcription factor0.061
snssticks and stones0.057
howheld out wings0.056
Ras85DRas oncogene at 85D0.056
Tm2Tropomyosin 20.053
RpS15AaRibosomal protein S15Aa0.052
EgfrEpidermal growth factor receptor0.052
Stat92ESignal-transducer and activator of transcription protein at 92E0.051
wupAwings up A0.050
Pkc98EProtein C kinase 98E0.050
Wnt4Wnt oncogene analog 40.050
toetwin of eyg0.049
vvlventral veins lacking0.049
l(2)gd1lethal (2) giant discs 10.046
dcodiscs overgrown0.045
fkhfork head0.040
CG34168CG34168 gene product from transcript CG34168-RA0.037
G-salpha60AG protein salpha 60A0.036
elavembryonic lethal abnormal vision0.035
Vrp1Verprolin 10.034
Zasp52Z band alternatively spliced PDZ-motif protein 520.031
cpacapping protein alpha0.031
eveeven skipped0.030
abd-Aabdominal A0.024
HLHm5E(spl) region transcript m50.024
E(spl)Enhancer of split0.023
Fas3Fasciclin 30.023
PvrPDGF- and VEGF-receptor related0.023
Vhlvon Hippel-Lindau0.023
sqhspaghetti squash0.022
Taf4TBP-associated factor 40.022
DatDopamine N acetyltransferase0.022
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TRIM63tripartite motif containing 630.998
JAG1jagged 10.822
NOTCH1notch 10.804
MYOZ1myozenin 10.620
FGF1fibroblast growth factor 1 (acidic)0.619
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.505
GMPPAGDP-mannose pyrophosphorylase A0.470
HDAC4histone deacetylase 40.385
SRFserum response factor (c-fos serum response element-binding transcription factor)0.328
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.302
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.278
STK4serine/threonine kinase 40.253
JUNjun proto-oncogene0.253
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.208
TCAPtitin-cap (telethonin)0.207
BMPR1Abone morphogenetic protein receptor, type IA0.193
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.177
NRP1neuropilin 10.174
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.173
STK3serine/threonine kinase 30.164
DTNAdystrobrevin, alpha0.150
FN1fibronectin 10.139
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.130
BCL6B-cell CLL/lymphoma 60.129
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.127
LTAlymphotoxin alpha (TNF superfamily, member 1)0.124
IGF2insulin-like growth factor 2 (somatomedin A)0.113
NCAM1neural cell adhesion molecule 10.112
HDAC9histone deacetylase 90.111
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.105
FSTL1follistatin-like 10.102
IQGAP1IQ motif containing GTPase activating protein 10.102
SETD8SET domain containing (lysine methyltransferase) 80.088
FLNAfilamin A, alpha0.086
MEF2Cmyocyte enhancer factor 2C0.078
OBSL1obscurin-like 10.076
APPamyloid beta (A4) precursor protein0.074
ACTN2actinin, alpha 20.072
PARVAparvin, alpha0.072
PTPN1protein tyrosine phosphatase, non-receptor type 10.071
SHC1SHC (Src homology 2 domain containing) transforming protein 10.066
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.059
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.057
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.056
FOSFBJ murine osteosarcoma viral oncogene homolog0.055
FLNCfilamin C, gamma0.052
NOTCH3notch 30.052
RASSF1Ras association (RalGDS/AF-6) domain family member 10.050
NCOR2nuclear receptor corepressor 20.050
ZFYVE9zinc finger, FYVE domain containing 90.049
ATF3activating transcription factor 30.049
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.048
FBLN1fibulin 10.046
BMP2bone morphogenetic protein 20.045
TNKS2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.043
TESK1testis-specific kinase 10.040
BCL2L1BCL2-like 10.038
MTMR12myotubularin related protein 120.038
TAL1T-cell acute lymphocytic leukemia 10.034
MEF2Amyocyte enhancer factor 2A0.032
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.032
CXCL11chemokine (C-X-C motif) ligand 110.032
CAV1caveolin 1, caveolae protein, 22kDa0.032
SPRY2sprouty homolog 2 (Drosophila)0.031
NCOR1nuclear receptor corepressor 10.031
RASSF3Ras association (RalGDS/AF-6) domain family member 30.030
SPTBN1spectrin, beta, non-erythrocytic 10.029
TNNI2troponin I type 2 (skeletal, fast)0.029
RASSF5Ras association (RalGDS/AF-6) domain family member 50.029
NFIL3nuclear factor, interleukin 3 regulated0.029
TNNI1troponin I type 1 (skeletal, slow)0.029
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.029
MYL9myosin, light chain 9, regulatory0.029
E2F1E2F transcription factor 10.026
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.026
DLL1delta-like 1 (Drosophila)0.026
CTGFconnective tissue growth factor0.025
ANXA2annexin A20.024
EPAS1endothelial PAS domain protein 10.024
CNOT8CCR4-NOT transcription complex, subunit 80.024
SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein)0.024
ACTA1actin, alpha 1, skeletal muscle0.023
SIN3ASIN3 homolog A, transcription regulator (yeast)0.023
PGFplacental growth factor0.023
DAXXdeath-domain associated protein0.022
FYNFYN oncogene related to SRC, FGR, YES0.022
ADAM12ADAM metallopeptidase domain 120.022
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.022
CHRNA1cholinergic receptor, nicotinic, alpha 1 (muscle)0.021
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.020
TNNT3troponin T type 3 (skeletal, fast)0.020
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.020
MRPL41mitochondrial ribosomal protein L410.019
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Pax3paired box gene 30.996
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.986
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.950
Gli2GLI-Kruppel family member GLI20.939
Bmp4bone morphogenetic protein 40.938
Mef2dmyocyte enhancer factor 2D0.934
Rargretinoic acid receptor, gamma0.929
Dmddystrophin, muscular dystrophy0.927
Prrx1paired related homeobox 10.907
Gli3GLI-Kruppel family member GLI30.885
Ikzf1IKAROS family zinc finger 10.878
Msx2homeobox, msh-like 20.875
Tbx15T-box 150.870
Mybphmyosin binding protein H0.850
Mapk14mitogen-activated protein kinase 140.837
Id1inhibitor of DNA binding 10.827
Fgfr2fibroblast growth factor receptor 20.826
Msx1homeobox, msh-like 10.825
Actc1actin, alpha, cardiac muscle 10.824
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.816
Bcl2B-cell leukemia/lymphoma 20.816
Acvr1activin A receptor, type 10.800
Ldb3LIM domain binding 30.793
Pitx2paired-like homeodomain transcription factor 20.778
Fgfr1fibroblast growth factor receptor 10.772
Smosmoothened homolog (Drosophila)0.772
Pax7paired box gene 70.765
Foxc1forkhead box C10.732
Prrx2paired related homeobox 20.724
Homer1homer homolog 1 (Drosophila)0.706
Spry2sprouty homolog 2 (Drosophila)0.688
Tnni2troponin I, skeletal, fast 20.686
Scn5asodium channel, voltage-gated, type V, alpha0.680
Id3inhibitor of DNA binding 30.675
Myf6myogenic factor 60.671
Hrchistidine rich calcium binding protein0.638
Tbx1T-box 10.637
Ckmcreatine kinase, muscle0.636
Cav3caveolin 30.634
Ccl2chemokine (C-C motif) ligand 20.632
Pitx1paired-like homeodomain transcription factor 10.631
Rarbretinoic acid receptor, beta0.629
Dkk1dickkopf homolog 1 (Xenopus laevis)0.625
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.624
Trp53transformation related protein 530.605
Otx2orthodenticle homolog 2 (Drosophila)0.599
Ednraendothelin receptor type A0.591
Pfn1profilin 10.573
Tnnc2troponin C2, fast0.570
Sox9SRY-box containing gene 90.560
Tcf3transcription factor 30.560
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.558
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.551
Hes1hairy and enhancer of split 1 (Drosophila)0.547
Nrapnebulin-related anchoring protein0.541
Runx2runt related transcription factor 20.536
Hspb2heat shock protein 20.534
Vegfavascular endothelial growth factor A0.523
Tcfap2atranscription factor AP-2, alpha0.517
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.514
Hdac4histone deacetylase 40.507
Myl1myosin, light polypeptide 10.501
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.493
Rararetinoic acid receptor, alpha0.492
Bmp7bone morphogenetic protein 70.475
Actn2actinin alpha 20.474
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.458
Hspg2perlecan (heparan sulfate proteoglycan 2)0.456
Actn3actinin alpha 30.456
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.455
Myl3myosin, light polypeptide 30.449
Myod1myogenic differentiation 10.446
Fgf8fibroblast growth factor 80.440
Disp1dispatched homolog 1 (Drosophila)0.440
Tnnt3troponin T3, skeletal, fast0.437
Pbx1pre B-cell leukemia transcription factor 10.435
Acta1actin, alpha 1, skeletal muscle0.426
Ptrfpolymerase I and transcript release factor0.419
Dlx5distal-less homeobox 50.408
Il1rninterleukin 1 receptor antagonist0.408
Wnt4wingless-related MMTV integration site 40.404
Cnn2calponin 20.400
Ror2receptor tyrosine kinase-like orphan receptor 20.388
Pdlim3PDZ and LIM domain 30.386
Lifleukemia inhibitory factor0.384
Rspo2R-spondin 2 homolog (Xenopus laevis)0.378
Cnn1calponin 10.374
Cd40CD40 antigen0.367
Tgfb1i1transforming growth factor beta 1 induced transcript 10.359
Myf5myogenic factor 50.359
Casq2calsequestrin 20.356
Zfp36l1zinc finger protein 36, C3H type-like 10.356
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism