The network for 'activation of protein kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation of protein kinase activity

Any process that initiates the activity of an inactive protein kinase.

NameDescriptionProbabilityFunc Analog Organism
YMR086Whypothetical protein0.013
YLR162Whypothetical protein0.012
YJR085Chypothetical protein0.011
YOL038C-Ahypothetical protein0.011
YLR264C-Ahypothetical protein0.011
YPR157Whypothetical protein0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
mpk-1Protein MPK-10.107
bar-1Protein BAR-10.071
let-60Protein LET-600.053
zfp-3Protein ZFP-30.053
unc-10Protein UNC-100.048
npp-7Protein NPP-70.035
mlk-1Protein MLK-10.029
cec-1Protein CEC-10.028
daf-1Protein DAF-10.027
mek-2Protein MEK-20.026
meg-2Protein MEG-20.024
nhr-34Protein NHR-340.022
K10D6.4Protein K10D6.40.021
nhr-6Protein NHR-60.021
nhr-79Protein NHR-790.020
K07C11.4Protein K07C11.40.020
gsk-3Protein GSK-30.018
tps-1Protein TPS-10.018
sur-2Protein SUR-20.018
clh-5Protein CLH-50.018
nhr-65Protein NHR-650.017
sax-7Protein SAX-70.016
K08E3.5Protein K08E3.50.016
CELE_Y57G11C.22Protein Y57G11C.220.015
smf-3Protein SMF-30.015
chd-7Protein CHD-70.014
cst-1Protein CST-10.014
pig-1Protein PIG-10.014
cutl-24Protein CUTL-240.014
mef-2Protein MEF-20.014
zer-1Protein ZER-10.014
dpy-22Protein DPY-220.013
kal-1Protein KAL-10.013
ist-1Protein IST-10.012
C11E4.6Protein C11E4.60.012
egl-18Protein EGL-180.012
lin-59Protein LIN-590.011
eor-2Protein EOR-20.011
tmc-2Protein TMC-20.011
smf-2Protein SMF-20.011
abl-1Protein ABL-10.011
K02A6.2Protein K02A6.20.011
gsr-1Protein GSR-10.010
unc-38Protein UNC-380.010
amph-1Protein AMPH-10.010
mpst-3Protein MPST-30.010
ksr-1Protein KSR-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.834
DadDaughters against dpp0.781
phlpole hole0.736
rictorrapamycin-insensitive companion of Tor0.374
FhosCG42610 gene product from transcript CG42610-RC0.352
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.306
aopanterior open0.298
Atg1Autophagy-specific gene 10.275
Akt1CG4006 gene product from transcript CG4006-RA0.242
Ras85DRas oncogene at 85D0.232
chicoCG5686 gene product from transcript CG5686-RB0.221
MadMothers against dpp0.202
par-1CG8201 gene product from transcript CG8201-RA0.190
EgfrEpidermal growth factor receptor0.158
JraJun-related antigen0.157
SaraSmad anchor for receptor activation0.124
InRInsulin-like receptor0.117
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.105
SmoxSmad on X0.094
Smg1CG32743 gene product from transcript CG32743-RA0.093
Src42ASrc oncogene at 42A0.093
Gap1GTPase-activating protein 10.091
AlkCG8250 gene product from transcript CG8250-RA0.086
Plc21CPhospholipase C at 21C0.083
S6kRPS6-p70-protein kinase0.080
PknProtein kinase related to protein kinase N0.079
CG31048CG31048 gene product from transcript CG31048-RB0.077
Pk61CProtein kinase 61C0.065
ftz-f1ftz transcription factor 10.065
Atf-2Activating transcription factor-20.064
Su(H)Suppressor of Hairless0.062
Cdc42CG12530 gene product from transcript CG12530-RA0.054
cbscentrosomin's beautiful sister0.045
CG1347CG1347 gene product from transcript CG1347-RB0.045
CG5794CG5794 gene product from transcript CG5794-RB0.038
Tao-1CG14217 gene product from transcript CG14217-RF0.037
CblCG7037 gene product from transcript CG7037-RB0.036
numbCG3779 gene product from transcript CG3779-RB0.034
AblAbl tyrosine kinase0.033
zfh1Zn finger homeodomain 10.033
PtenCG5671 gene product from transcript CG5671-RB0.032
Rac2CG8556 gene product from transcript CG8556-RA0.032
Hs6stHeparan sulfate 6-O-sulfotransferase0.032
trioCG18214 gene product from transcript CG18214-RA0.031
Eip71CDEcdysone-induced protein 28/29kD0.031
Dip3Dorsal interacting protein 30.030
lqfliquid facets0.029
Stat92ESignal-transducer and activator of transcription protein at 92E0.027
maskmultiple ankyrin repeats single KH domain0.026
Lk6CG17342 gene product from transcript CG17342-RA0.026
ninaEneither inactivation nor afterpotential E0.026
MrtfMyocardin-related transcription factor0.026
drongoCG3365 gene product from transcript CG3365-RH0.025
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.025
mbcmyoblast city0.024
Mmp1Matrix metalloproteinase 10.024
mewmultiple edematous wings0.024
myoglianinCG1838 gene product from transcript CG1838-RD0.023
jebjelly belly0.023
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide1.000
FGFR2fibroblast growth factor receptor 20.999
TRAF6TNF receptor-associated factor 60.999
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.999
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.999
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.999
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.998
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.998
FGF1fibroblast growth factor 1 (acidic)0.997
MAP3K5mitogen-activated protein kinase kinase kinase 50.997
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.996
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.996
TGFB1transforming growth factor, beta 10.995
IRAK2interleukin-1 receptor-associated kinase 20.995
FGFR1fibroblast growth factor receptor 10.994
MAP3K7mitogen-activated protein kinase kinase kinase 70.993
IL1R1interleukin 1 receptor, type I0.993
CAV1caveolin 1, caveolae protein, 22kDa0.987
STK11serine/threonine kinase 110.987
PTPN1protein tyrosine phosphatase, non-receptor type 10.984
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.982
MAP3K3mitogen-activated protein kinase kinase kinase 30.980
BCAR1breast cancer anti-estrogen resistance 10.973
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.963
MAP3K11mitogen-activated protein kinase kinase kinase 110.951
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.950
TOLLIPtoll interacting protein0.949
NRP1neuropilin 10.942
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.939
MAPK14mitogen-activated protein kinase 140.931
TEKTEK tyrosine kinase, endothelial0.927
VEGFAvascular endothelial growth factor A0.926
GRB2growth factor receptor-bound protein 20.925
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.921
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.920
AXLAXL receptor tyrosine kinase0.907
TRAF3TNF receptor-associated factor 30.898
MAPK8mitogen-activated protein kinase 80.898
PDPK13-phosphoinositide dependent protein kinase-10.898
MYD88myeloid differentiation primary response gene (88)0.898
GAB1GRB2-associated binding protein 10.885
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.874
METmet proto-oncogene (hepatocyte growth factor receptor)0.869
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.867
LRRK2leucine-rich repeat kinase 20.856
BMPR1Abone morphogenetic protein receptor, type IA0.853
PLCG1phospholipase C, gamma 10.853
NTRK2neurotrophic tyrosine kinase, receptor, type 20.852
TRAF1TNF receptor-associated factor 10.852
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.851
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.827
SH3KBP1SH3-domain kinase binding protein 10.827
DLG1discs, large homolog 1 (Drosophila)0.813
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.808
IGF1Rinsulin-like growth factor 1 receptor0.793
BIRC3baculoviral IAP repeat containing 30.786
BBS10Bardet-Biedl syndrome 100.777
FSTL1follistatin-like 10.773
UBCubiquitin C0.741
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.736
MAPK1mitogen-activated protein kinase 10.734
MAP3K14mitogen-activated protein kinase kinase kinase 140.731
BIRC2baculoviral IAP repeat containing 20.729
TGFB3transforming growth factor, beta 30.725
CDC37cell division cycle 37 homolog (S. cerevisiae)0.709
AKT1v-akt murine thymoma viral oncogene homolog 10.708
MAP2K7mitogen-activated protein kinase kinase 70.700
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.694
GRB7growth factor receptor-bound protein 70.688
LATlinker for activation of T cells0.685
GH1growth hormone 10.685
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.673
NTRK1neurotrophic tyrosine kinase, receptor, type 10.672
JAK2Janus kinase 20.671
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.649
SOCS1suppressor of cytokine signaling 10.645
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.641
PTPRBprotein tyrosine phosphatase, receptor type, B0.625
FKBP1AFK506 binding protein 1A, 12kDa0.623
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.620
MPDZmultiple PDZ domain protein0.612
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.590
BMP2bone morphogenetic protein 20.578
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.571
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.562
MAP3K1mitogen-activated protein kinase kinase kinase 10.559
SQSTM1sequestosome 10.558
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.554
BCL10B-cell CLL/lymphoma 100.544
PTPN11protein tyrosine phosphatase, non-receptor type 110.540
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.534
SHC1SHC (Src homology 2 domain containing) transforming protein 10.534
FASFas (TNF receptor superfamily, member 6)0.517
MAPK3mitogen-activated protein kinase 30.508
CASP8caspase 8, apoptosis-related cysteine peptidase0.500
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.487
CSNK1Ecasein kinase 1, epsilon0.485
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.477
SMAD7SMAD family member 70.476
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gna12guanine nucleotide binding protein (G protein) alpha 120.260
Cd4Cd4 molecule0.161
Fgfr2fibroblast growth factor receptor 20.156
RT1-BaRT1 class II, locus Ba0.141
Jak2Janus kinase 20.133
RGD1564664similar to LOC387763 protein0.120
Pnlippancreatic lipase0.117
Tbx3T-box 30.110
Glp1rglucagon-like peptide 1 receptor0.109
Sirpasignal-regulatory protein alpha0.102
Prph2peripherin 20.097
Egfrepidermal growth factor receptor0.094
Inpp5dinositol polyphosphate-5-phosphatase D0.089
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.089
Tgfbr2transforming growth factor, beta receptor II0.087
Mpripmyosin phosphatase Rho interacting protein0.084
Irs1insulin receptor substrate 10.080
Mpeg1macrophage expressed 10.079
Grb2growth factor receptor bound protein 20.074
Ptafrplatelet-activating factor receptor0.074
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.072
Ptpn7protein tyrosine phosphatase, non-receptor type 70.071
Plauplasminogen activator, urokinase0.070
Stat6signal transducer and activator of transcription 60.070
Mapk1mitogen activated protein kinase 10.069
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.068
Nrp1neuropilin 10.067
Sox17SRY (sex determining region Y)-box 170.067
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.063
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.063
Smad3SMAD family member 30.062
Calcrlcalcitonin receptor-like0.062
Atp12aATPase, H+/K+ transporting, nongastric, alpha polypeptide0.061
Itgamintegrin, alpha M0.060
Olr1278olfactory receptor 12780.060
Bcl2B-cell CLL/lymphoma 20.059
Drd1adopamine receptor D1A0.059
RorbRAR-related orphan receptor B0.059
Jak1Janus kinase 10.058
Nek9NIMA (never in mitosis gene a)- related kinase 90.058
RGD1564865similar to 20-alpha-hydroxysteroid dehydrogenase0.058
Usf2upstream transcription factor 2, c-fos interacting0.057
Sh2b3SH2B adaptor protein 30.057
Fgfr1Fibroblast growth factor receptor 10.056
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.055
Hoxb8homeo box B80.055
Ptpn6protein tyrosine phosphatase, non-receptor type 60.054
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.054
Cdh17cadherin 170.054
Agtr1aangiotensin II receptor, type 1a0.052
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.051
Calcrcalcitonin receptor0.051
Trhrthyrotropin releasing hormone receptor0.051
Chrna7cholinergic receptor, nicotinic, alpha 70.051
Cd38CD38 molecule0.051
Oprk1opioid receptor, kappa 10.051
Mapk9mitogen-activated protein kinase 90.051
Tacr1tachykinin receptor 10.050
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.050
Flt1FMS-related tyrosine kinase 10.050
Phox2apaired-like homeobox 2a0.049
Shox2short stature homeobox 20.048
Nrp2neuropilin 20.048
Notch1Notch homolog 1, translocation-associated (Drosophila)0.048
Grm7glutamate receptor, metabotropic 70.047
Tgfb1transforming growth factor, beta 10.047
Atp2b3ATPase, Ca++ transporting, plasma membrane 30.046
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.046
Gabra5gamma-aminobutyric acid (GABA) A receptor, alpha 50.046
Prkcdprotein kinase C, delta0.045
Slc7a12solute carrier family 7 (cationic amino acid transporter, y+ system), member 120.045
Metmet proto-oncogene0.045
Pla2g2cphospholipase A2, group IIC0.045
Gfra2GDNF family receptor alpha 20.045
Cx3cr1chemokine (C-X3-C motif) receptor 10.045
Slc5a7solute carrier family 5 (choline transporter), member 70.044
Cntn3contactin 3 (plasmacytoma associated)0.044
Foxj1forkhead box J10.043
Mmp10matrix metallopeptidase 100.043
Ghrlghrelin/obestatin prepropeptide0.043
Gpr45G protein-coupled receptor 450.043
Zfp382zinc finger protein 3820.043
Npy5rneuropeptide Y receptor Y50.042
Ccnd3cyclin D30.042
Slco2a1solute carrier organic anion transporter family, member 2a10.041
Sypl2synaptophysin-like 20.041
Dchs1dachsous 1 (Drosophila)0.041
Kcnf1potassium voltage-gated channel, subfamily F, member 10.041
Ptger2prostaglandin E receptor 2 (subtype EP2)0.041
CblCas-Br-M (murine) ecotropic retroviral transforming sequence0.041
Chrnb3cholinergic receptor, nicotinic, beta 30.040
Pdgfbplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.040
C5ar1complement component 5a receptor 10.040
Tgm1transglutaminase 1, K polypeptide0.040
Ciitaclass II, major histocompatibility complex, transactivator0.039
Creb1cAMP responsive element binding protein 10.039
Necab1N-terminal EF-hand calcium binding protein 10.039